Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19809-19814

  Rodriguez, Jairo ^a,b   Muñoz, Mar ^a   Vives, Laura ^a   Frangou, Costas G ^c   Groudine, Mark ^c   Peinado, Miguel A ^a,b  

^a Institut de Medicina Predictiva I Personalitzada del Càncer IMPPC   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Colorectal cancer; DNA methylation; Epigenetic memory; Transcriptional silencing

Indexed keywords

DNA; HISTONE; LYSINE; REPRESSOR PROTEIN;

ACETYLATION; ARTICLE; CANCER CELL; CARCINOGENESIS; CHROMATIN; COLON CANCER; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; GENE ACTIVATION; GENE LOCUS; GENE SILENCING; GENETIC TRANSCRIPTION; GENOMICS; MEMORY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN DOMAIN; TUMOR CELL; UPREGULATION; CELL TRANSFORMATION; CHROMOSOME 5; COLON TUMOR; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR GENE;

BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; CHROMOSOMES, HUMAN, PAIR 5; COLONIC NEOPLASMS; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENE THERAPY; GENES, NEOPLASM; HUMANS; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 58149395035     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810133105     Document Type: Article

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