Local anesthetic-induced inhibition of human neutrophil priming: The influence of structure, lipophilicity, and charge

Regional Anesthesia and Pain Medicine

Volumn 38, Issue 1, 2013, Pages 9-15

  Picardi, Susanne ^a   Cartellieri, Sibylle ^a   Groves, Danja ^a   Hahnenekamp, Klaus ^a   Gerner, Peter ^b   Durieux, Marcel E ^a   Stevens, Markus F ^c   Lirk, Philipp ^c   Hollmann, Markus W ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; CYTOCHROME C; ETIDOCAINE; LOCAL ANESTHETIC AGENT; SODIUM CHANNEL; SUPEROXIDE;

ARTICLE; CELL MEMBRANE; DOSE RESPONSE; EFFECT SIZE; HUMAN; HUMAN CELL; IC 50; LIPID SOLUBILITY; LIPOPHILICITY; NEUTROPHIL; PARTITION COEFFICIENT; PRIORITY JOURNAL;

ANESTHETICS, LOCAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEUTROPHILS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 84872093747     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0b013e31827a3cbe     Document Type: Article

References (14)

1. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology. 2000;93:858-875.
2. Gallos G, Jones DR, Nasr SH, Emala CW, Lee HT. Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis. Anesthesiology. 2004;101:902-911. (Pubitemid 39288040)
3. Herroeder S, Pecher S, Schonherr ME, et al. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg. 2007;246:192-200. (Pubitemid 47196515)
4. Condliffe AM, Kitchen E, Chilvers ER. Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci. 1998;94:461-471. (Pubitemid 28205909)
5. Ramaiah SK, Jaeschke H. Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicol Pathol. 2007;35:757-766. (Pubitemid 47613608)
6. Hollmann MW, Gross A, Jelacin N, Durieux ME. Local anesthetic effects on priming and activation of human neutrophils. Anesthesiology. 2001;95:113-122. (Pubitemid 32623004)
7. Pongracz J, Lord JM. Superoxide production in human neutrophils: evidence for signal redundancy and the involvement of more than one PKC isoenzyme class. Biochem Biophys Res Commun. 1998;247:624-629. (Pubitemid 28418442)
8. Christiansen NO. Pertussis toxin inhibits the fMLP-induced membrane association of protein kinase C in human neutrophils. J Leukoc. Biol. 1990;47:60-63. (Pubitemid 20015317)
9. 2+-independent route. J Immunol. 1989;142:623-628. (Pubitemid 19039986)
10. Fischer LG, Bremer A, Coleman EJ, et al. Local anesthetics attenuate lysophosphatidic acid-induced priming in human neutrophils. Anesth Analg. 2001;92:1041-1047. (Pubitemid 32239155)
11. Hagelüken A, Grunbaum L, Nurnberg B, Harhammer R, Schunack W, Seifert R. Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochem Pharmacol. 1994;47:1789-1795.
12. Hollmann MW, Wieczorek KS, Berger A, Durieux ME. Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Gq protein function. Mol Pharmacol. 2001;59:294-301. (Pubitemid 32108563)
13. Hollmann MW, Kurz K, Herroeder S, et al. The effects of S (j)-, R (+)-, and racemic bupivacaine on lysophosphatidate-induced priming of human neutrophils. Anesth Analg. 2003;97:1053-1058, table. (Pubitemid 37158688)
14. Ploppa A, Kiefer RT, Haverstick DM, Groves DS, Unertl KE, Durieux ME. Local anesthetic effects on human neutrophil priming and activation. Reg Anesth Pain Med. 2010;35:45-50.