Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF)

Journal of Cellular Physiology

Volumn 192, Issue 3, 2002, Pages 351-358

  Mammoto, Tadanori ^a   Higashiyama, Shigeki ^a   Mukai, Mutsuko ^a   Mammoto, Akiko ^b   Ayaki, Masako ^b   Mashimo, Takashi ^a   Hayashi, Yukio ^a   Kishi, Yoshihiko ^c   Nakamura, Hiroyuki ^c   Akedo, Hitoshi ^b  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIDOCAINE; SODIUM CHANNEL BLOCKING AGENT;

ANESTHESIA MECHANISM; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER INHIBITION; CANCER SURGERY; CELL INVASION; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ECTODERM; HUMAN; HUMAN CELL; LOCAL ANESTHESIA; LUNG METASTASIS; MEMBRANE STABILIZATION; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN;

ANESTHETICS, LOCAL; ANIMALS; CALCIUM; CELL MEMBRANE; CELL MOVEMENT; EPIDERMAL GROWTH FACTOR; HEPARIN; HUMANS; LIDOCAINE; LUNG NEOPLASMS; MICE; MICE, INBRED C3H; NEOPLASM INVASIVENESS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

MURINAE;

EID: 0036321571     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10145     Document Type: Article

References (29)

1. The phagokinetic tracks of 3T3 cells
2. Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung
3. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
4. Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2
5. Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C
6. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity
7. The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor
8. Wound-induced calcium waves in alveolar type II cells
9. Effect of cations and cation channel blockers on human natural killer cells
10. A metalloproteinase-disintegrin, MDC9/meltrin-γ/ADAM9 and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
11. Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells
12. Dissemination of cancer cells into circulation occurs by incisional biopsy of oral squamous cell carcinoma
13. Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury
14. Membrane-anchored growth factors
15. +)](i) oscillations in neonatal rat cardiomyocytes with increased extracellular K+ and is reversed with increased extracellular Mg (2+)
16. Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells
17. Reduced neutrophil superoxide anion release after prolonged infusions of lidocaine
18. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of pro-HB-EGF
19. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism
20. Cell shape changes induced by cationic anesthetics
21. The membrane actions of anesthetics and tranquilizers
22. Extracellular matrix 6: Roles of matrix metalloproteinases in tumor invasion and metastasis
23. Effect of local anaesthetics on human natural killer cell activity
24. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing
25. +]i increase and its transcriptional activation of immediate early genes is important in the regulation of motility
26. Epidermal growth factor and laminin receptors contribute to migratory and invasive properties of gliomas
27. Inhibition of human natural killer activity by lysosomotropic agents
28. Significant detection of circulating cancer cells in the blood by reverse transcriptase-polymerase chain reaction during colorectal cancer resection