Calcium-independent phospholipase A 2β is dispensable in inflammasome activation and its inhibition by bromoenol lactone

Journal of Innate Immunity

Volumn 1, Issue 6, 2009, Pages 607-617

  Franchi, Luigi ^a   Chen, Grace ^a   Marina Garcia, Noemi ^a   Abe, Akira ^a   Qu, Yan ^b   Bao, Shunzhong ^c   Shayman, James A ^a   Turk, John ^c   Dubyak, George R ^b   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Macrophage; Phospholipase A 2

Indexed keywords

ADENOSINE TRIPHOSPHATE; BROMOENOL LACTONE; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CATHEPSIN; FLAGELLIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; SERINE PROTEINASE; TOSYLLYSYL CHLOROMETHYL KETONE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENANTIOMER; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLOSIS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CASPASE 1; ENZYME ACTIVATION; GROUP IV PHOSPHOLIPASES A2; IMMUNOBLOTTING; INFLAMMATION; MACROPHAGES; MICE; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASES A2, CALCIUM-INDEPENDENT; PYRONES; STEREOISOMERISM;

EID: 77951234632     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000227263     Document Type: Article

References (40)

1. Burns K, Martinon F, Tschopp J: New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol 2003; 15: 26-30.
2. Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G: The inflammasome: A caspase-1- activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10: 241-247.
3. Franchi L, Park JH, Shaw MH, Marina-Garcia N, Chen G, Kim YG, Nunez G: Intracellular NOD-like receptors in innate immunity, infection and disease. Cell Microbiol 2008; 10: 1-8.
4. Franchi L, McDonald C, Kanneganti TD, Amer A, Nunez G: Nucleotide-binding oligomerization domain-like receptors: Intracellular pattern recognition molecules for pathogen detection and host defense. J Immunol 2006; 177: 3507-3513.
5. Martinon F, Tschopp J: Inflammatory caspases and inflammasomes: Master switches of inflammation. Cell Death Differ 2007; 14: 10-22.
6. Franchi L, Warner N, Viani K, Nunez G: Function of NOD-like receptors in microbial recognition and host defense. Immunol Rev 2009; 227: 106-128.
7. Schaloske RH, Dennis EA: The phospholipase A 2 superfamily and its group numbering system. Biochim Biophys Acta 2006; 1761: 1246-1259.
8. Qu Y, Franchi L, Nunez G, Dubyak GR: Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol 2007; 179: 1913-1925.
9. Kahlenberg JM, Dubyak GR: Mechanisms of caspase-1 activation by P2X7 receptor-mediated K + release. Am J Physiol Cell Physiol 2004; 286:C1100-1108.
10. Andrei C, Margiocco P, Poggi A, Lotti LV, Torrisi MR, Rubartelli A: Phospholipases C and A 2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. Proc Natl Acad Sci USA 2004; 101: 9745-9750.
11. Walev I, Klein J, Husmann M, Valeva A, Strauch S, Wirtz H, Weichel O, Bhakdi S: Potassium regulates IL-1 beta processing via calcium-independent phospholipase A 2 . J Immunol 2000; 164: 5120-5124.
12. Ackermann EJ, Conde-Frieboes K, Dennis EA: Inhibition of macrophage Ca(2+)-independent phospholipase A 2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 1995; 270: 445-450.
13. Song H, Ramanadham S, Bao S, Hsu FF, Turk J: A bromoenol lactone suicide substrate inactivates group via phospholipase A 2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols. Biochemistry 2006; 45: 1061-1073.
14. Daniels SB, Cooney E, Sofia MJ, Chakravarty PK, Katzenellenbogen JA: Haloenol lactones: potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin. J Biol Chem 1983; 258: 15046-15053.
15. Bao S, Miller DJ, Ma Z, Wohltmann M, Eng G, Ramanadham S, Moley K, Turk J: Male mice that do not express group via phospholipase A 2 produce spermatozoa with impaired motility and have greatly reduced fertility. J Biol Chem 2004; 279: 38194-38200.
16. Mariathasan S, Weiss DS, Newton K, Mc- Bride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM: Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440: 228-232.
17. Sutterwala FS, Ogura Y, Szczepanik M, Lara- Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galan JE, Askenase PW, Flavell RA: Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 2006; 24: 317-327.
18. Fuentes L, Perez R, Nieto ML, Balsinde J, Balboa MA: Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A 2 . J Biol Chem 2003; 278: 44683-44690.
19. Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Nunez G: Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in Salmonella -infected macrophages. Nat Immunol 2006; 7: 576-582.
20. Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A: Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 2006; 7: 569-575.
21. Moran JM, Buller RM, McHowat J, Turk J, Wohltmann M, Gross RW, Corbett JA: Genetic and pharmacologic evidence that calcium- independent phospholipase A 2 beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages. J Biol Chem 2005; 280: 28162-28168.
22. Jenkins CM, Han X, Mancuso DJ, Gross RW: Identification of calcium-independent phospholipase A 2 (iPLA 2 ) beta, and not iPLA 2 gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells: enantioselective mechanism-based discrimination of mammalian iPLA 2 S. J Biol Chem 2002; 277: 32807-32814.
23. Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J: Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group via phospholipase A 2 . J Biol Chem 2007; 282: 27100-27114.
24. Xie Z, Gong MC, Su W, Turk J, Guo Z: Group via phospholipase A 2 (iPLA 2 beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of G-protein signaling-2 in vascular smooth muscle cells. J Biol Chem 2007; 282: 25278-25289.
25. Lamkanfi M, Kanneganti TD, Franchi L, Nunez G: Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol 2007; 82: 220-225.
26. Nicholson DW: Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 1999; 6: 1028-1042.
27. Dowds TA, Masumoto J, Zhu L, Inohara N, Nunez G: Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 2004; 279: 21924-21928.
28. Martinon F, Burns K, Tschopp J: The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002; 10: 417-426.
29. Hilbi H, Puro RJ, Zychlinsky A: Tripeptidyl peptidase II promotes maturation of caspase- 1 in Shigella flexneri -induced macrophage apoptosis. Infect Immun 2000; 68: 5502-5508.
30. Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nunez G: Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella -infected macrophages. PLoS Pathog 2007; 3: e111.
31. Marina-Garcia N, Franchi L, Kim YG, Miller D, McDonald C, Boons GJ, Nunez G: Pannexin- 1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol 2008; 180: 4050-4057.
32. Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Nunez G: Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of tolllike receptor signaling. Immunity 2007; 26: 433-443.
33. Ozoren N, Masumoto J, Franchi L, Kanneganti TD, Body-Malapel M, Erturk I, Jagirdar R, Zhu L, Inohara N, Bertin J, Coyle A, Grant EP, Nunez G: Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol 2006; 176: 4337-4342.
34. Kanneganti TD, Ozoren N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Nunez G: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/ Nalp3. Nature 2006; 440: 233-236.
35. Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, Franchi L, Taraporewala ZF, Miller D, Patton JT, Inohara N, Nunez G: Critical role for cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006; 281: 36560-36568.
36. Franchi L, Kanneganti TD, Dubyak GR, Nunez G: Differential requirement of P2X7 receptor and intracellular K + for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem 2007; 282: 18810-18818.
37. Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J: Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 2007; 14: 1583-1589.
38. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E: Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 9: 847-856.
39. Jones JD, Dangl JL: The plant immune system. Nature 2006; 444: 323-329.
40. Chisholm ST, Coaker G, Day B, Staskawicz BJ: Host-microbe interactions: shaping the evolution of the plant immune response. Cell 2006; 124: 803-814.