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Volumn 78, Issue 2, 2010, Pages 572-578

MAB 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the DE2-7 epidermal growth factor receptor

Author keywords

de2 7 EGFR; Glioma; mAb 806; Radiation therapy; Radiosensitization

Indexed keywords

DE2-7 EGFR; GLIOMA; MAB 806; RADIATION THERAPY; RADIO-SENSITIZATION;

EID: 79551600490     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.03.027     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 33644869659 scopus 로고    scopus 로고
    • DD. Recent advances in the treatment of malignant astrocytoma
    • D.A. Reardon, J.N. Rich, and H.S. Friedman DD. Recent advances in the treatment of malignant astrocytoma J Clin Oncol 24 2006 1253 1265
    • (2006) J Clin Oncol , vol.24 , pp. 1253-1265
    • Reardon, D.A.1    Rich, J.N.2    Friedman, H.S.3
  • 2
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • R. Stupp, W.P. Mason, and M.J. van den Bent Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N Engl J Med 352 2005 987 996 comment 1036-1038
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 3
    • 0035880788 scopus 로고    scopus 로고
    • PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
    • J.S. Smith, I. Tachibana, and S.M. Passe PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme J Natl Cancer Inst 93 2001 1246 1256
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1246-1256
    • Smith, J.S.1    Tachibana, I.2    Passe, S.M.3
  • 4
    • 14644412873 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    • A.B. Heimberger, R. Hlatky, and D. Suki Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients Clin Cancer Res 11 2005 1462 1466
    • (2005) Clin Cancer Res , vol.11 , pp. 1462-1466
    • Heimberger, A.B.1    Hlatky, R.2    Suki, D.3
  • 5
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • N. Shinojima, K. Tada, and S. Shiraishi Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme Cancer Res 63 2003 6962 6970
    • (2003) Cancer Res , vol.63 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3
  • 6
    • 0025790916 scopus 로고
    • Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo
    • A.J. Ekstrand, C.D. James, and W.K. Cavenee Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo Cancer Res 51 1991 2164 2172
    • (1991) Cancer Res , vol.51 , pp. 2164-2172
    • Ekstrand, A.J.1    James, C.D.2    Cavenee, W.K.3
  • 7
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • N. Sugawa, A.J. Ekstrand, and C.D. James Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas Proc Natl Acad Sci U S A 87 1990 8602 8606
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3
  • 8
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • L. Frederick, X.Y. Wang, and G. Eley Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas Cancer Res 60 2000 1383 1387
    • (2000) Cancer Res , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3
  • 9
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • A.J. Ekstrand, N. Sugawa, and C.D. James Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails Proc Natl Acad Sci U S A 89 1992 4309 4313
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3
  • 10
    • 0023948602 scopus 로고
    • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts
    • P.A. Humphrey, A.J. Wong, and B. Vogelstein Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts Cancer Res 48 1988 2231 2238
    • (1988) Cancer Res , vol.48 , pp. 2231-2238
    • Humphrey, P.A.1    Wong, A.J.2    Vogelstein, B.3
  • 11
    • 0025111441 scopus 로고
    • A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors
    • H. Yamazaki, Y. Ohba, and N. Tamaoki A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors Jpn J Cancer Res 81 1990 773 779
    • (1990) Jpn J Cancer Res , vol.81 , pp. 773-779
    • Yamazaki, H.1    Ohba, Y.2    Tamaoki, N.3
  • 12
    • 33845698912 scopus 로고    scopus 로고
    • Expression of nine tumour antigens in a series of human glioblastoma multiforme: Interest of EGFRvIII, IL-13Ralpha2, gp100 and TRP-2 for immunotherapy
    • S. Saikali, T. Avril, and B. Collet Expression of nine tumour antigens in a series of human glioblastoma multiforme: Interest of EGFRvIII, IL-13Ralpha2, gp100 and TRP-2 for immunotherapy J Neurooncol 81 2007 139 148
    • (2007) J Neurooncol , vol.81 , pp. 139-148
    • Saikali, S.1    Avril, T.2    Collet, B.3
  • 13
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • I.K. Mellinghoff, M.Y. Wang, and I. Vivanco Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors N Engl J Med 353 2005 2012 2024
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 14
    • 0028800035 scopus 로고
    • Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors
    • D.K. Moscatello, M. Holgado-Madruga, and A.K. Godwin Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors Cancer Res 55 1995 5536 5539
    • (1995) Cancer Res , vol.55 , pp. 5536-5539
    • Moscatello, D.K.1    Holgado-Madruga, M.2    Godwin, A.K.3
  • 15
    • 0027225697 scopus 로고
    • Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas
    • I.E. Garcia de Palazzo, G.P. Adams, and P. Sundareshan Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas Cancer Res 53 1993 3217 3220
    • (1993) Cancer Res , vol.53 , pp. 3217-3220
    • Garcia De Palazzo, I.E.1    Adams, G.P.2    Sundareshan, P.3
  • 16
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • H.S. Huang, M. Nagane, and C.K. Klingbeil The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling J Biol Chem 272 1997 2927 2935
    • (1997) J Biol Chem , vol.272 , pp. 2927-2935
    • Huang, H.S.1    Nagane, M.2    Klingbeil, C.K.3
  • 17
    • 0042838298 scopus 로고    scopus 로고
    • EGFRvIII-mediated radioresistance through a strong cytoprotective response
    • G. Lammering, T.H. Hewit, and K. Valerie EGFRvIII-mediated radioresistance through a strong cytoprotective response Oncogene 22 2003 5545 5553
    • (2003) Oncogene , vol.22 , pp. 5545-5553
    • Lammering, G.1    Hewit, T.H.2    Valerie, K.3
  • 18
    • 3042581834 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
    • B. Li, M. Yuan, and I.A. Kim Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin Oncogene 23 2004 4594 4602
    • (2004) Oncogene , vol.23 , pp. 4594-4602
    • Li, B.1    Yuan, M.2    Kim, I.A.3
  • 19
    • 5144230736 scopus 로고    scopus 로고
    • Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity
    • G. Lammering, T.H. Hewit, and M. Holmes Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity Clin Cancer Res 10 2004 6732 6743
    • (2004) Clin Cancer Res , vol.10 , pp. 6732-6743
    • Lammering, G.1    Hewit, T.H.2    Holmes, M.3
  • 20
    • 24344434550 scopus 로고    scopus 로고
    • Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy
    • A. Abdollahi, D.W. Griggs, and H. Zieher Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy Clin Cancer Res 11 2005 6270 6279
    • (2005) Clin Cancer Res , vol.11 , pp. 6270-6279
    • Abdollahi, A.1    Griggs, D.W.2    Zieher, H.3
  • 21
    • 20944448672 scopus 로고    scopus 로고
    • Trimodal cancer treatment: Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy
    • P.E. Huber, M. Bischof, and J. Jenne Trimodal cancer treatment: Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy Cancer Res 65 2005 3643 3655
    • (2005) Cancer Res , vol.65 , pp. 3643-3655
    • Huber, P.E.1    Bischof, M.2    Jenne, J.3
  • 22
    • 0038756364 scopus 로고    scopus 로고
    • SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro
    • A. Abdollahi, K.E. Lipson, and X. Han SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro Cancer Res 63 2003 3755 3763
    • (2003) Cancer Res , vol.63 , pp. 3755-3763
    • Abdollahi, A.1    Lipson, K.E.2    Han, X.3
  • 23
    • 18244419396 scopus 로고    scopus 로고
    • Combined effects of angiostatin and ionizing radiation in antitumour therapy
    • H.J. Mauceri, N.N. Hanna, and M.A. Beckett Combined effects of angiostatin and ionizing radiation in antitumour therapy Nature 394 1998 287 291
    • (1998) Nature , vol.394 , pp. 287-291
    • Mauceri, H.J.1    Hanna, N.N.2    Beckett, M.A.3
  • 24
    • 0036848833 scopus 로고    scopus 로고
    • Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa)
    • A.B. Heimberger, C.A. Learn, and G.E. Archer Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa) Clini Cancer Res 8 2002 3496 3502
    • (2002) Clini Cancer Res , vol.8 , pp. 3496-3502
    • Heimberger, A.B.1    Learn, C.A.2    Archer, G.E.3
  • 25
    • 2442482627 scopus 로고    scopus 로고
    • Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme
    • C.A. Learn, T.L. Hartzell, and C.J. Wikstrand Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme Clin Cancer Res 10 2004 3216 3224
    • (2004) Clin Cancer Res , vol.10 , pp. 3216-3224
    • Learn, C.A.1    Hartzell, T.L.2    Wikstrand, C.J.3
  • 26
    • 21444450373 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    • D. Haas-Kogan, M. Prados, and T. Tihan Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib J Natl Cancer Inst 97 2005 880 887
    • (2005) J Natl Cancer Inst , vol.97 , pp. 880-887
    • Haas-Kogan, D.1    Prados, M.2    Tihan, T.3
  • 27
    • 0037457979 scopus 로고    scopus 로고
    • A monoclonal antibody recognizing human cancers with amplification/ overexpression of the human epidermal growth factor receptor
    • A.A. Jungbluth, E. Stockert, and H.J. Huang A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor Proc Natl Acad Sci U S A 100 2003 639 644
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 639-644
    • Jungbluth, A.A.1    Stockert, E.2    Huang, H.J.3
  • 28
    • 0035878671 scopus 로고    scopus 로고
    • Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR
    • R.B. Luwor, T.G. Johns, and C. Murone Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR Cancer Res 61 2001 5355 5361
    • (2001) Cancer Res , vol.61 , pp. 5355-5361
    • Luwor, R.B.1    Johns, T.G.2    Murone, C.3
  • 30
    • 9144229553 scopus 로고    scopus 로고
    • Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478
    • T.G. Johns, R.B. Luwor, and C. Murone Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478 Proc Natl Acad Sci U S A 100 2003 15871 15876
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15871-15876
    • Johns, T.G.1    Luwor, R.B.2    Murone, C.3
  • 31
    • 34247251270 scopus 로고    scopus 로고
    • A phase i clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors 10.1073/pnas.0611693104
    • A.M. Scott, F.-T. Lee, and N. Tebbutt A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors 10.1073/pnas.0611693104 Proc Natl Acad Sci U S A 104 2007 4071 4076
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4071-4076
    • Scott, A.M.1    Lee, F.-T.2    Tebbutt, N.3
  • 32
    • 0026694605 scopus 로고
    • Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation
    • R.B. Lichtner, M. Wiedemuth, and A. Kittmann Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation J Biol Chem 267 1992 11872 11880
    • (1992) J Biol Chem , vol.267 , pp. 11872-11880
    • Lichtner, R.B.1    Wiedemuth, M.2    Kittmann, A.3
  • 33
    • 24344438558 scopus 로고    scopus 로고
    • Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity
    • R.M. Perera, Y. Narita, and F.B. Furnari Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity Clin Cancer Res 11 2005 6390 6399
    • (2005) Clin Cancer Res , vol.11 , pp. 6390-6399
    • Perera, R.M.1    Narita, Y.2    Furnari, F.B.3
  • 34
    • 34250193662 scopus 로고    scopus 로고
    • The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization
    • T.G. Johns, R.M. Perera, and S.C. Vernes The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization Clin Cancer Res 13 2007 1911 1925
    • (2007) Clin Cancer Res , vol.13 , pp. 1911-1925
    • Johns, T.G.1    Perera, R.M.2    Vernes, S.C.3
  • 36
    • 20444492764 scopus 로고    scopus 로고
    • Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors
    • C.I. Sartor Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors Nat Clin Pract Oncol 1 2004 80 87
    • (2004) Nat Clin Pract Oncol , vol.1 , pp. 80-87
    • Sartor, C.I.1
  • 37
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • J. Mendelsohn, and J. Baselga The EGF receptor family as targets for cancer therapy Oncogene 19 2000 6550 6565
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 38
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • S.R. Datta, A. Brunet, and M.E. Greenberg Cellular survival: A play in three Akts Genes Dev 13 1999 2905 2927
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 39
    • 4644359805 scopus 로고    scopus 로고
    • Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
    • J. Feng, J. Park, and P. Cron Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase J Biol Chem 279 2004 41189 41196
    • (2004) J Biol Chem , vol.279 , pp. 41189-41196
    • Feng, J.1    Park, J.2    Cron, P.3
  • 40
    • 0030991386 scopus 로고    scopus 로고
    • High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase b and their influence on kinase activity
    • M. French, M. Andjelkovic, and E. Ingley High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase b and their influence on kinase activity J Biol Chem 272 1997 8474 8481
    • (1997) J Biol Chem , vol.272 , pp. 8474-8481
    • French, M.1    Andjelkovic, M.2    Ingley, E.3
  • 41
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • S.M. Huang, and P.M. Harari Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis Clin Cancer Res 6 2000 2166 2174
    • (2000) Clin Cancer Res , vol.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 42
    • 0031891006 scopus 로고    scopus 로고
    • Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
    • D. Bandyopadhyay, M. Mandal, and L. Adam Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells J Biol Chem 273 1998 1568 1573
    • (1998) J Biol Chem , vol.273 , pp. 1568-1573
    • Bandyopadhyay, D.1    Mandal, M.2    Adam, L.3
  • 43
    • 34250201533 scopus 로고    scopus 로고
    • Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance
    • S.A. Weppler, Y. Li, and L. Dubois Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance Radiother Oncol 83 2007 333 339
    • (2007) Radiother Oncol , vol.83 , pp. 333-339
    • Weppler, S.A.1    Li, Y.2    Dubois, L.3
  • 44
    • 0347928791 scopus 로고    scopus 로고
    • EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma
    • DOI 10.1016/S0360-3016(02)04357-2, PII S0360301602043572
    • B. Solomon, J. Hagekyriakou, and M.K. Trivett EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma: Epidermal growth factor receptor Int J Radiat Oncol Biol Physics 55 2003 713 723 (Pubitemid 36172491)
    • (2003) International Journal of Radiation Oncology Biology Physics , vol.55 , Issue.3 , pp. 713-723
    • Solomon, B.1    Hagekyriakou, J.2    Trivett, M.K.3    Stacker, S.A.4    McArthur, G.A.5    Cullinane, C.6
  • 45
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
    • S.M. Huang, J. Li, and E.A. Armstrong Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa) Cancer Res 62 2002 4300 4306
    • (2002) Cancer Res , vol.62 , pp. 4300-4306
    • Huang, S.M.1    Li, J.2    Armstrong, E.A.3
  • 46
    • 4444280232 scopus 로고    scopus 로고
    • Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft model
    • D. Raben, C. Bianco, and V. Damiano Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xenograft model Mol Cancer Ther 3 2004 977 983
    • (2004) Mol Cancer Ther , vol.3 , pp. 977-983
    • Raben, D.1    Bianco, C.2    Damiano, V.3
  • 47
    • 26444474990 scopus 로고    scopus 로고
    • Analysis of the epidermal growth factor receptor specific transcriptome: Effect of receptor expression level and an activating mutation
    • M.W. Pedersen, N. Pedersen, and L. Damstrup Analysis of the epidermal growth factor receptor specific transcriptome: Effect of receptor expression level and an activating mutation J Cell Biochem 96 2005 412 427
    • (2005) J Cell Biochem , vol.96 , pp. 412-427
    • Pedersen, M.W.1    Pedersen, N.2    Damstrup, L.3
  • 48
    • 0037139359 scopus 로고    scopus 로고
    • Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene
    • T.G. Johns, E. Stockert, and G. Ritter Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene Int J Cancer 98 2002 398 408
    • (2002) Int J Cancer , vol.98 , pp. 398-408
    • Johns, T.G.1    Stockert, E.2    Ritter, G.3
  • 49
    • 33845780061 scopus 로고    scopus 로고
    • Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer
    • C. Cao, J.M. Albert, and L. Geng Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer Cancer Res 66 2006 11409 11415
    • (2006) Cancer Res , vol.66 , pp. 11409-11415
    • Cao, C.1    Albert, J.M.2    Geng, L.3


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