Recurrent Autoimmunity Accelerates Destruction of Minor and Major Histoincompatible Islet Grafts in Nonobese Diabetic (NOD) Mice

American Journal of Transplantation

Volumn 1, Issue 2, 2001, Pages 138-145

  Okitsu, Teru ^a   Bartlett, Stephen T ^a   Hadley, Gregg A ^a   Drachenberg, Cinthia B ^a   Farney, Alan C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunrty; Islets of Langerhans; Major histocompatibility complex; NOD mouse; Rejection

Indexed keywords

MINOR HISTOCOMPATIBILITY ANTIGEN;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; AUTOIMMUNITY; BAGG ALBINO MOUSE; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GRAFT SURVIVAL; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET TRANSPLANTATION; PATHOLOGY; PHYSIOLOGY; TIME;

ANIMALS; AUTOIMMUNITY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; GRAFT SURVIVAL; ISLETS OF LANGERHANS TRANSPLANTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MINOR HISTOCOMPATIBILITY ANTIGENS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0035401164     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2001.10207.x     Document Type: Article

References (29)

1. Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986; 314: 1360-1368.
2. Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994; 33: 1428-1436.
3. Sutherland DE, Goetz FC, Sibley RK. Recurrence of disease in pancreas transplants. Diabetes 1989; 38 (Suppl. 1): 85-87.
4. Bartlett ST, Chin T, Dirden B, Quereshi A, Hadley G. Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: evidence of donor chimerism. Surgery 1995; 118: 392-398.
5. Bartlett ST, Killewich LA. Recurrent diabetes in pancreas transplants in the BB rat: evidence for a defect extrinsic to the beta cell. Transplant Proc 1991; 23 (Part 1): 689-690.
6. Wang T, Singh B, Warnock GL, Rajotte RV. Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy. Diabetes 1992; 41: 114-117.
7. Mottram PL, Murray-Segal LJ, Han W, Maguire J, Stein-Oakley A, Mandel TE. Long-term survival of segmental pancreas isografts in NOD/Lt mice treated with anti-CD4 and anti-CD8 monoclonal antibodies. Diabetes 1998; 47: 1399-1405.
8. Tyden G, Reinholt FP, Sundkvist G, Bounder J. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N Engl J Med 1996; 335: 860-863.
9. International Islet Transplantation Registry. Newsletter No. 7 1996; 6.
10. Wang Y, Pontesilli O, Gill RG, La Rosa FG, Lafferty KJ. The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc Natl Acad Sci USA 1991; 88: 527-531.
11. Markmann JF, Bassiri H, Desai NM et al. Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation 1992; 54: 1085-1089.
12. Stegall MD, Loberman Z, Ostrowska A, Coulombe M, Gill RG. Autoimmune destruction of islet grafts in the NOD mouse is resistant to 15-deoxyspergualin but sensitive to anti-CD4 antibody. J Surg Res 1996; 64: 156-160.
13. Markees TG, Serreze DV, Phillips NE et al. NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes 1999; 48: 967-974.
14. Guo Z, Mital D, Shen J et al. Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice. Transplantation 1998; 65: 1310-1314.
15. Takayama Y, Ichikawa T, Maki T. Effect of STZ administration on islet isograft and allograft survival in NOD mice. Diabetes 1993; 42: 324-329.
16. Prochazka M, Serreze DV, Frankel WN, Leiter EH. NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice. Diabetes 1992; 41: 98-106.
17. Serreze DV, Prochazka M, Reifsnyder PC, Bridgett MM, Leiter EH. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 1994; 180: 1553-1558.
18. Gotoh M, Maki T, Kiyoizumi T, Satomi S, Monaco AP. An improved method for isolation of mouse pancreatic islets. Transplantation 1985; 40: 437-438.
19. Itoh A, Maki T. Protection of nonobese diabetic mice from autoimmune diabetes by reduction of islet mass before insulitis. Proc Natl Acad Sci USA 1996; 93: 11053-11056.
20. Gomez Dumm CL, Console GM, Luna GC, Dardenne M, Goya RG. Quantitative immunohistochemical changes in the endocrine pancreas of nonobese diabetic (NOD) mice. Pancreas 1995; 11: 396-401.
21. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29: 267-274.
22. Kaufman DB, Platt JL, Rabe FL, Dunn DL, Bach FH, Sutherland DE. Differential roles of Mac-1 + cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts. J Exp Med 1990; 172: 291-302.
23. Mandrup-Poulsen T, Spinas GA et al. Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics. Diabetes 1987; 36: 641-647.
24. Pukel C, Baquerizo H, Rabinovitch A. Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 1988; 37: 133-136.
25. Nagata M, Mullen Y, Herrera M, Matsuo S. Non-specific vs. autoimmune destruction of islet grafts in mice. Horm Metab Res 1990; 25: 153-156.
26. Ling Z, In't Veld PA, Pipeleers DG. Interaction of interleukin-1 with islet beta-cells. Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression. Diabetes 1993; 42: 56-65.
27. Hamaguchi K, Leiter EH. Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes 1990; 39: 415-425.
28. Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A. Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction. Diabetes 1996; 45: 1350-1357.
29. Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.