Regional anaesthesia and cancer metastases: The implication of local anaesthetics

Acta Anaesthesiologica Scandinavica

Volumn 57, Issue 10, 2013, Pages 1211-1229

  Votta Velis, E G ^a   Piegeler, T ^a,b   Minshall, R D ^a   Aguirre, J ^c   Beck Schimmer, B ^b   Schwartz, D E ^a   Borgeat, A ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BARBITURIC ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRENORPHINE; CHLOROPROCAINE; FENTANYL; HALOTHANE; INTERCELLULAR ADHESION MOLECULE 1; ISOFLURANE; KETAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; METHADONE; MIDAZOLAM; MORPHINE; PETHIDINE; PLACEBO; PROPOFOL; PROTEIN TYROSINE KINASE; REMIFENTANIL; ROPIVACAINE; SUFENTANIL; TRAMADOL;

ACUTE LUNG INJURY; ANTIINFLAMMATORY ACTIVITY; CANCER CELL; CONTINUOUS INFUSION; DRUG MEGADOSE; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; INTESTINE FUNCTION; LOCAL ANESTHESIA; LONG TERM SURVIVAL; LOW DRUG DOSE; METASTASIS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REGIONAL ANESTHESIA; REVIEW; STRESS; TUMOR CELL; TUMOR GROWTH; TUMOR INVASION;

ACUTE LUNG INJURY; ANESTHESIA, CONDUCTION; ANESTHETICS, LOCAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; HUMANS; INFLAMMATION; NEOPLASM METASTASIS; NEOPLASTIC CELLS, CIRCULATING; NF-KAPPA B;

EID: 84886882085     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/aas.12210     Document Type: Review

References (123)

1. Heidland A, Klassen A, Rutkowski P, Bahner U,. The contribution of Rudolf Virchow to the concept of inflammation: what is still of importance? J Nephrol 2006; 19 (Suppl 10): S102-109.
2. Balkwill F, Charles KA, Mantovani A,. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211-217.
3. Lin E, Calvano SE, Lowry SF,. Cytokine response in abdominal surgery. In:, Schein M, Wise L, eds. Cytokines and the Abdominal Surgeon. Austin, TX: RG Landes, 1998: 17-34.
4. Brochner AC, Toft P,. Pathophysiology of the systemic inflammatory response after major accidental trauma. Scand J Trauma Resusc Emerg Med 2009; 17: 43.
5. Nishizaki T, Matsumata T, Kanematsu T, Yasunaga C, Sugimachi K,. Surgical manipulation of VX2 carcinoma in the rabbit liver evokes enhancement of metastasis. J Surg Res 1990; 49: 92-97.
6. Hayashi N, Egami H, Kai M, Kurusu Y, Takano S, Ogawa M,. No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer. Surgery 1999; 125: 369-374.
7. Eschwege P, Dumas F, Blanchet P, Le Maire V, Benoit G, Jardin A, Lacour B, Loric S,. Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy. Lancet 1995; 346: 1528-1530.
8. Weitz J, Kienle P, Lacroix J, Willeke F, Benner A, Lehnert T, Herfarth C, von Knebel Doeberitz M,. Dissemination of tumor cells in patients undergoing surgery for colorectal cancer. Clin Cancer Res 1998; 4: 343-348.
9. Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M, Mori M,. Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer. J Clin Oncol 2011; 29: 1547-1555.
10. Mao L, Lin S, Lin J,. The effects of anesthetics on tumor progression. Int J Physiol Pathophysiol Pharmacol 2013; 5: 1-10.
11. Tavare AN, Perry NJ, Benzonana LL, Takata M, Ma D,. Cancer recurrence after surgery: direct and indirect effects of anesthetic agents. Int J Cancer 2012; 130: 1237-1250.
12. Hollmann MW, Durieux ME,. Local anesthetics: effects on inflammation, wound healing and coagulation. Prog Anesthesiol 2000; 14: 291-304.
13. Hollmann MW, Durieux ME,. Local anesthetics: effects on the central nervous system and bronchial reactivity. Prog Anesthesiol 2000; 14: 323-336.
14. Hollmann MW, Durieux ME,. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology 2000; 93: 858-875.
15. Hollmann MW, Difazio CA, Durieux ME,. Ca-signaling G-protein-coupled receptors: a new site of local anesthetic action? Reg Anesth Pain Med 2001; 26: 565-571.
16. Hollmann MW, Wieczorek KS, Berger A, Durieux ME,. Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Galpha(q) protein function. Mol Pharmacol 2001; 59: 294-301.
17. Picardi S, Cartellieri S, Groves D, Hahnenekamp K, Gerner P, Durieux ME, Stevens MF, Lirk P, Hollmann MW,. Local anesthetic-induced inhibition of human neutrophil priming: the influence of structure, lipophilicity, and charge. Reg Anesth Pain Med 2013; 38: 9-15.
18. Hollmann MW, Gross A, Jelacin N, Durieux ME,. Local anesthetic effects on priming and activation of human neutrophils. Anesthesiology 2001; 95: 113-122.
19. Krause KH, Demaurex N, Jaconi M, Lew DP,. Ion channels and receptor-mediated Ca2+ influx in neutrophil granulocytes. Blood Cells 1993; 19: 165-173.
20. Eriksson AS, Sinclair R, Cassuto J, Thomsen P,. Influence of lidocaine on leukocyte function in the surgical wound. Anesthesiology 1992; 77: 74-78.
21. Cullen BF, Haschke RH,. Local anesthetic inhibition of phagocytosis and metabolism of human leukocytes. Anesthesiology 1974; 40: 142-146.
22. Kiefer RT, Ploppa A, Krueger WA, Plank M, Nohe B, Haeberle HA, Unertl K, Dieterich HJ,. Local anesthetics impair human granulocyte phagocytosis activity, oxidative burst, and CD11b expression in response to Staphylococcus aureus. Anesthesiology 2003; 98: 842-848.
23. Schreiner A, Hopen G,. Adhesion and locomotion of human leukocytes in vitro; importance of protein coating; effect of lidocain, ethanol and endotoxin. Acta Pathol Microbiol Scand C 1979; 87: 333-340.
24. Schiffer CA, Sanel FT, Young VB, Aisner J,. Reversal of granulocyte adherence to nylon fibers using local anesthetic agents: possible application to filtration leukapheresis. Blood 1977; 50: 213-225.
25. MacGregor RR, Thorner RE, Wright DM,. Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites. Blood 1980; 56: 203-209.
26. Martinsson T, Oda T, Fernvik E, Roempke K, Dalsgaard CJ, Svensjo E,. Ropivacaine inhibits leukocyte rolling, adhesion and CD11b/CD18 expression. J Pharmacol Exp Ther 1997; 283: 59-65.
27. Lan W, Harmon DC, Wang JH, Shorten GD, Redmond PH,. Activated endothelial interleukin-1beta, -6, and -8 concentrations and intercellular adhesion molecule-1 expression are attenuated by lidocaine. Anesth Analg 2005; 100: 409-412.
28. Raucher D, Sheetz MP,. Phospholipase C activation by anesthetics decreases membrane-cytoskeleton adhesion. J Cell Sci 2001; 114: 3759-3766.
29. Li CY, Tsai CS, Hsu PC, Chueh SH, Wong CS, Ho ST,. Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation. Anesth Analg 2003; 97: 1312-1316.
30. Cassuto J, Sinclair R, Bonderovic M,. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50: 265-282.
31. Sinclair R, Eriksson AS, Gretzer C, Cassuto J, Thomsen P,. Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro. Acta Anaesthesiol Scand 1993; 37: 159-165.
32. Gallos G, Jones DR, Nasr SH, Emala CW, Lee HT,. Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis. Anesthesiology 2004; 101: 902-911.
33. Lahav M, Levite M, Bassani L, Lang A, Fidder H, Tal R, Bar-Meir S, Mayer L, Chowers Y,. Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells. Clin Exp Immunol 2002; 127: 226-233.
34. Lang A, Ben Horin S, Picard O, Fudim E, Amariglio N, Chowers Y,. Lidocaine inhibits epithelial chemokine secretion via inhibition of nuclear factor kappa B activation. Immunobiology 2010; 215: 304-313.
35. Lahat A, Ben-Horin S, Lang A, Fudim E, Picard O, Chowers Y,. Lidocaine down-regulates nuclear factor-kappaB signalling and inhibits cytokine production and T cell proliferation. Clin Exp Immunol 2008; 152: 320-327.
36. Yardeni IZ, Beilin B, Mayburd E, Levinson Y, Bessler H,. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth Analg 2009; 109: 1464-1469.
37. Groudine SB, Fisher HA, Kaufman RP, Jr, Patel MK, Wilkins LJ, Mehta SA, Lumb PD,. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth Analg 1998; 86: 235-239.
38. Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML, Joris JL,. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology 2007; 106: 11-18.
39. Herroeder S, Pecher S, Schonherr ME, Kaulitz G, Hahnenkamp K, Friess H, Bottiger BW, Bauer H, Dijkgraaf MG, Durieux ME, Hollmann MW,. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 2007; 246: 192-200.
40. Baumann A, Audibert G, Klein O, Mertes PM,. Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury. Acta Anaesthesiol Scand 2009; 53: 128-130.
41. Blumenthal S, Borgeat A, Pasch T, Reyes L, Booy C, Lambert M, Schimmer RC, Beck-Schimmer B,. Ropivacaine decreases inflammation in experimental endotoxin-induced lung injury. Anesthesiology 2006; 104: 961-969.
42. Feng G, Liu S, Wang GL, Liu GJ,. Lidocaine attenuates lipopolysaccharide-induced acute lung injury through inhibiting NF-kappaB activation. Pharmacology 2008; 81: 32-40.
43. Shakhar G, Ben-Eliyahu S,. Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients? Ann Surg Oncol 2003; 10: 972-992.
44. Ben-Eliyahu S, Page GG, Yirmiya R, Shakhar G,. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int J Cancer 1999; 80: 880-888.
45. Weitz J, Herfarth C,. Surgical strategies and minimal residual disease detection. Semin Surg Oncol 2001; 20: 329-333.
46. Holmgren L, O'Reilly MS, Folkman J,. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995; 1: 149-153.
47. Ferrara N, Davis-Smyth T,. The biology of vascular endothelial growth factor. Endocr Rev 1997; 18: 4-25.
48. Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M, Sood AK,. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 2006; 6: 240-248.
49. Hofer SO, Molema G, Hermens RA, Wanebo HJ, Reichner JS, Hoekstra HJ,. The effect of surgical wounding on tumour development. Eur J Surg Oncol 1999; 25: 231-243.
50. Rao VS, Dyer CE, Jameel JK, Drew PJ, Greenman J,. Potential prognostic and therapeutic roles for cytokines in breast cancer (Review). Oncol Rep 2006; 15: 179-185.
51. Smyth MJ, Godfrey DI, Trapani JA,. A fresh look at tumor immunosurveillance and immunotherapy. Nat Immunol 2001; 2: 293-299.
52. Brittenden J, Heys SD, Ross J, Eremin O,. Natural killer cells and cancer. Cancer 1996; 77: 1226-1243.
53. Levy SM, Herberman RB, Maluish AM, Schlien B, Lippman M,. Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychol 1985; 4: 99-113.
54. Galley HF, DiMatteo MA, Webster NR,. Immunomodulation by anaesthetic, sedative and analgesic agents: does it matter? Intensive Care Med 2000; 26: 267-274.
55. Shapiro J, Jersky J, Katzav S, Feldman M, Segal S,. Anesthetic drugs accelerate the progression of postoperative metastases of mouse tumors. J Clin Invest 1981; 68: 678-685.
56. Melamed R, Bar-Yosef S, Shakhar G, Shakhar K, Ben-Eliyahu S,. Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. Anesth Analg 2003; 97: 1331-1339.
57. Beilin B, Shavit Y, Hart J, Mordashov B, Cohn S, Notti I, Bessler H,. Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period. Anesth Analg 1996; 82: 492-497.
58. Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, Hebbel RP,. Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 2002; 62: 4491-4498.
59. Singleton PA, Lingen MW, Fekete MJ, Garcia JG, Moss J,. Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res 2006; 72: 3-11.
60. Singleton PA, Moreno-Vinasco L, Sammani S, Wanderling SL, Moss J, Garcia JG,. Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. Am J Respir Cell Mol Biol 2007; 37: 222-231.
61. Lennon FE, Mirzapoiazova T, Mambetsariev B, Salgia R, Moss J, Singleton PA,. Overexpression of the mu-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis. Anesthesiology 2012; 116: 857-867.
62. Martinsson T,. Ropivacaine inhibits serum-induced proliferation of colon adenocarcinoma cells in vitro. J Pharmacol Exp Ther 1999; 288: 660-664.
63. Sakaguchi M, Kuroda Y, Hirose M,. The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg 2006; 102: 1103-1107.
64. Lucchinetti E, Awad AE, Rahman M, Feng J, Lou PH, Zhang L, Ionescu L, Lemieux H, Thebaud B, Zaugg M,. Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing. Anesthesiology 2012; 116: 841-856.
65. Procopio MA, Rassias AJ, DeLeo JA, Pahl J, Hildebrandt L, Yeager MP,. The in vivo effects of general and epidural anesthesia on human immune function. Anesth Analg 2001; 93: 460-465.
66. Koltun WA, Bloomer MM, Tilberg AF, Seaton JF, Ilahi O, Rung G, Gifford RM, Kauffman GL Jr,. Awake epidural anesthesia is associated with improved natural killer cell cytotoxicity and a reduced stress response. Am J Surg 1996; 171: 68-72.
67. Hole A, Unsgaard G, Breivik H,. Monocyte functions are depressed during and after surgery under general anaesthesia but not under epidural anaesthesia. Acta Anaesthesiol Scand 1982; 26: 301-307.
68. Wada H, Seki S, Takahashi T, Kawarabayashi N, Higuchi H, Habu Y, Sugahara S, Kazama T,. Combined spinal and general anesthesia attenuates liver metastasis by preserving TH1/TH2 cytokine balance. Anesthesiology 2007; 106: 499-506.
69. Bar-Yosef S, Melamed R, Page GG, Shakhar G, Shakhar K, Ben-Eliyahu S,. Attenuation of the tumor-promoting effect of surgery by spinal blockade in rats. Anesthesiology 2001; 94: 1066-1073.
70. Schlagenhauff B, Ellwanger U, Breuninger H, Stroebel W, Rassner G, Garbe C,. Prognostic impact of the type of anaesthesia used during the excision of primary cutaneous melanoma. Melanoma Res 2000; 10: 165-169.
71. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI,. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology 2006; 105: 660-664.
72. Christopherson R, James KE, Tableman M, Marshall P, Johnson FE,. Long-term survival after colon cancer surgery: a variation associated with choice of anesthesia. Anesth Analg 2008; 107: 325-332.
73. Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ,. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology 2008; 109: 180-187.
74. Tsui BC, Rashiq S, Schopflocher D, Murtha A, Broemling S, Pillay J, Finucane BT,. Epidural anesthesia and cancer recurrence rates after radical prostatectomy. Can J Anaesth 2010; 57: 107-112.
75. Ismail H, Ho KM, Narayan K, Kondalsamy-Chennakesavan S,. Effect of neuraxial anaesthesia on tumour progression in cervical cancer patients treated with brachytherapy: a retrospective cohort study. Br J Anaesth 2010; 105: 145-149.
76. Gottschalk A, Ford JG, Regelin CC, You J, Mascha EJ, Sessler DI, Durieux ME, Nemergut EC,. Association between epidural analgesia and cancer recurrence after colorectal cancer surgery. Anesthesiology 2010; 113: 27-34.
77. Wuethrich PY, Hsu Schmitz SF, Kessler TM, Thalmann GN, Studer UE, Stueber F, Burkhard FC,. Potential influence of the anesthetic technique used during open radical prostatectomy on prostate cancer-related outcome: a retrospective study. Anesthesiology 2010; 113: 570-576.
78. Myles PS, Peyton P, Silbert B, Hunt J, Rigg JR, Sessler DI,. Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial. BMJ 2011; 342: d1491.
79. de Oliveira GS Jr, Ahmad S, Schink JC, Singh DK, Fitzgerald PC, McCarthy RJ,. Intraoperative neuraxial anesthesia but not postoperative neuraxial analgesia is associated with increased relapse-free survival in ovarian cancer patients after primary cytoreductive surgery. Reg Anesth Pain Med 2011; 36: 271-277.
80. Cummings KC 3rd, Xu F, Cummings LC, Cooper GS,. A comparison of epidural analgesia and traditional pain management effects on survival and cancer recurrence after colectomy: a population-based study. Anesthesiology 2012; 116: 797-806.
81. Gottschalk A, Brodner G, Van Aken HK, Ellger B, Althaus S, Schulze HJ,. Can regional anaesthesia for lymph-node dissection improve the prognosis in malignant melanoma? Br J Anaesth 2012; 109: 253-259.
82. Balkwill F, Mantovani A,. Inflammation and cancer: back to Virchow? Lancet 2001; 357: 539-545.
83. Coussens LM, Werb Z,. Inflammation and cancer. Nature 2002; 420: 860-867.
84. Karin M,. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-436.
85. Mantovani A, Allavena P, Sica A, Balkwill F,. Cancer-related inflammation. Nature 2008; 454: 436-444.
86. Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY,. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem 2001; 276: 7614-7620.
87. Johnson JP,. Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev 1999; 18: 345-357.
88. Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J, Denissenko MF,. Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis 2005; 26: 943-950.
89. Kageshita T, Yoshii A, Kimura T, Kuriya N, Ono T, Tsujisaki M, Imai K, Ferrone S,. Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma. Cancer Res 1993; 53: 4927-4932.
90. Maurer CA, Friess H, Kretschmann B, Wildi S, Muller C, Graber H, Schilling M, Buchler MW,. Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. Int J Cancer 1998; 79: 76-81.
91. Natali PG, Hamby CV, Felding-Habermann B, Liang B, Nicotra MR, Di Filippo F, Giannarelli D, Temponi M, Ferrone S,. Clinical significance of alpha(v)beta3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions. Cancer Res 1997; 57: 1554-1560.
92. Hayes SH, Seigel GM,. Immunoreactivity of ICAM-1 in human tumors, metastases and normal tissues. Int J Clin Exp Pathol 2009; 2: 553-560.
93. Maruo Y, Gochi A, Kaihara A, Shimamura H, Yamada T, Tanaka N, Orita K,. ICAM-1 expression and the soluble ICAM-1 level for evaluating the metastatic potential of gastric cancer. Int J Cancer 2002; 100: 486-490.
94. Huang WC, Chan ST, Yang TL, Tzeng CC, Chen CC,. Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma- butyrolactone derivatives. Carcinogenesis 2004; 25: 1925-1934.
95. Roland CL, Harken AH, Sarr MG, Barnett CC, Jr,. ICAM-1 expression determines malignant potential of cancer. Surgery 2007; 141: 705-707.
96. Rahn JJ, Shen Q, Mah BK, Hugh JC,. MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1. J Biol Chem 2004; 279: 29386-29390.
97. Pollard JW,. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 71-78.
98. Barnett CC Jr, Moore EE, Mierau GW, Partrick DA, Biffl WL, Elzi DJ, Silliman CC,. ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease release. Am J Physiol 1998; 274: C1634-1644.
99. Wu QD, Wang JH, Condron C, Bouchier-Hayes D, Redmond HP,. Human neutrophils facilitate tumor cell transendothelial migration. Am J Physiol Cell Physiol 2001; 280: C814-822.
100. Hu G, Minshall RD,. Regulation of transendothelial permeability by Src kinase. Microvasc Res 2009; 77: 21-25.
101. Okutani D,. Src protein tyrosine kinase family and acute lung injury. Nihon Rinsho Meneki Gakkai Kaishi 2006; 29: 334-341.
102. Summy JM, Gallick GE,. Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 2003; 22: 337-358.
103. Weis S, Cui J, Barnes L, Cheresh D,. Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol 2004; 167: 223-229.
104. Guarino M,. Src signaling in cancer invasion. J Cell Physiol 2010; 223: 14-26.
105. Rollins BJ,. Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease. Mol Med Today 1996; 2: 198-204.
106. Rollins BJ, Walz A, Baggiolini M,. Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood 1991; 78: 1112-1116.
107. Goede V, Brogelli L, Ziche M, Augustin HG,. Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1. Int J Cancer 1999; 82: 765-770.
108. Cai Z, Chen Q, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q, Zhang J,. Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo. Neoplasia 2009; 11: 228-236.
109. Piegeler T, Votta-Velis EG, Liu G, Place AT, Schwartz DE, Beck-Schimmer B, Minshall RD, Borgeat A,. Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade. Anesthesiology 2012; 117: 548-559.
110. Villar-Garea A, Fraga MF, Espada J, Esteller M,. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 2003; 63: 4984-4989.
111. Tada M, Imazeki F, Fukai K, Sakamoto A, Arai M, Mikata R, Tokuhisa T, Yokosuka O,. Procaine inhibits the proliferation and DNA methylation in human hepatoma cells. Hepatol Int 2007; 1: 355-364.
112. Lirk P, Berger R, Hollmann MW, Fiegl H,. Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro. Br J Anaesth 2012; 109: 200-207.
113. Beitner R,. Calmodulin antagonists and cell energy metabolism in health and disease. Mol Genet Metab 1998; 64: 161-168.
114. Karniel M, Beitner R,. Local anesthetics induce a decrease in the levels of glucose 1, 6-bisphosphate, fructose 1,6-bisphosphate, and ATP, and in the viability of melanoma cells. Mol Genet Metab 2000; 69: 40-45.
115. Kusukawa J, Suefuji Y, Ryu F, Noguchi R, Iwamoto O, Kameyama T,. Dissemination of cancer cells into circulation occurs by incisional biopsy of oral squamous cell carcinoma. J Oral Pathol Med 2000; 29: 303-307.
116. Seeman P,. The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 1972; 24: 583-655.
117. Tysnes BB, Haugland HK, Bjerkvig R,. Epidermal growth factor and laminin receptors contribute to migratory and invasive properties of gliomas. Invasion Metastasis 1997; 17: 270-280.
118. Price JT, Tiganis T, Agarwal A, Djakiew D, Thompson EW,. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism. Cancer Res 1999; 59: 5475-5478.
119. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A,. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402: 884-888.
120. Tokumaru S, Higashiyama S, Endo T, Nakagawa T, Miyagawa JI, Yamamori K, Hanakawa Y, Ohmoto H, Yoshino K, Shirakata Y, Matsuzawa Y, Hashimoto K, Taniguchi N,. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol 2000; 151: 209-220.
121. Mammoto T, Higashiyama S, Mukai M, Mammoto A, Ayaki M, Mashimo T, Hayashi Y, Kishi Y, Nakamura H, Akedo H,. Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF). J Cell Physiol 2002; 192: 351-358.
122. Peach G, Kim C, Zacharakis E, Purkayastha S, Ziprin P,. Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review. Br J Cancer 2010; 102: 1327-1334.
123. Yoon JR, Whipple RA, Balzer EM, Cho EH, Matrone MA, Peckham M, Martin SS,. Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells. Breast Cancer Res Treat 2011; 129: 691-701.