Extrathymic development of murine T cells after bone marrow transplantation

Journal of Clinical Investigation

Volumn 122, Issue 12, 2012, Pages 4716-4726

  Holland, Amanda M ^a,b   Zakrzewski, Johannes L ^a   Tsai, Jennifer J ^a,b   Hanash, Alan M ^a   Dudakov, Jarrod A ^a   Smith, Odette M ^a   West, Mallory L ^a   Singer, Natalie V ^a   Brill, Jessie ^a   Sun, Joseph C ^a   Van Den Brink, Marcel R M ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; EX VIVO STUDY; IMMUNITY; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; RECIPIENT; T LYMPHOCYTE; THYMUS;

ADOPTIVE TRANSFER; AGE FACTORS; ANIMALS; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; LYMPH NODES; MESENTERY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; NFATC TRANSCRIPTION FACTORS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 84870482851     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI60630     Document Type: Article

References (44)

1. Cook MC, Tangye SG. Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections. Int Immunol. 2009;21(9):1003-1011.
2. Edgar JD. T cell immunodeficiency. J Clin Pathol. 2008; 61(9):988-993.
3. Appelbaum FR. The current status of hematopoietic cell transplantation. Annu Rev Med. 2003;54:491-512. (Pubitemid 37386409)
4. Wils EJ, et al. Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients. Haematologica. 2011;96(12):1846-1854.
5. Parkman R, Weinberg KI. Immunological reconstitution following bone marrow transplantation. Immunol Rev. 1997;157:73-78. (Pubitemid 27303122)
6. Steinmann GG. Changes in the human thymus during aging. Curr Top Pathol. 1986;75:43-88.
7. Appay V, Sauce D, Prelog M. The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging (Albany NY). 2010;2(2):78-81.
8. Holland AM, van den Brink MR. Rejuvenation of the aging T cell compartment. Curr Opin Immunol. 2009; 21(4):454-459.
9. Haynes L, Maue AC. Effects of aging on T cell function. Curr Opin Immunol. 2009;21(4):414-417.
10. den Braber I, et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity. 2012;36(2):288-297.
11. Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood. 1993;82(8):2585-2594. (Pubitemid 23304286)
12. Mackall CL, Gress RE. Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy. Immunol Rev. 1997;157:61-72. (Pubitemid 27303121)
13. McElhaney JE, Dutz JP. Better influenza vaccines for older people: what will it take? J Infect Dis. 2008; 198(5):632-634.
14. Litzow MR. Acute lymphoblastic leukemia in adults. Curr Treat Options Oncol. 2000;1(1):19-29.
15. Small TN, et al. Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis. Biol Blood Marrow Transplant. 1997; 3(2):65-75. (Pubitemid 127529979)
16. Zakrzewski JL, et al. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat Med. 2006;12(9):1039-1047. (Pubitemid 44353385)
17. Zakrzewski JL, et al. Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol. 2008;26(4):453-461. (Pubitemid 351501816)
18. McClory S, et al. Evidence for a stepwise program of extrathymic T cell development within the human tonsil. J Clin Invest. 2012;122(4):1403-1415.
19. Guy-Grand D, et al. Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J Exp Med. 2003;197(3):333-341. (Pubitemid 36184240)
20. Blais ME, et al. Why T cells of thymic versus extrathymic origin are functionally different. J Immunol. 2008;180(4):2299-2312.
21. Blais ME, Gerard G, Martinic MM, Roy-Proulx G, Zinkernagel RM, Perreault C. Do thymically and strictly extrathymically developing T cells generate similar immune responses? Blood. 2004; 103(8):3102-3110. (Pubitemid 38451687)
22. Boileau C, Houde M, Dulude G, Clegg CH, Perreault C. Regulation of extrathymic T cell development and turnover by oncostatin M. J Immunol. 2000; 164(11):5713-5720. (Pubitemid 30389813)
23. Dulude G, et al. Thymic and extrathymic differentiation and expansion of T lymphocytes following bone marrow transplantation in irradiated recipients. Exp Hematol. 1997;25(9):992-1004. (Pubitemid 27368291)
24. Louis I, et al. Changes in the lymph node microenvironment induced by oncostatin M. Blood. 2003; 102(4):1397-1404. (Pubitemid 36988049)
25. Terra R, Labrecque N, Perreault C. Thymic and extrathymic T cell development pathways follow different rules. J Immunol. 2002;169(2):684-692. (Pubitemid 34753423)
26. Terra R, Louis I, Le Blanc R, Ouellet S, Zuniga- Pflucker JC, Perreault C. T-cell generation by lymph node resident progenitor cells. Blood. 2005; 106(1):193-200. (Pubitemid 40967192)
27. Dejbakhsh-Jones S, Jerabek L, Weissman IL, Strober S. Extrathymic maturation of alpha beta T cells from hemopoietic stem cells. J Immunol. 1995; 155(7):3338-3344.
28. Dejbakhsh-Jones S, Garcia-Ojeda ME, Chatterjea- Matthes D, Zeng D, Strober S. Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway. Proc Natl Acad Sci U S A. 2001;98(13):7455-7460. (Pubitemid 32567970)
29. Garcia-Ojeda ME, et al. Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus. J Immunol. 2005;175(7):4363-4373. (Pubitemid 41361971)
30. Arcangeli ML, et al. Extrathymic hemopoietic progenitors committed to T cell differentiation in the adult mouse. J Immunol. 2005;174(4):1980-1988.
31. Gautreau L, et al. Identification of an IL-7-dependent pre-T committed population in the spleen. J Immunol. 2007;179(5):2925-2935.
32. Maillard I, et al. Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood. 2006;107(9):3511-3519.
33. Na IK, et al. Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo. Blood. 2010; 116(11):e18-e25.
34. Rincon M, Flavell RA. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells. Mol Cell Biol. 1996;16(3):1074-1084. (Pubitemid 26061679)
35. Cante-Barrett K, Winslow MM, Crabtree GR. Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007;179(1):103-110. (Pubitemid 46986523)
36. Rossi FM, et al. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol. 2005;6(6):626-634. (Pubitemid 41710734)
37. Veerman KM, et al. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007; 8(5):532-539. (Pubitemid 46605921)
38. Uehara S, Grinberg A, Farber JM, Love PE. A role for CCR9 in T lymphocyte development and migration. J Immunol. 2002;168(6):2811-2819. (Pubitemid 34211660)
39. De Togni P, et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994;264(5159):703-707. (Pubitemid 24185880)
40. Mariathasan S, Matsumoto M, Baranyay F, Nahm MH, Kanagawa O, Chaplin DD. Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration. J Inflamm. 1995; 45(1):72-78.
41. Fletcher AL, et al. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010;207(4):689-697.
42. Link A, et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 2007;8(11):1255-1265. (Pubitemid 350011765)
43. Alpdogan O, et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood. 2006;107(6):2453-2460. (Pubitemid 43345567)
44. Ahmed R, Salmi A, Butler LD, Chiller JM, Oldstone MB. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med. 1984;160(2):521-540. (Pubitemid 14052514)