Micromixers - A review on passive and active mixing principles

Chemical Engineering Science

Volumn 60, Issue 8-9 SPEC. ISS., 2005, Pages 2479-2501

  Hessel, Volker ^a   Löwe, Holger ^a   Schönfeld, Friedhelm ^a  

^a INSTITUT FÜR MIKROTECHNIK MAINZ GMBH   (Germany)

Author keywords

Active mixing; Chemical microprocess engineering; Micromixers; Microreactors; Mixing principles; Passive mixing

Indexed keywords

ELECTRIC FIELDS; ENERGY ABSORPTION; MIXING; SOLUBILITY; ULTRASONICS; WETTING;

MICROMIXERS; MICROSTIRRERS; MICROSTRUCTURED MIXER DEVICES; MIXING PRINCIPLES;

MIXERS (MACHINERY);

MIXING;

EID: 14544286392     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2004.11.033     Document Type: Conference Paper

References (100)

1. Aref, H., 1984. Stirring by chaotic advection. Journal of Fluid Mechanics 143, 1-21.
2. Aubin, J., et al., 2003. Characterization of the mixing quality in micromixers. Chemical Engineering and Technology 26 (12), 1262-1270.
3. Auroux, P.A., et al., 2002. Micro total analysis systems, 2: analytical standard operations and applications. Analytical Chemistry 74 (12), 2637-2652.
4. Bayer, T., Himmler, K., Kessel, V., 2003. Don't be baffled by static mixers. Chemical Engineering (5), 2-9.
5. Bertsch, A., et al., 2001. Static micromixers based on large-scale industrial mixer geometry. Lab on a Chip 1, 56-60.
6. Bessoth, F.G., de Mello, A.J., Manz, A., 1999. Microstructure for efficient continuous flow mixing. Analytical Communications 36, 213-215.
7. Böhm, S., et al. (Eds.), 2001. A rapid vortex micromixer for studying high-speed chemical reactions. In: Ramsey, J.M., van den Bag, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 25-27.
8. Bökenkamp, D., et al., 1998. Microfabricated silicon mixers for submillisecond quench flow analysis. Analytical Chemistry 70, 232-236.
9. Branebjerg, J., Larsen, U.D., Blankenstein, G. (Eds.), 1996. Fast mixing by parallel multilayer lamination. Proceedings of the Second International Symposium on Miniaturized Total Analysis Systems; Analytical Methods & Instrumentation, Special Issue μTAS'96, Basel, pp. 228-230.
10. de Mello, A., Wootton, R., 2002. But what is it good for? Applications of microreactor technology for the fine chemical industry. Lab on a Chip 2, 7N-13N.
11. Drese, K., 2003. Optimization of interdigital micromixers via analytical modeling - exemplified with the SuperFocus mixer. Chemical Engineering Journal 101 (1-3), 403-407.
12. Ehlers, S., et al., 2000. Mixing in the offstream of a microchannel system. Chemical Engineering and Processing 39, 291-298.
13. Ehrfeld, W., et al., 1999. Characterization of mixing in micromixers by a test reaction: single mixing units and mixer arrays. Industrial & Engineering Chemistry Research 38 (3), 1075-1082.
14. Ehrfeld, W., Hessel, V., Löwe, H., 2000. Microreactors. Wiley-VCH, Weinheim.
15. Ehrnström, R., 2002. Miniaturization and integration: challenges and breakthroughs in microfluidics. Lab on a Chip 2, 26N-30N.
16. Fletcher, P.D.I., et al., 2002. Micro reactors: principle and applications in organic synthesis. Tetrahedron 58 (24), 4735-4757.
17. Floyd, T.M., et al. (Eds.), 2000. Novel liquid phase microreactors for safe production of hazardous speciality chemicals. Microreaction Technology. Third International Conference on Microreaction Technology. Proceedings of IMRET 3, Springer, Berlin, pp. 171-180.
18. Freitas, S., et al., 2003. Solvent extraction employing a static micromixer: a simple, robust and versatile technology for the microencapsulation of proteins. Journal of Microencapsulation 20 (1), 67-85.
19. Gavriilidis, A., et al., 2002. Technology and application of microengineeted reactors. Transactions IChemE 80/A (1), 3-30.
20. Glasgow, I., Aubry, N., 2003. Enhancement of microfluidic mixing using time pulsing. Lab on a Chip 3, 114-120.
21. Gobby, D., Angeli, P., Gavriilidis, A., 2001. Mixing characteristics of T-type microfluidic mixers. Journal of Micromechanics and Microengineering 11, 126-132.
22. Graveson, P., Branjeberg, J., Jensen, O.S., 1993. Microfluidies - a review. Journal of Micromechanics and Microengineering 3 (4), 168-182.
23. Haas-Santo, K., et al. (Eds.), 2001. A Microstructure Reactor System for the Controlled Oxidation of Hydrogen for Possible Application in Space. Springer, Berlin.
24. Hardt, S., Schönfeld, F., 2003. Laminar mixing in different interdigital micromixers - part 2: numerical simulations. A.I.Ch.E. Journal 49 (3), 578-584.
25. Hardt, S., et al., 2001a. Simulation of droplet formation in micromixers. In: Fourth International Conference on Modeling and Simulations of Microsystems, Hilton Head Island, SC, pp. 223-226.
26. Hardt, S., et al., 2001b. Mixing and emulsification processes in micromixers. In: Computational Methods for Multiphase Flow, Orlando, USA, pp. 217-228.
27. Hardt, S., et al., 2002. Radial and tangential injection of liquid/liquid and gas/liquid streams and focusing thereof in a special cyclone mixer. In: Rinard, I., Hoch, B. (Eds.) Sixth International Conference on Microreaction Technology, IMRET 6, New Orleans, USA. A.I.Ch.E. Publications No. 164, pp. 329-344.
28. Haswell, S.T., Watts, P., 2003. Green chemistry: synthesis in micro reactors. Green Chemistry 5, 240-249.
29. He, B., et al., 2001. A picoliter-volume mixer for microfluidic analytical systems. Analytical Chemistry 73 (9), 1942-1947.
30. Hessel, V., Löwe, H., 2003. Micro chemical engineering: components - plant concepts - user acceptance. Chemical Engineering and Technology 26(1)(Part I), 13-24.
31. Hessel, V., et al., 2003. Laminar mixing in different interdigital micromixers - part I: experimental characterization. A.I.Ch.E. Journal 49 (3), 566-577.
32. Hessel, V., Hardt, S., Löwe, H., 2004. Chemical Micro Process Engineering - Fundamentals, Modelling and Reactions. Wiley-VCH, Weinheim.
33. Hong, C.-C., Choi, J.-W., Ahn, C.H. (Eds.), 2001. A novel in-plane passive micromixer using coanda effect. In: Ramsey, J.M., van den Berg, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 31-33.
34. Jähnisch, K., et al., 2004. Chemistry in microstructured reactors. Angewandte Chemie - International Edition 43 (4), 406-446.
35. Jen, C.-P., et al., 2003. Design and simulation of the micromixer with chaotic advection in twisted microchannels. Lab on a Chip 3, 77-81.
36. Jensen, K.F., 1998. Smaller, faster chemistry. Nature 393 (6), 735-736.
37. Jensen, K.F., 2001. Microreaction engineering - is small better? Chemical Engineering Science 56, 293-303.
38. Jiang, F., et al., 2004. Helical flows and chaotic mixing in curved micro channels. A.I.Ch.E. Journal 50 (9), 2297-2305.
39. Kakuta, M., et al., 2003a. Time-resolved Fourier transform infrared spectrometry using a microfabricated continuous flow mixer: application to protein conformation study using the example of ubiquitin. Lab on a Chip 3, 82-85.
40. Kakuta, M., et al., 2003b. Micromixer-based time-resolved NMR: applications to ubiquitin protein conformation. Analytical Chemistry 75 (4), 956-960.
41. Kang, T.G., Kwon, T.H., 2004. Colored particle tracking method for mixing analysis of chaotic micromixers. Journal of Micromechanics and Microengineering 14, 891-899.
42. Kestenbaum, H., et al., 2000a. Silver-catalyzed oxidation of ethylene to ethylene oxide in a microreaction system. Industrial & Engineering Chemistry Research 41 (4), 710-719.
43. Kestenbaum, H., et al., 2000b. Synthesis of ethylene oxide in a catalytic microreactor system. Studies in Surface Science and Catalysis 130, 2741-2746.
44. Knapp, M.R., et al., 2001. Commercialized and emerging Lab-on-a-Chip applications. In: Ramsey, J.M., van den Berg, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 7-9.
45. Knight, J.B., et al., 1998. Hydrodynamic focussing on a silicon chip: mixing nanoliters in microseconds. Physical Review Letters 80 (17), 3863.
46. Lee, Y.-K., et al., 2001. Chaotic mixing in electrokinetically and pressure driven micro flows. In: Microreaction Technology - IMRET 5: Proceedings of the Fifth International Conference on Microreaction Technology.Springer, Berlin, pp. 185-191.
47. Liu, R.H., et al., 2001. Plastic on-line chaotic micromixer for biological applications. In: Ramsey, J.M., van den Berg, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 163-164.
48. Liu, R.H., et al., 2002. Bubble-induced acoustic micromixing. Lab on a Chip 2, 151-157.
49. Liu, R.H., et al., 2003. Hybridization enhancement using cavitation microstreaming. Analytical Chemistry 75 (8), 1911-1917.
50. Löb, P., et al., 2004. Steering of liquid mixing speed in interdigital micromixers - from very fast to deliberately slow mixing. Chemical Engineering and Technology 27 (3), 340-345.
51. Loebbecke, S., et al., 2000. Applications of FTIR microscopy for process monitoring in silicon microreactors. In: VDE World Microtechnologies Congress, MICRO.tec 2000, EXPO Hannover.VDE Verlag, Berlin, pp. 789-791.
52. Loebbecke, S., et al., 2002. Black box microreactor? Possibilities for a better control and understanding of microreaction processes by applying suitable analytics. In: Sixth International Conference on Microreaction Technology, IMRET 6, New Orleans, USA. A.I.Ch.E. Publications No. 164, pp. 37-38.
53. Loebbecke, S., et al., 2004. Experimental approaches to better understanding of mixing efficiency of microfluidic devices. Chemical Engineering Journal 101 (1-3), 409-419.
54. Löwe, H., et al., 2000. Micromixing technology. In: Fourth International Conference on Microreaction Technology, IMRET 4, Atlanta, USA. A.I.Ch.E. Topical Conference Proceedings, pp. 31-47.
55. Lu, L.-H., Ryu, K.S., Liu, C. (Eds.), 2001. A novel microstirrer and arrays for microfluidic mixing. In: Ramsey, J.M., van den Berg, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 28-30.
56. Manz, A., Becker, H. (Eds.), 1998. Microsystem Technology in Chemistry and Life Science, vol. 194. Springer, Heidelberg.
57. Mengeaud, V., Josserand, J., Girault, H.H., 2002. Mixing processes in a zigzag microchannel: finite element simulations and optical study. Analytical Chemistry 74, 4279-4286.
58. Miyake, R., et al., 1993. Micromixer with fast diffusion. In: IEEE-MEMS'93. Fort Lauderdale, USA, pp. 248-253.
59. Niu, X., Lee, Y.-K., 2003. Efficient spatial-temporal chaotic mixing in micro-channels. Journal of Micromechanics and Microengineering 13, 454-462.
60. Oddy, M.H., Santiago, J.G., Mikkelsen, J.C., 2001. Electrokinetic instability micromixing. Analytical Chemistry 73 (24), 5822-5832.
61. Oroskar, A.R., Vanden Bussche, K., Towler, G., 2000. Scale up vs numbering up - can miniaturization change the rules in chemical processing. In: VDE World Microtechnologies Congress, MICRO.tec 2000, EXPO Hannover.VDE Verlag, Berlin, pp. 385-392.
62. Ottino, J.M., 1989. The Kinematics of Mixing Stretching, Chaos, and Transport. Cambridge University Press, Cambridge.
63. Palk, P., Pamula, V.K., Fair, R.B., 2003. Rapid droplet mixers for digital microfluidic systems. Lab on a Chip 3, 253-259.
64. Pennemann, H., et al., 2004a. Investigations on pulse broadening for transient catalyst screening in gas/liquid systems. A.I.Ch.E. Journal 50 (8), 1814-1823.
65. Pennemann, H., et al., 2004b. Application of micro reactors: benchmarking for analytical applications and lab-scale synthesis. Organic Process Research & Development 8 (3), 422-435.
66. Pennemann, H., Hessel, V., Löwe, H., 2004c. Chemical micro process technology - from laboratory-scale to production. Chemical Engineering Science 59 (22-23), 4789-4794.
67. Penth, B., 1999. Method and device for carrying out chemical and physical processes, WO 00/61275. Germany.
68. Penth, B., 2000. New non-clogging microreactor for chemical processing and nano materials. In: Micro.tec 2000, VDE World Microtechnologies Congress Expo 2000, Hannover, Germany.VDE Verlag, Berlin, pp. 401-405.
69. Qian, S., Bau, H.H., 2002. A chaotic electroosmotic stirrer. Analytical Chemistry 74 (15), 3616-3625.
70. Ramsey, J.M. (Ed.), 1996. Miniature chemical measurement systems. Proceedings of the Second International Symposium on Miniaturized Total Analysis Systems; Analytical Methods & Instrumentation, Special Issue μTAS'96, Basel, pp. 24-27.
71. Reyes, D.R., et al., 2002. Micro total analysis systems, 1: introduction, theory, and technology. Analytical Chemistry 74 (12), 2623-2636.
72. Roessler, A., Rys, P., 2001. Selektivität mischungsmaskierter reaktionen: Wenn die Rührgeschwindigkeit die Produktverteilung bestimmt. Chemie in unserer Zeit 35 (5), 314-322.
73. Schenk, R., et al., 2002. Micromixers as a tool for powder production. Chemical Engineering Transactions (1), 909-914.
74. Schenk, R., et al., 2004. Nanopowders produced using microreactors. Encyclopedia of Nanoscience and Nanotechnology 7, 287-296.
75. Schierholz, W., Lauschke, G., Ott, S., 1997. Kontinuierlicher chaotischer Konvektionsmischer, -wärmetauscher und -reaktor, DE 19731891: 7. Hoechst AG, Germany.
76. Schönfeld, F., Hardt, S., 2003. Simulation of helical flows in microchannels. A.I.Ch.E. Journal 50 (4), 2297-2305.
77. Schönfeld, F., Hessel, V., Hofmann, C., 2004. An optimised split-and-recombine micro mixer with uniform 'chaotic' mixing. Lab on a Chip 4, 65-69.
78. Schubert, K., et al., 1994. Method and device for performing chemical reactions with the aid of microstructure mixing, WO 95/30476: 35. Bayer Aktiengesellschaft, Forschungszentrum Karlsruhe GmbH, Germany.
79. Schubert, K., et al., 2001. Microstructure devices for applications in thermal and chemical process engineering. Microscale Thermophysical Engineering 5, 17-39.
80. Schwesinger, N., Frank, T., 1995. Device for mixing small quantities of liquids, WO 96/30113. Merck Patent GmbH; Darmstadt, Germany.
81. Schwesinger, N., Frank, T., Wurmus, H., 1996. A modular microfluidic system with an integrated micromixer. Journal of Micromechanics and Microengineering 6, 99-102.
82. Seidel, R.U., et al. (Eds.), 2000. A capillary force filled auto-mixing device. Microreaction Technology: Third International Conference on Microreaction Technology. Proceedings of IMRET 3. Springer, Berlin, pp. 189-197.
83. Skelton, V., et al., 2000. Micro reaction technology: synthetic chemical optimisation methodology of Wittig synthesis enabling a semi-automated micro reactor for combinatorial screening. In: Fourth International Conference on Microreaction Technology, IMRET 4, Atlanta, USA. A.I.Ch.E. Topical Conference Proceedings, pp. 78-88.
84. Solomon, T.N., Mezic, I., 2003. Uniform resonant chaotic mixing in fluid flows. Nature 425 (9), 376-380.
85. Stroock, A.D., et al., 2002a. Chaotic mixing in microchannels. Science 295 (1), 647-651.
86. Stroock, A.D., et al., 2002b. Patterning flows using grooved surfaces. Analytical Chemistry 74 (20), 5306-5312.
87. Tatterson, G.B., 1994. Scaleup and Design of Industrial Mixing Processes. McGraw-Hill, New York.
88. van den Berg, A., Bergveld, P., 1995. μ-TAS: miniaturized total chemical analysis systems. In: van den Berg, A., Bergveld, P. (Eds.) Micro Total Analysis Systems. Kluwer Academic Press, Dordrecht, Amsterdam, pp. 1-4.
89. van den Berg, A., Lammerink, T.S.J., 1998. Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications. Topics in Current Chemistry, vol. 194. Springer, Heidelberg, pp. 21-49.
90. Veenstra, T.T., et al., 1998. Characterization method for a new diffusion mixer applicable in micro flow injection analysis systems. Journal of Micromechanics and Microengineering 9, 199-202.
91. 2 oxidation in a high-temperature catalytic microreactor. Chemical Engineering Science 56, 1265-1273.
92. Villermaux, J., et al., 1991. Use of parallel competing reactions to characterize micromixing efficiency. A.I.Ch.E. Symposium Series 88 (286), 6.
93. Voldman, J., Gray, M.L., Schmidt, M.A., 1998. Liquid mixing studies with an integrated mixer/valve. In: Harrison, J., van den Berg, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 181-184.
94. Werner, B., et al., 2002. Specially suited micromixers for process involving strong fouling. In: Sixth International Conference on Microreaction Technology, IMRET 6, New Orleans, USA. A.I.Ch.E. Publications No. 164, pp. 168-183.
95. Werner, B., Hessel, V., Löb, P., 2005. Mixers with microstructural foils for chemical production purposes. Chemical Engineering and Technology, in press.
96. West, J., et al., 2002. Application of magnetohydrodynamic actuation to continuous flow chemistry. Lab on a Chip 2, 224-230.
97. Woias, P., Hauser, K., Yacoub-George, E. (Eds.), 2000. An active silicon micromixer for μTAS applications. In: van den Berg, A., Olthuis, W., Bergveld, P. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 277-282.
98. Yang, Z., et al., 1998. Micro mixer incorporated with piezoelectrically driven valveless micropump. In: Harrison, J., van den Berg, A. (Eds.) Micro Total Analysis Systems. Kluwer Academic Publishers, Dordrecht, pp. 177-180.
99. Yang, Z., et al., 2001. Ultrasonic micromixer for microfluidic systems. Sensors and Actuators A 93, 266-272.
100. Zech, T., et al., 2000. Superior performance of static micromixers. In: Fourth International Conference on Microreaction Technology, IMRET 4, Atlanta, USA. A.I.Ch.E. Topical Conference Proceedings, pp. 390-399.