Micro Process Technology and Novel Process Windows - Three Intensification Fields

Process Intensification for Green Chemistry: Engineering Solutions for Sustainable Chemical Processing

Volumn , Issue , 2013, Pages 91-156

  Borukhova, Svetlana ^a   Hessel, Volker ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Adipic acid manufacture; Chemical intensification; Exothermic reactions; Industrial demonstration; Micro heat exchangers; Micro novel windows; Transport intensification

Indexed keywords

EID: 84886650755     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118498521.ch4     Document Type: Chapter

References (309)

1. J.-C. Charpentier, Process intensification by miniaturization. Chem. Eng. Technol., 28, 255-258 (2005).
2. P. Gravesen, J. Branebjerg and O. Sondergard Jensen, Microfluidics -a review. J. Micromech. Microeng., 3, 168-182 (1993).
3. D. J. Laser and J. G. Santiago, A review of micropumps. J. Micromech. Microeng., 14, R35-64 (2004).
4. C.Wiles and P.Watts, Continuous flow reactors: a perspective. Green Chem., 14, 38-54 (2012).
5. W. Ehrfeld, V. Hessel and H. Lowe, Microreactos: New Technology for Modern Chemistry, Wiley-VCH (2000).
6. D. C. Hendershot, Process minimization: making plants safer. Chem. Eng. Prog. 23 (2000).
7. R. Jachuck, Process intensification for responsive processing. Chem. Eng. Res. Dev., 80, 233-238 (2002).
8. V. Hessel, B. Cortese and M. H. J. M.de Croon, Novel process windows -concept, proposition and evaluation methodology, and intensified superheated processing. Chem. Eng. Sci., 66, 1426-1448 (2011).
9. K. Geyer, J. D. C. Codée and P. H. Seeberger, Microreactors as tools for synthetic chemists -the chemists' round-bottomed flask of the 21st century? Chem. Eur. J., 12, 8434-8442 (2006).
10. H. Pennemann, V. Hessel and H. L€owe, Chemical microprocess technology -from laboratory-scale to production. Chem. Eng. Sci., 59, 4789-4794 (2004).
11. J. Fischer, C. Liebner, H. Hieronymus and E. Klemm, Maximum safe diameters of microcapillaries for a stoichiometric ethene/oxygen mixture. Chem. Eng. Sci., 64, 2951-2956 (2009).
12. D. M. Roberge, L. Ducry, N. Bieler, P. Cretton and B. Zimmermann, Microreactor technology: a revolution for the fine chemical and pharmaceutical industries? Chem. Eng. Technol., 28, 318-323 (2005).
13. K. F. Jensen, Microreaction engineering -is small better? Chem. Eng. Sci., 56, 293-303 (2001).
14. K. F. Jensen, Microchemical systems: status, challenges, and opportunities. AIChE J., 45, 2051-2054 (1999).
15. J. C. Charpentier, In the frame of globalization and sustainability, process intensification, a path to the future of chemical and process engineering (molecules into money). Chem. Eng. J., 134, 84-92 (2007).
16. J. C. Charpentier, Four main objectives for the future of chemical and process engineering mainly concerned by the science and technologies of new materials production, Chem. Eng. J., 107, 3-17 (2005).
17. A. Tonkovich, D. Kuhlmann, A. Rogers, J. Mcdaniel, S. Fitzgerald, R. Arora and T. Yuschak, Microchannel technology scale-up to commercial capacity. Chem. Eng. Res. Des., 83, 634-639 (2005).
18. J. Wegner, S. Ceylan and A. Kirschninga, Flow chemistry -a key enabling technology for (multistep) organic synthesis. Adv. Synth. Catal., 354, 17-57 (2012).
19. S. Kee and A. Gavriilidis, Design and performance of a microstructured PEEK reactor for continuous poly-l-leucine-catalysed chalcone epoxidation. Org. Process Res. Dev., 13, 941-951 (2009).
20. P. S. Dittrich and A. Manz, Lab-on-a-chip: microfluidics in drug discovery. Nat. Rev. Drug Discovery, 5, 210-218 (2006).
21. J. Khandurina and A. Guttman, Microchip-based high-throughput screening analysis ofcombinatorial libraries. Curr. Opin. Chem. Biol., 6, 359-366 (2002).
22. R. A. Potyrailo, R. J. Wroczynski, J. P. Lemmon, W. P. Flanagan and O. P. Siclovan, Fluorescence spectroscopy and multivariate spectral descriptor analysis for high-throughput multiparameter optimization of polymerization conditions of combinatorial 96-microreactor arrays. J. Comb. Chem., 5, 8-17 (2003).
23. C. Wiles and P. Watts, Recent advances in micro reaction technology. Chem. Commun, 47, 6512-6535 (2011).
24. V. Hessel, Novel process windows -gate to maximizing process intensification via flow chemistry. Chem. Eng. Technol., 32, 1655-1681 (2009).
25. P. Watts and C. Wiles, Micro reactors: a new tool for the synthetic chemist. Org. Biomol. Chem, 5, 727-732 (2007).
26. B. Ahmed-Omer, J. C. Brandt and T. Wirth, Advanced organic synthesis using microreactor technology. Org. Biomol. Chem., 5, 733-740 (2007).
27. P. P. Lange, L. J. Gooén, P. Podmore, T. Underwood and N. Sciammetta, Decarboxylative biaryl synthesis in a continuous flow reactor, Chem. Commun., 47, 3628-3630 (2011).
28. F. Venturoni, N. Nikbin, S. V. Ley and I. R. Baxendale, The application of flow microreactors to the preparation of a family of casein kinase I inhibitors. Org. Biomol. Chem., 8, 1798-1806 (2010).
29. J. de Jong, R. G. H. Lammertink and M. Wessling, Membranes and microfluidics: a review. Lab Chip, 6, 1125-1139 (2006).
30. Y. Seike, E. Kamio, T. Ono and H. Yoshizawa, Extraction of ethyl ester of polyunsaturated fatty acids by utilizing slug flow prepared by microreactor. J. Chem. Eng. Jpn, 40, 1076-1084 (2007).
31. G. M. Rios, M. P. Belleville, D. Paolucci and J. Sanchez, Progress in enzymatic membrane reactors -a review. J. Membr. Sci., 242, 189-196 (2004).
32. S. M. Lai, C. P. Ng, R. Martin-Aranda and K. L. Yeung, Knoevenagel condensation reaction in zeolite membrane microreactor. Microporous and Mesoporous Mater., 66, 239-252 (2003).
33. A. Gorak and A. Stankiewicz, Intensified reaction and separation systems. Annu. Rev. Chem. Biomol. Eng., 2, 431-451 (2011).
34. V. Kumar, M. Paraschivoiu and K. D. P. Nigam, Single-phase fluid flow and mixing in microchannels. Chem. Eng. Sci., 66, 1329-1373 (2011).
35. S. Yao and O. Bakajin, Improvements in mixing time and mixing uniformity in devices designed for studies of protein folding kinetics. Anal. Chem., 79, 5753-5759 (2007).
36. A. Cantu-Perez, Shuang Bi, S. Barrass, M. Wood and A. Gavriilidis, Residence time distribution studies in microstructured plate reactors. Appl. Therm. Eng., 31, 634-639 (2011).
37. M. Worner, Approximate residence time distribution of fully develop laminar flow in a straight rectangular channel. Chem. Eng. Sci., 65, 3499-3507 (2010).
38. J. Aubin, M. Ferrando and V. Jiricny, Current methods for characterising mixing and flow in microchannels. Chem. Eng. Sci., 65, 2065-2093 (2010).
39. J. Aubin, L. Prat, C. Xuereb and C. Gourdon, Effect of microchannel aspect ratio on residence timedistributions and the axial dispersion coefficient. Chem. Eng. Process., 48, 554-559 (2009).
40. N. Nguen, Micromixers: Fundamentals, Design and Fabrication, 2nd edition, Elsevier: Waltham, MA, 10-22 (2012).
41. I. Papautsky, J. Brazzle, T. Ameel and A. B. Frazier, Laminar fluid behavior in microchannels using micropolar fluid theory. Sens. Actuators, A, 73, 101-108 (1999).
42. D. J. Beebe, G. A. Mensing and G. M. Walker, Physics and application of microfluidic in biology. Annu. Rev. Biomed. Eng., 4, 261-286 (2002).
43. J. Baldyga and J. R. Bourne, Simplification of micromixing calculations. I. Derivation and application of new model. Chem. Eng. J., 42, 83-92 (1989).
44. B. Weigl, R. Bardell and C. Cabrera, Lab-on-a-chip for drug development. Adv. Drug Deliv. Rev., 55, 349-377 (2003).
45. S. Taghavi-Moghadam, A. Kleemann and K. Georg Golbig, Microreaction technology as a novel approach to drug design, process development and reliability. Org. Process Res. Dev., 5, 652-658 (2001).
46. T. J. Johnson, D. Ross and L. E. Locascio, Rapid microfluidic mixing. Anal. Chem., 74, 45-51 (2002).
47. F. G. Bessoth, A. J. deMello and A. Manz, Microstructure for efficient continuous flow mixing. Anal. Commun., 36, 213-215 (1999).
48. L. Falk and J. M. Commenge, Characterization of mixing and segregation in homogeneous flow systems, in Micro Process Engineering, Vol. 1: Fundamentals, Operations and Catalysts, V. Hessel, A. Renken and J. C. Schouten (Eds.), Wiley-VCH, pp. 147-170 (2009).
49. A. Bertsch, S. Heimgartner, P. Cousseaub and P. Renauda, Static micromixers based on largescale industrial mixer geometry. Lab Chip, 1, 56-60 (2001).
50. N. Nguyen and Z. Wu, Micromixers -a review. J Micromech Microeng, 15, R1 (2005).
51. V. Hessel, H. Lowe and F. Schonfeld, Micromixers -a review on passive and active mixing principles. Chem Eng Sci, 60, 2479-2501 (2005).
52. G. Jeong, S. Chung, C. Kim and S. Lee, Applications of micromixing technology. Analyst, 135, 460-473 (2010).
53. S. Dreher, N. Kockmann and P.Woias, Characterization of laminar transient flow regimes and mixing in T-shaped micromixers. Heat Transfer Eng., 30, 91-100 (2011).
54. L. Capretto,W. Cheng, M. Hill and X. Zhang, Micromixing within microfluidic devices. Top. Curr. Chem., 304, 27-68 (2011).
55. B. He, B. J. Burke, X. Zhang, R. Zhang and F. E. Regnier, A picoliter-volume mixer for microfluidic analytical systems. Anal. Chem., 73, 1942-1947 (2001).
56. A. Kamholz, B. Weigl, B. Finlayson and P. Yager, Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor. Anal. Chem., 71, 5340-5347 (1999).
57. D. Gobby, P. Angeli and A. Gavriilidis, Mixing characteristics of T-type microfluidic mixers. J. Micromech. Microeng., 11, 126 (2001).
58. R. Ismagilov, A. Stroock, P. Kenis, G. Whitesides and H. Stone, Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels. Appl. Phys. Lett., 76, 2376-2379 (2000).
59. A. Soleymani, E. Kolehmainen and I. Turunen, Numerical and experimental investigations of liquid mixing in T-type micromixers. Chem. Eng. J., 135, S219-S228 (2008).
60. S. Wong, P. Bryant, M. Ward and C. Wharton, Investigation of mixing in a cross-shaped micromixer with static mixing elements for reaction kinetics studies. Sens. Actuators. B Chem, 95, 414-424 (2003).
61. S. Wong, M. Ward and C. Wharton, Micro T-mixer as a rapid mixing micromixer. Sens. Actuators. B Chem, 100, 359-379 (2004).
62. S. Hardt, K. S. Drese, V. Hessel and F. Schonfeld, Passive micromixers for applications in the microreactor and mTAS field. Microfluid. Nanofluid., 1, 108-118 (2005).
63. K. S. Drese, Optimization of interdigital micromixers via analytical modeling -exemplified with the SuperFocus mixer. Chem. Eng. J., 101, 403-407 (2004).
64. P. Lob, K. Drese, V. Hessel, S. Hardt, C. Hofmann, H. Lowe, R. Schenk, F. Schonfeld and B. Werner, Steering of liquid mixing speed in interdigital micro mixers-from very fast to deliberately slow mixing. Chem. Eng. Technol., 27, 340-345 (2004).
65. S. Ehlers, K. Elgeti, T. Menzel and G.Wiemeier, Mixing in the offstream of a microchannel system. Chem. Eng. Process., 39, 291-298 (2000).
66. S. Hardt and F. Schonfeld, Laminar mixing in different interdigital micromixers: II. Numerical simulations. AIChE J., 49, 578-584 (2003).
67. V. Hessel, S. Hardt, H. Lowe and F. Schonfeld, Laminar mixing in different interdigital micromixers: I. Experimental characterization. AIChE J., 49, 566-577 (2003).
68. W. Ehrfeld, V. Hessel and V. Haverkamp, Microreactors, in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH: Weinheim (1999).
69. T. Veenstra, T. Lammerink, M. Elwenspoek and A.van den Berg, A characterization method for a new diffusion mixer applicable in micro flow injection analysis systems. J. Micromech. Microeng., 9, 199 (1999).
70. J. Cha, J. Kim, S. Ryu, J. Park, Y. Jeong, S. Park, H. Kim and K. Chun, A highly efficient 3D micromixer using soft PDMS bonding. J. Micromech. Microeng., 16, 1778 (2006).
71. C. Lin, C. Tsai and L. Fu, A rapid three-dimensional vortex micromixer utilizing selfrotation effects under low Reynolds number conditions. J. Micromech. Microeng., 15, 935 (2005).
72. Y. Chung, Y. Hsu, C. Jen, M. Lu and Y. Lin, Design of passive mixers utilizing microfluidic self-circulation in the mixing chamber. Lab. Chip., 4, 70-77 (2004).
73. K. Jahnisch, V. Hessel, H. Lowe and M. Baerns, Chemistry in microstructured reactors. Angew. Chem. Int. Ed., 43, 406-446 (2004).
74. S. Hardt, T. Dietrich, A. Freitag, V. Hessel, H. Loewe, C. Hofmann, A. Oroskar and F. Schonfeld, Radial and tangential injection of liquid/liquid and gas/liquid streams and focusing thereof in a special cyclone mixer, in Sixth International Conference on Microreaction Technology, IMRET 6, New Orleans, USA, I. Rinard and B. Hoch (Eds.), AIChE Publications, 164, 329-344 (2002).
75. J. Lee and S. Kwon, Mixing efficiency of a multilamination micromixer with consecutive recirculation zones. Chem. Eng. Sci., 64, 1223-1231 (2009).
76. S. Chang and Y. H. Cho, Static micromixers using alternating whirls and lamination. J. Micromech. Microeng., 15, 1397-1405 (2005).
77. J. Knight, A. Vishwanath, J. Brody and R. Austin, Hydrodynamic focusing on a silicon chip: mixing nanoliters in microseconds. Phys. Rev. Lett., 80, 3863-3866 (1998).
78. T. Vestad, D. Marr and J. Oakey, Flow control for capillary-pumped microfluidic systems. J. Micromech. Microeng., 14, 1503 (2004).
79. H. Park, X. Qiu, E. Rhoades, J. Korlach, L. Kwok, W. Zipfel, W. Webb and L. Pollack, Achieving uniform mixing in a microfluidic device: hydrodynamic focusing prior to mixing. Anal. Chem., 78, 4465-4473 (2006).
80. C. Chang, Z. Huang and R. Yang, Three-dimensional hydrodynamic focusing in two-layer polydimethylsiloxane (PDMS) microchannels. J. Micromech. Microeng., 17, 1479 (2007).
81. C. Simonnet and A. Groisman, Two-dimensional hydrodynamic focusing in a simple microfluidic device. Appl. Phys. Lett., 87, 114104 (2005).
82. N. Sundararajan, M. Pio, L. Lee and A. Berlin, Three-dimensional hydrodynamic focusing in polydimethylsiloxane (PDMS) microchannels. J.Microelectromech. Syst., 13, 559-567 (2004).
83. R. Yang, D. Feeback andW.Wang, Microfabrication and test of a three-dimensional polymer hydro-focusing unit for flow cytometry applications. Sens. Actuators. A Phys., 118, 259-267 (2005).
84. X. Mao, S. Lin, C. Dong and T. Huang, Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing. Lab Chip, 9, 1583-1589 (2009).
85. X. Mao, J. Waldeisen and T. Huang, 'Microfluidic drifting' -implementing three-dimensional hydrodynamic focusing with a single-layer planar microfluidic device. Lab Chip, 7, 1260-1262 (2007).
86. T. Lim, Y. Son, Y. Jeong, D. Yang, H. Kong, K. Lee and D. Kim, Three-dimensionally crossing manifold micro-mixer for fast mixing in a short channel length. Lab Chip, 11, 100-103 (2010).
87. F. Sch€onfeld, V. Hessel and C. Hofmann, An optimised split-and-recombine micro-mixer with uniform 'chaotic' mixing. Lab Chip, 4, 65-69 (2004).
88. A. Sudarsan and V. Ugaz, Multivortex micromixing. Proc. Natl Acad. Sci. USA, 103, 7228-7233 (2006).
89. A. D. Stroock, S. K. Dertinger, G. M. Whitesides and A. Ajdari, Pattering flow using grooved surfaces. Anal. Chem., 74, 5306-5312 (2002).
90. A. D. Stroock, S. K. W. Dertinger, A. Ajdari, I. Mezic, H. A. Stone and G. M. Whitesides, Chaotic mixer for microchannels. Science, 295, 647-651 (2002).
91. A. Gunther and K. F. Jensen, Multiphase microfluidics: from flow characteristics to chemical and materials synthesis. Lab Chip, 6, 1487-1503 (2006).
92. K. Handique and M. Burns, Mathematical modeling of drop mixing in a slit-type microchannel. J. Micromech. Microeng., 11, 548 (2001).
93. L. Yobas, S. Martens, W. Ong and N. Ranganathan, High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets. Lab Chip, 6, 1073-1079 (2006).
94. H. Song, D. L. Chen and R. F. Ismagilov, Reactions in droplets in microfluidic channels. Angew. Chem. Int. Ed., 45, 7336-7356 (2006).
95. L. Ducry and D. M. Roberge, Controlled autocatalytic nitration of phenol in a microreactor. Angew. Chem. Int. Ed., 44, 7972-7975 (2005).
96. T. Iwasaki, J. Yoshida, V. Hessel, C. Sera and H. Loewe, Free radical polymerization in microreactors: significant improvement in molecular weight distribution control. Macromolecules, 38, 1159 (2005).
97. J. L. Steinbacher and D. T. McQuade, Polymer chemistry in flow: new polymers, beads, capsules, and fibers. J. Polym. Sci., 44, 6505-6533 (2006).
98. R. D. Chambers and R. C. H. Spink, Microreactors for elemental fluorine. Chem. Commun. 883-884 (1999).
99. R. D. Chambers, D. Holling, R. C. H. Spink and G. Sandford, Elemental fluorine. Part 13. Gas-liquid thin film microreactors for selective direct fluorination. Lab Chip, 1, 132-137 (2001).
100. R. D. Chambers, M. A. Fox, D. Holling, T. Nakano, T. Okazoe and G. Sandford, Elemental fluorine. Part 16. Versatile thin-film gas-liquid multi-channel microreactors for effective scale-out. Lab Chip, 5, 191-198 (2005).
101. R. D. Chambers, M. A. Fox, D. Holling, T. Nakano, T. Okazoe and G. Sandford, Versatile gas/liquid microreactors for industry. Chem. Eng. Technol, 28, 344-352 (2005).
102. K. Kawai, T. Ebata and T. Kitazume, The synthesis of fluorinated materials in microreactors. J. Fluor. Chem., 126, 956-961 (2005).
103. K. Jahnisch, M. Baerns, V. Hessel, W. Ehrfeld, V. Haverkamp, H. Lowe, C. Wille and A. Guber, Direct fluorination of toluene using elemental fluorine in gas/liquid microreactors. J. Fluor. Chem., 105, 117-128 (2000).
104. P. Lob, H. Lowe and V. Hessel, Fluorinations, chlorinations and brominations of organic compounds in micro reactors. J. Fluor. Chem., 125, 1677-1694 (2004).
105. K. Schubert, J. Brandner, M. Fichtner, G. Linder, U. Schygulla and A.Wenka, Microstructure devices for applications in thermal and chemical process engineering. Microscale Thermophys. Eng., 5, 17-39 (2001).
106. U. Schygulla, A. Wenka, J. J. Brandner, W. Benzinger, U. Schygulla and K. Schubert, Microstructure devices for efficient heat transfer. Microgravity Sci. Technol., XIX-3/4 (2007).
107. W. Ehrfeld, C. Grartner, K. Golbig, V. Hessel, R. Konrad, H. Lowe, T. Richter and T. Schulz, Fabrication of components and systems for chemical and biological microreactors, in Microreaction Technology, Proc. of the 1st Int. Conf. on Microreaction Technology, W. Ehrfeld (Ed.), Springer-Verlag: Berlin, 72-90 (1997).
108. D. B. Tuckerman and R. F.W. Pease, High-performance heat sinking for VLSI. IEEE Electron Device Lett., 2, 126-129 (1981).
109. J. J. Brandner, E. Anurjew, L. Bohn, E. Hansjosten, T. Henning, U. Schygulla, A.Wenka and K. Schubert, Concepts and realization of microstructure heat exchangers for enhanced heat transfer. Exp. Therm. Fluid Sci., 30, 801-809 (2006).
110. W. Qu and A. Siu-Ho, Liquid single-phase flow in an array of micro-pin-fins: part II -pressure drop characteristics. J. Heat Transfer, 130, 124501-1-124501-4 (2008).
111. S. Hardt, W. Ehrfeld, V. Hessel and K. M. Vanden Bussche, Strategies for size reduction of microreactors by heat transfer enhancement effects. Chem. Eng. Commun., 190, 540-559 (2003).
112. F. Benaskar, V. Hessel, U. Krtschil, P. Loeb and A. Stark, Intensification of the capillary-based Kolbe-Schmitt synthesis from resorcinol by reactive ionic liquids, microwave heating, or a combination thereof. Org. Process Res. Dev., 13, 970-982 (2009).
113. T. Henning, J. J. Brandner and K. Schubert, Characterisation of electrically powered micro heat exchangers. Chem. Eng. J., 101/1-3, 339-345 (2004).
114. Labtrix Start: http://www.chemtrix.com/products/1/LABTRIX%C2%AE-START, last accessed 14 September 2012.
115. C. O. Kappe, Microwave dielectric heating in synthetic organic chemistry. Chem. Soc. Rev., 37, 1127-1139 (2008).
116. C. O. Kappe, Controlled microwave heating in modern organic synthesis. Angew. Chem. Int. Ed., 43, 6250-6284 (2004).
117. M. Damm, T. N. Glasnov and C. Oliver Kappe, Translating high-temperature microwave chemistry to scalable continuous flow processes. Org. Process Res. Dev., 14, 215-224 (2010).
118. N. G. Patil, A. I. G. Hermans, F. Benaskar, E. Rebrov, J. Meuldijk, L. A. Hulshof, V. Hessel and J. C. Schouten, Energy efficient and controlled flow processing under microwave heating by using a milli reactor-heat exchanger. J. Chem. Eng. Res. Dev. (submitted).
119. D. Liedtke, in Warmebehandlung von Eisenwerkstoffen I, Vol. 8, D. Liedtke (Ed.), Expert Verlag: Renningen (2008).
120. D. Zhao, H. Zhang, X. Zeng, Q. Xia and J. Tang, Inductive heat property of Fe3O4/polymer composite nanoparticles in an ac magnetic field for localized hyperthermia. Biomed. Mater., 1, 198-201 (2006).
121. S. Ceylan, C. Friese, C. Lammel, K. Mazac and A. Kirschning, Inductive heating for organic synthesis by using functionalized magnetic nanoparticles inside microreactors. Angew. Chem. Int. Ed., 47, 8950-8953 (2008).
122. J. Wegner, S. Ceylan, C. Friese and A. Kirschning, Inductively heated oxides inside microreactors -facile oxidations under flowconditions. Eur. J. Org. Chem., 2010, 4372-4375 (2010).
123. G. Veser, Experimental and theoretical investigation of H2 oxidation in a high-temperature catalytic microreactor. Chem. Eng. Sci., 56, 1265-1273 (2001).
124. A. Leclerc, M. Alamé, D. Schweich, P. Pouteau, C. Delattre and C.de Bellefon, Gas-liquid selective oxidations with oxygen under explosive conditions in a micro-structured reactor. Lab Chip, 8, 814-817 (2008).
125. M. Struempel, B. Ondruschka, R. Daute and A. Stark, Making diazomethane accessible for R&D and industry: generation and direct conversion in a continuous micro-reactor set-up. Green Chem., 10, 41-43 (2008).
126. A. Kursawe and D. H€onicke, Selective oxidation of 1-butene to maleic anhydride-comparison of the performance between microchannel reactors and fixed bed reactors, in Proc. of IMRET 5: 5th Int. Conf. on Microreaction Technology, M. Matlosz, W. Ehrfeld and J. P. Baselt (Eds.), Springer-Verlag: Berlin, 240 (2001).
127. H. Kestenbaum, A. L.de Oliveira, W. Schmidt and F. Sch€uth, Silver-catalyzed oxidation of ethylene to ethylene oxide in a microreaction system. Ind. Eng. Chem. Res., 41, 710 (2000).
128. H. Kestenbaum, A. Lange de Oliveira, W. Schmidt, F. Sch€uth, W. Ehrfeld, K. Gebauer, H. L€owe and Th. Richter, Synthesis of ethylene oxide in a catalytic microreactor system. Stud. Surf. Sci. Catal., 130, 2741 (2000).
129. T. Gustafsson, F. Pontén and P. H. Seeberger, Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral. Chem. Commun. 1100 (2008).
130. H. Pennemann, S. Hardt, V. Hessel, P. L€ob and F. Weise, Micromixer based liquid/liquid dispersion. Chem. Eng. Technol., 28, 501 (2005).
131. S. K. Ajmera, M. W. Losey, K. F. Jensen and M. A. Schmidt, Microfabricated packed-bed reactor for phosgene synthesis. AIChE J., 47, 1639 (2001).
132. M. Baumann, I. R. Baxendale, L. J. Martin and S. V. Ley, Development of fluorination methods using continuous-flow microreactors. Tetrahedron, 65, 6611-6625 (2009).
133. T. Fukuyama, M. Kobayashi, M. T. Rahman, N. Kamata and I. Ryu, Spurring radical reactions of organic halides with tin hydride and TTMSS using microreactors. Org. Lett., 10, 533 (2008).
134. O. Klais, F. Westphal, W. Benaissa and D. Carson, Guidance on safety/health for process intensification including MS design; part I: reaction hazards. Chem. Eng. Technol., 32, 1831-1844 (2009).
135. O. Klais, F. Westphal, W. Benaissa and D. Carson, Guidance on safety/health for process intensification including MS design; part II: explosion hazards. Chem. Eng. Technol., 32, 1966-1973 (2009).
136. O. Klais, F.Westphal,W. Benaissa, D. Carson and J. Albrecht, Guidance on safety/health for process intensification including MS design; part III: risk analysis. Chem. Eng. Technol., 33, 444-454 (2010).
137. O. Klais, J. Albrecht, D. Carson, M. Kraut, P. Lob, C. Minnich, F. Olschewski, C. Reimers, A. Simoncelli and M. Uerdingen, Guidance on safety/health for process intensification including MS design; part IV: case studies. Chem. Eng. Technol., 33, 1159-1168 (2010).
138. H. Usutani, Y. Tomida, A. Nagaki, H. Okamoto, T. Nokami and J. Yoshida, Generation and reactions of o-Bromophenyllithium without benzyne formation using a microreactor. J. Am. Chem. Soc., 129, 3046-3047 (2007).
139. J. Yoshida, Flash Chemistry: Fast Organic Synthesis in Microsystems, Wiley-Blackwell, (2008).
140. J. Yoshida, A. Nagaki and T. Yamada, Flash chemistry: fast chemical synthesis by using microreactors. Chem. Eur. J., 14, 7450-7459 (2008).
141. R. L. Hartman and K. F. Jensen, Microchemical systems for continuous-flow synthesis. Lab Chip, 9, 2495-2507 (2009).
142. B. Xu, R. Zhang, X. Liu, H.Wang, Y. Zhang, H. Jiang, L.Wang, Z. Ma, J. Ku, F. Xiao and H. Sun, On-chip fabrication of silver microflower arrays as a catalyticmicroreactor for allowing in situ SERS monitoring. Chem. Commun., 48, 1680 (2012).
143. T. McCreedy and N. G.Wilson, Microfabricated reactors for on-chip heterogeneous catalysis. Analyst, 126, 21 (2001).
144. N. G. Wilson and T. McCreedy, On-chip catalysis using a lithographically fabricated glass microreactor -the dehydration of alcohols using sulfated zirconia. Chem.Commun. 733 (2000).
145. R. D. Chambers and J. Hutchinson, Elemental fluorine: part 9, catalysis of the direct fluorination of 2-substituted carbonyl compounds. J. Fluor. Chem., 92, 45-52 (1998).
146. R. D. Chambers, M. A. Fox, G. Sandford, J. Trmcic and A. Goeta, Elemental fluorine: part 20, direct fluorination of deactivated aromatic systems using microreactor techniques. J. Fluor. Chem., 1228, 29-33 (2007).
147. N.de Mas, A. G€unther, M. A. Schmidt and K. F. Jensen, Increasing productivity of microreactors for fast gas-liquid reactions: the case of direct fluorination of toluene. Ind. Eng. Chem. Res., 48, 1428-1434 (2009).
148. M. Nobis and D. M. Roberge, Mastering ozonolysis: production from laboratory to ton scale in continuous flow. Chem. Today, 29, 56-58 (2011).
149. M. O'Brien, I. R. Baxendale and S. V. Ley, Flow ozonolysis using a semipermeable teflon AF-2400 membrane to effect gas-liquid contact. Org. Lett., 12, 1596-1598 (2010).
150. M. Irfan, T. N. Glasnov and C. O. Kappe, Continuous flow ozonolysis in a laboratory scale reactor. Org. Lett., 13, 984-987 (2011).
151. T. P. Petersen, A. Polyzos, M. O'Brien, T. Ulven, I. R. Baxendale and S. V. Ley, The oxygenmediated synthesis of 1,3-butadiynes in continuous flow: using teflon AF-2400 to effect gas/liquid contact. ChemSusChem, 5, 274-277 (2012).
152. L. Gooén, N. Rodríguez and K. Gooén, Carboxylic acids as substrates in homogeneous catalysis. Angew. Chem. Int. Ed., 47, 3100-3120 (2008).
153. T. Sakakura, J. C. Choi and H. Yasuda, Transformation of carbon dioxide. Chem. Rev., 107, 2365-2387 (2007).
154. A. Metzger, S. Bernhardt, G. Manolikakes and P. Knochel, MgCl2-accelerated addition of functionalized organozinc reagents to aldehydes, ketones, and carbon dioxide. Angew. Chem. Int. Ed., 49, 4665-4668 (2010).
155. C. Wiles and P. Watts, Micro Reaction Technology in Organic Synthesis, CRC Press (2011).
156. A. Nagaki, A. Kenmoku, Y. Moriwaki, A. Hayashi and J. Yoshida, Cross-coupling in a flow microreactor: space integration of lithiation and murahashi coupling. Angew. Chem. Int. Ed., 49, 7543-7547 (2010).
157. A. Nagaki, S. Yamada, M. Doi, Y. Tomida, N. Takabayashi and J. Yoshida, Flow microreactor synthesis of disubstituted pyridines from dibromopyridines via Br/Li exchange without using cryogenic conditions. Green Chemistry, 13, 1110 (2011).
158. T. No€el and S. L. Buchwald, Cross-coupling in flow. Chem. Soc. Rev., 40, 5010-5029 (2011).
159. R. C. R. Wootton, R. Fortt and A. J.de Mello, On-chip generation and reaction of unstable intermediates -monolithic nanoreactors for diazonium chemistry: Azo dyes. Lab Chip, 2, 5 (2002).
160. K. Uehata, M. Nishida and A. Nishida, A novel and efficient method for the preparation of unstable tetramethylzirconium and its application using a microflow system. Chem. Let., 41, 73-75 (2012).
161. T. Schwalbe, D. Kadzimirsz and G. Jas, Synthesis of a library of ciprofloxacin analogues by means of sequential organic synthesis in microreactors. QSAR Comb. Sci., 24, 758-768 (2005).
162. K. Tanaka, S. Motomatsu, K. Koyama, S. Tanaka and K. Fukase, Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step. Org. Lett., 9, 299-302 (2007).
163. A. R. Bogdan, S. L. Poe, D. C. Kubis, S. J. Broadwater and D. T. McQuade, The continuousflow synthesis of ibuprofen. Angew. Chem. Int. Ed., 48, 8547-8550 (2009).
164. M. D. Hopkin, I. R. Baxendale and S. V. Ley, A flow-based synthesis of Imatinib: the API of Gleevec. Chem. Commun., 46, 2450-2452 (2010).
165. T. L. LaPorte, M. Hamedi, J. S. DePue, L. Shen, D. Watson and D. Hsieh, Development and scale-up of three consecutive continuous reactions for production of 6-hydroxybuspirone. Org. Process Res. Dev., 12, 956-966 (2008).
166. Z. Qian, I. R. Baxendale and S. V. Ley, A flow process using microreactors for the preparation of a quinolone derivative as a potent 5HT1B antagonist. Synlett, 4, 505-508 (2010).
167. I. R. Baxendale, S. V. Ley, A. C. Mansfield and C. D. Smith, Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles. Angew. Chem. Int. Ed., 48, 4017-4021 (2009).
168. I. R. Baxendale, J. Deeley, C. M. Griffiths-Jones, S. V. Ley, S. Saaby and G. K. Tranmer, A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. Chem. Commun. 2566-2568 (2006).
169. I. R. Baxendale, C. M. Griffiths-Jones, S. Ley and G. K. Tranmer, Preparation of the neolignan natural product grossamide by a continuous-flow process. Chem. Inform., 37, 2566-2568 (2006).
170. D. Grant, R. Dahl and N. D. P. Cosford, Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence. J. Org. Chem., 73, 7219-7223 (2008).
171. T. P. Petersen, A. Ritzen and T. Ulven, A multistep continuous-flow system for rapid ondemand synthesis of receptor ligands. Org. Lett., 11, 5134-5137 (2009).
172. A. Stefanescu, A. C. van Veen, C. Mirodatos, J. C. Beziat and E. Duval-Brunel, Wall coating optimization for microchannel reactors. Catal. Today, 125, 16-23 (2007).
173. V. Sebastian, O. de la Iglesia, R. Mallada, L. Casado, G. Kolb, V. Hessel and J. Santamarí, Preparation of zeolite films as catalytic coatings on microreactor channels. J. Microporous and Mesoporous Materials, 115, 147-155 (2008).
174. E. A. S. Doherty, R. J. Meagher, M. N. Albarghouthi and A. E. Barron, Microchannel wall coatings for protein separations by capillary and chip electrophoresis. Electrophoresis, 24, 34-54 (2003).
175. M. S. Thomsen and B. Nidetzky, Coated-wall microreactor for continuous biocatalytic transformations using immobilized enzymes. Biotechnol. J., 4, 98-107 (2009).
176. J. M. Bolivar, J. Wiesbauer and B. Nidetzky, Biotransformations in microstructured reactors: more than flowing with the stream. Trends in Biotechnol., 29, 333 (2011).
177. D. A. Cowan and R. Fernandez-Lafuente, Enhancing the functional properties of thermophilic enzymes by chemical modification and immobilization. Enzyme Microb. Technol., 49, 326 (2011).
178. A. Schwarz, M. S. Thomsen and B. Nidetzky, Enzymatic synthesis of b-glucosylglycerol using a continuous-flow microreactor containing thermostable b-glycoside hydrolase CelB immobilized on coated microchannel walls. Biotechnol. Bioeng., 103, 5 (2009).
179. N. Zotova, F. J. Roberts, G. H. Kelsall, A. S. Jessiman, K. Hellgardt and K. Hii, Catalysis in flow: Au-catalysed alkylation of amines by alcohols. Green Chem., 14, 226 (2012).
180. M. Irfan, T. N. Glasnov and C. O. Kappe, Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors. ChemSusChem, 4, 300-316 (2011).
181. T. Chinnusamy, S. Yudha, M. Hager, P. Kreitmeier and O. Reiser, Application of metalbased reagents and catalysts in microstructured flow devices. ChemSusChem, 5, 247-255 (2012).
182. N. Hoffmann, Photochemical reactions as key steps in organic synthesis. Chem. Rev., 108, 1052-1103 (2008).
183. P. Esser, B. Pohlmann and H. D. Scharf, The photochemical synthesis of fine chemicals with sunlight. Angew. Chem. Int. Ed., 33, 2009-2023 (1994).
184. M. Fagnoni, D. Dondi, D. Ravelli and A. Albini, Photocatalysis for the formation of the C-C bond. Chem. Rev., 107, 2725-2756 (2007).
185. A. M. Braun, M. Maurette and E. Oliveros, Photochemical Technology, John Wiley & Sons: Chichester (1991).
186. F. R. Bou-Hamdanab and P. H. Seeberger, Visible-light-mediated photochemistry: accelerating Ru(bpy)3 2{thorn}-catalyzed reactions in continuous flow. Chem. Sci., 3, 1612-1616 (2012).
187. F. Lévesque and P. H. Seeberger, Continuous-flow synthesis of the anti-malaria drug artemisinin. Angew. Chem. Int. Ed., 51, 1706-1709 (2012).
188. W. B. Zimmerman, Electrochemical microfluidics. Chem. Eng. Sci., 66, 1412-1425 (2011).
189. A. Nagaki, M. Togai, S. Suga, N. Aoki, K. Mae and J. Yoshida, Control of extremely fast competitive consecutive reactions using micromixing: selective Friedel-Crafts aminoalkylation. J. Am. Chem. Soc., 127, 11 666-11 675 (2005).
190. V. Hessel, C. Hofmann, P. Leb, J. Lehndorf, H. Lewe and A. Ziogas, Aqueous KolbeŚchmitt synthesis using resorcinol in a microreactor laboratory rig under high-p,T conditions. Org. Process Res. Dev., 9, 479 (2005).
191. K. F. Jensen, Silicon-based microchemical systems: characteristics and applications. Mater. Res. Soc. Bull., 31, 101-107 (2006).
192. S. Marre, A. Adamo, S. Basak, C. Aymonier and K. F. Jensen, Design and packaging of microreactors for high pressure and high temperature applications. Ind. Eng. Chem. Res., 49, 11 310-11 320 (2010).
193. S. Borukhova, A. C. Varas, V. Hessel, Q. Wang, P. Watts and C. Wiles, 1,3-dipolar Huisgen cycloaddition to rufinamide and the impact of pressure on reaction environment and kinetic parameters, in Proceedings of the 12th International Conference on Microreaction Technology, IMRET12, February 20-22, 2012, Lyon, France (2012).
194. http://www.rsc.org/chemistryworld, last accessed 14 September 2012.
195. E. R. Murphy, J. R. Martinelli, N. Zaborenko, S. L. Buchwald and K. F. Jensen, Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions. Angew. Chem., 119, 1764-1767 (2007).
196. R. Schmitt, Beitrag zur Kenntniss der Kolbe'schen Salicyls€aure Synthese. J. Prakt. Chem, 31, 397 (1885).
197. T. Razzaq, T. N. Glasnov and C. O. Kappe, Accessing novel process windows in a high-temperature/pressure capillary flow reactor. Chem. Eng. Technol., 32, 1702-1716 (2009).
198. G. Shore, M. Tsimerman and M. G. Organ, Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS). Beilstein J. Org. Chem., 5, 35 (2009).
199. T. N. Glasnov, D. J. Vugts, M. M. Koningstein, B. Desai,W. M. F. Fabian, R. V. A. Orru and C. O. Kappe, Microwave-assisted Dimroth rearrangement of thiazines to dihydropyrimidinethiones: synthetic and mechanistic aspects. QSAR Comb. Sci., 25, 509-518 (2006).
200. R. E. Martin, F. Morawitz, C. Kuratli, A. M. Alker and A. I. Alanine, Synthesis of annulated pyridines by intramolecular inverse-electron-demand hetero-Diels-Alder reaction under superheated continuous flow conditions. Eur. J. Org. Chem. 47-52 (2012).
201. D. Cantillo, H. Sheibani and C. O. Kappe, Flash flow pyrolysis: mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment. J. Org. Chem., 77, 2463-2473 (2012).
202. M. Viviano, T. N. Glasnov, B. Reichart, G. Tekautz and C. O. Kappe, A scalable two-step continuous flow synthesis of nabumetone and related 4-Aryl-2-butanones. Org. Process Res. Dev., 15, 858-870 (2011).
203. D. Obermayer, T. N. Glasnov and C. O. Kappe, Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides. J. Org. Chem., 76, 6657-6669 (2011).
204. T. Razzaq, T. N. Glasnov and C. O. Kappe, Continuous-flow microreactor chemistry under high-temperature/pressure conditions. Eur. J. Org. Chem. 1321-1325 (2009).
205. P. Loeb, V. Hessel, H. Klefenz, H. Loewe and K. Mazanek, Bromination of thiophene in microreactors. Lett. Org. Chem., 2, 767-779 (2005).
206. M. Sato, H. Kawanami, M. Chatterjee, N. Otabe, T. Tuji, Y. Ikushima, T. Yokoyama and T. M. Suzuki, Highly selective non-catalytic Claisen re-arrangement in a high pressure and high pressure and high temperature water microreaction system. 11th International Conference on Microreaction Technology, Kyoto, Japan, 50-51 (2011).
207. F. Benito-Lopez, R. J. M. Egberink, D. N. Reinhoudt and W. Verboom, High pressure in organic chemistry on the way to miniaturization. Tetrahedron, 64, 10 023-10 040 (2008).
208. C. McKee, M. Mortimer, in Chemical Kinetics and Mechanism: The Molecular World, M. Mortimer and P. G. Taylor (Eds.), Royal Society of Chemistry: Cambridge, UK, p. 86 (2002).
209. K. A. Swiss and R. A. Firestone, Phantom activation volumes. J. Phys. Chem. A, 104, 3057-3063 (2000).
210. A. Shito, T. Takahashi, Y. Ohga, T. Asano, H. Saito, K. Matsuo and H. D. Z. Luedemann, Pressure effects on the thermal Z/E isomerization of 4-(dimethylamino)-40-nitroazobenzene in a liquid polymer: a comparison of dynamic solvent effects in polymeric and monomeric solvents. Z. Naturforsch., 55a, 616-622 (2000).
211. K. P. Pimparkar, D. J. Miller and J. E. Jackson, Hydrogenation of amino acid mixtures to amino alcohols. Ind. Eng. Chem. Res., 47, 7648-7653 (2008).
212. F. Trachsel, C. Hutter and P. R. Rohr, Transparent silicon/glass microreactor for high-pressure and high-trmperature reactions. Chem. Eng. J., 135, S309-S316 (2007).
213. R. M. Tiggelaar, F. Benito-Lopez, D. C. Hermesa, H. Rathgen, R. J. M. Egberink, F. G. Mugele, D. N. Reinhoudt, A.van den Berg, W. Verboom and H. J. G. E. Gardeniers, Fabrication, mechanical testing and application of high-pressure glass microreactor chips. Chem. Eng. J., 131, 163-170 (2007).
214. D. J. C. Constable, C. Jimenez-Gonzalez and R. K. Henderson, Perspective on solvent use in the pharmaceutical industry. Org. Proc. Res. Dev., 11, 133-137 (2007).
215. C. Li and T. Chan, Water can act as green and safe reaction media for organic reactions and thus can in some instances replace organic solvents: diverse applications have been explored in both industry and academic laboratories. Comprehensive Organic Reactions in Aqueous Media, 2nd Edition, July 2007.
216. L. A.de Cienfuegos, R. Robles, D. Miguel, J. Justicia and M. Juan, Reduction reactions in green solvents: water, supercritical carbon dioxide, and ionic liquids. ChemSusChem, 4, 1035-1048 (2011).
217. S. Liu and J. Xiao, Toward green catalytic synthesis -transition metal-catalyzed reactions in non-conventional media. J. Mol. Cat. A: Chem., 270, 1-43 (2007).
218. S. Marre, Y. Roig and C. Aymonier, Supercritical microfluidics: opportunities in flow-through chemistry and materials science. J. Supercrit. Fluids (2011).
219. A. K. Goodwin and G. L. Rorrer, Conversion of glucose to hydrogen-rich gas by supercritical water in a microchannel reactor. Industrial & Engineering Chemistry Research, 47, 4106-4114 (2008).
220. S. Marre, J. Baek, J. Park, M. G. Bawendi and K. F. Jensen, High-pressure/high-temperature microreactors for nanostructure synthesis. JALA, 14, 367-373 (2009).
221. E. A. Oosterbroek, D. C. Hermes, M. Kakuta, F. Benito-Lopez, J. G. E. Gardeniers, W. Verboom, D. N. Reinhoudt and A.van den Berg, Fabrication and mechanical testing of glass chips for high-pressure synthetic and analytical chemistry. Microsyst. Technol., 12, 450 (2006).
222. F. Benito-Lopez, R. M. Tiggelaar, K. Salbut, J. Huskens, R. J. M. Egberink, D. N. Reinhoudt, H. J. G. E. Gardeniers and W. Verboom, Substantial rate enhancements of the esterification reaction of phthalic anhydride with methanol at high pressure and using supercritical CO2 as a co-solvent in a glass microreactor. Lab Chip, 7, 1345 (2007).
223. W. Verboom, Selected examples of high-pressure reactions in glass microreactors. Chem. Eng. Technol., 32, 1695 (2009).
224. F. Benito-Lopez, A. J. Kettelarij, R. J. M. Egberink, A. H. Velders, R. M. Tiggelaar, H. J. G. E. Gardeniers, D. N. Reinhoudt and W. Verboom, A capillary micro-reactor as a tool to study pressurized reactions: the influence of pressure on the stereoselectivity of the Diels-Alder reaction of 2-and 3-furylmethanol. Chim. Oggi, 28, 16 (2010).
225. F. Trachsel, B. Tidona, S. Desportes and R.von Rohr, Solid catalyzed hydrogenation in a Si/glass microreactor using supercritical CO2 as the reaction solvent. J. Supercriti. Fluids, 48, 146-153 (2009).
226. J. R. Hyde and M. Poliakoff, Supercritical hydrogenation and acid-catalysed reactions 'without gases'. Chem. Commun. 1482-1483 (2004).
227. J. R. Hyde, B. Walsh, J. Singh and M. Poliakoff, Continuous hydrogenation reactions in supercritical CO2 'without gases'. Green Chem., 7, 357-361 (2005).
228. N. M. Islam, M. Chatterjee, Y. Ikushima, T. Yokoyama and H. Kawanami, Development of a novel catalytic membrane reactor for heterogeneous catalysis in supercritical CO2. Int. J. Mol. Sci., 11, 164-172 (2010).
229. F. Patcas, C. Maniut, C. Ionescu, S. Pitter and E. Dinjus, Supercritical carbon dioxide as an alternative reaction medium for hydroformylation with integrated catalyst recycling. Appl. Catal. B, 70, 630-636 (2007).
230. C. Yan, J. Fraga-Dubeuil, E. Garcia-Verdugo, P. A. Hamley, M. Poliakoff, I. Pearson and A. Suart Coote, The continuous synthesis of e-caprolactam from 6-aminocapronitrile in hightemperature water. Green Chem., 10, 98 (2008).
231. M. Sato, K. Matsushima, H. Kawanami and Y. Ikuhsima, A highly selective, high-speed, and hydrolysis-free O-acylation in subcritical water in the absence of a catalyst. Angew. Chem. Int. Ed., 46, 6284-6288 (2007).
232. Y. Ikushima, K. Hatakeda, O. Sato, T. Yokoyama and M. Arai, Structure and base catalysis of supercritical water in the noncatalytic benzaldehyde disproportionation using water at high temperatures and pressures. Angew. Chem. Int. Ed. Engl., 40, 210 (2001).
233. Y. Ikushima, K. Hatakeda, O. Sato, T. Yokoyama and M. Arai, Acceleration of synthetic organic reactions using supercritical water: noncatalytic Beckmann and Pinacol rearrangements. J. Am. Chem. Soc., 122, 1908 (2000).
234. G. Anitescu, A. Deshpande and L. L. Tavlarides, Integrated technology for supercritical biodiesel production and power cogeneration. Energy Fuels, 22, 1391 (2008).
235. T. Razzaq and C. O. Kappe, Continuous flow organic synthesis under high-temperature/-pressure conditions. Chem. Asian J., 5, 1274-1289 (2010).
236. N. V. Plechkova and K. R. Seddon, Ionic liquids: 'designer' solvents for green chemistry, in Methods and Reagents for Green Chemistry: An Introduction, P. Tundo, A. Perosa and F. Zecchini (Eds.), John Wiley & Sons: Hoboken, NJ, pp. 103-130 (2007).
237. S. Mallakpour and Z. Rafiee, Ionic liquids as novel and green media for clean synthesis of soluble aromatic-aliphatic poly(amide-ester)s containing hydroxynaphthalene urazole moiety. Polym. Adv. Technol., 19, 1015-1023 (2008).
238. J. Xu, C. Qian, B. Liu, Q. Wu and X. Lin, A fast and highly efficient protocol for Michael addition of N-heterocycles to a,b-unsaturated compound using basic ionic liquid [bmIm]OH as catalyst and green solvent. Tetrahedron, 63, 986-990 (2007).
239. Y. Zhang, B. R. Bakshi and E. S. Demessie, Life cycle assessment of an ionic liquid versus molecular solvents and their applications. Environ. Sci. Technol., 42, 1724-1730 (2008).
240. D. A.Waterkamp, M. Heiland, M. Schl€uter, J. C. Sauvageau, T. Beyersdorff and J. Th€oming, Synthesis of ionic liquids in micro-reactors -a process intensification study. Green Chem., 9, 1084-1090 (2007).
241. A. Renken, V. Hessel, P. L€ob, R. Miszczuk, M. Uerdingen, L. Kiwi-Minsker, Ionic liquid synthesis in a microstructured reactor for process intensification. Chem. Eng. Process., 46, 840-845 (2007).
242. Y. G€ok, -I.€Ozdemir and E. SCetinkaya, Ionic liquids as solvents/catalysts for selective alkylation of amines with alkyl halides. Chin. J. Catal., 28, 489-491 (2007).
243. M. Teijeira, Y. Fall, F. Santamarta and E. Tojo, Efficient and rapid experimental procedure for the synthesis of furan diol from d-glucal using ionic liquid. Tetrahedron Lett., 48, 7926-7929 (2007).
244. D. J. C. Constable, C. Jimenez-Gonzalez and R. K. Henderson, Perspective on solvent use in the pharmaceutical industry. Org. Process Res. Dev., 11, 133-137 (2007).
245. W. Wu, G. Qian, X. Zhou and W. Yuan, Peroxidization of methyl ethyl ketone in a microchannel reactor. Chem. Eng. Sci., 62, 5127-5132 (2007).
246. L. Kong, Q. Lin, X. Lv, Y. Yang, Y. Jia and Y. Zhou, Efficient Claisen rearrangement of allyl para-substituted phenyl ethers using microreactors. Green Chem., 11, 1108 (2009).
247. H. Loewe, V. Hessel, P. Lob and S. Hubbard, Addition of secondary amines to r,a-unsaturated carbonyl compounds and nitriles by using microstructured reactors. Org. Process Res. Dev., 10, 1144-1152 (2006).
248. R. F. Ludlow and S. Otto, Systems chemistry. Chem. Soc. Rev., 37, 101 (2008).
249. U. Sauer, Systems biology: getting closer to the whole picture. Science, 316, 550 (2007).
250. High Level Group on the Competitiveness of the European Chemicals Industry, Final Report: European Chemical Industry, Enabler of a Sustainable Future, European Communities (2009).
251. V. Hessel and I. Vural-Gursel, Potential analysis of smart flow processing and micro process technology for fastening process development -use of chemistry and process design as intensification fields. Chem. Eng. Technol. (2012).
252. D. Kralisch, E. Santacesaria, B. Cortese, M. H. J. M.de Croon and V. Hessel, Transfer of the epoxidation of soybean oil from batch to flow chemistry guided by cost and environmental issues. ChemSusChem, 5, 300-311 (2012).
253. S. R. Deshmukh and D. G. Vlachos, CFD Simulations of coupled, countercurrent combustor/reformer microdevices for hydrogen production. Ind. Eng. Chem. Res., 44, 4982 (2005).
254. G. Kolios, B. Gloeckler, A. Gritsch, A. Morillo and G. Eigenberger, Heat-integrated reactor concepts for hydrogen production by methane steam reforming. Fuel Cells Bull., 5, 52 (2005).
255. M. S. Mettler, G. D. Stefanidis and D. G. Vlachos, Scale-out of microreactor stacks for portable and distributed processing: coupling of exothermic and endothermic processes for syngas production. Ind. Eng. Chem. Res., 49, 10 942-10 955 (2010).
256. R. C. Ramaswamy, P. A. Ramachandran and M. P. Dudukovic, Coupling exothermic and endothermic reactions in adiabatic reactors. 63, 1654-1667 (2008).
257. C. Bramsiepe, S. Sievers, T. Seifert, G. D. Stefanidis, D. G. Vlachos, H. Schnitzer, B. Muster, C. Brunner, J. P. M. Sanders, M. E. Bruins and G. Schembecker, Low-cost small scale processing technologies for production applications in various environments -mass produced factories. Chem. Eng. Process., 51, 32-52 (2012).
258. Technische Universitat Darmstadt, Center of Smart Interfaces (CSI), www.csi.tu-darmstadt.de, last accessed 14 September 2012.
259. C. Ramshaw, Higee distillation -an example of process intensification. Chem. Eng., 389, 13-14 (1983).
260. W. T. Cross and C. Ramshaw, Process intensification -laminar-flow heat-transfer. Chem. Eng. Res. Des., 64, 293-301 (1986).
261. A. Aoune and C. Ramshaw, Process intensification: heat and mass transfer characteristics of liquid film on rotating discs. Int. J. Heat Mass Trans., 42, 2543-2556 (1999).
262. I. Vural-Gursel, Q. Wang, V. Hessel, T. Noel and J. Lang, Microreactors for faster and ecoefficient process development -process design as 3. intensification field. Chem. Eng. Technol. (2012).
263. N. M. Nikacevic, A. E. M. Huesman, P. M. J.van den Hof and A. I. Stankiewicz, Chemical engineering & technology; opportunities and challenges for process control in process intensification. Chem. Eng. Process., 52, 1-15 (2012).
264. K. Sato, M. Aoki and R. Noyori, A 'green' route to adipic acid: direct oxidation of cyclohexenes with 30 percent hydrogen peroxide. Science, 281, 1646-1647 (1998).
265. V. Hessel, J. Lang and D. Kralisch, Shining a light: new routes in process chemistry and plant conception, http://www.chemanager-online.com/en/topics/plant-engineering-components/shining-light, last accessed 14 September 2012.
266. M. Henig, Invite and F3 factory, the European che mical factory of the future is taking shape at the Invite Research Cent er in Germany. Process (2011). http://www.process-worldwide.com.
267. A. Geipel-Kern, F3 project what will tomorrow's chemical plant look like? Process (2010). http://www.process-worldwide.com.
268. F3 Factory Newsletter, Issue 1 (2010). http://f3factory.com/scripts/pages/en/newsevents/F3_FactoryNewsletter_1.pdf, last accessed 14 September 2012.
269. F3 Factory Newsletter, Issue 2 (2011). http://f3factory.com/scripts/pages/en/newsevents/F3_FactoryNewsletter_2.pdf, last accessed 14 September 2012.
270. I. Vural, V. Hessel, J. Lang, T. Noel and Q. Wang. Green Proc. Synth (submitted).
271. M. T. Musser and E. I. DuPont de Nemours & Co. Adipic Acid, in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH (2003).
272. Adipic Acid, in Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons: Hoboken, NJ, pp. 553-581 (2007).
273. A. Castellan, J. C. J. Bart and S. Cavallaro, Industrial production and use of adipic acid. Catal Today, 9, 237-254 (1991).
274. R. A. Reimer, C. S. Slaten, M. Seapan, M.W. Lower and P. E. Tomlinson, Abatement of N2O emissions produced in the adipic acid industry. Environ Prog, 13, 134-137 (1994).
275. Y. Q. Deng, Z. F. Ma, K.Wang and J. Chen, Clean synthesis of adipic acid by direct oxidation of cyclohexene with H2O2 over peroxytungstate -organic complex catalysts. Green Chem., 1, 275-276 (1999).
276. K. Sato, M. Aoki, M. Ogawa, T. Hashimoto and R. Noyori, A practical method for epoxidation of terminal olefins with 30% hydrogen peroxide under halide-free conditions. J. Org. Chem., 61, 8310-8311 (1996).
277. P. R. Patnaik, Multi-unit integration in microfluidic processes: current status and future horizons. Int. J. Bioautomation, 15, 77-84 (2011).
278. C. Cremers, A. Pelz, U. Stimming, K. Haas-Santo, O. Goerke, P. Pfeifer and K. Schubert, Micro-structured methane steam reformer with integrated catalytic combustor. Fuel Cells Bull., 7, 91-98 (2007).
279. A. M. Karim, J. A. Federici and D. G. Vlachos, Portable power production from methanol in an integrated thermoeletric/microreactor system. J. Power Sources, 179, 113-120 (2008).
280. T. Honda, M. Miyazaki, Y. Yamaguchi, H. Nakamura and H. Maeda, Integrated microreaction system for optical resolution of racemic amino acids. Lab Chip, 7, 366-372 (2007).
281. W. N. Lau, K. L. Yeung and R. Martin-Aranda, Knoevenagel condensation reaction between benzaldehyde and ethyl acetoacetate in microreactor and membrane microreactor. Microporous and Mesoporous Mater., 115, 156-163 (2008).
282. W. N. Lau, K. L. Yeung, X. F. Zhang and R. Martin-Aranda, Zeolite membrane microrectors and their performance. Stud. Surf. Sci. Catal., 170B, 1460-1465 (2007).
283. J. P. McMullen and K. F. Jensen, Integrated microreactors for reaction automation: new approaches to reaction development. Annu. Rev. Anal. Chem., 3, 19-42 (2010).
284. W. C. Shin, An integrated micro chemical reactor system with effective control strategies. Dissertation Abstracts International, DAI/B 68-03 (2007).
285. D. J. Quiram, K. F. Jensen, M. A. Schmidt, P. L. Mills, J. F. Ryley, M. D. Wetzel and D. J. Kraus, Integrated microreactor system for gas-phase catalytic reactions. 1. Scale-up microreactor design and fabrication, Ind. Eng. Chem. Res., 46, 8292-8305 (2007).
286. D. J. Quiram, K. F. Jensen, M. A. Schmidt, P. L. Mills, J. F. Ryley, M. D. Wetzel and D. J. Kraus, Integrated microreactor system for gas phase reactions, in Micro Instrumentation, M. V. Koch, K. VandenBusche and R. W. Chrisman (Eds.), pp. 363-406 (2007).
287. K. Shah and R. S. Besser, Understanding thermal integration issues and heat loss pathways in a planar microscale fuel processor: demonstration of an integrated silicon microreactor-based methanol steam reformer. Chem. Eng. J., 135, S46-S56 (2008).
288. K. Shah and R. S. Besser, Key issues in the microchemical systems-based methanol fuel processor: energy density, thermal integration, and heat loss mechanisms. J. Power Sources, 166, 177-193 (2007).
289. D. J. Quiram, K. F. Jensen, M. A. Schmidt, P. L. Mills, J. F. Ryley, M. D. Wetzel and D. J. Kraus, Integrated microreactor system for gas-phase catalytic reactions. 3. Microreactor system design and system automation. Ind. Eng. Chem. Res., 46, 8319-8335 (2007).
290. V. Hessel, C. Hofmann, H. L€owe, A. Meudt, S. Scherer, F. Sch€onfeld and B. Werner, Selectivity gains and energy savings for the industrial phenyl boronic acid process using micromixer/tubular reactors. Org. Proc. Res. Dev., 8, 511-523 (2004).
291. J. Fischer, T. Lange, R. Boehling, A. Rehfinger and E. Klemm, Uncatalyzed selective oxidation of liquid cyclohexane with air in a microcapillary reactor. Chem. Eng. Sci., 65, 4866 (2010).
292. P. Loeb, V. Hessel, H. Loewe, C. Hofmann, K. Mazanek and H. Klefenz, Brominations in micro reactors using high and low p, T-processing, in Proceedings of the 8th International Conference on Microreaction Technology (IMRET 8), Atlanta, GA, p. 1341 (2005).
293. P. B. Palde and T. F. Jamison, Safe and efficient tetrazole synthesis in a continuous-flow microreactor. Angew. Chem. Int. Ed., 50, 3525 (2011).
294. http://europic.jeppix.eu/. Last visited April 13, 2012.
295. P. Poechlauer, M. Vorbach, M. Kotthaus, S. Braune, R. Reintjens, F. Mascarello and G. Kwant, Microreactor plant for the large-scale production of a fine chemical intermediate: a technical case study, in Micro Process Engineering: A Comprehensive Handbook, vol. 1, V. Hessel, A. Renken, J. C. Schouten and J.-I. Yoshida (Eds.),Wiley-VCH:Weinheim, pp. 249-254 (2009).
296. D. Kralisch, U. Krtschil, D. M. Roberge,V. Hessel and D. Schmalz, The economic potential of microreaction technology, in Micro Process Engineering: A Comprehensive Handbook, Vol. 3: System, Process and Plant Engineering 3: System, V. Hessel, A. Renken, J. C. Schouten and J. Yoshida (Eds.), Wiley-VCH: Weinheim, pp. 279-294 (2009).
297. V. Hessel, P. Lob and H. Lowe, Industrial microreactor process development up to production, in: Microreactors in Organic Synthesis and Catalysis, T.Wirth (Ed.),Wiley-VCH:Weinheim, pp. 211-275 (2008).
298. M. Nobis and D. M. Roberge, Mastering ozonolysis: production from laboratory to ton scale in continuous flow. Chim Oggi, 29, 56-58 (2011).
299. N. Kockmann and D. M. Roberge, Harsh reaction conditions in continuous-flow microreactors for pharmaceutical production. Chem. Eng. Technol., 32, 1682-1694 (2009).
300. P. Barthe, C. Guermeur, O. Lobet, M. Moreno, P. Woehl, D. M. Roberge, N. Bieler and B. Zimmermann, Continuous multi-injection reactor for multipurpose production -part I. Chem. Eng. Technol., 31, 1146-1154 (2008).
301. D. M. Roberge, N. Bieler, M. Mathier, M. Eyholzer, B. Zimmermann, P. Barthe, C. Guermeur, O. Lobet, M. Moreno and P.Woehl, Development of an industrial multi-injection microreactor for fast and exothermic reactions -part II. Chem. Eng. Technol., 31, 1155-1161 (2008).
302. D. M. Roberge, N. Bieler and M. Thalmann, Microreactor technology and continuous processes in the fine chemical and pharmaceutical industries. PharmaChem, 28, 14 (2006).
303. N. Kockmann, M. Gottsponer and D. M. Roberge, Scale-up concept of single-channel microreactors from process development to industrial production. Chem. Eng. J., 167, 718-726 (2011).
304. W. B. White, T. J. Schnitzer, R. Fleming, B. Duquesroix and M. Beekman, Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. Am. J. Cardiol., 104(6), 840-845 (2009).
305. V. Hessel, A. Renken, J. C. Schouten and J. Yoshida, Micro Process Engineering: A Comprehensive Handbook, 1st edition, Wiley-VCH: Weinheim (2009).
306. D. Kirschneck and G. Tekautz, Integration of a microreactor in an existing production plant. Chem. Eng. Technol., 30, 305-308 (2007).
307. Green Car Congress, Velocys signs microchannel GTL agreement with Petrobras and Partners: targeting GTL deployment on FPSO, www.greencarcongress.com, last accessed 14 September 2012.
308. Velocys Inc., GTL demonstration at Petrobras, Financial Announcement. www.velocys.com, last accessed 14 September 2012.
309. Toyo Engineering Cooperation, TOYO signs joint development agreement with MODEC and Velocys for offshore GTL plant, in Newsletter, Tec Communications, vol. 13, www.toyo-eng.co.jp, last accessed 14 September 2012.