The new diterpene isodojaponin D inhibited LPS-induced microglial activation through NF-kappaB and MAPK signaling pathways

European Journal of Pharmacology

Volumn 642, Issue 1-3, 2010, Pages 10-18

  Lim, Ji Youn ^a   Won, Tae Joon ^b   Hwang, Bang Yeon ^c   Kim, Hak Rim ^d   Hwang, Kwang Woo ^b   Sul, Donggeun ^a   Park, So Young ^a,d  

^a Korea University College of Medicine   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

^c Chungbuk National University   (South Korea)

^d Dankook University   (South Korea)

Author keywords

BV2 cells; COX 2; Cytokines; INOS; Isodojaponin D (19 hydroxy 1,6 diacetoxy 6,7 seco ent kaur 16 en 15 one 7,20 olide); Lipopolysaccharide; MAPKs; NF B

Indexed keywords

CYCLOOXYGENASE 2; DITERPENE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISODOJAPONIN D; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR KAPPA B P50; NUCLEIC ACID BINDING PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 19-HYDROXY-1ALPHA,6-DIACETOXY-6,7-SECO-ENT-KAUR-16-EN-15-ONE-7,20-OLIDE; ANTIINFLAMMATORY AGENT; CYTOKINE; NITRIC OXIDE; PROSTAGLANDIN E2;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; ISODON; ISODON JAPONICUS; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL NUCLEUS; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; DITERPENES; ENZYME ACTIVATION; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 77954617272     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.047     Document Type: Article

References (34)

1. Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 2005, 76:77-98.
2. Chen J.C., Ho F.M., Pei-Dawn Lee C., Chen C.P., Jeng K.C., Hsu H.B., Lee S.T., Wen Tung W., Lin W.W. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur. J. Pharmacol. 2005, 521:9-20.
3. Choi Y., Lee M.K., Lim S.Y., Sung S.H., Kim Y.C. Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells. Br. J. Pharmacol. 2009, 156:933-940.
4. Combs C.K., Karlo J.C., Kao S.C., Landreth G.E. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 2001, 21:1179-1188.
5. Drew P.D., Storer P.D., Xu J., Chavis J.A. Hormone regulation of microglial cell activation: relevance to multiple sclerosis. Brain Res. Brain Res. Rev. 2005, 48:322-327.
6. Giovannini M.G., Scali C., Prosperi C., Bellucci A., Pepeu G., Casamenti F. Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors. Int. J. Immunopathol. Pharmacol. 2003, 16:31-40.
7. Gonzalez-Scarano F., Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 1999, 22:219-240.
8. Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
9. Hansen S.K., Baeuerle P.A., Blasi F. Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. Mol. Cell. Biol. 1994, 14:2593-2603.
10. Hong S.S., Lee S.A., Han X.H., Hwang J.S., Lee C., Lee D., Hong J.T., Kim Y., Lee H., Hwang B.Y. ent-Kaurane diterpenoids from Isodon japonicus. J. Nat. Prod. 2008, 71:1055-1058.
11. Jang J.H., Surh Y.J. Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway. Free Radic. Biol. Med. 2005, 38:1604-1613.
12. Ji C., Aisa H.A., Yang N., Li Q., Wang T., Zhang L., Qu K., Zhu H.B., Zuo P.P. Gossypium herbaceam extracts inhibited NF-kappaB activation to attenuate spatial memory impairment and hippocampal neurodegeneration induced by amyloid-beta in rats. J. Alzheimers Dis. 2008, 14:271-283.
13. Jung W.K., Heo S.J., Jeon Y.J., Lee C.M., Park Y.M., Byun H.G., Choi Y.H., Park S.G., Choi I.W. Inhibitory Effects and Molecular Mechanism of Dieckol Isolated from Marine Brown Alga on COX-2 and iNOS in Microglial Cells. J. Agric. Food Chem. 2009, 57(10):4439-4446.
14. Kim S.H., Smith C.J., Van Eldik L.J. Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiol. Aging 2004, 25:431-439.
15. Kim H.S., Lim J.Y., Sul D., Hwang B.Y., Won T.J., Hwang K.W., Park S.Y. Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells. Eur. J. Pharmacol. 2009, 622(1-3):25-31.
16. Kujubu D.A., Fletcher B.S., Varnum B.C., Lim R.W., Herschman H.R. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 1991, 266:12866-12872.
17. Lee S.Y., Son D.J., Lee Y.K., Lee J.W., Lee H.J., Yun Y.W., Ha T.Y., Hong J.T. Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-kappaB activation and target gene expression in cultured rat astrocytes. Neurosci. Res. 2006, 56:204-212.
18. Li B., Tian X. Enmein type diterpenoids from Isodon japonica. Phytochemistry 2001, 58:543-546.
19. Longpre F., Garneau P., Christen Y., Ramassamy C. Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic. Biol. Med. 2006, 41:1781-1794.
20. Lu Y.C., Yeh W.C., Ohashi P.S. LPS/TLR4 signal transduction pathway. Cytokine 2008, 42:145-151.
21. MacMicking J., Xie Q.W., Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 1997, 15:323-350.
22. McAlpine F.E., Lee J.K., Harms A.S., Ruhn K.A., Blurton-Jones M., Hong J., Das P., Golde T.E., LaFerla F.M., Oddo S., Blesch A., Tansey M.G. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol. Dis. 2009, 34:163-177.
23. Minghetti L., Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol. 1998, 54:99-125.
24. Murphy S. Production of nitric oxide by glial cells: regulation and potential roles in the CNS. Glia 2000, 29:1-13.
25. Orsucci D., Calsolaro V., Mancuso M., Siciliano G. Neuroprotective effects of tetracyclines: molecular targets, animal models and human disease. CNS Neurol. Disord. Drug Targets 2009, 8:222-231.
26. Qin Z.H., Tao L.Y., Chen X. Dual roles of NF-kappaB in cell survival and implications of NF-kappaB inhibitors in neuroprotective therapy. Acta Pharmacol. Sin. 2007, 28:1859-1872.
27. Rogers J., Cooper N.R., Webster S., Schultz J., McGeer P.L., Styren S.D., Civin W.H., Brachova L., Bradt B., Ward P., et al. Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 1992, 89:10016-10020.
28. Rojo L.E., Fernandez J.A., Maccioni A.A., Jimenez J.M., Maccioni R.B. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch. Med. Res. 2008, 39:1-16.
29. Singh S., Aggarwal B.B. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J. Biol. Chem. 1995, 270:24995-25000.
30. Sriram K., O'Callaghan J.P. Divergent roles for tumor necrosis factor-alpha in the brain. J. Neuroimmune Pharmacol. 2007, 2:140-153.
31. Terai K., Matsuo A., McGeer E.G., McGeer P.L. Enhancement of immunoreactivity for NF-kappa B in human cerebral infarctions. Brain Res. 1996, 739:343-349.
32. Xie Z., Smith C.J., Van Eldik L.J. Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38. Glia 2004, 45:170-179.
33. Xing B., Liu M., Bing G. Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity. J. Neuroimmunol. 2007, 192:89-98.
34. Zipp F., Aktas O. The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci. 2006, 29:518-527.