TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model

Surgery Today

Volumn 39, Issue 12, 2009, Pages 1046-1053

  Ohta, Manabu ^a   Kawabata, Toshiki ^a   Yamamoto, Masayoshi ^a   Tanaka, Tatsuo ^a   Kikuchi, Hirotoshi ^a   Hiramatsu, Yoshihiro ^a   Kamiya, Kinji ^a   Baba, Megumi ^a   Konno, Hiroyuki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiangiogenic agent; Interstitial fluid pressure; Normalization; Receptor tyrosine kinase inhibitor

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; ALPHA SMOOTH MUSCLE ACTIN; ANGIOGENESIS INHIBITOR; CD31 ANTIGEN; FIBROBLAST GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; NUDE MOUSE; TISSUE PRESSURE; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; COLON; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HUMANS; INDOLES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PROPIONIC ACIDS; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SENSITIVITY AND SPECIFICITY; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 72949117051     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-009-4020-y     Document Type: Article

References (33)

1. J. Folkman 2007 Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6 273 286 10.1038/nrd2115 1:CAS:528:DC%2BD2sXjs1SisL4%3D 17396134 (Pubitemid 46505878)
2. H. Hurwitz L. Fehrenbacher W. Novotny T. Cartwright J. Hainsworth W. Heim, et al. 2004 Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer N Engl J Med 350 2335 2342 10.1056/NEJMoa032691 1:CAS:528:DC%2BD2cXks1Gjt74%3D 15175435 (Pubitemid 38702844)
3. A. Sandler R. Gray M.C. Perry J. Brahmer J.H. Schiller A. Dowlati, et al. 2006 Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2542 2550 10.1056/NEJMoa061884 1:CAS:528: DC%2BD28XhtlWqsbzI 17167137 (Pubitemid 44917502)
4. B. Ramaswamy A.D. Elias N.T. Kelbick A. Dodley M. Morrow M. Hauger, et al. 2006 Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients Clin Cancer Res 12 3124 3129 10.1158/1078-0432.CCR-05-2603 1:CAS:528:DC%2BD28Xks1Ciurw%3D 16707611 (Pubitemid 43837360)
5. K. Senior 2006 Combination treatment improves breast-cancer survival Lancet Oncol 7 370 10.1016/S1470-2045(06)70682-9 16696166
6. National Comprehensive Cancer Network. NCCN colon and rectal cancer treatment guidelines for patients, version IV. 2005. http://www.nccn.org
7. R.K. Jain D.G. Duda J.W. Clark J.S. Loeffler 2006 Lessons from phase III clinical trials on anti-VEGF therapy for cancer Nat Clin Pract Oncol 3 24 40 10.1038/ncponc0403 1:CAS:528:DC%2BD28XhtVynsL0%3D 16407877 (Pubitemid 43108832)
8. C.G. Willett Y. Boucher E. di Tomaso D.G. Duda L.L. Munn R.T. Tong, et al. 2004 Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer Nat Med 10 145 147 10.1038/nm988 1:CAS:528:DC%2BD2cXoslKmtQ%3D%3D 14745444 (Pubitemid 38524883)
9. R.T. Tong Y. Boucher S.V. Kozin F. Winkler D.J. Hicklin R.K. Jain 2004 Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors Cancer Res 64 3731 3736 10.1158/0008-5472.CAN-04-0074 1:CAS:528:DC%2BD2cXksVKgur8%3D 15172975 (Pubitemid 38697278)
10. R.K. Jain 2005 Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy Science 307 58 62 10.1126/science.1104819 1:CAS:528:DC%2BD2MXnvFar 15637262 (Pubitemid 40093472)
11. T.T. Batchelor A.G. Sorensen E. di Tomaso W.T. Zhang D.G. Duda K.S. Cohen, et al. 2007 AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients Cancer Cell 11 83 95 10.1016/j.ccr.2006.11.021 1:CAS:528:DC%2BD2sXhtFClsLc%3D 17222792 (Pubitemid 46075199)
12. R.K. Jain 2001 Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy Nat Med 7 987 989 10.1038/nm0901-987 1:CAS:528:DC%2BD3MXmvFOmsrc%3D 11533692 (Pubitemid 32937367)
13. R.K. Jain R.T. Tong L.L. Munn 2007 Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model Cancer Res 67 2729 2735 10.1158/0008-5472.CAN-06-4102 1:CAS:528:DC%2BD2sXivV2nsLw%3D 17363594 (Pubitemid 46548961)
14. C. Miki K. Tanaka Y. Inoue T. Araki M. Ohi Y. Mohri, et al. 2008 Perioperative host-tumor inflammatory interactions: a potential trigger for disease recurrence following a curative resection for colorectal cancer Surg Today 38 579 584 10.1007/s00595-007-3674-6 18612780 (Pubitemid 351977650)
15. R.M. Shaheen D.W. Davis W. Liu B.K. Zebrowski M.R. Wilson C.D. Bucana, et al. 1999 Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis Cancer Res 59 5412 5416 1:CAS:528:DyaK1MXnt1Gjtbg%3D 10554007
16. T. Tanaka H. Konno I. Matsuda S. Nakamura S. Baba 1995 Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470 Cancer Res 55 836 839 1:CAS:528:DyaK2MXjslelt7w%3D 7531615
17. T. Kanai H. Konno T. Tanaka K. Matsumoto M. Baba S. Nakamura, et al. 1997 Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice Int J Cancer 71 838 841 10.1002/(SICI)1097-0215(19970529)71:5<838::AID-IJC23>3.0.CO;2-2 1:CAS:528:DyaK2sXktlagtLw%3D 9180154 (Pubitemid 27237207)
18. T. Kanai H. Konno T. Tanaka M. Baba K. Matsumoto S. Nakamura, et al. 1998 Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth- factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice Int J Cancer 77 933 936 10.1002/(SICI)1097-0215(19980911)77:6<933::AID-IJC23>3.0.CO;2-0 1:CAS:528:DyaK1cXltlKkt7s%3D 9714067 (Pubitemid 28378146)
19. A.D. Laird P. Vajkoczy L.K. Shawver A. Thurnher C. Liang M. Mohammadi, et al. 2000 SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors Cancer Res 60 4152 4160 1:CAS:528: DC%2BD3cXlvFOkt7s%3D 10945623
20. U. Ozerdem A.R. Hargens 2005 A simple method for measuring interstitial fluid pressure in cancer tissues Microvasc Res 70 116 120 10.1016/j.mvr.2005.07. 003 1:CAS:528:DC%2BD2MXhtFyktrfP 16137719 (Pubitemid 41565417)
21. K. Gono T. Obi M. Yamaguchi N. Ohyama H. Machida Y. Sano, et al. 2004 Appearance of enhanced tissue features in narrow-band endoscopic imaging J Biomed Opt 9 568 577 10.1117/1.1695563 15189095
22. K. Shibuya H. Hoshino M. Chiyo A. Iyoda S. Yoshida Y. Sekine, et al. 2003 High magnification bronchovideoscopy combined with narrow band imaging could detect capillary loops of angiogenic squamous dysplasia in heavy smokers at high risk for lung cancer Thorax 58 989 995 10.1136/thorax.58.11.989 1:STN:280:DC%2BD3srhtVWquw%3D%3D 14586056 (Pubitemid 37392812)
23. J.S. Young C.E. Lumsden A.L. Stalker 1950 The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit J Pathol Bacteriol 62 313 333 10.1002/path.1700620303 1:STN:280:DyaG3M%2FhsVCntA%3D%3D 14784896
24. Y. Boucher J.M. Kirkwood D. Opacic M. Desantis R.K. Jain 1991 Interstitial hypertension in superficial metastatic melanomas in humans Cancer Res 51 6691 6694 1:STN:280:DyaK38%2Fns1Cjtw%3D%3D 1742743
25. H.D. Roh Y. Boucher S. Kalnicki R. Buchsbaum W.D. Bloomer R.K. Jain 1991 Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response Cancer Res 51 6695 6698 1:STN:280:DyaK38%2Fns1CjtA%3D%3D 1742744
26. J.R. Less M.C. Posner Y. Boucher D. Borochovitz N. Wolmark R.K. Jain 1992 Interstitial hypertension in human breast and colorectal tumors Cancer Res 52 6371 6374 1:STN:280:DyaK3s%2Fks1WntA%3D%3D 1423283
27. E.K. Rofstad S.H. Tunheim B. Mathiesen B.A. Graff E.F. Halsor K. Nilsen, et al. 2002 Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts Cancer Res 62 661 664 1:CAS:528:DC%2BD38Xht1Krtbw%3D 11830516
28. R. Gutmann M. Leunig J. Feyh A.E. Goetz K. Messmer E. Kastenbauer, et al. 1992 Interstitial hypertension in head and neck tumors in patients: correlation with tumor size Cancer Res 52 1993 1995 1:STN:280:DyaK383gtVChsw%3D%3D 1551128
29. M. Milosevic A. Fyles D. Hedley M. Pintilie W. Levin L. Manchul, et al. 2001 Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements Cancer Res 61 6400 6405 1:CAS:528:DC%2BD3MXmsF2jsLs%3D 11522633
30. G. Griffon-Etienne Y. Boucher C. Brekken H.D. Suit R.K. Jain 1999 Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications Cancer Res 59 3776 3782 1:CAS:528:DyaK1MXltFCns78%3D 10446995
31. A.G. Taghian R. Abi-Raad S.I. Assaad A. Casty M. Ancukiewicz E. Yeh, et al. 2005 Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications J Clin Oncol 23 1951 1961 10.1200/JCO.2005.08.119 1:CAS:528:DC%2BD2MXjt1Cku7o%3D 15774788 (Pubitemid 46211374)
32. C. Gheorghe 2006 Narrow-band imaging endoscopy for diagnosis of malignant and premalignant gastrointestinal lesions J Gastrointest Liver Dis 15 77 82
33. R.M. Shaheen W.W. Tseng D.W. Davis W. Liu N. Reinmuth R. Vellagas, et al. 2001 Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms Cancer Res 61 1464 1468 1:CAS:528:DC%2BD3MXhvVeltLw%3D 11245452