Homeostatic T cell proliferation: How far can T cells be activated to self-ligands?

Journal of Experimental Medicine

Volumn 192, Issue 4, 2000, Pages

  Surh, Charles D ^a   Sprent, Jonathan ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE; T LYMPHOCYTE RECEPTOR;

CELL SURVIVAL; HOMEOSTASIS; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MEMORY CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0034698825     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.4.F9     Document Type: Note

References (47)

1. Positive selection of thymocytes
2. Intrathymic and extrathymic clonal deletion of T cells
3. Selecting and maintaining a diverse T-cell repertoire
4. + T cells but affect their long-term life span
5. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells
6. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
7. Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses
8. Differential requirements for survival and proliferation of CD8 naive or memory T cells
9. + thymic emigrants
10. Persistence of memory CD8 T cells in MHC class I-deficient mice
11. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival
12. Lymphocyte lifespan: Homeostasis, selection and competition
13. The peripheral T-cell pool: Regulation by non-antigen induced proliferation?
14. Restoration of T-cell homeostasis after T-cell depletion
15. Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
16. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
17. Lymphocyte homeostasis
18. The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells
19. Peripheral T lymphocytes: Expansion potential and homeostatic regulation of pool sizes and CD4/8 ratios in vivo
20. TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host
21. Naive cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?
22. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide: Self-MHC complex recognition
23. + T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection
24. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
25. + T cells in lymphopenic hosts
26. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands
27. Mature CD4+ T cells perceive a positively selecting class II MHC/peptide complex in the periphery
28. Antigen presentation and T cell development in H2-M-deficient mice
29. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
30. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
31. Peripheral selection of the T cell repertoire
32. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation
33. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells
34. Naive T cells masquerading as memory cells
35. Interconversion of CD45R subsets of CD4 T cells in vivo
36. Following the development of a CD4 T cell response in vivo: From activation to memory formation
37. Class II-independent generation of CD4 memory T cells from effectors
38. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15
39. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
40. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
41. Control of homeostasis of CD8+ memory T cells by opposing cytokines
42. + T cells throughout life, from newborns to centenarians: Implications for T cell memory
43. The aging immune system: Primer and prospectus
44. Lymphocyte life-span and memory
45. Function and specificity of T-cell subsets in the mouse
46. Liver regeneration
47. Size control: The regulation of cell numbers in animal development