A polymerase mechanism-based strategy for viral attenuation and vaccine development

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 31618-31622

  Weeks, Spencer A ^a   Lee, Cheri A ^a   Zhao, Yan ^a   Smidansky, Eric D ^a   August, Avery ^a,b   Arnold, Jamie J ^a   Cameron, Craig E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Department of Molecular Biology and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC EFFICIENCIES; EMPIRICAL METHOD; IMMUNE RESPONSE; LYSINE RESIDUES; RNA VIRUS; VACCINE DEVELOPMENT;

AMINO ACIDS; PLANNING; POLYMERS; RNA; VIRUSES;

VACCINES;

ARGININE; COMPLEMENTARY DNA; LIVE VACCINE; LYSINE; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG DESIGN; ENZYME MECHANISM; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPLICON; VIRUS ATTENUATION; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BIOTECHNOLOGY; CATALYSIS; CATALYTIC DOMAIN; CULTURE MEDIA, SERUM-FREE; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; GENETIC ENGINEERING; HELA CELLS; HUMANS; KINETICS; LYSINE; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; SEQUENCE HOMOLOGY, AMINO ACID; VACCINES, ATTENUATED; VIRAL PROTEINS;

RNA VIRUSES; UCHIDA;

EID: 84866423000     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C112.401471     Document Type: Article

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