MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo

Journal of Immunology

Volumn 175, Issue 4, 2005, Pages 2309-2316

  Kupfer, Tinalyn M ^a   Crawford, Megan L ^a   Pham, Kim ^a   Gill, Ronald G ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 23444442762     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.4.2309     Document Type: Article

References (47)

1. Sutherland, D. E., R. Sibley, X. Z. Xu, A. Michael, A. M. Srikanta, F. Taub, J. Najarian, and F. C. Goetz. 1984. Twin-to-twin pancreas transplantation: reversal and reenactment of the pathogenesis of type I diabetes. Trans. Assoc. Am. Physicians 97: 80-87.
2. Sutherland, D. E., F. C. Goetz, and R. K. Sibley. 1989. Recurrence of disease in pancreas transplants. Diabetes 38(Suppl. 1): 85-87.
3. Sibley, R. K., D. E. Sutherland, F. Goetz, and A. F. Michael. 1985. Recurrent diabetes mellitus in the pancreas iso- and allograft: a light and electron microscopic and immunohistochemical analysis of four cases. Lab. Invest. 53: 132-144.
4. Tyden, G., F. P. Reinholt, G. Sundkvist, and J. Bounder. 1996. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N. Engl. J. Med. 335: 860-863.
5. Stegall, M. D., K. J. Lafferty, I. Kam, and R. G. Gill. 1996. Evidence of recurrent autoimmunity in human allogeneic islet transplantation. Transplantation 61: 1272-1274.
6. Bosi, E., S. Braghi, P. Maffi, M. Scirpoli, F. Bertuzzi, G. Pozza, A. Secchi, and B. E. 2001. Autoantibody response to islet transplantation in type 1 diabetes. Diabetes 50: 2464-2471.
7. Koike, T., Y. Itoh, T. Ishii, I. Ito, K. Takabayashi, N. Maruyama, H. Tomioka, and S. Yoshida. 1987. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes 36: 539-541.
8. Shizuru, J. A., C. Taylor-Edwards, B. A. Banks, A. K. Gregory, and C. G. Fathman. 1988. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 240: 659-662.
9. Hayward, A. R., M. Shriber, A. Cooke, and H. Waldmann. 1993. Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4. J. Autoimmun. 6: 301-310.
10. + T cells in the initiation of insulin-dependent diabetes mellitus. Eur. J. Immunol. 26: 1762-1769.
11. + T cells in β cell destruction. J. Autoimmun. 3(Suppl. 1): 101-109.
12. Charlton, B., A. Bacelj, and T. E. Mandel. 1988. Administration of silica particles or anti-Lyt2 antibody prevents β-cell destruction in NOD mice given cyclophosphamide. Diabetes 37: 930-935.
13. Daniel, D., R. G. Gill, N. Schloot, and D. Wegmann. 1995. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25: 1056-1062.
14. Peterson, J. D., and K. Haskins. 1996. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones: differential requirement for CD8 T-cells. Diabetes 45: 328-336.
15. Pakala, S. V., M. Chivetta, C. B. Kelly, and J. D. Katz. 1999. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor α. J. Exp. Med. 189: 1053-1062.
16. Wong, F. S., I. Visintin, L. Wen, R. A. Flavell, and C. A. Janeway, Jr. 1996. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183: 67-76.
17. + T-cell clones in vivo. Diabetes 45: 1121-1131.
18. Graser, R. T., T. P. DiLorenzo, F. Wang, G. J. Christianson, H. D. Chapman, D. C. Roopenian, S. G. Nathenson, and D. V. Serreze. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J. Immunol. 164: 3913-3918.
19. + T cell in allograft rejection. J. Immunol. 139: 4022-4026.
20. + T cells are both necessary and sufficient for islet xenograft rejection. Transplant. Proc. 26: 1203.
21. + T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc. Natl. Acad. Sci. USA 88: 527-531.
22. Makhlouf, L., K. Kishimoto, R. N. Smith, R. Abdi, M. Koulmanda, H. J. Winn, H. Auchincloss, Jr., and M. H. Sayegh. 2002. The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade. Diabetes 51: 3202-3210.
23. Naji, A., D. Bellgrau, A. Anderson, W. K. Silvers, and C. F. Barker. 1982. Transplantation of islets and bone marrow cells to animals with immune insulitis. Diabetes 31(Suppl. 4): 84-91.
24. Lafferty, K. J., H. S. Warren, J. A. Woolnough, and D. W. Talmage. 1978. Immunological induction of T lymphocytes: role of antigen and the lymphocyte costimulator. Blood Cells 4: 395-406.
25. Gould, D. S., and H. Auchincloss, Jr. 1999. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol. Today 20: 77-82.
26. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089-1100.
27. Gotoh, M., T. Maki, T. Kiyoizumi, S. Satomi, and A. P. Monaco. 1985. An improved method for isolation of mouse pancreatic islets. Transplantation 40: 437-438.
28. Chang, C. H., S. Guerder, S. C. Hong, W. van Ewijk, and R. A. Flavell. 1996. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity 4: 167-178.
29. Chang, C. H., J. D. Fontes, M. Peterlin, and R. A. Flavell. 1994. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180: 1367-1374.
30. Young, H. Y., P. Zucker, R. A. Flavell, A. M. Jevnikar, and B. Singh. 2004. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation 78: 509-515.
31. Haskins, K., M. Portas, B. Bergman, K. Lafferty, and B. Bradley. 1989. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 86: 8000-8004.
32. Bergman, B., and K. Haskins. 1994. Islet-specific T-cell clones from the NOD mouse respond to β-granule antigen. Diabetes 43: 197-203.
33. Kurrer, M. O., S. V. Pakala, H. L. Hanson, and J. D. Katz. 1997. β cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94: 213-218.
34. Haskins, K., M. Portas, B. Bradley, D. Wegmann, and K. Lafferty. 1988. T-lymphocyte clone specific for pancreatic islet antigen. Diabetes 37: 1444-1448.
35. Crawford, M., D. Daniel, D. Wegmann, H. Yang, and R. G. Gill. 1997. Autoimmune islet damage mediated by insulin-specific T cells. Transplant Proc. 29: 758-759.
36. + T cells in major histocompatibility complex class II-deficient mice. Science 253: 1417-1420.
37. Sarukhan, A., O. Lechner, and H. von Boehmer. 1999. Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet β-cells. Eur. J. Immunol. 29: 3410-3416.
38. Auchincloss, H., Jr. 1988. Xenogeneic transplantation: a review. Transplantation 46: 1-20.
39. Mandrup-Poulsen, T., S. Helqvist, L. D. Wogensen, J. Molvig, F. Pociot, J. Johannesen, and J. Nerup. 1990. Cytokine and free radicals as effector molecules in the destruction of pancreatic β cells. Curr. Top. Microbiol. Immunol. 164: 169-193.
40. Eizirik, D. L., and T. Mandrup-Poulsen. 2001. A choice of death: the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44: 2115-2133.
41. Heitmeier, M. R., M. Amush, A. L. Scarim, and J. A. Corbett. 2001. Pancreatic β-cell damage mediated by β-cell production of interleukin-1: a novel mechanism for virus-induced diabetes. J. Biol. Chem. 276: 11151-11158.
42. Sumoski, W., H. Baquerizo, and A. Rabinovitch. 1989. Oxygen free radical scavengers protect rat islet cells from damage by cytokines. Diabetologia 32: 792-796.
43. Kolb, H., and V. Kolb-Bachofen. 1992. Nitric oxide: a pathogenetic factor in autoimmunity. Immunol. Today 13: 157-160.
44. Rabinovitch, A., and W. L. Suarez-Pinzon. 1998. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus. Biochem. Pharmacol. 55: 1139-1149.
45. Nomikos, I. N., S. J. Prowse, P. Carotenuto, and K. J. Lafferty. 1986. Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice. Diabetes 35: 1302-1304.
46. 2 radicals in 'autoimmune' diabetes. Immunol. Cell Biol. 67(Pt. 1): 85-87.
47. Piganelli, J. D., S. C. Flores, C. Cruz, J. Koepp, I. Batinic-Haberle, J. Crapo, B. Day, R. Kachadourian, R. Young, B. Bradley, and K. Haskins. 2002. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 51: 347-355.