High-Fructose Corn Syrup: Controversies and Common Sense

American Journal of Lifestyle Medicine

Volumn 4, Issue 6, 2010, Pages 515-520

  White, John S ^a   Foreyt, John P ^b   Melanson, Kathleen J ^c   Angelopoulos, Theodore J ^d  

^a White Technical Research   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF RHODE ISLAND   (United States)

^d UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

HFCS; high fructose corn syrup; metabolism; obesity; sucrose; sugars; sweeteners

Indexed keywords

EID: 84990386110     PISSN: 15598276     EISSN: None     Source Type: Journal    
DOI: 10.1177/1559827610378960     Document Type: Review

References (34)

1. Bray GA, Nielsen SJ, Popkin BM Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004; 79: 537-543.
2. Melanson K., Angelopoulos T., Nguyen V., Zukley L., Lowndes J., Rippe J. High-fructose corn syrup, energy intake, and appetite regulation. Am J Clin Nutr. 2008; 88(suppl):1738S.
3. Stanhope K., Havel P. Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup. Am J Clin Nutr. 2008; 88(suppl):18335S.
4. Tappy L., Lê K-A. Metabolic effects of fructose and the worldwide increase of obesity. Physiol Rev. 2010; 90: 23-46.
5. Melanson K., Zukley L., Lowndes J., Nguyen V., Angelopoulos T., Rippe J. Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition. 2007; 23: 103-112.
6. Lowndes J., Zukley L., Nguyen V., Angelopoulos T., Rippe J. The effect of high-fructose corn syrup on uric acid levels in obese women. Obesity. 2007; 15(suppl):498-P.
7. Zukley L., Lowndes J., Melanson K., Nguyen V., Angelopoulos TJ, Rippe JM The effect of high-fructose corn syrup on triglycerides in obese females. Obesity. 2007; 15(suppl):500-P.
8. Angelopoulos TJ, Lowndes J., Zukley L., et al: The effect of high-fructose corn syrup consumption on triglycerides and uric acid. J Nutr. 2009; 139: 1242S-1245S.
9. Soenen S., Westerterp-Plantenga MS No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr. 2007; 86: 1586-1594.
10. Stanhope K., Griffen S., Bair B., Swarbrick M., Keim N., Havel P. Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr. 2008;87: 1194-1203.
11. Fulgoni V. High-fructose corn syrup: everything you wanted to know, but were afraid to ask. Am J Clin Nutr. 2008; 88(suppl):1715S.
12. White J. Straight talk about high-fructose corn syrup: what it is and what it ain-t. Am J Clin Nutr. 2008; 88: 1716S-1721S.
13. Duffey KJ, Popkin BM High-fructose corn syrup: is this what-s for dinner? Am J Clin Nutr. 2008;88(suppl):1722S-1732S.
14. Murphy SP The state of the science on dietary sweeteners containing fructose: summary and issues to be resolved. J Nutr. 2009; 139: 1269S-1270S.
15. White JS Misconceptions about high-fructose corn syrup: is it uniquely responsible for obesity, reactive dicarbonyl compounds, and advanced glycation end-products? J Nutr. 2009; 139: 1219S-1227S.
16. American Medical Association. Report 3 of the Council on Science and Public Health (A-08): The Health Effects of High Fructose Corn Syrup. Chicago: American Medical Association; 2008.
17. American Dietetic Association. Use of nutritive and nonnutritive sweeteners. J Am Diet Assoc. 2004; 104: 255-275.
18. Buck AW High fructose corn syrup. In: Nabors LO, ed. Alternative Sweeteners. 3rd ed. New York: Marcel Dekker; 2001: 391-411.
19. Life Sciences Research Office. SCOGS-50: Evaluation of the Health Aspects of Corn Sugar (Dextrose), Corn Syrups, and Invert Sugar as Food Ingredients. Bethesda, MD: Federation of American Societies for Experimental Biology; 1976.
20. Glinsmann WH, Irausquin H., Park YK Evaluation of health aspects of sugars contained in carbohydrate sweeteners. Report of Sugars Task Force 1986. J Nutr. 1986; 116: 11S-216.
21. Glinsmann WH, Bowman BA The public health significance of dietary fructose. Am J Clin Nutr. 1993; 58: 820S-823S.
22. Office of the Federal Register, National Archives and Records Administration. Direct food substances affirmed as generally recognized as safe: high fructose corn syrup. Fed Regist. 1983; 48: 5715-5719.
23. World Health Organization. Compare countries: using WHO comparable estimates. Global Infobase Online 2005 ed. https://apps.who.int/infobase/comparestart.aspx
24. Office of Disease Prevention and Health Promotion, US Department of Health and Human Services. Dietary Guidelines for Americans 2005. Washington, DC: Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services; 2005.
25. Fereday N., Forber G., Giradello S., et al. HFCS industry annual review: a year of changing expectations. In: Sweetener Analysis. Oxford, UK: LMC International Ltd; 2007: 1-8.
26. Anderson GH Much ado about high-fructose corn syrup: the meat of the matter. Am J Clin Nutr. 2007; 86: 1577.
27. Teff KL, Grudziak J., Townsend RR, et al. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab. 2009; 94: 1562-1569.
28. Johnson RJ, Segal MS, Sautin Y., et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr. 2007; 86: 899-906.
29. Bocarsly ME, Powell ES, Avena NM, Hoebel BG High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels. Pharmacol Biochem Behav. 2010 Feb 26. [Epub ahead of print]
30. Marriott BP, Cole N., Lee E. National estimates of dietary fructose intake increased from 1977 to 2004 in the United States. J Nutr. 2009; 139: 1228S-1235S.
31. US Department of Health and Human Services, Office of the Surgeon General. The Surgeon General-s Call to Action to Prevent and Decrease Overweight and Obesity. Washington, DC: US Department of Health and Human Services, Office of the Surgeon General; 2007.
32. Buzby J., Wells HF Loss-adjusted food availability data: calories. USDA-Economic Research Service, 2007. www.ers.usda.gov/Data/FoodConsumption/spreadsheets/foodloss/Calories.xls. Accessed March 15, 2007.
33. Hudson CJ, Wallis JA, Juekendrup AE. Exogenous CHO oxidation with glucose plus fructose intake during exercise. Med Sci Sports Exerc. 2009; 41: 357-363.
34. Currell K., Urch J., Cerri E., Jentjens RL, Blannin AK, Jeukendrup AE Plasma deuterium oxide accumulation following ingestion of different carbohydrate beverages. Appl Physiol Nutr Metab. 2008; 33: 1067-1072.