Rational biosynthetic engineering for optimization of geldanamycin analogues

ChemBioChem

Volumn 10, Issue 7, 2009, Pages 1243-1251

  Kim, Woncheol ^a,b   Lee, Dongho ^c   Hong, Seong Su ^c   Na, Zhu ^a,d,e   Shin, Jin Chul ^a,b   Roh, Su Heun ^a   Wu, Cheng Zhu ^a   Choi, Oksik ^a   Lee, Kyeong ^a   Shen, Yue Mao ^d   Paik, Sang Gi ^b   Lee, Jung Joon ^a   Hong, Young Soo ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea University   (South Korea)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Biosynthesis; Geldanamycin; Natural products; Polyketides; Site directed mutagenesis

Indexed keywords

DHQ1; DHQ2; DHQ3; DHQ4; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BENZOQUINONE DERIVATIVE; DHQ3 COMPOUND; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; POLYKETIDE SYNTHASE;

ARTICLE; BIOENGINEERING; BIOSYNTHESIS; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; DRUG ANTAGONISM; GENETIC ENGINEERING; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; GENETIC ENGINEERING; HSP90 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS, SITE-DIRECTED; POLYKETIDE SYNTHASES; SEQUENCE ALIGNMENT;

EID: 67650483124     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800763     Document Type: Article

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