Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways

Oncogene

Volumn 31, Issue 40, 2012, Pages 4409-4419

  Dallosso, A R ^a   Oster B ^b   Greenhough, A ^a   Thorsen, K ^b   Curry, T J ^a   Owen, C ^a   Hancock, A L ^a   Szemes, M ^a   Paraskeva, C ^a   Frank, M ^c   Andersen, C L ^b   Malik, K ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

colorectal cancer; epigenetic silencing; mTOR; protocadherin; Wnt

Indexed keywords

DNA; SMALL INTERFERING RNA;

ARTICLE; CANCER STAGING; CARCINOGENESIS; CHROMOSOME 5Q; COLON MUCOSA; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LONG RANGE EPIGENETIC SILENCING; METHYLATION; PRIORITY JOURNAL; PROTOCADHERIN GENE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CADHERINS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 5; COLORECTAL NEOPLASMS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HCT116 CELLS; HUMANS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84867233454     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.609     Document Type: Article

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