Negative Regulation of Activin Signal Transduction

Vitamins and Hormones

Volumn 85, Issue , 2011, Pages 79-104

  Choi, Sun Cheol ^a   Han, Jin Kwan ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Activin; Antagonist; Inhibitor; Negative Regulators; Nodal; Signaling

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR;

ANIMAL; BOOK; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS; ACTIVINS; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; SIGNAL TRANSDUCTION;

EID: 79951936070     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385961-7.00005-6     Document Type: Book

References (95)

1. Adkins H.B., Bianco C., Schiffer S.G., Rayhorn P., Zafari M., Cheung A.E., Orozco O., Olson D., De Luca A., Chen L.L., et al. Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J. Clin. Invest. 2003, 112:575-587.
2. Alarcon C., Zaromytidou A.I., Xi Q., Gao S., Yu J., Fujisawa S., Barlas A., Miller A.N., Manova-Todorova K., Macias M.J., et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 2009, 139:757-769.
3. Alliston T., Ko T.C., Cao Y., Liang Y.Y., Feng X.H., Chang C., Derynck R. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J. Biol. Chem. 2005, 280:24227-24237.
4. Atfi A., Dumont E., Colland F., Bonnier D., L'Helgoualc'h A., Prunier C., Ferrand N., Clement B., Wewer U.M., Theret N. The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J. Cell Biol. 2007, 178:201-208.
5. Batut J., Schmierer B., Cao J., Raftery L.A., Hill C.S., Howell M. Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling. Development 2008, 135:2927-2937.
6. Bianco C., Normanno N., Salomon D.S., Ciardiello F. Role of the cripto (EGF-CFC) family in embryogenesis and cancer. Growth Factors 2004, 22:133-139.
7. Bilezikjian L.M., Blount A.L., Donaldson C.J., Vale W.W. Pituitary actions of ligands of the TGF-beta family: Activins and inhibins. Reproduction 2006, 132:207-215.
8. Chen C.L., Huang S.S., Huang J.S. Cellular heparan sulfate negatively modulates transforming growth factor-beta1 (TGF-beta1) responsiveness in epithelial cells. J. Biol. Chem. 2006, 281:11506-11514.
9. Cheng S.K., Olale F., Bennett J.T., Brivanlou A.H., Schier A.F. EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1. Genes Dev. 2003, 17:31-36.
10. Cheong S.M., Kim H., Han J.K. Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos. J. Biol. Chem. 2009, 284:17052-17060.
11. Cheyette B.N., Waxman J.S., Miller J.R., Takemaru K., Sheldahl L.C., Khlebtsova N., Fox E.P., Earnest T., Moon R.T. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev. Cell 2002, 2:449-461.
12. Choi S.C., Kim G.H., Lee S.J., Park E., Yeo C.Y., Han J.K. Regulation of activin/nodal signaling by Rap2-directed receptor trafficking. Dev. Cell 2008, 15:49-61.
13. Cordenonsi M., Dupont S., Maretto S., Insinga A., Imbriano C., Piccolo S. Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell 2003, 113:301-314.
14. Cordenonsi M., Montagner M., Adorno M., Zacchigna L., Martello G., Mamidi A., Soligo S., Dupont S., Piccolo S. Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science 2007, 315:840-843.
15. Dai F., Chang C., Lin X., Dai P., Mei L., Feng X.H. Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. Mol. Cell. Biol. 2007, 27:6183-6194.
16. Degen W.G., Weterman M.A., van Groningen J.J., Cornelissen I.M., Lemmers J.P., Agterbos M.A., Geurts van Kessel A., Swart G.W., Bloemers H.P. Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts. Int. J. Cancer 1996, 65:460-465.
17. Di Guglielmo G.M., Le Roy C., Goodfellow A.F., Wrana J.L. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat. Cell Biol. 2003, 5:410-421.
18. Dupont S., Zacchigna L., Cordenonsi M., Soligo S., Adorno M., Rugge M., Piccolo S. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 2005, 121:87-99.
19. Dupont S., Mamidi A., Cordenonsi M., Montagner M., Zacchigna L., Adorno M., Martello G., Stinchfield M.J., Soligo S., Morsut L., et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 2009, 136:123-135.
20. Escalona R.M., Stenvers K.L., Farnworth P.G., Findlay J.K., Ooi G.T. Reducing betaglycan expression by RNA interference (RNAi) attenuates inhibin bioactivity in LbetaT2 gonadotropes. Mol. Cell. Endocrinol. 2009, 307:149-156.
21. Feng X.H., Derynck R. Specificity and versatility in TGF-beta signaling through Smads. Annu. Rev. Cell Dev. Biol. 2005, 21:659-693.
22. Funaba M., Zimmerman C.M., Mathews L.S. Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. J. Biol. Chem. 2002, 277:41361-41368.
23. Gao S., Alarcon C., Sapkota G., Rahman S., Chen P.Y., Goerner N., Macias M.J., Erdjument-Bromage H., Tempst P., Massague J. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol. Cell 2009, 36:457-468.
24. Gray P.C., Greenwald J., Blount A.L., Kunitake K.S., Donaldson C.J., Choe S., Vale W. Identification of a binding site on the type II activin receptor for activin and inhibin. J. Biol. Chem. 2000, 275:3206-3212.
25. Gray P.C., Bilezikjian L.M., Vale W. Antagonism of activin by inhibin and inhibin receptors: A functional role for betaglycan. Mol. Cell. Endocrinol. 2002, 188:254-260.
26. Gray P.C., Harrison C.A., Vale W. Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proc. Natl. Acad. Sci. USA 2003, 100:5193-5198.
27. Grimm O.H., Gurdon J.B. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat. Cell Biol. 2002, 4:519-522.
28. Grotewold L., Plum M., Dildrop R., Peters T., Ruther U. Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech. Dev. 2001, 100:327-330.
29. Hamada H., Meno C., Watanabe D., Saijoh Y. Establishment of vertebrate left-right asymmetry. Nat. Rev. Genet. 2002, 3:103-113.
30. Harrison C.A., Gray P.C., Vale W.W., Robertson D.M. Antagonists of activin signaling: Mechanisms and potential biological applications. Trends Endocrinol. Metab. 2005, 16:73-78.
31. Hashimoto O., Nakamura T., Shoji H., Shimasaki S., Hayashi Y., Sugino H. A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J. Biol. Chem. 1997, 272:13835-13842.
32. He W., Dorn D.C., Erdjument-Bromage H., Tempst P., Moore M.A., Massague J. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 2006, 125:929-941.
33. Iratni R., Yan Y.T., Chen C., Ding J., Zhang Y., Price S.M., Reinberg D., Shen M.M. Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science 2002, 298:1996-1999.
34. Ito T., Williams J.D., Fraser D.J., Phillips A.O. Hyaluronan regulates transforming growth factor-beta1 receptor compartmentalization. J. Biol. Chem. 2004, 279:25326-25332.
35. Itoh S., ten Dijke P. Negative regulation of TGF-beta receptor/Smad signal transduction. Curr. Opin. Cell Biol. 2007, 19:176-184.
36. Janssens V., Goris J. Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 2001, 353:417-439.
37. Jullien J., Gurdon J. Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction. Genes Dev. 2005, 19:2682-2694.
38. Kavsak P., Rasmussen R.K., Causing C.G., Bonni S., Zhu H., Thomsen G.H., Wrana J.L. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol. Cell 2000, 6:1365-1375.
39. Kelber J.A., Shani G., Booker E.C., Vale W.W., Gray P.C. Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal. J. Biol. Chem. 2008, 283:4490-4500.
40. Kelber J.A., Panopoulos A.D., Shani G., Booker E.C., Belmonte J.C., Vale W.W., Gray P.C. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene 2009, 28:2324-2336.
41. Keutmann H.T., Schneyer A.L., Sidis Y. The role of follistatin domains in follistatin biological action. Mol. Endocrinol. 2004, 18:228-240.
42. Kowanetz M., Lonn P., Vanlandewijck M., Kowanetz K., Heldin C.H., Moustakas A. TGFbeta induces SIK to negatively regulate type I receptor kinase signaling. J. Cell Biol. 2008, 182:655-662.
43. Kretzschmar M., Doody J., Timokhina I., Massague J. A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras. Genes Dev. 1999, 13:804-816.
44. Ku M., Sokol S.Y., Wu J., Tussie-Luna M.I., Roy A.L., Hata A. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol. Cell. Biol. 2005, 25:7144-7157.
45. Lebrun J.J., Vale W.W. Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol. Cell. Biol. 1997, 17:1682-1691.
46. Lewis K.A., Gray P.C., Blount A.L., MacConell L.A., Wiater E., Bilezikjian L.M., Vale W. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 2000, 404:411-414.
47. Li Z.D., Wu Y., Bao Y.L., Yu C.L., Guan L.L., Wang Y.Z., Meng X.Y., Li Y.X. Identification and characterization of human ARIP2 and its relation to breast cancer. Cytokine 2009, 46:251-259.
48. Lin X., Duan X., Liang Y.Y., Su Y., Wrighton K.H., Long J., Hu M., Davis C.M., Wang J., Brunicardi F.C., et al. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 2006, 125:915-928.
49. Liu Z.H., Tsuchida K., Matsuzaki T., Bao Y.L., Kurisaki A., Sugino H. Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling. J. Endocrinol. 2006, 189:409-421.
50. Liu H.Y., Chen F.F., Ge J.Y., Wang Y.N., Zhang C.H., Cui X.L., Yu F., Tai G.X., Liu Z.H. Expression and localization of activin receptor-interacting protein 2 in mouse tissues. Gen. Comp. Endocrinol. 2009, 161:276-282.
51. Luo K. Ski and SnoN: Negative regulators of TGF-beta signaling. Curr. Opin. Genet. Dev. 2004, 14:65-70.
52. Luo K., Stroschein S.L., Wang W., Chen D., Martens E., Zhou S., Zhou Q. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev. 1999, 13:2196-2206.
53. Martens J.W., de Winter J.P., Timmerman M.A., McLuskey A., van Schaik R.H., Themmen A.P., de Jong F.H. Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. Endocrinology 1997, 138:2928-2936.
54. Mathews L.S., Vale W.W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 1991, 65:973-982.
55. Matsuzaki T., Hanai S., Kishi H., Liu Z., Bao Y., Kikuchi A., Tsuchida K., Sugino H. Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. J. Biol. Chem. 2002, 277:19008-19018.
56. Mitchell H., Choudhury A., Pagano R.E., Leof E.B. Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. Mol. Biol. Cell 2004, 15:4166-4178.
57. Miura S., Takeshita T., Asao H., Kimura Y., Murata K., Sasaki Y., Hanai J.I., Beppu H., Tsukazaki T., Wrana J.L., et al. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol. Cell. Biol. 2000, 20:9346-9355.
58. Moustakas A., Heldin C.H. The regulation of TGFbeta signal transduction. Development 2009, 136:3699-3714.
59. Onichtchouk D., Chen Y.G., Dosch R., Gawantka V., Delius H., Massague J., Niehrs C. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999, 401:480-485.
60. Pessah M., Prunier C., Marais J., Ferrand N., Mazars A., Lallemand F., Gauthier J.M., Atfi A. c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. Proc. Natl. Acad. Sci. USA 2001, 98:6198-6203.
61. Saito S., Sidis Y., Mukherjee A., Xia Y., Schneyer A. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. Endocrinology 2005, 146:5052-5062.
62. Sasai N., Yakura R., Kamiya D., Nakazawa Y., Sasai Y. Ectodermal factor restricts mesoderm differentiation by inhibiting p53. Cell 2008, 133:878-890.
63. Schier A.F. Nodal signaling in vertebrate development. Annu. Rev. Cell Dev. Biol. 2003, 19:589-621.
64. Schmierer B., Hill C.S. TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility. Nat. Rev. Mol. Cell Biol. 2007, 8:970-982.
65. Schneyer A.L., Rzucidlo D.A., Sluss P.M., Crowley W.F. Characterization of unique binding kinetics of follistatin and activin or inhibin in serum. Endocrinology 1994, 135:667-674.
66. Schneyer A., Tortoriello D., Sidis Y., Keutmann H., Matsuzaki T., Holmes W. Follistatin-related protein (FSRP): A new member of the follistatin gene family. Mol. Cell. Endocrinol. 2001, 180:33-38.
67. Sekiya T., Adachi S., Kohu K., Yamada T., Higuchi O., Furukawa Y., Nakamura Y., Nakamura T., Tashiro K., Kuhara S., et al. Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J. Biol. Chem. 2004, 279:6840-6846.
68. Sekiya T., Oda T., Matsuura K., Akiyama T. Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. Biochem. Biophys. Res. Commun. 2004, 320:680-684.
69. Shi W., Sun C., He B., Xiong W., Shi X., Yao D., Cao X. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. J. Cell Biol. 2004, 164:291-300.
70. Shoji H., Tsuchida K., Kishi H., Yamakawa N., Matsuzaki T., Liu Z., Nakamura T., Sugino H. Identification and characterization of a PDZ protein that interacts with activin type II receptors. J. Biol. Chem. 2000, 275:5485-5492.
71. Sidis Y., Schneyer A.L., Sluss P.M., Johnson L.N., Keutmann H.T. Follistatin: Essential role for the N-terminal domain in activin binding and neutralization. J. Biol. Chem. 2001, 276:17718-17726.
72. Stamler R., Keutmann H.T., Sidis Y., Kattamuri C., Schneyer A., Thompson T.B. The structure of FSTL3. activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J. Biol. Chem. 2008, 283:32831-32838.
73. Strizzi L., Bianco C., Normanno N., Salomon D. Cripto-1: A multifunctional modulator during embryogenesis and oncogenesis. Oncogene 2005, 24:5731-5741.
74. Su Y., Zhang L., Gao X., Meng F., Wen J., Zhou H., Meng A., Chen Y.G. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J. 2007, 21:682-690.
75. ten Dijke P., Hill C.S. New insights into TGF-beta-Smad signalling. Trends Biochem. Sci. 2004, 29:265-273.
76. Thompson T.B., Lerch T.F., Cook R.W., Woodruff T.K., Jardetzky T.S. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. Dev. Cell 2005, 9:535-543.
77. Tortoriello D.V., Sidis Y., Holtzman D.A., Holmes W.E., Schneyer A.L. Human follistatin-related protein: A structural homologue of follistatin with nuclear localization. Endocrinology 2001, 142:3426-3434.
78. Tsang M., Kim R., de Caestecker M.P., Kudoh T., Roberts A.B., Dawid I.B. Zebrafish nma is involved in TGFbeta family signaling. Genesis 2000, 28:47-57.
79. Tsuchida K., Arai K.Y., Kuramoto Y., Yamakawa N., Hasegawa Y., Sugino H. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J. Biol. Chem. 2000, 275:40788-40796.
80. Tsuchida K., Nakatani M., Matsuzaki T., Yamakawa N., Liu Z., Bao Y., Arai K.Y., Murakami T., Takehara Y., Kurisaki A., et al. Novel factors in regulation of activin signaling. Mol. Cell. Endocrinol. 2004, 225:1-8.
81. Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., Wrana J.L. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998, 95:779-791.
82. Valdimarsdottir G., Goumans M.J., Itoh F., Itoh S., Heldin C.H., ten Dijke P. Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. BMC Cell Biol. 2006, 7:16.
83. Watanabe Y., Itoh S., Goto T., Ohnishi E., Inamitsu M., Itoh F., Satoh K., Wiercinska E., Yang W., Shi L., et al. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell 2010, 37:123-134.
84. Welt C., Sidis Y., Keutmann H., Schneyer A. Activins, inhibins, and follistatins: From endocrinology to signaling. A paradigm for the new millennium. Exp. Biol. Med. 2002, 227:724-752.
85. Wiater E., Lewis K.A., Donaldson C., Vaughan J., Bilezikjian L., Vale W. Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes. Mol. Endocrinol. 2009, 23:1033-1042.
86. Wrighton K.H., Lin X., Feng X.H. Critical regulation of TGFbeta signaling by Hsp90. Proc. Natl. Acad. Sci. USA 2008, 105:9244-9249.
87. Wu J.W., Krawitz A.R., Chai J., Li W., Zhang F., Luo K., Shi Y. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-beta signaling. Cell 2002, 111:357-367.
88. Xia Y., Schneyer A.L. The biology of activin: Recent advances in structure, regulation and function. J. Endocrinol. 2009, 202:1-12.
89. Yamaguchi T., Kurisaki A., Yamakawa N., Minakuchi K., Sugino H. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. 2006, 36:569-579.
90. Yan X., Lin Z., Chen F., Zhao X., Chen H., Ning Y., Chen Y.G. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J. Biol. Chem. 2009, 284:30097-30104.
91. Yeo C., Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol. Cell 2001, 7:949-957.
92. Yun C.H., Choi S.C., Park E., Kim S.J., Chung A.S., Lee H.K., Lee H.J., Han J.K. Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation. Development 2007, 134:769-777.
93. Zhang L., Zhou H., Su Y., Sun Z., Zhang H., Zhang Y., Ning Y., Chen Y.G., Meng A. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science 2004, 306:114-117.
94. Zhang X.L., Topley N., Ito T., Phillips A. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J. Biol. Chem. 2005, 280:12239-12245.
95. Zhang S., Fei T., Zhang L., Zhang R., Chen F., Ning Y., Han Y., Feng X.H., Meng A., Chen Y.G. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 2007, 27:4488-4499.