메뉴 건너뛰기




Volumn 85, Issue 8, 2007, Pages 582-589

The vicious cycle of apoptotic β-cell death in type 1 diabetes

Author keywords

Autoimmune insulitis; B cell apoptosis; Cytokines; Pathophysiology; Type 1 diabetes

Indexed keywords

CHEMOKINE; CYTOKINE;

EID: 36849089218     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/sj.icb.7100093     Document Type: Review
Times cited : (35)

References (137)
  • 2
  • 3
    • 33744972068 scopus 로고    scopus 로고
    • Does physiological β cell turnover initiate autoimmune diabetes in the regional lymph nodes?
    • Pearl-Yafe M, Iskovich S, Kaminitz A, Stein J, Yaniv I, Askenasy N. Does physiological β cell turnover initiate autoimmune diabetes in the regional lymph nodes? Autoim Rev 2006; 5: 338-343.
    • (2006) Autoim Rev , vol.5 , pp. 338-343
    • Pearl-Yafe, M.1    Iskovich, S.2    Kaminitz, A.3    Stein, J.4    Yaniv, I.5    Askenasy, N.6
  • 6
    • 0033579877 scopus 로고    scopus 로고
    • The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • Jun HS, Yoon CS, Zbytnuik L, van Rooijen N, Yoon JW. The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Exp Med 1999; 189: 347-358.
    • (1999) J Exp Med , vol.189 , pp. 347-358
    • Jun, H.S.1    Yoon, C.S.2    Zbytnuik, L.3    van Rooijen, N.4    Yoon, J.W.5
  • 7
    • 22144450700 scopus 로고    scopus 로고
    • Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes
    • Cvetkovic I, Al-Abed Y, Miljkovic D, Maksimovic-Ivanic D, Roth J, Bacher M et al. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology 2005; 146: 2942-2951.
    • (2005) Endocrinology , vol.146 , pp. 2942-2951
    • Cvetkovic, I.1    Al-Abed, Y.2    Miljkovic, D.3    Maksimovic-Ivanic, D.4    Roth, J.5    Bacher, M.6
  • 8
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin-dependent diabetes
    • Katz JD, Benoist C, Mathis D. T helper cell subsets in insulin-dependent diabetes. Science 1995; 268: 1185-1188.
    • (1995) Science , vol.268 , pp. 1185-1188
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 9
    • 28744452210 scopus 로고    scopus 로고
    • Antigen-specific induction of regulatory T cells for type 1 diabetes therapy
    • Filippi C, Bresson D, Herrath M. Antigen-specific induction of regulatory T cells for type 1 diabetes therapy. Int Rev Immunol 2005; 24: 341-360.
    • (2005) Int Rev Immunol , vol.24 , pp. 341-360
    • Filippi, C.1    Bresson, D.2    Herrath, M.3
  • 10
    • 28744436698 scopus 로고    scopus 로고
    • Immunotherapy for the prevention and treatment of type 1 diabetes
    • Goudy KS, Tisch R. Immunotherapy for the prevention and treatment of type 1 diabetes. Int Rev Immunol 2005; 24: 307-326.
    • (2005) Int Rev Immunol , vol.24 , pp. 307-326
    • Goudy, K.S.1    Tisch, R.2
  • 11
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74: 1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 12
    • 0033579875 scopus 로고    scopus 로고
    • Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
    • Hoglund P, Mintern J, Waltzinger C, Heath W, Benoist C, Mathis D. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med 1999; 189: 331-339.
    • (1999) J Exp Med , vol.189 , pp. 331-339
    • Hoglund, P.1    Mintern, J.2    Waltzinger, C.3    Heath, W.4    Benoist, C.5    Mathis, D.6
  • 13
    • 0037025990 scopus 로고    scopus 로고
    • Pancreatic lymph nodes are required for priming of β cell reactive T cells in NOD mice
    • Gagnerault MC, Luan JJ, Lotton C, Lepault F. Pancreatic lymph nodes are required for priming of β cell reactive T cells in NOD mice. J Exp Med 2002; 196: 369-377.
    • (2002) J Exp Med , vol.196 , pp. 369-377
    • Gagnerault, M.C.1    Luan, J.J.2    Lotton, C.3    Lepault, F.4
  • 14
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005; 435: 224-228.
    • (2005) Nature , vol.435 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6
  • 15
    • 0037047063 scopus 로고    scopus 로고
    • Restricted islet-cell reactive T cell repetoire of early pancreatic islet infiltrates in NOD mice
    • Baker F, Lee M, Chien Y, Davis M. Restricted islet-cell reactive T cell repetoire of early pancreatic islet infiltrates in NOD mice. Proc Natl Acad Sci USA 2002; 99: 9374-9379.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9374-9379
    • Baker, F.1    Lee, M.2    Chien, Y.3    Davis, M.4
  • 17
    • 0031025574 scopus 로고    scopus 로고
    • Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
    • French MB, Allison J, Cram DS, Thomas HE, Dempsey-Collier M, Silva A et al Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 1997; 46: 34-39.
    • (1997) Diabetes , vol.46 , pp. 34-39
    • French, M.B.1    Allison, J.2    Cram, D.S.3    Thomas, H.E.4    Dempsey-Collier, M.5    Silva, A.6
  • 18
    • 0242486680 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells
    • Mukherjee R, Chaturvedi P, Qin HY, Singh B. CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells. J Autoimmun 2003; 21: 221-237.
    • (2003) J Autoimmun , vol.21 , pp. 221-237
    • Mukherjee, R.1    Chaturvedi, P.2    Qin, H.Y.3    Singh, B.4
  • 19
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D et al Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005; 435: 220-223.
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3    Babaya, N.4    Liu, E.5    Miao, D.6
  • 20
    • 2442567829 scopus 로고    scopus 로고
    • Back to central tolerance
    • Mathis D, Benoist C. Back to central tolerance. Immunity 2004; 20: 509-516.
    • (2004) Immunity , vol.20 , pp. 509-516
    • Mathis, D.1    Benoist, C.2
  • 21
    • 28544431941 scopus 로고    scopus 로고
    • Immunology: Insulin auto-antigenicity in type 1 diabetes
    • Wilson DB. Immunology: Insulin auto-antigenicity in type 1 diabetes. Nature 2005; 438: E5-E6.
    • (2005) Nature , vol.438
    • Wilson, D.B.1
  • 22
    • 5444222000 scopus 로고    scopus 로고
    • Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
    • Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol 2004; 5: 1028-1035.
    • (2004) Nat Immunol , vol.5 , pp. 1028-1035
    • Jaeckel, E.1    Lipes, M.A.2    von Boehmer, H.3
  • 23
    • 0038621437 scopus 로고    scopus 로고
    • Gene- and cell-based therapeutics for type I diabetes mellitus
    • Bottino R, Lemarchand P, Trucco M, Giannoukakis N. Gene- and cell-based therapeutics for type I diabetes mellitus. Gene Ther 2003; 10: 875-889.
    • (2003) Gene Ther , vol.10 , pp. 875-889
    • Bottino, R.1    Lemarchand, P.2    Trucco, M.3    Giannoukakis, N.4
  • 24
    • 33644559971 scopus 로고    scopus 로고
    • The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation
    • Pearl-Yafe M, Yolcu ES, Yaniv I, Stein J, Shirwan H, Askenasy N. The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation. BioEssays 2006; 28: 211-222.
    • (2006) BioEssays , vol.28 , pp. 211-222
    • Pearl-Yafe, M.1    Yolcu, E.S.2    Yaniv, I.3    Stein, J.4    Shirwan, H.5    Askenasy, N.6
  • 25
    • 0027979956 scopus 로고
    • Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant
    • Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 1994; 43: 505-509.
    • (1994) Diabetes , vol.43 , pp. 505-509
    • Serreze, D.V.1    Leiter, E.H.2    Christianson, G.J.3    Greiner, D.4    Roopenian, D.C.5
  • 26
    • 13344294394 scopus 로고    scopus 로고
    • CD8T cell clones from young NOD islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4T cells
    • Wong FS, Visintin I, Wen L, Flavell R, Janeway Jr CA. CD8T cell clones from young NOD islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4T cells. J Exp Med 1996; 183: 67-76.
    • (1996) J Exp Med , vol.183 , pp. 67-76
    • Wong, F.S.1    Visintin, I.2    Wen, L.3    Flavell, R.4    Janeway Jr, C.A.5
  • 27
    • 0031968921 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells
    • Yoon JW, Jun HS, Santamaria P. Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 1998; 27: 109-122.
    • (1998) Autoimmunity , vol.27 , pp. 109-122
    • Yoon, J.W.1    Jun, H.S.2    Santamaria, P.3
  • 28
    • 0032521025 scopus 로고    scopus 로고
    • Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes
    • Arnush M, Scarim AL, Heitmeier MR, Kelly CB, Corbett JA. Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J Immunol 1998; 160: 2684-2691.
    • (1998) J Immunol , vol.160 , pp. 2684-2691
    • Arnush, M.1    Scarim, A.L.2    Heitmeier, M.R.3    Kelly, C.B.4    Corbett, J.A.5
  • 29
    • 0033960945 scopus 로고    scopus 로고
    • Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage
    • Zumsteg U, Frigerio S, Hollander GA. Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage. Diabetes 2000; 49: 39-47.
    • (2000) Diabetes , vol.49 , pp. 39-47
    • Zumsteg, U.1    Frigerio, S.2    Hollander, G.A.3
  • 30
    • 16044371193 scopus 로고    scopus 로고
    • CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
    • Lenschow DJ, Herold KC, Rhee L, Patel B, Kooms A, Qin HY et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 1996; 5: 285-293.
    • (1996) Immunity , vol.5 , pp. 285-293
    • Lenschow, D.J.1    Herold, K.C.2    Rhee, L.3    Patel, B.4    Kooms, A.5    Qin, H.Y.6
  • 31
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12: 431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6
  • 32
    • 0029773865 scopus 로고    scopus 로고
    • Diabetogenic T-cell clones
    • Haskins K, Wegmann D. Diabetogenic T-cell clones. Diabetes 1996; 45: 1299-1305.
    • (1996) Diabetes , vol.45 , pp. 1299-1305
    • Haskins, K.1    Wegmann, D.2
  • 34
    • 0032701409 scopus 로고    scopus 로고
    • The role of CD4 vs CD8T cells in IDDM
    • Wong FS, Janeway Jr CA. The role of CD4 vs CD8T cells in IDDM. J Autoimmun 1999; 13: 290-295.
    • (1999) J Autoimmun , vol.13 , pp. 290-295
    • Wong, F.S.1    Janeway Jr, C.A.2
  • 35
    • 0033858841 scopus 로고    scopus 로고
    • Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse
    • Thomas HE, Kay TWH. Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse. Diabetes Metab Res Rev 2000; 16: 251-261.
    • (2000) Diabetes Metab Res Rev , vol.16 , pp. 251-261
    • Thomas, H.E.1    Kay, T.W.H.2
  • 39
    • 0033011514 scopus 로고    scopus 로고
    • Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFNgamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice
    • Shinomiya M, Fazle Akbar SM, Shinomiya H, Shinomiya H, Onji M. Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFNgamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol 1999; 117: 38-43.
    • (1999) Clin Exp Immunol , vol.117 , pp. 38-43
    • Shinomiya, M.1    Fazle Akbar, S.M.2    Shinomiya, H.3    Shinomiya, H.4    Onji, M.5
  • 40
    • 0034655834 scopus 로고    scopus 로고
    • A dendritic cell line genetically modified to express CTLA4-Ig as a means to prolong islet allograft survival
    • O'Rourke RW, Kang SM, Lower JA, Feng S, Ascher NL, Baekkeskov S et al. A dendritic cell line genetically modified to express CTLA4-Ig as a means to prolong islet allograft survival. Transplantation 2000; 69: 1440-1446.
    • (2000) Transplantation , vol.69 , pp. 1440-1446
    • O'Rourke, R.W.1    Kang, S.M.2    Lower, J.A.3    Feng, S.4    Ascher, N.L.5    Baekkeskov, S.6
  • 41
    • 0036700932 scopus 로고    scopus 로고
    • Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities
    • Marleau AM, Singh B. Myeloid dendritic cells in non-obese diabetic mice have elevated costimulatory and T helper-1-inducing abilities. J Autoimmun 2002; 19: 23-35.
    • (2002) J Autoimmun , vol.19 , pp. 23-35
    • Marleau, A.M.1    Singh, B.2
  • 42
    • 0037248946 scopus 로고    scopus 로고
    • Dendritic cells transduced to express IL-4 prevent diabetes in nonobese diabetes with advanced insulitis
    • Feili-Hariri M, Falkner D, Gambotto A, Papworth GD, Watkins SC, Robbins PD et al. Dendritic cells transduced to express IL-4 prevent diabetes in nonobese diabetes with advanced insulitis. Hum Gene Ther 2003; 14: 13-23.
    • (2003) Hum Gene Ther , vol.14 , pp. 13-23
    • Feili-Hariri, M.1    Falkner, D.2    Gambotto, A.3    Papworth, G.D.4    Watkins, S.C.5    Robbins, P.D.6
  • 44
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TIM. Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes. Diabetes 2005; 54: 92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.M.6
  • 48
    • 0027443570 scopus 로고
    • Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: Defective regulation of cytokine receptors and protein kinase C
    • Serreze D, Gaedeke J, Leiter E. Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C. Proc Natl Acad Sci USA 1993; 90: 9625-9629.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9625-9629
    • Serreze, D.1    Gaedeke, J.2    Leiter, E.3
  • 49
    • 0037441994 scopus 로고    scopus 로고
    • NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages
    • Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M et al. NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol 2003; 170: 1770-1780.
    • (2003) J Immunol , vol.170 , pp. 1770-1780
    • Sen, P.1    Bhattacharyya, S.2    Wallet, M.3    Wong, C.P.4    Poligone, B.5    Sen, M.6
  • 50
    • 0035424898 scopus 로고    scopus 로고
    • Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase
    • Weaver Jr DJ, Poligone B, Bui T, Abdel-Motal UM, Baldwin Jr AS, Tisch R. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase. J Immunol 2001; 167: 1461-1468.
    • (2001) J Immunol , vol.167 , pp. 1461-1468
    • Weaver Jr, D.J.1    Poligone, B.2    Bui, T.3    Abdel-Motal, U.M.4    Baldwin Jr, A.S.5    Tisch, R.6
  • 51
    • 0036006693 scopus 로고    scopus 로고
    • Elevated NF, kappa}B activation in nonobese diabetic mouse dendritic cells results in enhanced APC function
    • Poligone B, Weaver DJ, Sen P, Baldwin AS, Tisch R. Elevated NF-{kappa}B activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol 2002; 168: 188-196.
    • (2002) J Immunol , vol.168 , pp. 188-196
    • Poligone, B.1    Weaver, D.J.2    Sen, P.3    Baldwin, A.S.4    Tisch, R.5
  • 52
    • 0032826041 scopus 로고    scopus 로고
    • Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus
    • Kreuwel HT, Morgan DJ, Krahl T, Ko A, Sarvetnick N, Sherman LA. Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus. J Immunol 1999; 163: 4335-4341.
    • (1999) J Immunol , vol.163 , pp. 4335-4341
    • Kreuwel, H.T.1    Morgan, D.J.2    Krahl, T.3    Ko, A.4    Sarvetnick, N.5    Sherman, L.A.6
  • 53
    • 0141993915 scopus 로고    scopus 로고
    • Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes
    • Apostolou I, Hao Z, Rajewsky K, von Boehmer H. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 2003; 198: 1103-1106.
    • (2003) J Exp Med , vol.198 , pp. 1103-1106
    • Apostolou, I.1    Hao, Z.2    Rajewsky, K.3    von Boehmer, H.4
  • 54
    • 0033561630 scopus 로고    scopus 로고
    • TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
    • Kagi D, Ho A, Odermatt B, Zakarian A, Ohashi PS, Mak TW. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J Immunol 2003; 162: 4598-4605.
    • (2003) J Immunol , vol.162 , pp. 4598-4605
    • Kagi, D.1    Ho, A.2    Odermatt, B.3    Zakarian, A.4    Ohashi, P.S.5    Mak, T.W.6
  • 56
    • 0030800122 scopus 로고    scopus 로고
    • Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
    • Itoh N, Imagawa A, Hanafusa T, Waguri M, Yamamoto K, Iwahashi H et al. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med 1997; 186: 613-618.
    • (1997) J Exp Med , vol.186 , pp. 613-618
    • Itoh, N.1    Imagawa, A.2    Hanafusa, T.3    Waguri, M.4    Yamamoto, K.5    Iwahashi, H.6
  • 57
    • 1842289172 scopus 로고    scopus 로고
    • Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
    • Kagi D, Odermatt B, Seiler P, Zinkernagel RM, Mak TW, Hengartner H. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J Exp Med 1997; 186: 989-997.
    • (1997) J Exp Med , vol.186 , pp. 989-997
    • Kagi, D.1    Odermatt, B.2    Seiler, P.3    Zinkernagel, R.M.4    Mak, T.W.5    Hengartner, H.6
  • 58
    • 0032506224 scopus 로고    scopus 로고
    • Mechanisms of β cell death in diabetes: A minor role for CD95
    • Allison J, Strasser A. Mechanisms of β cell death in diabetes: a minor role for CD95. Proc Natl Acad Sci USA 1998; 95: 13818-13822.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13818-13822
    • Allison, J.1    Strasser, A.2
  • 59
    • 0033560930 scopus 로고    scopus 로고
    • Perforinin-dependent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice
    • Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P. Perforinin-dependent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 1999; 103: 1201-1209.
    • (1999) J Clin Invest , vol.103 , pp. 1201-1209
    • Amrani, A.1    Verdaguer, J.2    Anderson, B.3    Utsugi, T.4    Bou, S.5    Santamaria, P.6
  • 60
    • 0032932324 scopus 로고    scopus 로고
    • Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets
    • Suarez-Pinzon W, Sorensen O, Bleackley RC, Elliott JF, Rajotte RV, Rabinovitch A. Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets. Diabetes 1999; 48: 21-28.
    • (1999) Diabetes , vol.48 , pp. 21-28
    • Suarez-Pinzon, W.1    Sorensen, O.2    Bleackley, R.C.3    Elliott, J.F.4    Rajotte, R.V.5    Rabinovitch, A.6
  • 61
    • 0033621893 scopus 로고    scopus 로고
    • IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes
    • Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P. IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes. J Clin Invest 2000; 105: 459-468.
    • (2000) J Clin Invest , vol.105 , pp. 459-468
    • Amrani, A.1    Verdaguer, J.2    Thiessen, S.3    Bou, S.4    Santamaria, P.5
  • 62
    • 0034602775 scopus 로고    scopus 로고
    • A mouse CD8T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: Possible role of membrane TNF
    • Herrera PL, Harlan DM, Vassalli P. A mouse CD8T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF. Proc Natl Acad Sci USA 2000; 97: 279-284.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 279-284
    • Herrera, P.L.1    Harlan, D.M.2    Vassalli, P.3
  • 63
    • 0034162513 scopus 로고    scopus 로고
    • Significant role for Fas in the pathogenesis of autoimmune diabetes
    • Su X, Hu Q, Kristan JM, Costa C, Shen Y, Gero D et al. Significant role for Fas in the pathogenesis of autoimmune diabetes. J Immunol 2000; 164: 2523-2532.
    • (2000) J Immunol , vol.164 , pp. 2523-2532
    • Su, X.1    Hu, Q.2    Kristan, J.M.3    Costa, C.4    Shen, Y.5    Gero, D.6
  • 64
    • 0033816201 scopus 로고    scopus 로고
    • Fas ligand-mediated mechanisms are involved in autoimmune destruction of islet β cells in non-obese diabetic mice
    • Suarez-Pinzon WL, Power RF, Rabinovitch A. Fas ligand-mediated mechanisms are involved in autoimmune destruction of islet β cells in non-obese diabetic mice. Diabetologia 2000; 43: 1149-1156.
    • (2000) Diabetologia , vol.43 , pp. 1149-1156
    • Suarez-Pinzon, W.L.1    Power, R.F.2    Rabinovitch, A.3
  • 65
    • 7044235585 scopus 로고    scopus 로고
    • Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet β-cell reactive T-cells
    • Vence L, Benoist C, Mathis D. Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet β-cell reactive T-cells. Diabetes 2004; 53: 2797-2803.
    • (2004) Diabetes , vol.53 , pp. 2797-2803
    • Vence, L.1    Benoist, C.2    Mathis, D.3
  • 66
    • 0034653419 scopus 로고    scopus 로고
    • Inhibition of autoimmune diabetes by Fas ligand: The paradox is solved
    • Kim S, Kim KA, Hwang DY, Lee TH, Kayagaki N, Yagita H et al. Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved. J Immunol 2000; 164: 2931-2936.
    • (2000) J Immunol , vol.164 , pp. 2931-2936
    • Kim, S.1    Kim, K.A.2    Hwang, D.Y.3    Lee, T.H.4    Kayagaki, N.5    Yagita, H.6
  • 67
    • 0027990811 scopus 로고    scopus 로고
    • Yang X, Tisch R, Singer SM, Cao ZA, Liblau RS, Schreiber RD et al. Effect of tumor necrosis factor {alpha} on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med 2004; 180: 995-1004.
    • Yang X, Tisch R, Singer SM, Cao ZA, Liblau RS, Schreiber RD et al. Effect of tumor necrosis factor {alpha} on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med 2004; 180: 995-1004.
  • 68
    • 13544277369 scopus 로고    scopus 로고
    • Induction of tolerance using Fas ligand: A double-edged immunomodulator
    • Askenasy N, Yolcu ES, Yaniv I, Shirwan H. Induction of tolerance using Fas ligand: a double-edged immunomodulator. Blood 2005; 105: 1396-1404.
    • (2005) Blood , vol.105 , pp. 1396-1404
    • Askenasy, N.1    Yolcu, E.S.2    Yaniv, I.3    Shirwan, H.4
  • 69
    • 0032214715 scopus 로고    scopus 로고
    • Local expression of TNFa in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
    • Green EA, Eynon EE, Flavell RA. Local expression of TNFa in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 1998; 9: 733-743.
    • (1998) Immunity , vol.9 , pp. 733-743
    • Green, E.A.1    Eynon, E.E.2    Flavell, R.A.3
  • 70
    • 0036268641 scopus 로고    scopus 로고
    • Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing
    • Christen U, Von Herrath MG. Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing. Ann NY Acad Sci 2002; 958: 166-169.
    • (2002) Ann NY Acad Sci , vol.958 , pp. 166-169
    • Christen, U.1    Von Herrath, M.G.2
  • 71
    • 0030972396 scopus 로고    scopus 로고
    • Allison J, Georgiou HM, Strasser A, Vaux DL. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci USA 1997; 94: 3943-3947.
    • Allison J, Georgiou HM, Strasser A, Vaux DL. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci USA 1997; 94: 3943-3947.
  • 72
    • 0030842535 scopus 로고    scopus 로고
    • Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
    • Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG et al. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med 1997; 3: 738-743.
    • (1997) Nat Med , vol.3 , pp. 738-743
    • Kang, S.M.1    Schneider, D.B.2    Lin, Z.3    Hanahan, D.4    Dichek, D.A.5    Stock, P.G.6
  • 73
    • 0037988807 scopus 로고    scopus 로고
    • Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene
    • Silva DG, Petrovsky N, Socha L, Slattery R, Gatenby P, Charlton B. Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene. J Immunol 2003; 170: 4996-5002.
    • (2003) J Immunol , vol.170 , pp. 4996-5002
    • Silva, D.G.1    Petrovsky, N.2    Socha, L.3    Slattery, R.4    Gatenby, P.5    Charlton, B.6
  • 74
    • 0036276370 scopus 로고    scopus 로고
    • The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice
    • Petrovsky N, Silva D, Socha L, Slattery R, Charlton B. The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice. Ann NY Acad Sci 2002; 958: 204-208.
    • (2002) Ann NY Acad Sci , vol.958 , pp. 204-208
    • Petrovsky, N.1    Silva, D.2    Socha, L.3    Slattery, R.4    Charlton, B.5
  • 75
    • 0029093781 scopus 로고
    • Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells
    • Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T, Nakamura M et al. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes 1995; 44: 733-738.
    • (1995) Diabetes , vol.44 , pp. 733-738
    • Kaneto, H.1    Fujii, J.2    Seo, H.G.3    Suzuki, K.4    Matsuoka, T.5    Nakamura, M.6
  • 77
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi G, De Maria R, Trucco G, Rudert W, Testi R, Galluzzo A et al. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 1997; 186: 1193-1200.
    • (1997) J Exp Med , vol.186 , pp. 1193-1200
    • Stassi, G.1    De Maria, R.2    Trucco, G.3    Rudert, W.4    Testi, R.5    Galluzzo, A.6
  • 78
    • 0035066941 scopus 로고    scopus 로고
    • The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM)
    • Kreuwel HT, Sherman LA. The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM). J Clin Immunol 2001; 21: 15-18.
    • (2001) J Clin Immunol , vol.21 , pp. 15-18
    • Kreuwel, H.T.1    Sherman, L.A.2
  • 79
    • 0042977338 scopus 로고    scopus 로고
    • Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct
    • Nicoletti F, Di Marco R, Papaccio G, Conget I, Gomis R, Bernardini R et al. Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct. Eur J Immunol 2003; 33: 2278-2286.
    • (2003) Eur J Immunol , vol.33 , pp. 2278-2286
    • Nicoletti, F.1    Di Marco, R.2    Papaccio, G.3    Conget, I.4    Gomis, R.5    Bernardini, R.6
  • 80
    • 0042839568 scopus 로고    scopus 로고
    • Role of cytokines in the pathogenesis of autoimmune diabetes mellitus
    • Rabinovitch A, Suarez-Pinzon WL. Role of cytokines in the pathogenesis of autoimmune diabetes mellitus. Rev Endocr Metab Disord 2003; 4: 291-299.
    • (2003) Rev Endocr Metab Disord , vol.4 , pp. 291-299
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 81
    • 0032055842 scopus 로고    scopus 로고
    • Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse
    • Dahlen E, Dawe K, Ohlsson L, Hedlund G. Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse. J Immunol 1998; 160: 3585-3593.
    • (1998) J Immunol , vol.160 , pp. 3585-3593
    • Dahlen, E.1    Dawe, K.2    Ohlsson, L.3    Hedlund, G.4
  • 82
  • 83
    • 0036913215 scopus 로고    scopus 로고
    • Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
    • Frigerio S, Junt T, Lu B, Gerard C, Zumsteg U, Hollander GA et al. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med 2002; 8: 1414-1420.
    • (2002) Nat Med , vol.8 , pp. 1414-1420
    • Frigerio, S.1    Junt, T.2    Lu, B.3    Gerard, C.4    Zumsteg, U.5    Hollander, G.A.6
  • 84
    • 1942539074 scopus 로고    scopus 로고
    • Fas and Fas ligand immunoexpression in pancreatic islets of NOD mice during spontaneous and cyclophosphamide-accelerated diabetes
    • Reddy S, Ross JM. Fas and Fas ligand immunoexpression in pancreatic islets of NOD mice during spontaneous and cyclophosphamide-accelerated diabetes. Ann NY Acad Sci 2003; 1005: 166-169.
    • (2003) Ann NY Acad Sci , vol.1005 , pp. 166-169
    • Reddy, S.1    Ross, J.M.2
  • 85
    • 0344457352 scopus 로고    scopus 로고
    • The role of CD8+ cells, cell degeneration, and Fas ligand in insulitis after intraperitoneal transfer of NOD splenocytes
    • Sainio-Pollanen S, Liukas A, Pollanen P, Simell O. The role of CD8+ cells, cell degeneration, and Fas ligand in insulitis after intraperitoneal transfer of NOD splenocytes. Pancreas 1999; 18: 282-293.
    • (1999) Pancreas , vol.18 , pp. 282-293
    • Sainio-Pollanen, S.1    Liukas, A.2    Pollanen, P.3    Simell, O.4
  • 88
    • 10744228165 scopus 로고    scopus 로고
    • Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    • Zheng XX, Sanchez-Fueyo A, Sho M, Domenig C, Sayegh MH, Strom TB. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 2003; 19: 503-514.
    • (2003) Immunity , vol.19 , pp. 503-514
    • Zheng, X.X.1    Sanchez-Fueyo, A.2    Sho, M.3    Domenig, C.4    Sayegh, M.H.5    Strom, T.B.6
  • 90
    • 0034456726 scopus 로고    scopus 로고
    • Prevention of spontaneous autoimmune diabetes in NOD mice by transferring in vitro antigenpulsed syngeneic dendritic cells
    • Papaccio G, Nicoletti F, Pisanti FA, Bendtzen K, Galdieri M. Prevention of spontaneous autoimmune diabetes in NOD mice by transferring in vitro antigenpulsed syngeneic dendritic cells. Endocrinology 2000; 141: 1500-1505.
    • (2000) Endocrinology , vol.141 , pp. 1500-1505
    • Papaccio, G.1    Nicoletti, F.2    Pisanti, F.A.3    Bendtzen, K.4    Galdieri, M.5
  • 91
    • 0035923675 scopus 로고    scopus 로고
    • Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets
    • Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y et al. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci USA 2001; 98: 13838-13843.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13838-13843
    • Naumov, Y.N.1    Bahjat, K.S.2    Gausling, R.3    Abraham, R.4    Exley, M.A.5    Koezuka, Y.6
  • 92
    • 0037987977 scopus 로고    scopus 로고
    • Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo
    • Wakkach A, Fournier N, Brun V, Breittmayer JP, Cottrez F, Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003; 18: 605-617.
    • (2003) Immunity , vol.18 , pp. 605-617
    • Wakkach, A.1    Fournier, N.2    Brun, V.3    Breittmayer, J.P.4    Cottrez, F.5    Groux, H.6
  • 93
    • 33644691658 scopus 로고    scopus 로고
    • On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes
    • Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y et al. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 2005; 54: 3395-3401.
    • (2005) Diabetes , vol.54 , pp. 3395-3401
    • Bruder, D.1    Westendorf, A.M.2    Hansen, W.3    Prettin, S.4    Gruber, A.D.5    Qian, Y.6
  • 95
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39: 1005-1029.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 96
    • 0031426764 scopus 로고    scopus 로고
    • Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM?
    • Eizirik DL, Pavlovic D. Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM? Diabetes Metab Rev 1997; 13: 293-307.
    • (1997) Diabetes Metab Rev , vol.13 , pp. 293-307
    • Eizirik, D.L.1    Pavlovic, D.2
  • 97
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44: 2115-2133.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 98
    • 0035123795 scopus 로고    scopus 로고
    • Distinction between interleukin-1-induced necrosis and apoptosis of islet cells
    • Hoorens A, Stange G, Pavlovic D, Pipeleers D. Distinction between interleukin-1-induced necrosis and apoptosis of islet cells. Diabetes 2001; 50: 551-557.
    • (2001) Diabetes , vol.50 , pp. 551-557
    • Hoorens, A.1    Stange, G.2    Pavlovic, D.3    Pipeleers, D.4
  • 99
    • 4744355191 scopus 로고    scopus 로고
    • Death effectors of beta-cell apoptosis in type 1 diabetes
    • Lee MS, Chang I, Kim S. Death effectors of beta-cell apoptosis in type 1 diabetes. Mol Genet Metab 2004; 83: 82-92.
    • (2004) Mol Genet Metab , vol.83 , pp. 82-92
    • Lee, M.S.1    Chang, I.2    Kim, S.3
  • 101
    • 0033949313 scopus 로고    scopus 로고
    • Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-)
    • Liu D, Pavlovic D, Chen MC, Flodstrom M, Sandler S, Eizirik DL. Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes 2000; 49: 1116-1122.
    • (2000) Diabetes , vol.49 , pp. 1116-1122
    • Liu, D.1    Pavlovic, D.2    Chen, M.C.3    Flodstrom, M.4    Sandler, S.5    Eizirik, D.L.6
  • 102
    • 0033561630 scopus 로고    scopus 로고
    • TNF receptor-1-dependent β cell toxicity as an effector pathway in autoimmune diabetes
    • Kagi D, Ho A, Odermatt B, Zakarian A, Ohashi PS, Mak TW. TNF receptor-1-dependent β cell toxicity as an effector pathway in autoimmune diabetes. J Immunol 1999; 162: 4598-4605.
    • (1999) J Immunol , vol.162 , pp. 4598-4605
    • Kagi, D.1    Ho, A.2    Odermatt, B.3    Zakarian, A.4    Ohashi, P.S.5    Mak, T.W.6
  • 103
    • 0025735450 scopus 로고
    • Macrophage cytotoxicity towards isolated rat islet cells: Neither lysis nor its protection by nicotinamide are beta-cell specific
    • Kroncke KD, Funda J, Berschick B, Kolb H, Kolb-Bachofen V. Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are beta-cell specific. Diabetologia 1991; 34: 232-238.
    • (1991) Diabetologia , vol.34 , pp. 232-238
    • Kroncke, K.D.1    Funda, J.2    Berschick, B.3    Kolb, H.4    Kolb-Bachofen, V.5
  • 104
    • 0028900805 scopus 로고
    • Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase
    • Corbett JA, McDaniel ML. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J Exp Med 1995; 181: 559-568.
    • (1995) J Exp Med , vol.181 , pp. 559-568
    • Corbett, J.A.1    McDaniel, M.L.2
  • 105
    • 0035856952 scopus 로고    scopus 로고
    • Cell death during progression to diabetes
    • Mathis D, Vence L, Benoist C. Cell death during progression to diabetes. Nature 2001; 414: 792-798.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 106
    • 0023779707 scopus 로고
    • Destruction of rat islet cell monolayers by cytokines: Synergistic interaction of interferon-g, tumor necrosis factor, lymphotoxin, and interleukin 1
    • Pukel C, Baquerizo H, Rabinovitch A. Destruction of rat islet cell monolayers by cytokines: synergistic interaction of interferon-g, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 1988; 37: 133-136.
    • (1988) Diabetes , vol.37 , pp. 133-136
    • Pukel, C.1    Baquerizo, H.2    Rabinovitch, A.3
  • 107
    • 0036710448 scopus 로고    scopus 로고
    • Transmembrane TNF and IFN-γ induce caspase-independent death of primary mouse pancreatic beta cells
    • Irawaty W, Kay TWH, Thomas HE. Transmembrane TNF and IFN-γ induce caspase-independent death of primary mouse pancreatic beta cells. Autoimmunity 2002; 35: 369-375.
    • (2002) Autoimmunity , vol.35 , pp. 369-375
    • Irawaty, W.1    Kay, T.W.H.2    Thomas, H.E.3
  • 108
    • 0023601773 scopus 로고
    • Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity
    • Mandrup-Poulsen T, Bendtzen K, Dinarello CA, Nerup J. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J Immunol 1987; 139: 4077-4082.
    • (1987) J Immunol , vol.139 , pp. 4077-4082
    • Mandrup-Poulsen, T.1    Bendtzen, K.2    Dinarello, C.A.3    Nerup, J.4
  • 109
    • 0344667679 scopus 로고    scopus 로고
    • CMV-hFasL transgenic mice are sensitive to low doses of streptozotocin-induced type I diabetes mellitus
    • Lin B, Zhang ZL, Yu LY, Guo LH. CMV-hFasL transgenic mice are sensitive to low doses of streptozotocin-induced type I diabetes mellitus. Acta Pharmacol Sin 2003; 24: 1199-1204.
    • (2003) Acta Pharmacol Sin , vol.24 , pp. 1199-1204
    • Lin, B.1    Zhang, Z.L.2    Yu, L.Y.3    Guo, L.H.4
  • 110
    • 0028985199 scopus 로고
    • Accelerated β-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-a and granzyme A in the intra-islet infiltrates
    • Mueller C, Held W, Imboden MA, Carnaud C. Accelerated β-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-a and granzyme A in the intra-islet infiltrates. Diabetes 1995; 44: 112-117.
    • (1995) Diabetes , vol.44 , pp. 112-117
    • Mueller, C.1    Held, W.2    Imboden, M.A.3    Carnaud, C.4
  • 111
    • 0033526068 scopus 로고    scopus 로고
    • In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor a
    • Pakala SV, Chivetta M, Kelly CB, Katz JD. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor a. J Exp Med 1999; 189: 1053-1062.
    • (1999) J Exp Med , vol.189 , pp. 1053-1062
    • Pakala, S.V.1    Chivetta, M.2    Kelly, C.B.3    Katz, J.D.4
  • 112
    • 0032963384 scopus 로고    scopus 로고
    • Fas is expressed in murine pancreatic islet cells and an insulinoma cell line but does not mediate their apoptosis in vitro
    • Lee MS, Kim S, Chung JH, Lee MK, Kim KW. Fas is expressed in murine pancreatic islet cells and an insulinoma cell line but does not mediate their apoptosis in vitro. Autoimmunity 1999; 29: 189-199.
    • (1999) Autoimmunity , vol.29 , pp. 189-199
    • Lee, M.S.1    Kim, S.2    Chung, J.H.3    Lee, M.K.4    Kim, K.W.5
  • 113
    • 18744416830 scopus 로고    scopus 로고
    • Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection
    • Yolcu SE, Askenasy N, Singh PN, Lamhamedi Cherradi SE, Shirwan H. Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. Immunity 2002; 17: 795-808.
    • (2002) Immunity , vol.17 , pp. 795-808
    • Yolcu, S.E.1    Askenasy, N.2    Singh, P.N.3    Lamhamedi Cherradi, S.E.4    Shirwan, H.5
  • 114
    • 0033178741 scopus 로고    scopus 로고
    • Evidence that beta cell death in the nonobese diabetic mouse is Fas independent
    • Thomas HE, Darwiche R, Corbett JA, Kay TW. Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. J Immunol 1999; 163: 1562-1569.
    • (1999) J Immunol , vol.163 , pp. 1562-1569
    • Thomas, H.E.1    Darwiche, R.2    Corbett, J.A.3    Kay, T.W.4
  • 115
    • 0033995129 scopus 로고    scopus 로고
    • Monitoring gene expression of TNFR family members by beta-cells during development of autoimmune diabetes
    • Walter U, Franzke A, Sarukhan A, Zober C, von Boehmer H, Buer J et al. Monitoring gene expression of TNFR family members by beta-cells during development of autoimmune diabetes. Eur J Immunol 2000; 30: 1224-1232.
    • (2000) Eur J Immunol , vol.30 , pp. 1224-1232
    • Walter, U.1    Franzke, A.2    Sarukhan, A.3    Zober, C.4    von Boehmer, H.5    Buer, J.6
  • 116
    • 0032750928 scopus 로고    scopus 로고
    • Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset type I diabetes mellitus
    • Moriwaki M, Itoh N, Miyagawa J, Yamamoto K, Imagawa A, Yamagata K et al. Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset type I diabetes mellitus. Diabetologia 1999; 42: 1332-1340.
    • (1999) Diabetologia , vol.42 , pp. 1332-1340
    • Moriwaki, M.1    Itoh, N.2    Miyagawa, J.3    Yamamoto, K.4    Imagawa, A.5    Yamagata, K.6
  • 117
    • 0037942773 scopus 로고    scopus 로고
    • Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice
    • Darwiche R, Chong MM, Santamaria P, Thomas HE, Kay TW. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J Immunol 2003; 170: 6292-6297.
    • (2003) J Immunol , vol.170 , pp. 6292-6297
    • Darwiche, R.1    Chong, M.M.2    Santamaria, P.3    Thomas, H.E.4    Kay, T.W.5
  • 118
    • 0031897507 scopus 로고    scopus 로고
    • Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation
    • Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 1998; 47: 727-732.
    • (1998) Diabetes , vol.47 , pp. 727-732
    • Loweth, A.C.1    Williams, G.T.2    James, R.F.3    Scarpello, J.H.4    Morgan, N.G.5
  • 119
    • 0035432491 scopus 로고    scopus 로고
    • Glucose induces b-cell apoptosis via upregulation of the Fas-receptor in human islets
    • Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A et al. Glucose induces b-cell apoptosis via upregulation of the Fas-receptor in human islets. Diabetes 2001; 50: 1683-1690.
    • (2001) Diabetes , vol.50 , pp. 1683-1690
    • Maedler, K.1    Spinas, G.A.2    Lehmann, R.3    Sergeev, P.4    Weber, M.5    Fontana, A.6
  • 121
    • 0037062429 scopus 로고    scopus 로고
    • FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication
    • Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J et al. FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication. Proc Natl Acad Sci USA 2002; 99: 8236-8241.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8236-8241
    • Maedler, K.1    Fontana, A.2    Ris, F.3    Sergeev, P.4    Toso, C.5    Oberholzer, J.6
  • 122
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet β-cell failure: A link between type 1 and type 2 diabetes
    • Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 2003; 81: 455-470.
    • (2003) J Mol Med , vol.81 , pp. 455-470
    • Donath, M.Y.1    Storling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 123
    • 0028973284 scopus 로고
    • Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: Evidence for the involvement of nuclear factor kappa B in the signaling mechanism
    • Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML. Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. Endocrinology 1995; 136: 4790-4795.
    • (1995) Endocrinology , vol.136 , pp. 4790-4795
    • Kwon, G.1    Corbett, J.A.2    Rodi, C.P.3    Sullivan, P.4    McDaniel, M.L.5
  • 124
    • 0029665049 scopus 로고    scopus 로고
    • Cytokines activate the nuclear factor kappa B (NFkappa B) and induce nitric oxide production in human pancreatic islets
    • Flodstrom M, Welsh N, Eizirik DL. Cytokines activate the nuclear factor kappa B (NFkappa B) and induce nitric oxide production in human pancreatic islets. FEBS Lett 1996; 385: 4-6.
    • (1996) FEBS Lett , vol.385 , pp. 4-6
    • Flodstrom, M.1    Welsh, N.2    Eizirik, D.L.3
  • 125
    • 0035432603 scopus 로고    scopus 로고
    • Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP
    • Darville MI, Eizirik DL. Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP. Diabetes 2001; 50: 1741-1748.
    • (2001) Diabetes , vol.50 , pp. 1741-1748
    • Darville, M.I.1    Eizirik, D.L.2
  • 126
    • 6344265234 scopus 로고    scopus 로고
    • Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1 beta
    • Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA. Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1 beta. J Clin Endocrinol Metab 2004; 89: 5059-5066.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5059-5066
    • Zeender, E.1    Maedler, K.2    Bosco, D.3    Berney, T.4    Donath, M.Y.5    Halban, P.A.6
  • 127
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    • Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110: 851-860.
    • (2002) J Clin Invest , vol.110 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3    Oberholzer, J.4    Joller-Jemelka, H.I.5    Spinas, G.A.6
  • 128
    • 2542541353 scopus 로고    scopus 로고
    • Leptin modulates cell expression of IL-1 receptor antagonist and release of IL-1 in human islets
    • Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T et al. Leptin modulates cell expression of IL-1 receptor antagonist and release of IL-1 in human islets. Proc Natl Acad Sci USA 2004; 101: 8138-8143.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8138-8143
    • Maedler, K.1    Sergeev, P.2    Ehses, J.A.3    Mathe, Z.4    Bosco, D.5    Berney, T.6
  • 129
    • 20144367154 scopus 로고    scopus 로고
    • A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta
    • Papaccio G, Graziano A, D'Aquino R, Valiante S, Naro F. A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta. J Cell Physiol 2005; 204: 124-130.
    • (2005) J Cell Physiol , vol.204 , pp. 124-130
    • Papaccio, G.1    Graziano, A.2    D'Aquino, R.3    Valiante, S.4    Naro, F.5
  • 130
    • 16844377896 scopus 로고    scopus 로고
    • High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkB
    • Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC. High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkB. Diabetologia 2005; 48: 496-505.
    • (2005) Diabetologia , vol.48 , pp. 496-505
    • Elouil, H.1    Cardozo, A.K.2    Eizirik, D.L.3    Henquin, J.C.4    Jonas, J.C.5
  • 131
    • 33644669584 scopus 로고    scopus 로고
    • Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
    • Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P et al. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes 2005; 54: 3238-3244.
    • (2005) Diabetes , vol.54 , pp. 3238-3244
    • Welsh, N.1    Cnop, M.2    Kharroubi, I.3    Bugliani, M.4    Lupi, R.5    Marchetti, P.6
  • 132
    • 0141993915 scopus 로고    scopus 로고
    • Effective destruction of Fas-deficient insulin-producing β cells in type 1 diabetes
    • Apostolou I, Hao Z, Rajewsky K, von Boehmer H. Effective destruction of Fas-deficient insulin-producing β cells in type 1 diabetes. J Exp Med 2003; 198: 1103-1106.
    • (2003) J Exp Med , vol.198 , pp. 1103-1106
    • Apostolou, I.1    Hao, Z.2    Rajewsky, K.3    von Boehmer, H.4
  • 133
    • 0024440115 scopus 로고
    • MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an 'occult' class I-like antigen in NOD/Lt mice
    • Leiter EH, Christianson GJ, Serreze DV, Ting AT, Worthen SM. MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an 'occult' class I-like antigen in NOD/Lt mice. J Exp Med 1989; 170: 1243-1262.
    • (1989) J Exp Med , vol.170 , pp. 1243-1262
    • Leiter, E.H.1    Christianson, G.J.2    Serreze, D.V.3    Ting, A.T.4    Worthen, S.M.5
  • 134
    • 0032531099 scopus 로고    scopus 로고
    • IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
    • Thomas HE, Parker JL, Schreiber RD, Kay TW. IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J Clin Invest 1998; 102: 1249-1257.
    • (1998) J Clin Invest , vol.102 , pp. 1249-1257
    • Thomas, H.E.1    Parker, J.L.2    Schreiber, R.D.3    Kay, T.W.4
  • 136
    • 0346366975 scopus 로고    scopus 로고
    • Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens
    • Yamanouchi J, Verdaguer J, Han B, Amrani A, Serra P, Santamaria P. Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens. J Immunol 2003; 171: 6900-6909.
    • (2003) J Immunol , vol.171 , pp. 6900-6909
    • Yamanouchi, J.1    Verdaguer, J.2    Han, B.3    Amrani, A.4    Serra, P.5    Santamaria, P.6
  • 137
    • 0030587871 scopus 로고    scopus 로고
    • RIP-β2- microglobulin transgene expression restores insulitis, but not diabetes, in β2-microglobulinnull nonobese diabetic mice
    • Kay T, Parker J, Stephens L, Thomas H, Allison J. RIP-β2- microglobulin transgene expression restores insulitis, but not diabetes, in β2-microglobulinnull nonobese diabetic mice. J Immunol 1996; 157: 3688-3693.
    • (1996) J Immunol , vol.157 , pp. 3688-3693
    • Kay, T.1    Parker, J.2    Stephens, L.3    Thomas, H.4    Allison, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.