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An interesting study providing insight into the potential role for microglia in PD pathology. This study is important for appreciating other changes in the SN beyond the degenerating DA neurons, •
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Yasuda Y, Shinagawa R, Yamada M, Mori T, Tateishi N, Fujita S: Long-lasting reactive changes observed in microglia in the striatum and substantia nigra of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res (2007) 1138:196-202. • An interesting study providing insight into the potential role for microglia in PD pathology. This study is important for appreciating other changes in the SN beyond the degenerating DA neurons.
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Pattarini R, Smeyne RJ, Morgan JI: Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrimidine model of Parkinson's disease. Neurosci (2007) 145(2):645-668. • A systematic study of inflammatory mediators in the MPTP model of PD in mice. This study emphasized the importance of a series of pathological changes leading ultimately to the expression of full-blown PD.
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Pattarini R, Smeyne RJ, Morgan JI: Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrimidine model of Parkinson's disease. Neurosci (2007) 145(2):645-668. • A systematic study of inflammatory mediators in the MPTP model of PD in mice. This study emphasized the importance of a series of pathological changes leading ultimately to the expression of full-blown PD.
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An important study of complement activation in the SN in PD, •
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Vijitruth R, Liu M, Choi D-Y, Nguyen XV, Hunter RL, Bing G: Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease. J Neuroinflammation (2006) 3:6. •• This is an important paper on the relationship between COX-2 and microglial activation in the MPTP model. It is particularly interesting in light of the serious adverse events associated with some COX-2 inhibitors.
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