Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells

Molecular Oncology

Volumn 7, Issue 6, 2013, Pages 1129-1141

  Forn, Marta ^a   Muñoz, Mar ^a   Tauriello, Daniele V F ^b   Merlos Suárez, Anna ^b   Rodilla, Verónica ^c   Bigas, Anna ^c   Batlle, Eduard ^b,d   Jordà, Mireia ^a   Peinado, Miguel A ^a  

^a Institute of Predictive and Personalized Medicine of Cancer IMPPC   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Cell differentiation; Chromatin marks; Colorectal cancer; DNA methylation; Gene silencing; Histone modification; Long range epigenetic silencing

Indexed keywords

TRANSCRIPTION FACTOR CTCF;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER REGRESSION; CELL DIFFERENTIATION; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE CELL; INTESTINE TUMOR; LONG RANGE EPIGENETIC SILENCING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

MURINAE; MUS;

CELL DIFFERENTIATION; CHIP; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN MARKS; COLORECTAL CANCER; DNA METHYLATION; GENE SILENCING; HISTONE MODIFICATION; INTESTINAL STEM CELLS; ISC; LONG RANGE EPIGENETIC SILENCING; LRES;

ANIMALS; CACO-2 CELLS; CHROMATIN; COLONIC NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; GENE SILENCING; HISTONES; HUMANS; MICE; NEOPLASM PROTEINS;

EID: 84887990323     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2013.08.008     Document Type: Article

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