T cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients

Transplantation

Volumn 74, Issue 10, 2002, Pages 1454-1460

  Bagley, Jessamyn ^a   Tian, Chaorui ^a   Sachs, David H ^a   Iacomini, John ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; GENE THERAPY; IRRADIATION; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; SKIN GRAFT; SURVIVAL; T LYMPHOCYTE;

EID: 0036851361     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200211270-00019     Document Type: Article

References (25)

1. Sykes M. Mixed chimerism and transplant tolerance. Immunity 2001;14: 417-424.
2. Bagley J, Bracy J, Tian C, et al. Establishing immunological tolerance through the induction of molecular chimerism. Front Biosci 2002;7:1331-1337.
3. Bagley J, Tian C, Sachs DH, et al. Induction of T cell tolerance to a MHC class I alloantigen by gene therapy. Blood 2002 99:4394-4399.
4. Bracy JL, Iacomini J. Induction of B cell tolerance by retroviral gene therapy. Blood 2000;96:3008-3015.
5. Matzinger P, Bevan MJ. Why do so many lymphocytes respond to major histocompatibility complex antigens? Cell Immunol 1977;29:1-5.
6. Riviere I, Brose K, Mulligan RC. Effects of retroviral vector design on expression of human adenosine deaminase in murine marrow transplant recipients engrafted with genetically modified cells. Proc Natl Acad Sci U S A 1998;92:6733-6737.
7. Finer MH, Dull TJ, Qin L, et al. Kat: A high-efficiency retroviral transduction system for primary human T lymphocytes. Blood 1994;83:43-50.
8. Ory DS, Neugeboren BA, Mulligan RC. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A 1996;93:11400-11406.
9. Sarmiento M, Glasebrook AL, Fitch FW. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol 1980;125:2665-2672.
10. Dialynas DP, Quan ZS, Wall KA, et al. Characterization of the murine T cell surface molecule designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu 3/T4 molecule. J Immunol 1984;131:2445-2451.
11. Crawford F, Kozono H, White J, et al. Detection of antigen specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 1998;8:675-682.
12. Sawada T, Wu Y, Sachs DH, et al. CD4+ T cells are able to reject class I disparate allografts. Transplantation 1997;64:335-340.
13. Bagley J, Aboody-Guterman K, Breakefield X, et al. Long-term expression of the gene encoding green fluorescent protein in murine hematopoietic cells using retroviral gene transfer. Transplantation 1998;65:1233-1240.
14. Foy TM, Aruffo A, Bajorath J, et al. Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol 1996;14:591-617.
15. Noelle RJ, Roy M, Shepherd DM, et al. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci U S A 1992;89:6550-6554.
16. Wekerle T, Sayegh MH, Ito H, et al. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation 1999;68:1348-1355.
17. Wekerle T, Kurtz J, Ito H, et al. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med 2000;6:464-469.
18. Wekerle T, Sayegh MH, Hill J, et al. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med 1998;187:2037-2044.
19. Foy TM, Shepherd DM, Durie FH, et al. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity, II: Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J Exp Med 1993;178:1567-1575.
20. Hollenbaugh D, Ochs HD, Noelle RJ, et al. The role of CD40 and its ligand in the regulation of the immune response. Immunol Rev 1994;138:23-37.
21. Foy TM, Durie FH, Noelle RJ. The expansive role of CD40 and its ligand, gp39, in immunity. Semin Immunol 1994;6:259-266.
22. Markees TG, Phillips NE, Noelle RJ, et al. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation 1997;64:329-335.
23. Sachs DH, Arn JS, Hansen TH. Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles. J Immunol 1979;123:1965-1969.
24. Wekerle T, Sykes M. Mixed chimerism and transplantation tolerance. Annu Rev Med 2001;52:353-370.
25. Kuzmin AI, Galenko O, Eisensmith RC. An immunomodulatory procedure that stabilizes transgene expression and permits readministration of E1-deleted adenovirus vectors. Mol Ther 2001;3:293-301.