Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans

American Journal of Clinical Nutrition

Volumn 96, Issue 5, 2012, Pages 1008-1016

  Theytaz, Fanny ^a   Noguchi, Yasushi ^b   Egli, Léonie ^a   Campos, Vanessa ^a   Buehler, Tania ^c   Hodson, Leanne ^d   Patterson, Bruce W ^e   Nishikata, Natsumi ^b   Kreis, Roland ^c   Mittendorfer, Bettina ^e   Fielding, Barbara ^d,f   Boesch, Chris ^c   Tappy, Luc ^a,g  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b AJINOMOTO CO INC   (Japan)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF SURREY   (United Kingdom)

^g LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ESSENTIAL AMINO ACID; FRUCTOSE; ISOLEUCINE; LEUCINE; LIPID; LYSINE; MALTODEXTRIN; PALMITIC ACID; THREONINE; TRIACYLGLYCEROL; VALINE; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; DIETARY INTAKE; HUMAN; HUMAN EXPERIMENT; LIVER; MALE; NORMAL HUMAN; OVERNUTRITION; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION;

AMINO ACIDS, ESSENTIAL; CROSS-OVER STUDIES; DIETARY CARBOHYDRATES; DIETARY SUPPLEMENTS; FRUCTOSE; HUMANS; LIPID METABOLISM; LIVER; MALE; PALMITATES; SINGLE-BLIND METHOD; TRIGLYCERIDES; YOUNG ADULT;

EID: 84867815144     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.035139     Document Type: Article

References (32)

1. Bray GA. Soft drink consumption and obesity: it is all about fructose. Curr Opin Lipidol 2010;21:51-7.
2. Greenfield V, Cheung O, Sanyal AJ. Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol 2008;24:320-7. (Pubitemid 351535891)
3. Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci USA 2011;108:16381-5.
4. Bizeau ME, Pagliassotti MJ. Hepatic adaptations to sucrose and fructose. Metabolism 2005;54:1189-201. (Pubitemid 41206880)
5. Lê KA, Ith M, Kreis R, Faeh D, Bortolotti M, Tran C, Boesch C, Tappy L. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 2009;89:1760-5.
6. Pichon L, Huneau JF, Fromentin G, Tomé D. A high-protein, high-fat, carbohydrate-free diet reduces energy intake, hepatic lipogenesis, and adiposity in rats. J Nutr 2006;136:1256-60.
7. Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, Tappy L. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 2005; 54:1907-13. [Published erratum appears in Diabetes 2006;55(2):563.] (Pubitemid 40911251)
8. Stepien M, Gaudichon C, Fromentin G, Even P, Tomé D, Azzout-Marniche D. Increasing protein at the expense of carbohydrate in the diet down-regulates glucose utilization as glucose sparing effect in rats. PLoS ONE 2011;6:e14664.
9. Blouet C, Mariotti F, Azzout-Marniche D, Bos C, Mathé V, Tomé D, Huneau JF. The reduced energy intake of rats fed a high-protein low-carbohydrate diet explains the lower fat deposition, but macronutrient substitution accounts for the improved glycemic control. J Nutr 2006;136:1849-54. (Pubitemid 43973587)
10. Hamad EM, Taha SH, Abou Dawood AG, Sitohy MZ, Abdel-Hamid M. Protective effect of whey proteins against nonalcoholic fatty liver in rats. Lipids Health Dis 2011;10:57.
11. Bortolotti M, Kreis R, Debard C, Cariou B, Faeh D, Chetiveaux M, Ith M, Vermathen P, Stefanoni N, Le KA, et al. High protein intake reduces intrahepatocellular lipid deposition in humans. Am J Clin Nutr 2009;90:1002-10.
12. Bortolotti M, Maiolo E, Corazza M, Van Dijke E, Schneiter P, Boss A, Carrel G, Giusti V, Lê KA, Quo Chong DG, et al. Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients. Clin Nutr 2011;30:494-8.
13. Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. PLoS ONE 2010;5:e12057.
14. Nishikata N, Shikata N, Kimura Y, Noguchi Y. Dietary lipid-dependent regulation of de novo lipogenesis and lipid partitioning by ketogenic essential amino acids in mice. Nutr Diabetes 2011;1:e5.
15. Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, Klein S. Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Res 2002;43:223-33. (Pubitemid 34184009)
16. Normand S, Pachiaudi C, Khalfallah Y, Guilluy R, Mornex R, Riou JP. 13C appearance in plasma glucose and breath CO2 during feeding with naturally 13C-enriched starchy food in normal humans. Am J Clin Nutr 1992;55:430-5.
17. Bickerton AS, Roberts R, Fielding BA, Hodson L, Blaak EE, Wagenmakers AJ, Gilbert M, Karpe F, Frayn KN. Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period. Diabetes 2007;56:168-76.
18. Thesen S, Heid O, Mueller E, Schad LR. Prospective acquisition correction for head motion with image-based tracking for real-time fMRI. Magn Reson Med 2000;44:457-65.
19. Chong DG, Kreis R, Bolliger CS, Boesch C, Slotboom J. Two-dimensional linear-combination model fitting of magnetic resonance spectra to define the macromolecule baseline using FiTAID, a Fitting Tool for Arrays of Interrelated Datasets. MAGMA 2011;24:147-64.
20. de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 2004;230:652-9. (Pubitemid 38252858)
21. Kreis R, Vermathen P, Ith M, LêKA, Tappy L, Boesch C. Cardiac/respiratory double triggering for 1H MR spectroscopy of the liver. Proceedings of the 14th Meeting of the International Society of Magnetic Resonance in Medicine, 2006:2257
22. Sharma P, Martin DR, Pineda N, Xu Q, Vos M, Anania F, Hu X. Quantitative analysis of T2-correction in single-voxel magnetic resonance spectroscopy of hepatic lipid fraction. J Magn Reson Imaging 2009;29:629-35.
23. Machann J, Stefan N, Schick F. (1)H MR spectroscopy of skeletal muscle, liver and bone marrow. Eur J Radiol 2008;67:275-84.
24. Debodo RC, Steele R, Altszuler N, Dunn A, Bishop JS. On the hormonal regulation of carbohydrate metabolism: studies with C14 glucose. Recent Prog Horm Res 1963;19:445-88.
25. Tounian P, Schneiter P, Henry S, Jéquier E, Tappy L. Effects of infused fructose on endogenous glucose production, gluconeogenesis, and glycogen metabolism. Am J Physiol 1994;267:E710-7.
26. Chong MF, Fielding BA, Frayn KN. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 2007;85:1511-20. (Pubitemid 46890417)
27. Parks EJ, HellersteinMK. Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr 2000;71:412-33. (Pubitemid 30061218)
28. Bortolotti M, Dubuis J, Schneiter P, Tappy L. Effects of dietary protein on lipid metabolism in high fructose fed humans. Clin Nutr 2012;31:238-45.
29. Lecoultre V, Benoit R, Carrel G, Schutz Y, Millet GP, Tappy L, Schneiter P. Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose. Am J Clin Nutr 2010;92:1071-9.
30. Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, et al. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 2006;49:3049-57. (Pubitemid 44730309)
31. Aggarwal D, Fernandeza ML, Soliman GA. Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs. Metabolism 2006;55:794-802.
32. Macotela Y, Emanuelli B, Bång AM, Espinoza DO, Boucher J, Beebe K, Gall W, Kahn CR. Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS ONE 2011;6:e21187.