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Volumn 359, Issue 1-2, 2005, Pages 127-137

Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity

Author keywords

5 and 3 untranslated regions; Alternative transcripts; Gene of neuron specific protein; Promoter, in silico analysis

Indexed keywords

COMPLEXIN 2; CYTOPLASM PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 25144453368     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2005.07.005     Document Type: Article
Times cited : (7)

References (34)
  • 2
    • 0030916203 scopus 로고    scopus 로고
    • Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites
    • S. Anand, F.D. Batista, T. Tkach, D.G. Efremov, and O.R. Burrone Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites Mol. Immunol. 34 1997 175 183
    • (1997) Mol. Immunol. , vol.34 , pp. 175-183
    • Anand, S.1    Batista, F.D.2    Tkach, T.3    Efremov, D.G.4    Burrone, O.R.5
  • 3
    • 0029936752 scopus 로고    scopus 로고
    • Regulation of gene expression by alternative promoters
    • T.A. Ayoubi, and W.J. van de Ven Regulation of gene expression by alternative promoters FASEB J. 10 1996 453 460
    • (1996) FASEB J. , vol.10 , pp. 453-460
    • Ayoubi, T.A.1    Van De Ven, W.J.2
  • 4
    • 0022470649 scopus 로고
    • Murine myb protooncogene mRNA: CDNA sequence and evidence for 5′ heterogeneity
    • T.P. Bender, and W.M. Kuehl Murine myb protooncogene mRNA: cDNA sequence and evidence for 5′ heterogeneity Proc. Natl. Acad. Sci. U. S. A. 83 1986 3204 3208
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 3204-3208
    • Bender, T.P.1    Kuehl, W.M.2
  • 6
  • 7
    • 0023277545 scopus 로고
    • Single-step method of mRNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction
    • P. Chomczynski, and N. Sacchi Single-step method of mRNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156 159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 8
    • 0035463344 scopus 로고    scopus 로고
    • Brain-specific sequence Hfb1 is part of the 3'-untranslated region of the human complexin 2 gene: New data from in vitro and in silico experiments
    • L.V. Dergunova Brain-specific sequence Hfb1 is part of the 3'-untranslated region of the human complexin 2 gene: new data from in vitro and in silico experiments Mol. Biol. (Mosk.) 35 2001 778 786
    • (2001) Mol. Biol. (Mosk.) , vol.35 , pp. 778-786
    • Dergunova, L.V.1
  • 9
    • 0037272981 scopus 로고    scopus 로고
    • Structural and functional analyses of the Hfb1, Hmob3, and Hmob33 cDNAs as an example of human brain-specific gene studies
    • L.V. Dergunova, N.M. Raevskaya, I.P. Vladychenskaya, and S.A. Limborska Structural and functional analyses of the Hfb1, Hmob3, and Hmob33 cDNAs as an example of human brain-specific gene studies Mol. Biol. (Mosk.) 37 2003 315 324
    • (2003) Mol. Biol. (Mosk.) , vol.37 , pp. 315-324
    • Dergunova, L.V.1    Raevskaya, N.M.2    Vladychenskaya, I.P.3    Limborska, S.A.4
  • 10
    • 0037355136 scopus 로고    scopus 로고
    • Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3′-untranslated region
    • L.V. Dergunova, N.M. Raevskaya, I.P. Vladychenskaya, and S.A. Limborska Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3′-untranslated region Biomol. Eng. 20 2003 91 96
    • (2003) Biomol. Eng. , vol.20 , pp. 91-96
    • Dergunova, L.V.1    Raevskaya, N.M.2    Vladychenskaya, I.P.3    Limborska, S.A.4
  • 11
    • 0008024807 scopus 로고    scopus 로고
    • Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: A study of complexin mRNA
    • S.L. Eastwood, and P.J. Harrison Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNA Mol. Psychiatry 5 2000 425 432
    • (2000) Mol. Psychiatry , vol.5 , pp. 425-432
    • Eastwood, S.L.1    Harrison, P.J.2
  • 12
    • 11844304923 scopus 로고    scopus 로고
    • Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: Further evidence for a synaptic pathology affecting glutamate neurons
    • S.L. Eastwood, and P.J. Harrison Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons Schizophr. Res. 73 2005 159 172
    • (2005) Schizophr. Res. , vol.73 , pp. 159-172
    • Eastwood, S.L.1    Harrison, P.J.2
  • 13
    • 0035898259 scopus 로고    scopus 로고
    • Cerebellar synaptic protein expression in schizophrenia
    • S.L. Eastwood, D. Cotter, and P.J. Harrison Cerebellar synaptic protein expression in schizophrenia Neuroscience 105 2001 219 229
    • (2001) Neuroscience , vol.105 , pp. 219-229
    • Eastwood, S.L.1    Cotter, D.2    Harrison, P.J.3
  • 14
    • 0041731977 scopus 로고    scopus 로고
    • Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II
    • J.M. Edwardson Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II J. Biol. Chem. 278 2003 30849 30853
    • (2003) J. Biol. Chem. , vol.278 , pp. 30849-30853
    • Edwardson, J.M.1
  • 15
    • 2342586760 scopus 로고    scopus 로고
    • Differential messenger RNA expression of complexins in mouse brain
    • W. Freeman, and A.J. Morton Differential messenger RNA expression of complexins in mouse brain Brain Res. Bull. 63 2004 33 44
    • (2004) Brain Res. Bull. , vol.63 , pp. 33-44
    • Freeman, W.1    Morton, A.J.2
  • 16
    • 0037428395 scopus 로고    scopus 로고
    • Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus
    • R.P. Friday, S.L. Pietropaolo, J. Profozich, M. Trucco, and M. Pietropaolo Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus J. Biol. Chem. 278 2003 853 863
    • (2003) J. Biol. Chem. , vol.278 , pp. 853-863
    • Friday, R.P.1    Pietropaolo, S.L.2    Profozich, J.3    Trucco, M.4    Pietropaolo, M.5
  • 17
    • 2442621222 scopus 로고    scopus 로고
    • Genomic structure and 5′-flanking sequences of rat N-acetylglucosaminyltransferase I gene and regulatory role of its transcriptional diversity
    • T. Fukada, M. Ono, S. Sakata, N. Kioka, H. Sakai, and T. Komano Genomic structure and 5′-flanking sequences of rat N-acetylglucosaminyltransferase I gene and regulatory role of its transcriptional diversity Biosci. Biotechnol. Biochem. 67 2003 1515 1521
    • (2003) Biosci. Biotechnol. Biochem. , vol.67 , pp. 1515-1521
    • Fukada, T.1    Ono, M.2    Sakata, S.3    Kioka, N.4    Sakai, H.5    Komano, T.6
  • 18
    • 0032807628 scopus 로고    scopus 로고
    • Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1)
    • M. Gong, K.H. Cowan, J. Gudas, and J.A. Moscow Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1) Gene 233 1999 21 31
    • (1999) Gene , vol.233 , pp. 21-31
    • Gong, M.1    Cowan, K.H.2    Gudas, J.3    Moscow, J.A.4
  • 19
    • 14844282772 scopus 로고    scopus 로고
    • Expression of axin2 is regulated by the alternative 5′-untranslated regions of its mRNA
    • T.A. Hughes, and H.J. Brady Expression of axin2 is regulated by the alternative 5′-untranslated regions of its mRNA J. Biol. Chem. 280 2005 8581 8588
    • (2005) J. Biol. Chem. , vol.280 , pp. 8581-8588
    • Hughes, T.A.1    Brady, H.J.2
  • 20
    • 0032889591 scopus 로고    scopus 로고
    • Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex
    • T. Ishizuka, H. Saisu, S. Odani, T. Kumanishi, and T. Abe Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex Neuroscience 88 1999 295 306
    • (1999) Neuroscience , vol.88 , pp. 295-306
    • Ishizuka, T.1    Saisu, H.2    Odani, S.3    Kumanishi, T.4    Abe, T.5
  • 21
    • 0034087513 scopus 로고    scopus 로고
    • Structure of the pig sterol 14 alpha-demethylase (CYP51) gene and its expression in the testis and other tissues
    • M. Kojima, T. Morozumi, A. Onishi, and T. Mitsuhashi Structure of the pig sterol 14 alpha-demethylase (CYP51) gene and its expression in the testis and other tissues J. Biochem. (Tokyo) 127 2000 805 811
    • (2000) J. Biochem. (Tokyo) , vol.127 , pp. 805-811
    • Kojima, M.1    Morozumi, T.2    Onishi, A.3    Mitsuhashi, T.4
  • 22
    • 0024414469 scopus 로고
    • Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs
    • M. Kozak Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs Mol. Cell. Biol. 9 1989 5134 5142
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5134-5142
    • Kozak, M.1
  • 23
    • 0037028497 scopus 로고    scopus 로고
    • Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements
    • J. Li, M. Rehli, B. Timblin, F. Tan, S.W. Krause, and R.A. Skidgel Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements Gene 284 2002 189 202
    • (2002) Gene , vol.284 , pp. 189-202
    • Li, J.1    Rehli, M.2    Timblin, B.3    Tan, F.4    Krause, S.W.5    Skidgel, R.A.6
  • 24
    • 0028880456 scopus 로고
    • Complexins: Cytosolic proteins that regulate SNAP receptor function
    • H.T. McMahon, M. Missler, C. Li, and T.C. Sudhof Complexins: cytosolic proteins that regulate SNAP receptor function Cell 83 1995 111 119
    • (1995) Cell , vol.83 , pp. 111-119
    • McMahon, H.T.1    Missler, M.2    Li, C.3    Sudhof, T.C.4
  • 25
    • 0342723790 scopus 로고    scopus 로고
    • Frequent alternative splicing of human genes
    • A.A. Mironov, J.W. Fickett, and M.S. Gelfand Frequent alternative splicing of human genes Genome Res. 9 1999 1288 1293
    • (1999) Genome Res. , vol.9 , pp. 1288-1293
    • Mironov, A.A.1    Fickett, J.W.2    Gelfand, M.S.3
  • 26
    • 18544407805 scopus 로고    scopus 로고
    • Regulatory roles of complexins in neurotransmitter release from mature presynaptic nerve terminals
    • S. Ono Regulatory roles of complexins in neurotransmitter release from mature presynaptic nerve terminals Eur. J. Neurosci. 10 1998 2143 2152
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2143-2152
    • Ono, S.1
  • 27
    • 0037040873 scopus 로고    scopus 로고
    • Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis
    • S. Pabst, M. Margittai, D. Vainius, R. Langen, R. Jahn, and D. Fasshauer Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis J. Biol. Chem. 277 2002 7838 7848
    • (2002) J. Biol. Chem. , vol.277 , pp. 7838-7848
    • Pabst, S.1    Margittai, M.2    Vainius, D.3    Langen, R.4    Jahn, R.5    Fasshauer, D.6
  • 28
    • 0035802386 scopus 로고    scopus 로고
    • Structural and functional features of eukaryotic mRNA untranslated regions
    • G. Pesole, F. Mignone, C. Gissi, G. Grillo, F. Licciulli, and S. Liuni Structural and functional features of eukaryotic mRNA untranslated regions Gene 276 2001 73 81
    • (2001) Gene , vol.276 , pp. 73-81
    • Pesole, G.1    Mignone, F.2    Gissi, C.3    Grillo, G.4    Licciulli, F.5    Liuni, S.6
  • 29
    • 0033572824 scopus 로고    scopus 로고
    • Characterization of a novel transcript of prostaglandin endoperoxide H synthase 1 with a tissue-specific profile of expression
    • M.H. Plant, and O. Laneuville Characterization of a novel transcript of prostaglandin endoperoxide H synthase 1 with a tissue-specific profile of expression Biochem. J. 344 1999 677 685
    • (1999) Biochem. J. , vol.344 , pp. 677-685
    • Plant, M.H.1    Laneuville, O.2
  • 30
    • 8744252596 scopus 로고    scopus 로고
    • Structural basis for the inhibitory role of tomosyn in exocytosis
    • A. Pobbati, A. Razeto, M. Boddener, S. Becker, and D. Fasshauer Structural basis for the inhibitory role of tomosyn in exocytosis J. Biol. Chem. 279 2004 47192 47200
    • (2004) J. Biol. Chem. , vol.279 , pp. 47192-47200
    • Pobbati, A.1    Razeto, A.2    Boddener, M.3    Becker, S.4    Fasshauer, D.5
  • 31
    • 0041828787 scopus 로고    scopus 로고
    • Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5′ leader sequence
    • J. Rohwedel, S. Kugler, T. Engebrecht, W. Purschke, P.K. Muller, and C. Kruse Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5′ leader sequence Cell. Mol. Life Sci. 60 2003 1705 1715
    • (2003) Cell. Mol. Life Sci. , vol.60 , pp. 1705-1715
    • Rohwedel, J.1    Kugler, S.2    Engebrecht, T.3    Purschke, W.4    Muller, P.K.5    Kruse, C.6
  • 32
    • 0035805637 scopus 로고    scopus 로고
    • Genomic structure of the promoters of the human estrogen receptor-alpha gene demonstrate changes in chromatin structure induced by AP2gamma
    • E.R. Schuur, L.A. McPherson, G.P. Yang, and R.G. Weigel Genomic structure of the promoters of the human estrogen receptor-alpha gene demonstrate changes in chromatin structure induced by AP2gamma J. Biol. Chem. 276 2001 15519 15526
    • (2001) J. Biol. Chem. , vol.276 , pp. 15519-15526
    • Schuur, E.R.1    McPherson, L.A.2    Yang, G.P.3    Weigel, R.G.4
  • 33
  • 34
    • 0029117211 scopus 로고
    • Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses
    • S. Takahashi Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses FEBS Lett. 368 1995 455 460
    • (1995) FEBS Lett. , vol.368 , pp. 455-460
    • Takahashi, S.1


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