Diblock copolymers with tunable pH transitions for gene delivery

Biomaterials

Volumn 33, Issue 7, 2012, Pages 2301-2309

  Manganiello, Matthew J ^a   Cheng, Connie ^a   Convertine, Anthony J ^a   Bryers, James D ^a   Stayton, Patrick S ^a  

^a University of Washington   (United States)

Author keywords

Cell culture; Copolymer; DNA; Drug delivery; Gene therapy; Micelle

Indexed keywords

BUTYL METHACRYLATES; CATIONIC CHARGES; CELL LINES; COPOLYMER COMPOSITIONS; CORE-SHELL; DIETHYLAMINOETHYL; DNA TRANSFECTION; GENE DELIVERY; GFP EXPRESSION; HYDROPHOBIC CONTENT; MACROCHAIN-TRANSFER AGENTS; PDMAEMA; PH VALUE; PHYSIOLOGICAL PH; PLASMID DNA (PDNA); POLY(N ,N-DIMETHYLAMINOETHYL METHACRYLATE); RELATIVE FEED; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SOLUTION PH;

BIOLOGICAL MEMBRANES; BLOCK COPOLYMERS; CELL CULTURE; COPOLYMERS; DNA; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; GENE TRANSFER; HYDROPHOBICITY; MICELLES; PH; POLYDISPERSITY; PROTONATION;

GENE THERAPY;

COPOLYMER; METHACRYLIC ACID BUTYL ESTER; PLASMID DNA; POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE]; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISPERSION; DNA TRANSFECTION; ELECTROSTATIC PRECIPITATION; ENDOSOME; FRAGMENTATION REACTION; GENE TARGETING; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIGHT SCATTERING; LYSOSOME; MICELLE; MOLECULAR WEIGHT; MONOCYTE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER;

ANIMALS; CELL LINE; DNA; GENE TRANSFER TECHNIQUES; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; METHACRYLATES; MICE; MICELLES; MOLECULAR STRUCTURE; PARTICLE SIZE; PLASMIDS; POLYMERS; TRANSFECTION;

EID: 84855749317     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.019     Document Type: Article

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