High-fructose corn syrup and sucrose have equivalent effects on energy-regulating hormones at normal human consumption levels

Nutrition Research

Volumn 33, Issue 12, 2013, Pages 1043-1052

  Yu, Zhiping ^a   Lowndes, Joshua ^a   Rippe, James ^a,b,c  

^a Rippe Lifestyle Institute   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

^c Rippe Health Evaluation   (United States)

Author keywords

Active ghrelin; Added sugar; Fructose; Insulin; Leptin; Metabolic effects; Obesity

Indexed keywords

FRUCTOSE; GHRELIN; GLUCOSE; HIGH FRUCTOSE CORN SYRUP; INSULIN; LEPTIN; SUCROSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID;

ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; CALORIC INTAKE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MILK; NORMAL HUMAN; PRIORITY JOURNAL; SUGAR INTAKE;

ZEA MAYS;

ACTIVE GHRELIN; ADDED SUGAR; AHA; AMERICAN HEART ASSOCIATION; AREA UNDER THE CURVE; AUC; BMI; BODY MASS INDEX; FRUCTOSE; HFCS; HIGH-FRUCTOSE CORN SYRUP; INSULIN; LEPTIN; METABOLIC EFFECTS; OBESITY;

ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; DIET; DIETARY SUCROSE; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FEMALE; FRUCTOSE; GHRELIN; HUMANS; INSULIN; LEPTIN; MALE; MIDDLE AGED; OBESITY; PEPTIDE HORMONES; POSTPRANDIAL PERIOD; PROSPECTIVE STUDIES; SWEETENING AGENTS; TRIGLYCERIDES; URIC ACID; YOUNG ADULT; ZEA MAYS;

EID: 84888034810     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2013.07.020     Document Type: Article

References (52)

1. Wells H.F., Buzby J.C. Dietary assessment of major trends in the US food consumption, 1970-2005, Economic Information Bullertin No. 33 2008, Economic Research Service, U.S. Dept. of Agriculture, Beltsville, MD.
2. Flegal K.M., Carroll M.D., Kit B.K., Ogden C.L. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012, 307:491-497.
3. Johnson R.K., Appel L.J., Brands M., Howard B.V., Lefevre M., Lustig R.H., et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 2009, 120:1011-1020.
4. Trumbo P., Schlicker S., Yates A.A., Poos M. Food, Nutrition Board of the Institute of Medicine TNA. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc 2002, 102:1621-1630.
5. Services USDoAaUSDoHaH Dietary Guidelines for Americans, 2010 2010, U.S. Government Printing Office, Washington, DC. 7th ed.
6. Bray G.A., Nielsen S.J., Popkin B.M. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004, 79:537-543.
7. Melanson K.J., Angelopoulos T.J., Nguyen V., Zukley L., Lowndes J., Rippe J.M. High-fructose corn syrup, energy intake, and appetite regulation. Am J Clin Nutr 2008, 88:1738S-1744S.
8. Soenen S., Westerterp-Plantenga M.S. No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr 2007, 86:1586-1594.
9. Stanhope K.L., Griffen S.C., Bair B.R., Swarbrick M.M., Keim N.L., Havel P.J. Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr 2008, 87:1194-1203.
10. Association A.M. Report 3 of the Council on Science and Public Health (A-08) 2008.
11. American Dietetic Association Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. J Am Diet Assoc 2004, 104:255-275.
12. Bray G.A. Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard. J Diabetes Sci Technol 2010, 4:1003-1007.
13. Teff K.L., Grudziak J., Townsend R.R., Dunn T.N., Grant R.W., Adams S.H., et al. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 2009, 94:1562-1569.
14. Stanhope K.L., Schwarz J.M., Keim N.L., Griffen S.C., Bremer A.A., Graham J.L., et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009, 119:1322-1334.
15. White J.S., Foreyt J.P., Melanson K.J., Angelopoulos T.J. High-fructose corn syrup. controversies and common sense. Am J Lifestyle Med 2010, 4:515-520.
16. Johnson R.J., Segal M.S., Sautin Y., Nakagawa T., Feig D.I., Kang D.H., et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007, 86:899-906.
17. Ventura E.E., Davis J.N., Goran M.I. Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content. Obesity (Silver Spring) 2010, 19:868-874.
18. Goran M.I., Ulijaszek S.J., Ventura E.E. High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 2013, 8:55-64.
19. Hellerstein M.K. Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk. Curr Opin Lipidol 2002, 13:33-40.
20. Mensink R.P., Zock P.L., Kester A.D., Katan M.B. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003, 77:1146-1155.
21. Appel L.J., Sacks F.M., Carey V.J., Obarzanek E., Swain J.F., Miller E.R., et al. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA 2005, 294:2455-2464.
22. Fried S.K., Rao S.P. Sugars, hypertriglyceridemia, and cardiovascular disease. Am J Clin Nutr 2003, 78:873S-880S.
23. Bantle J.P., Raatz S.K., Thomas W., Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000, 72:1128-1134.
24. Chong M.F., Fielding B.A., Frayn K.N. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 2007, 85:1511-1520.
25. Lustig R. Letter to the editor. J Am Diet Assoc 2011, 111:990-993.
26. Hudgins L.C., Parker T.S., Levine D.M., Hellerstein M.K. A dual sugar challenge test for lipogenic sensitivity to dietary fructose. J Clin Endocrinol Metab 2011, 96:861-868.
27. Marriott B.P., Cole N., Lee E. National estimates of dietary fructose intake increased from 1977 to 2004 in the United States. J Nutr 2009, 139:1228S-1235S.
28. Mifflin M.D., St Jeor S.T., Hill L.A., Scott B.J., Daugherty S.A., Koh Y.O. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990, 51:241-247.
29. Maersk M., Belza A., Stødkilde-Jørgensen H., Ringgaard S., Chabanova E., Thomsen H., et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr 2012, 95:283-289.
30. Rodin J. Effects of pure sugar versus mixed starch fructose loads on food intake. Appetite 1991, 17:213-219.
31. Woods S.C., Lotte r.E.C., McKay L.D., Porte D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979, 282:503.
32. Havel P.J. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005, 63:133-157.
33. Schwartz M.W., Woods S.C., Porte D.J., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature 2000, 404:61-671.
34. Friedman J.M. Leptin, leptin receptors, and the control of body weight. Nutr Rev 1998, 56:s54-s75.
35. Malik V.S., Schulze M.B., Hu F.B. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 2006, 84:274-288.
36. Malik V.S., Popkin B.M., Bray G.A., Despres J.P., Hu F.B. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation 2010, 121:1356-1364.
37. Bachman C.M., Baranowski T., Nicklas T.A. Is there an association between sweetened beverages and adiposity?. Nutr Rev 2006, 64:153-174.
38. Vartanian L.R., Schwartz M.B., Brownell K.D. Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. Am J Public Health 2007, 97:667-675.
39. Committee on Accelerating Progress in Obesity Prevention; Food and Nutrition Board; Institute of Medicine of the National Academies: accelerating progress in obesity prevention: solving the weight of the nation 2012, The National Academies Press, Washington, DC. D.P.L. Glickman, L.J. Slim, H. Del Valle Cook, E.A. Miller (Eds.).
40. Hall K.D., Heymsfield S.B., Kemnitz J.W., Klein S., Schoeller D.A., Speakman J.R. Energy balance and its components: implications for body weight regulation. Am J Clin Nutr 2012, 95:989-994.
41. Dolan L.C., Potter S.M., Burdock G.A. Evidence-based review on the effect of normal dietary consumption of fructose on development of hyperlipidemia and obesity in healthy, normal weight individuals. Crit Rev Food Sci Nutr 2010, 50:53-84.
42. Dolan L.C., Potter S.M., Burdock G.A. Evidence-based review on the effect of normal dietary consumption of fructose on blood lipids and body weight of overweight and obese individuals. Crit Rev Food Sci Nutr 2010, 50:889-918.
43. Sievenpiper J.L., de Souza R.J., Mirrahimi A., Yu M.E., Carleton A.J., Beyene J., et al. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med 2012, 156:291-304.
44. Cozma A.I., Sievenpiper J.L., de Souza R.J., Chiavaroli L., Ha V., Wang D.D., et al. Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials. Diabetes Care 2012, 35:1611-1620.
45. Position statement: standards of medical care in diabetes-2012. Diabetes Care 2012, 35(Suppl 1):S11-S63.
46. Nutrition Committee of the British Diabetic Association's Professional Advisory Committee Dietary recommendations for people with diabetes: an update for the 1990s. Diabet Med 1992, 9:189-202.
47. Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD). 1. Diabetes Nutr Metab 1995, 8:186-189.
48. National Nutrition Committee CDA Guidelines for the nutritional management of diabetes mellitus in the new millennium: a position statement by the Canadian Diabetes Association. Can J Diabetes Care 1999, 23:56-69.
49. Wang D., Sievenpiper J.L., de Souza R., Chiavaroli L., Ha V., Cosma A., et al. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 2012, 142:916-923.
50. Bortolotti M., Kreis R., Debard C., Cariou B., Faeh D., Chetiveaux M., et al. High protein intake reduces intrahepatocellular lipid deposition in humans. Am J Clin Nutr 2009, 90:1002-1010.
51. Bortolotti M., Dubuis J., Schneiter P., Tappy L. Effects of dietary protein on lipid metabolism in high fructose fed humans. Clin Nutr 2012, 31:238-245.
52. Theytaz F., Noguchi Y., Egli L., Campos V., Buehler T., Hodson L., et al. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am J Clin Nutr 2012, 96:1008-1016.