Combined spinal and general anesthesia attenuates liver metastasis by preserving Th1/Th2 cytokine balance

Anesthesiology

Volumn 106, Issue 3, 2007, Pages 499-506

  Wada, Hiroki ^a   Seki, Shuhji ^a   Takahashi, Tetsuya ^a   Kawarabayashi, Nobuaki ^a   Higuchi, Hideyuki ^b   Habu, Yoshiko ^a   Sugahara, Shinya ^a   Kazama, Tomiei ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; MORPHINE SULFATE; SEVOFLURANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; C57BL 6 MOUSE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; GENERAL ANESTHESIA; IN VITRO STUDY; INOCULATION; KILLER CELL; LAPAROTOMY; LIVER CELL; LIVER METASTASIS; LIVER SURGERY; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SPINAL ANESTHESIA; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

ANALGESICS, OPIOID; ANESTHESIA, GENERAL; ANESTHESIA, SPINAL; ANESTHETICS, COMBINED; ANESTHETICS, INHALATION; ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CYTOKINES; INTERFERON TYPE II; INTERLEUKIN-4; KILLER CELLS, NATURAL; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOMA, T-CELL; MALE; METHYL ETHERS; MICE; MICE, INBRED C57BL; MORPHINE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NERVE BLOCK; T-LYMPHOCYTES, HELPER-INDUCER; TUMOR CELLS, CULTURED;

EID: 34247541620     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200703000-00014     Document Type: Article

References (56)

1. Salo M: Effects of anaesthesia and surgery on the immune response. Acta Anaesthesiol Scand 1992; 36:201-20
2. Lundy J, Lovett EJ III, Hamilton S, Conran P: Halothane, surgery, immunosuppression and artificial pulmonary metastases. Cancer 1978; 41:827-30
3. Herberman RB, Ortaldo JR: Natural killer cells: Their roles in defenses against disease. Science 1981; 214:24-30
4. Eggermont AM, Steller EP, Sugarbaker PH: Laparotomy enhances intraperitoneal tumor growth and abrogates the antitumor effects of interleukin-2 and lymphokine-activated killer cells. Surgery 1987; 102:71-8
5. Ben-Eliyahu S, Page GG, Yirmiya R, Shakhar G: Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int J Cancer 1999; 80:880-8
6. Kurosawa S, Matsuzaki G, Harada M, Ando T, Nomoto K: Early appearance and activation of natural killer cells in tumor-infiltrating lymphoid cells during tumor development. Eur J Immunol 1993; 23:1029-33
7. Abbas ALA, Pober J: Cellular and Molecular Immunology, 4th edition. Philadelphia, WB Saunders, 2000; 283-7, 384-94
8. Klein HG: Immunomodulatory aspects of transfusion: A once and future risk? ANESTHESIOLOGY 1999; 91:861-5
9. Ben-Eliyahu S, Shakhar G, Rosenne E, Levinson Y, Beilin B: Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: A role for adrenergic mechanisms. ANESTHESIOLOGY 1999; 91:732-40
10. Pollock RE, Lotzova E, Stanford SD, Romsdahl MM: Effect of surgical stress on murine natural killer cell cytotoxicity. J Immunol 1987; 138:171-8
11. Markovic SN, Murasko DM: Anesthesia inhibits poly I:C induced stimulation of natural killer cell cytotoxicity in mice. Clin Immunol Immunopathol 1990; 56:202-9
12. Griffith CD, Kamath MB: Effect of halothane and nitrous oxide anaesthesia on natural killer lymphocytes from patients with benign and malignant breast disease. Br J Anaesth 1986; 58:540-3
13. Markovic SN, Knight PR, Murasko DM: Inhibition of interferon stimulation of natural killer cell activity in mice anesthetized with halothane or isoflurane. ANESTHESIOLOGY 1993; 78:700-6
14. Lennard TW, Shenton BK, Borzotta A, Donnelly PK, White M, Gerrie LM, Proud G, Taylor RM: The influence of surgical operations on components of the human immune system. Br J Surg 1985; 72:771-6
15. Baxevanis CN, Papilas K, Dedoussis GV, Pavlis T, Papamichail M: Abnormal cytokine serum levels correlate with impaired cellular immune responses after surgery. Clin Immunol Immunopathol 1994; 71:82-8
16. Allendorf JD, Bessler M, Horvath KD, Marvin MR, Laird DA, Whelan RL: Increased tumor establishment and growth after open versus laparoscopic bowel resection in mice. Surg Endosc 1998; 12:1035-8
17. Oka M, Hazama S, Suzuki M, Wang F, Shimoda K, Iizuka N, Wadamori K, Suzuki T, Attwood S: Depression of cytotoxicity of nonparenchymal cells in the liver after surgery. Surgery 1994; 116:877-82
18. Tonnesen E, Wahlgreen C: Influence of extradural and general anaesthesia on natural killer cell activity and lymphocyte subpopulations in patients undergoing hysterectomy. Br J Anaesth 1988; 60:500-7
19. Greisen J, Hokland M, Grofte T, Hansen PO, Jensen TS, Vilstrup H, Tonnesen E: Acute pain induces an instant increase in natural killer cell cytotoxicity in humans and this response is abolished by local anaesthesia. Br J Anaesth 1999; 83:235-40
20. Liu S, Carpenter RL, Neal JM: Epidural anesthesia and analgesia: Their role in postoperative outcome. ANESTHESIOLOGY 1995; 82:1474-506
21. Tonnesen E, Brinklov MM, Christensen NJ, Olesen AS, Madsen T: Natural killer cell activity and lymphocyte function during and after coronary artery bypass grafting in relation to the endocrine stress response. ANESTHESIOLOGY 1987; 67:526-33
22. Shakhar G, Ben-Eliyahu S: Potential prophylactic measures against postoperative immunosuppression: Could they reduce recurrence rates in oncological patients? Ann Surg Oncol 2003; 10:972-92
23. Bar-Yosef S, Melamed R, Page GG, Shakhar G, Shakhar K, Ben-Eliyahu S: Attenuation of the tumor-promoting effect of surgery by spinal blockade in rats. ANESTHESIOLOGY 2001; 94:1066-73
24. Barlozzari T, Leonhardt J, Wiltrout RH, Herberman RB, Reynolds CW: Direct evidence for the role of LGL in the inhibition of experimental tumor metastases. J Immunol 1985; 134:2783-9
25. Seki S, Habu Y, Kawamura T, Takeda K, Dobashi H, Ohkawa T, Hiraide H: The liver as a crucial organ in the first line of host defense: The roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev 2000; 174:35-46
26. Seki S, Abo T, Ohteki T, Sugiura K, Kumagai K: Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J Immunol 1991; 147:1214-21
27. Ohteki T, MacDonald HR: Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J Exp Med 1994; 180:699-704
28. Hashimoto W, Takeda K, Anzai R, Ogasawara K, Sakihara H, Sugiura K, Seki S, Kumagai K: Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12. J Immunol 1995; 154:4333-40
29. Takeda K, Seki S, Ogasawara K, Anzai R, Hashimoto W, Sugiura K, Takahashi M, Satoh M, Kumagai K: Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis. J Immunol 1996; 156:3366-73
30. Nakagawa R, Nagafune I, Tazunoki Y, Ehara H, Tomura H, Iijima R, Motoki K, Kamishohara M, Seki S: Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. J Immunol 2001; 166:6578-84
31. Le Cras AE, Galley HF, Webster NR: Spinal but not general anesthesia increases the ratio of T helper 1 to T helper 2 cell subsets in patients undergoing transurethral resection of the prostate. Anesth Analg 1998; 87:1421-5
32. Morita M, Motoki K, Akimoto K, Natori T, Sakai T, Sawa E, Yamaji K, Koezuka Y, Kobayashi E, Fukushima H: Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice. J Med Chem 1995; 38:2176-87
33. Motoki K, Maeda K, Ueno H, Kobayashi E, Uchida T, Fukushima H, Koezuka Y: Antitumor activities of combined treatment with a novel immunomodulator, (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-2-(N-hexacosanoylamino)-1,3, 4-octadecanetriol (KRN7000), and radiotherapy in tumor-bearing mice. Oncol Res 1996; 8:155-62
34. Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, Ueno H, Nakagawa R, Sato H, Kondo E, Koseki H, Taniguchi M: CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 1997; 278:1626-9
35. Burdin N, Brossay L, Koezuka Y, Smiley ST, Grusby MJ, Gui M, Taniguchi M, Hayakawa K, Kronenberg M: Selective ability of mouse CD1 to present glycolipids: Alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol 1998; 161:3271-81
36. Hylden JL, Wilcox GL: Intrathecal morphine in mice: A new technique. Eur J Pharmacol 1980; 67:313-6
37. Seki S, Hashimoto W, Ogasawara K, Satoh M, Watanabe H, Habu Y, Hiraide H, Takeda K: Antimetastatic effect of NK1+ T cells on experimental haematogenous tumour metastases in the liver and lungs of mice. Immunology 1997; 92:561-6
38. Tsukahara A, Seki S, Iiai T, Moroda T, Watanabe H, Suzuki S, Tada T, Hiraide H, Hatakeyama K, Abo T: Mouse liver T cells: Their change with aging and in comparison with peripheral T cells. Hepatology 1997; 26:301-9
39. Ogasawara K, Takeda K, Hashimoto W, Satoh M, Okuyama R, Yanai N, Obinata M, Kumagai K, Takada H, Hiraide H, Seki S: Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction. J Immunol 1998; 160:3522-7
40. Tonnesen E, Huttel MS, Christensen NJ, Schmitz O: Natural killer cell activity in patients undergoing upper abdominal surgery: relationship to the endocrine stress response. Acta Anaesthesiol Scand 1984; 28:654-60
41. Faenza A, Cunsolo A, Selleri S, Lucarelli S, Farneti PA, Gozzetti G: Correlation between plasma or blood transfusion and survival after curative surgery for colorectal cancer. Int Surg 1992; 77:264-9
42. Beilin B, Shavit Y, Razumovsky J, Wolloch Y, Zeidel A, Bessler H: Effects of mild perioperative hypothermia on cellular immune responses. ANESTHESIOLOGY 1998; 89:1133-40
43. Pollock RE, Lotzova E, Stanford SD: Mechanism of surgical stress impairment of human perioperative natural killer cell cytotoxicity. Arch Surg 1991; 126:338-42
44. Glaser R, Rabin B, Chesney M, Cohen S, Natelson B: Stress-induced immunomodulation: Implications for infectious diseases? JAMA 1999; 281:2268-70
45. Page GG, Blakely WP, Ben-Eliyahu S: Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain 2001; 90:191-9
46. Inui T, Nakagawa R, Ohkura S, Habu Y, Koike Y, Motoki K, Kuranaga N, Fukasawa M, Shinomiya N, Seki S: Age-associated augmentation of the synthetic ligand-mediated function of mouse NK1.1 Ag(+) T cells: Their cytokine production and hepatotoxicity in vivo and in vitro. J Immunol 2002; 169:6127-32
47. Tabata T, Hazama S, Yoshino S, Oka M: Th2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers. Am J Surg 1999; 177:203-8
48. Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP: Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications. Proc Assoc Am Physicians 1996; 108:374-81
49. Bellinghausen I, Brand U, Steinbrink K, Enk AH, Knop J, Saloga J: Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: Differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol 2001; 108:242-9
50. Tonnesen E, Mickley H, Grunnet N: Natural killer cell activity during premedication, anaesthesia and surgery. Acta Anaesthesiol Scand 1983; 27:238-41
51. Ogawa K, Hirai M, Katsube T, Murayama M, Hamaguchi K, Shimakawa T, Naritake Y, Hosokawa T, Kajiwara T: Suppression of cellular immunity by surgical stress. Surgery 2000; 127:329-36
52. Beilin B, Shavit Y, Cohn S, Kedar E: Narcotic-induced suppression of natural killer cell activity in ventilated and nonventilated rats. Clin Immunol Immunopathol 1992; 64:173-6
53. Fuchs BA, Pruett SB: Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: Involvement of both opiate and glucocorticoid receptors. J Pharmacol Exp Ther 1993; 266:417-23
54. Page GG, McDonald JS, Ben-Eliyahu S: Pre-operative versus postoperative administration of morphine: Impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery. Br J Anaesth 1998; 81:216-23
55. Maneckjee R, Minna JD: Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ 1994; 5:1033-40
56. Beilin B, Shavit Y, Hart J, Mordashov B, Cohn S, Notti I, Bessler H: Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period. Anesth Analg 1996; 82:492-7