Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro

British Journal of Anaesthesia

Volumn 109, Issue 2, 2012, Pages 200-207

  Lirk, P ^a,b   Berger, R ^b   Hollmann, M W ^a   Fiegl, H ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

cancer; demethylation; epigenetics; lidocaine; local anaesthetic

Indexed keywords

GLUTATHIONE TRANSFERASE P1; LIDOCAINE; MESSENGER RNA; MYOD1 PROTEIN; PROCAINE; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84863917349     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aes128     Document Type: Article

References (38)

1. Snyder GL, Greenberg S. Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth 2010; 105: 106-15
2. Gottschalk A, Sharma S, Ford J, Durieux ME, Tiouririne M. The role of the perioperative period in recurrence after cancer surgery. Anesth Analg 2010; 110: 1636-43
3. Herroeder S, Pecher S, Schonherr ME, et al. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 2007; 246: 192-200 (Pubitemid 47196515)
4. Schlagenhauff B, Ellwanger U, Breuninger H, Stroebel W, Rassner G, Garbe C. Prognostic impact of the type of anaesthesia used during the excision of primary cutaneous melanoma. Melanoma Res 2000; 10: 165-9 (Pubitemid 30256879)
5. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology 2006; 105: 660-4 (Pubitemid 44477309)
6. Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI, Buggy DJ. Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology 2008; 109: 180-7
7. Tsui BC, Rashiq S, Schopflocher D, et al. Epidural anesthesia and cancer recurrence rates after radical prostatectomy. Can J Anaesth 2009; 57: 107-12
8. Gottschalk A, Ford JG, Regelin CC, et al. Association between epidural analgesia and cancer recurrence after colorectal cancer surgery. Anesthesiology 2010; 113: 27-34
9. Tada M, Imazeki F, Fukai K, et al. Procaine inhibits the proliferation and DNA methylation in human hepatoma cells. Hepatol Int 2007; 1: 355-64
10. Perez-Castro R, Patel S, Garavito-Aguilar ZV, et al. Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg 2009; 108: 997-1007
11. Esposito M, Fulco RA, Collecchi P, et al. Improved therapeutic index of cisplatin by procaine hydrochloride. J Natl Cancer Inst 1990; 82: 677-84 (Pubitemid 20154275)
12. Zwischenberger JB, Vertrees RA, Bedell EA, McQuitty CK, Chernin JM, Woodson LC. Percutaneous venovenous perfusion-induced systemic hyperthermia for lung cancer: a phase I safety study. Ann Thorac Surg 2004; 77: 1916-24
13. Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol 2003; 4: 351-8 (Pubitemid 36748422)
14. Teschendorff AE, Menon U, Gentry-Maharaj A, et al. Agedependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 2010; 20: 440-6
15. Villar-Garea A, Fraga MF, Espada J, Esteller M. Procaine is a DNAdemethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 2003; 63: 4984-9 (Pubitemid 37022635)
16. Castellano S, Kuck D, Sala M, Novellino E, Lyko F, Sbardella G. Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1. J Med Chem 2008; 51: 2321-5 (Pubitemid 351503289)
17. Parson W, Kirchebner R, Muhlmann R, et al. Cancer cell line identification by short tandem repeat profiling: power and limitations. FASEB J 2005; 19: 434-6 (Pubitemid 40316541)
18. Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38: 787-93 (Pubitemid 43980599)
19. Eads CA, Danenberg KD, Kawakami K, et al. MethyLight: a highthroughput assay to measure DNA methylation. Nucleic Acids Res 2000; 28: E32
20. Park SY, Kwon HJ, Lee HE, et al. Promoter CpG island hypermethylation during breast cancer progression. Virchows Arch 2011; 458: 73-84
21. Widschwendter M, Apostolidou S, Raum E, et al. Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study. PLoS One 2008; 3: e2656
22. Muller HM, Fiegl H, Goebel G, et al. MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status. Br J Cancer 2003; 89: 1934-9 (Pubitemid 37533273)
23. Bieche I, Onody P, Laurendeau I, et al. Real-time reverse transcription-PCR assay for future management of ERBB2-based clinical applications. Clin Chem 1999; 45: 1148-56 (Pubitemid 29424251)
24. Hollmann MW, Wieczorek KS, Smart M, Durieux ME. Epidural anesthesia prevents hypercoagulation in patients undergoing major orthopedic surgery. Reg Anesth Pain Med 2001; 26: 215-22 (Pubitemid 32476582)
25. Christopherson R, James KE, Tableman M, Marshall P, Johnson FE. Long-term survival after colon cancer surgery: a variation associated with choice of anesthesia. Anesth Analg 2008; 107: 325-32
26. Myles PS, Peyton P, Silbert B, Hunt J, Rigg JR, Sessler DI. Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial. Br Med J 2011; 342: d1491
27. Gupta A, Bjornsson A, Fredriksson M, Hallbook O, Eintrei C. Reduction in mortality after epidural anaesthesia and analgesia in patients undergoing rectal but not colonic cancer surgery: a retrospective analysis of data from 655 patients in central Sweden. Br J Anaesth 2011; 107: 164-70
28. Wuethrich PY, Hsu Schmitz SF, Kessler TM, et al. Potential influence of the anesthetic technique used during open radical prostatectomy on prostate cancer-related outcome: a retrospective study. Anesthesiology 2010; 113: 570-6
29. Lin L, Liu C, Tan H, Ouyang H, Zhang Y, Zeng W. Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis. Br J Anaesth 2011; 106: 814-22
30. de Oliveira GS Jr, Ahmad S, Schink JC, Singh DK, Fitzgerald PC, McCarthy RJ. Intraoperative neuraxial anesthesia but not postoperative neuraxial analgesia is associated with increased relapse-free survival in ovarian cancer patients after primary cytoreductive surgery. Reg Anesth Pain Med 2011; 36: 271-7
31. Ismail H, Ho KM, Narayan K, Kondalsamy-Chennakesavan S. Effect of neuraxial anaesthesia on tumour progression in cervical cancer patients treated with brachytherapy: a retrospective cohort study. Br J Anaesth 2010; 105: 145-9
32. Lai R, Peng Z, Chen D, et al. The effects of anesthetic technique on cancer recurrence in percutaneous radiofrequency ablation of small hepatocellular carcinoma. Anesth Analg 2012; 114: 290-6
33. Arai Y, Kondo T, Tanabe K, et al. Enhancement of hyperthermia-induced apoptosis by local anesthetics on human histiocytic lymphoma U937 cells. J Biol Chem 2002; 277: 18986-93 (Pubitemid 34952461)
34. Mammoto T, Higashiyama S, Mukai M, et al. Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF). J Cell Physiol 2002; 192: 351-8 (Pubitemid 34827611)
35. Laird PW, Jackson-Grusby L, Fazeli A, et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995; 81: 197-205
36. Kennedy KA, Hait WN, Lazo JS. Chemical modulation of bleomycin induced toxicity. Int J Radiat Oncol Biol Phys 1986; 12: 1367-70 (Pubitemid 16030618)
37. Deegan CA, Murray D, Doran P, Ecimovic P, Moriarty DC, Buggy DJ. Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitro. Br J Anaesth 2009; 103: 685-90
38. Tang P, Skinner KA, Hicks DG. Molecular classification of breast carcinomas by immunohistochemical analysis: are we ready? Diagn Mol Pathol 2009; 18: 125-32