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Volumn 4, Issue 5, 2013, Pages e201301008-

LC-MS-based metabolomics of xenobiotic-induced toxicities

Author keywords

Biomarker; Lc Ms; Metabolomics; Xenobiotic; Xenobiotic Induced Toxicity

Indexed keywords


EID: 84888002982     PISSN: None     EISSN: 20010370     Source Type: Journal    
DOI: 10.5936/csbj.201301008     Document Type: Short Survey
Times cited : (22)

References (75)
  • 3
    • 33847358695 scopus 로고    scopus 로고
    • Analytical strategies in metabonomics
    • DOI 10.1021/pr0605217
    • Lenz EM, Wilson ID (2007) Analytical strategies in metabonomics. J Proteome Res 6: 443-458. (Pubitemid 46340149)
    • (2007) Journal of Proteome Research , vol.6 , Issue.2 , pp. 443-458
    • Lenz, E.M.1    Wilson, I.D.2
  • 4
    • 34547344360 scopus 로고    scopus 로고
    • New analytical strategies in studying drug metabolism
    • DOI 10.1007/s00216-007-1367-z, Analytical Toxicol
    • Staack RF, Hopfgartner G (2007) New analytical strategies in studying drug metabolism. Anal Bioanal Chem 388: 1365-1380. (Pubitemid 47150867)
    • (2007) Analytical and Bioanalytical Chemistry , vol.388 , Issue.7 , pp. 1365-1380
    • Staack, R.F.1    Hopfgartner, G.2
  • 6
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • DOI 10.1093/toxsci/kfi102
    • Robertson DG (2005) Metabonomics in toxicology: a review. Toxicol Sci 85: 809-822. (Pubitemid 40846857)
    • (2005) Toxicological Sciences , vol.85 , Issue.2 , pp. 809-822
    • Robertson, D.G.1
  • 7
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson JK, Wilson ID (2003) Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2: 668-676. (Pubitemid 37361770)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 9
    • 33646595378 scopus 로고    scopus 로고
    • The Cinderella story of metabolic profiling: Does metabolomics get to go to the functional genomics ball?
    • DOI 10.1098/rstb.2005.1734
    • Griffin JL (2006) The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos Trans RSocLondB Biol Sci 361: 147-161. (Pubitemid 44858949)
    • (2006) Philosophical Transactions of the Royal Society B: Biological Sciences , vol.361 , Issue.1465 , pp. 147-161
    • Griffin, J.L.1
  • 10
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological nmr spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29: 1181.
    • (1999) Xenobiotica , vol.29 , pp. 1181
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 11
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: A platform for studying drug toxicity and gene function
    • DOI 10.1038/nrd728
    • Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1: 153-161. (Pubitemid 41646523)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.2 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 12
    • 33947307759 scopus 로고    scopus 로고
    • Plant metabolomics: Towards biological function and mechanism
    • DOI 10.1016/j.tplants.2006.08.007, PII S1360138506002238
    • Schauer N, Fernie AR (2006) Plant metabolomics: towards biological function and mechanism. Trends in plant science 11: 508-516. (Pubitemid 44443000)
    • (2006) Trends in Plant Science , vol.11 , Issue.10 , pp. 508-516
    • Schauer, N.1    Fernie, A.R.2
  • 13
    • 20944448468 scopus 로고    scopus 로고
    • Microbial metabolomics: Replacing trial-and-error by the unbiased selection and ranking of targets
    • DOI 10.1007/s10295-005-0231-4
    • van der Werf MJ, Jellema RH, Hankemeier T (2005) Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets. J Ind Microbiol Biotechnol 32: 234-252. (Pubitemid 40869002)
    • (2005) Journal of Industrial Microbiology and Biotechnology , vol.32 , Issue.6 , pp. 234-252
    • Van Der Werf, M.J.1    Jellema, R.H.2    Hankemeier, T.3
  • 16
    • 34548410134 scopus 로고    scopus 로고
    • High-performance liquid chromatography separations coupled with coulometric electrode array detectors: A unique approach to metabolomics
    • Kristal BS, Shurubor YI, Kaddurah-Daouk R, Matson WR (2007) High-performance liquid chromatography separations coupled with coulometric electrode array detectors: a unique approach to metabolomics. Methods Mol Biol 358: 159-174.
    • (2007) Methods Mol Biol , vol.358 , pp. 159-174
    • Kristal, B.S.1    Shurubor, Y.I.2    Kaddurah-Daouk, R.3    Matson, W.R.4
  • 17
    • 78751476295 scopus 로고    scopus 로고
    • Metabolic fingerprinting of biofluids by infrared spectroscopy: Modeling and optimization of flow rates for laminar fluid diffusion interface sample preconditioning
    • Schattka B, Alexander M, Ying SL, Man A, Shaw RA (2011) Metabolic fingerprinting of biofluids by infrared spectroscopy: modeling and optimization of flow rates for laminar fluid diffusion interface sample preconditioning. Anal Chem 83: 555-562.
    • (2011) Anal Chem , vol.83 , pp. 555-562
    • Schattka, B.1    Alexander, M.2    Ying, S.L.3    Man, A.4    Shaw, R.A.5
  • 18
    • 33750480850 scopus 로고    scopus 로고
    • Metabolic profiling technologies for biomarker discovery in biomedicine and drug development
    • DOI 10.2217/14622416.7.7.1055
    • Schlotterbeck G, Ross A, Dieterle F, Senn H (2006) Metabolic profiling technologies for biomarker discovery in biomedicine and drug development. Pharmacogenomics 7: 1055-1075. (Pubitemid 44644785)
    • (2006) Pharmacogenomics , vol.7 , Issue.7 , pp. 1055-1075
    • Schlotterbeck, G.1    Ross, A.2    Dieterle, F.3    Senn, H.4
  • 19
    • 34548388291 scopus 로고    scopus 로고
    • LC-MS-based metabolomics in drug metabolism
    • DOI 10.1080/03602530701497804, PII 781831943
    • Chen C, Gonzalez FJ, Idle JR (2007) LC-MS-based metabolomics in drug metabolism. Drug Metab Rev 39: 581-597. (Pubitemid 47355739)
    • (2007) Drug Metabolism Reviews , vol.39 , Issue.2-3 , pp. 581-597
    • Chen, C.1    Gonzalez, F.J.2    Idle, J.R.3
  • 20
    • 33846109344 scopus 로고    scopus 로고
    • Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics
    • DOI 10.1007/s00216-006-0687-8
    • Pan Z, Raftery D (2007) Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics. Anal Bioanal Chem 387: 525-527. (Pubitemid 46067468)
    • (2007) Analytical and Bioanalytical Chemistry , vol.387 , Issue.2 , pp. 525-527
    • Pan, Z.1    Raftery, D.2
  • 21
    • 20544466649 scopus 로고    scopus 로고
    • Metabonomics in toxicology: A review
    • DOI 10.1093/toxsci/kfi102
    • Robertson DG (2005) Metabonomics in Toxicology: A Review. Toxicological Sciences 85: 809-822. (Pubitemid 40846857)
    • (2005) Toxicological Sciences , vol.85 , Issue.2 , pp. 809-822
    • Robertson, D.G.1
  • 23
    • 33847377098 scopus 로고    scopus 로고
    • From exogenous to endogenous: The inevitable imprint of mass spectrometry in metabolomics
    • DOI 10.1021/pr060505+
    • Want EJ, Nordstrom A, Morita H, Siuzdak G (2007) From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J Proteome Res 6: 459-468. (Pubitemid 46340150)
    • (2007) Journal of Proteome Research , vol.6 , Issue.2 , pp. 459-468
    • Want, E.J.1    Nordstrom, A.2    Morita, H.3    Siuzdak, G.4
  • 25
    • 34548550473 scopus 로고    scopus 로고
    • Shotgun metabolomics approach for the analysis of negatively charged water-soluble cellular metabolites from mouse heart tissue
    • DOI 10.1021/ac070843+
    • Sun G, Yang K, Zhao Z, Guan S, Han X, Gross RW (2007) Shotgun metabolomics approach for the analysis of negatively charged water-soluble cellular metabolites from mouse heart tissue. Anal Chem 79: 6629-6640. (Pubitemid 47395048)
    • (2007) Analytical Chemistry , vol.79 , Issue.17 , pp. 6629-6640
    • Sun, G.1    Yang, K.2    Zhao, Z.3    Guan, S.4    Han, X.5    Gross, R.W.6
  • 29
    • 84859790909 scopus 로고    scopus 로고
    • Optimizing high-throughput metabolomic biomarker screening: A study of quenching solutions to freeze intracellular metabolism in cho cells
    • Kronthaler J, Gstraunthaler G, Heel C (2012) Optimizing high-throughput metabolomic biomarker screening: a study of quenching solutions to freeze intracellular metabolism in CHO cells. OMICS 16: 90-97.
    • (2012) OMICS , vol.16 , pp. 90-97
    • Kronthaler, J.1    Gstraunthaler, G.2    Heel, C.3
  • 31
    • 66149126908 scopus 로고    scopus 로고
    • Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry
    • Bruce SJ, Tavazzi I, Parisod V, Rezzi S, Kochhar S, Guy PA (2009) Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry. Anal Chem 81: 3285-3296.
    • (2009) Anal Chem , vol.81 , pp. 3285-3296
    • Bruce, S.J.1    Tavazzi, I.2    Parisod, V.3    Rezzi, S.4    Kochhar, S.5    Guy, P.A.6
  • 34
    • 78650632013 scopus 로고    scopus 로고
    • Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry
    • Santa T (2011) Derivatization reagents in liquid chromatography/ electrospray ionization tandem mass spectrometry. Biomed Chromatogr 25: 1-10.
    • (2011) Biomed Chromatogr , vol.25 , pp. 1-10
    • Santa, T.1
  • 35
    • 82555187047 scopus 로고    scopus 로고
    • Simultaneous determination of 23 amino acids and 7 biogenic amines in fermented food samples by liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Jia S, Kang YP, Park JH, Lee J, Kwon SW (2011) Simultaneous determination of 23 amino acids and 7 biogenic amines in fermented food samples by liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr A 1218: 9174-9182.
    • (2011) J Chromatogr A , vol.1218 , pp. 9174-9182
    • Jia, S.1    Kang, Y.P.2    Park, J.H.3    Lee, J.4    Kwon, S.W.5
  • 36
    • 80052922434 scopus 로고    scopus 로고
    • Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: General principles and applications
    • Xu F, Zou L, Liu Y, Zhang Z, Ong CN (2011) Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications. Mass Spectrom Rev 30: 1143-1172.
    • (2011) Mass Spectrom Rev , vol.30 , pp. 1143-1172
    • Xu, F.1    Zou, L.2    Liu, Y.3    Zhang, Z.4    Ong, C.N.5
  • 37
    • 26444543861 scopus 로고    scopus 로고
    • Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives
    • DOI 10.1016/j.jchromb.2005.04.021, PII S1570023205003016, Improving Sensitivity in Liquid Chromatography-Mass Spectrometry
    • Gao S, Zhang ZP, Karnes HT (2005) Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives. J Chromatogr B Analyt Technol Biomed Life Sci 825: 98-110. (Pubitemid 41423593)
    • (2005) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.825 , Issue.2 , pp. 98-110
    • Gao, S.1    Zhang, Z.-P.2    Karnes, H.T.3
  • 38
    • 33748784390 scopus 로고    scopus 로고
    • Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry
    • DOI 10.1021/ac0607616
    • Coulier L, Bas R, Jespersen S, Verheij E, van der Werf MJ, Hankemeier T (2006) Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry. Anal Chem 78: 6573-6582. (Pubitemid 44413611)
    • (2006) Analytical Chemistry , vol.78 , Issue.18 , pp. 6573-6582
    • Coulier, L.1    Bas, R.2    Jespersen, S.3    Verheij, E.4    Van Der Werf, M.J.5    Hankemeier, T.6
  • 39
    • 17444404226 scopus 로고    scopus 로고
    • High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
    • DOI 10.1021/pr049769r
    • Wilson ID, Nicholson JK, Castro-Perez J, Granger JH, Johnson KA, Smith BW, Plumb RS (2005) High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res 4: 591-598. (Pubitemid 40548168)
    • (2005) Journal of Proteome Research , vol.4 , Issue.2 , pp. 591-598
    • Wilson, I.D.1    Nicholson, J.K.2    Castro-Perez, J.3    Granger, J.H.4    Johnson, K.A.5    Smith, B.W.6    Plumb, R.S.7
  • 41
    • 42949089041 scopus 로고    scopus 로고
    • Capillary electrophoresis-fourier transform ion cyclotron resonance mass spectrometry for the identification of cationic metabolites via a pH-mediated stacking-transient isotachophoretic method
    • DOI 10.1021/ac800007q
    • Baidoo EE, Benke PI, Neususs C, Pelzing M, Kruppa G, Leary JA, Keasling JD (2008) Capillary electrophoresis-fourier transform ion cyclotron resonance mass spectrometry for the identification of cationic metabolites via a pH-mediated stacking-transient isotachophoretic method. Anal Chem 80: 3112-3122. (Pubitemid 351620695)
    • (2008) Analytical Chemistry , vol.80 , Issue.9 , pp. 3112-3122
    • Baidoo, E.E.K.1    Benke, P.I.2    Neususs, C.3    Pelzing, M.4    Kruppa, G.5    Leary, J.A.6    Keasling, J.D.7
  • 42
    • 40549100747 scopus 로고    scopus 로고
    • Metabolomics data analysis, visualization, and integration
    • Plant Bioinformatics - Methods and Protocols
    • Sumner LW, Urbanczyk-Wochniak E, Broeckling CD (2007) Metabolomics data analysis, visualization, and integration. Methods Mol Biol 406: 409-436. (Pubitemid 351367185)
    • (2007) Methods in Molecular Biology , vol.406 , pp. 409-436
    • Sumner, L.W.1    Urbanczyk-Wochniak, E.2    Broeckling, C.D.3
  • 44
    • 33646754900 scopus 로고    scopus 로고
    • Metabolomic database annotations via query of elemental compositions: Mass accuracy is insufficient even at less than 1 ppm
    • Kind T, Fiehn O (2006) Metabolomic database annotations via query of elemental compositions: mass accuracy is insufficient even at less than 1 ppm. BMC Bioinformatics 7: 234.
    • (2006) BMC Bioinformatics , vol.7 , pp. 234
    • Kind, T.1    Fiehn, O.2
  • 45
    • 33748902567 scopus 로고    scopus 로고
    • Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data
    • DOI 10.1124/dmd.106.009241
    • Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H (2006) Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab Dispos 34: 1722-1733. (Pubitemid 44427475)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1722-1733
    • Zhu, M.1    Ma, L.2    Zhang, D.3    Ray, K.4    Zhao, W.5    Humphreys, W.G.6    Skiles, G.7    Sanders, M.8    Zhang, H.9
  • 46
    • 25144438177 scopus 로고    scopus 로고
    • Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
    • DOI 10.1002/rcm.2111
    • Mortishire-Smith RJ, O'Connor D, Castro-Perez JM, Kirby J (2005) Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun Mass Spectrom 19: 2659-2670. (Pubitemid 41338609)
    • (2005) Rapid Communications in Mass Spectrometry , vol.19 , Issue.18 , pp. 2659-2670
    • Mortishire-Smith, R.J.1    O'Connor, D.2    Castro-Perez, J.M.3    Kirby, J.4
  • 47
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • Guengerich FP (2001) Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 14:611-650. (Pubitemid 32565712)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.6 , pp. 611-650
    • Guengerich, F.P.1
  • 49
    • 33745320763 scopus 로고    scopus 로고
    • A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse
    • DOI 10.1021/tx0600402
    • Giri S, Idle JR, Chen C, Zabriskie TM, Krausz KW, Gonzalez FJ (2006) A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Chem Res Toxicol 19: 818-827. (Pubitemid 43939061)
    • (2006) Chemical Research in Toxicology , vol.19 , Issue.6 , pp. 818-827
    • Giri, S.1    Idle, J.R.2    Chen, C.3    Zabriskie, T.M.4    Krausz, K.W.5    Gonzalez, F.J.6
  • 50
    • 66649118903 scopus 로고    scopus 로고
    • Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics
    • Liu A, Patterson AD, Yang Z, Zhang X, Liu W, Qiu F, Sun H, Krausz KW, Idle JR, Gonzalez FJ, Dai R (2009) Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics. Drug Metab Dispos 37: 1157-1163.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1157-1163
    • Liu, A.1    Patterson, A.D.2    Yang, Z.3    Zhang, X.4    Liu, W.5    Qiu, F.6    Sun, H.7    Krausz, K.W.8    Idle, J.R.9    Gonzalez, F.J.10    Dai, R.11
  • 51
    • 41549100628 scopus 로고    scopus 로고
    • A metabolomic perspective of melatonin metabolism in the mouse
    • DOI 10.1210/en.2007-1412
    • Ma X, Chen C, Krausz KW, Idle JR, Gonzalez FJ (2008) A metabolomic perspective of melatonin metabolism in the mouse. Endocrinology 149: 1869-1879. (Pubitemid 351468324)
    • (2008) Endocrinology , vol.149 , Issue.4 , pp. 1869-1879
    • Ma, X.1    Chen, C.2    Krausz, K.W.3    Idle, J.R.4    Gonzalez, F.J.5
  • 52
    • 84871598157 scopus 로고    scopus 로고
    • Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling
    • Yao D, Shi X, Wang L, Gosnell BA, Chen C (2013) Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling. Drug Metab Dispos 41: 79-88.
    • (2013) Drug Metab Dispos , vol.41 , pp. 79-88
    • Yao, D.1    Shi, X.2    Wang, L.3    Gosnell, B.A.4    Chen, C.5
  • 53
    • 41949134860 scopus 로고    scopus 로고
    • Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and cyp2el-null mice
    • Chen C, Krausz KW, Idle JR, Gonzalez FJ (2008) Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2el-null mice. J Biol Chem 283: 4543-4559.
    • (2008) J Biol Chem , vol.283 , pp. 4543-4559
    • Chen, C.1    Krausz, K.W.2    Idle, J.R.3    Gonzalez, F.J.4
  • 54
    • 84863170205 scopus 로고    scopus 로고
    • Identification of n-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis
    • Shi X, Yao D, Chen C (2012) Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. J Biol Chem 287: 6336-6349.
    • (2012) J Biol Chem , vol.287 , pp. 6336-6349
    • Shi, X.1    Yao, D.2    Chen, C.3
  • 55
    • 79951893032 scopus 로고    scopus 로고
    • Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models
    • Jiang XL, Gonzalez FJ, Yu AM (2011) Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. Drug Metab Rev 43: 27-40.
    • (2011) Drug Metab Rev , vol.43 , pp. 27-40
    • Jiang, X.L.1    Gonzalez, F.J.2    Yu, A.M.3
  • 56
    • 34047250288 scopus 로고    scopus 로고
    • A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach
    • DOI 10.1021/tx600320w
    • Chen C, Ma X, Malfatti MA, Krausz KW, Kimura S, Felton JS, Idle JR, Gonzalez FJ (2007) A comprehensive investigation of 2-amino-l-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach. Chem Res Toxicol 20: 531-542. (Pubitemid 46548699)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.3 , pp. 531-542
    • Chen, C.1    Ma, X.2    Malfatti, M.A.3    Krausz, K.W.4    Kimura, S.5    Felton, J.S.6    Idle, J.R.7    Gonzalez, F.J.8
  • 57
    • 79952079197 scopus 로고    scopus 로고
    • Metabolomics in toxicology: Preclinical and clinical applications
    • Robertson DG, Watkins PB, Reily MD (2011) Metabolomics in toxicology: preclinical and clinical applications. Toxicol Sci 120 Suppl l:S146-170.
    • (2011) Toxicol Sci , vol.120 , Issue.SUPPL. 1
    • Robertson, D.G.1    Watkins, P.B.2    Reily, M.D.3
  • 59
    • 33750431077 scopus 로고    scopus 로고
    • Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders
    • DOI 10.2217/14622416.7.7.1095
    • Griffin JL, Nicholls AW (2006) Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders. Pharmacogenomics 7: 1095-1107. (Pubitemid 44649115)
    • (2006) Pharmacogenomics , vol.7 , Issue.7 , pp. 1095-1107
    • Griffin, J.L.1    Nicholls, A.W.2
  • 60
    • 22144478635 scopus 로고    scopus 로고
    • The emerging field of lipidomics
    • DOI 10.1038/nrd1776
    • Wenk MR (2005) The emerging field of lipidomics. Nat Rev Drug Discov4: 594-610. (Pubitemid 40975712)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.7 , pp. 594-610
    • Wenk, M.R.1
  • 61
    • 84867356237 scopus 로고    scopus 로고
    • Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity
    • Shi X, Yao D, Gosnell BA, Chen C (2012) Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. J Lipid Res 53: 2318-2330.
    • (2012) J Lipid Res , vol.53 , pp. 2318-2330
    • Shi, X.1    Yao, D.2    Gosnell, B.A.3    Chen, C.4
  • 63
    • 77949417518 scopus 로고    scopus 로고
    • Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity
    • Beger RD, Sun J, Schnackenberg LK (2010) Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Toxicol Appl Pharmacol 243: 154-166.
    • (2010) Toxicol Appl Pharmacol , vol.243 , pp. 154-166
    • Beger, R.D.1    Sun, J.2    Schnackenberg, L.K.3
  • 64
    • 41949108590 scopus 로고    scopus 로고
    • Metabolic profiling as a tool for understanding mechanisms of toxicity
    • Clarke CJ, Haselden JN (2008) Metabolic profiling as a tool for understanding mechanisms of toxicity. Toxicol Pathol 36: 140-147.
    • (2008) Toxicol Pathol , vol.36 , pp. 140-147
    • Clarke, C.J.1    Haselden, J.N.2
  • 65
    • 17844404232 scopus 로고    scopus 로고
    • Gut microorganisms, mammalian metabolism and personalized health care
    • DOI 10.1038/nrmicro1152
    • Nicholson JK, Holmes E, Wilson ID (2005) Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 3: 431-438. (Pubitemid 40590386)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.5 , pp. 431-438
    • Nicholson, J.K.1    Holmes, E.2    Wilson, I.D.3
  • 67
    • 77954758654 scopus 로고    scopus 로고
    • The impact of the microbiota on the pathogenesis of ibd: Lessons from mouse infection models
    • Nell S, Suerbaum S, Josenhans C (2010) The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat Rev Microbiol 8: 564-577.
    • (2010) Nat Rev Microbiol , vol.8 , pp. 564-577
    • Nell, S.1    Suerbaum, S.2    Josenhans, C.3
  • 68
    • 74249119678 scopus 로고    scopus 로고
    • Obesity and the human microbiome
    • Ley RE (2010) Obesity and the human microbiome. Curr Opin Gastroenterol 26: 5-11.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 5-11
    • Ley, R.E.1
  • 69
    • 79551577263 scopus 로고    scopus 로고
    • Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes
    • Musso G, Gambino R, Cassader M (2011) Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annu Rev Med 62: 361-380.
    • (2011) Annu Rev Med , vol.62 , pp. 361-380
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 71
    • 0034790149 scopus 로고    scopus 로고
    • Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
    • Kassie F, Rabot S, Kundi M, Chabicovsky M, Qin HM, Knasmuller S (2001) Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo [4,5-fjquinoline. Carcinogenesis 22: 1721-1725. (Pubitemid 32952153)
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1721-1725
    • Kassie, F.1    Rabot, S.2    Kundi, M.3    Chabicovsky, M.4    Qin, H.-M.5    Knasmuller, S.6
  • 72
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A 106: 14728-14733.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.