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Volumn 135, Issue 45, 2013, Pages 16809-16812

In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase

Author keywords

[No Author keywords available]

Indexed keywords

6-DEOXYERYTHRONOLIDE B SYNTHASE; ASSEMBLED SYSTEM; ASSEMBLY LINE; NATURALLY OCCURRING; POLYKETIDE ASSEMBLY; POLYKETIDE SYNTHASES; PURIFIED PROTEIN; TURNOVER RATE;

EID: 84887669505     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja409048k     Document Type: Article
Times cited : (65)

References (41)
  • 40
    • 0343865079 scopus 로고
    • The tolerance of DEBS module 3 for incorporation of an ethylmalonyl-CoA extender unit in competition with the natural methylmalonyl-CoA stands in intriguing contrast to the apparent intrinsic substrate specificity of the heptamodular tylactone synthase, TYLS, for which the product tylactone, in common with many other 16-membered macrolide lactones, carries a 6-ethyl group and an 8-methyl group. Module 5 of TYLS (corresponding to module 4 of DEBS) must therefore be strictly specific for ethylmalonyl-CoA while module 4 of TYLS (corresponding to module 3 of DEBS) must be specific for only methylmalonyl-CoA. O'Hagan, D.; Robinson, J. A.; Turner, D. L. J. Chem. Soc., Chem. Commun. 1983, 1337-1340
    • (1983) J. Chem. Soc., Chem. Commun. , pp. 1337-1340
    • O'Hagan, D.1    Robinson, J.A.2    Turner, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.