메뉴 건너뛰기




Volumn 154, Issue 11, 2013, Pages 3990-3999

Food for thought: Understanding the multifaceted nature of orexins

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN;

EID: 84886580431     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1488     Document Type: Review
Times cited : (18)

References (144)
  • 1
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92: 573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3
  • 2
    • 0032940785 scopus 로고    scopus 로고
    • The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin
    • Edwards CM, Abusnana S, Sunter D, Murphy KG, Ghatei MA, Bloom SR. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol. 1999;160:R7-R12.
    • (1999) J Endocrinol , vol.160
    • Edwards, C.M.1    Abusnana, S.2    Sunter, D.3    Murphy, K.G.4    Ghatei, M.A.5    Bloom, S.R.6
  • 3
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
    • Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999; 98: 437-451.
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3
  • 4
    • 22244443005 scopus 로고    scopus 로고
    • Discharge of identified orexin/ hypocretin neurons across the sleep-waking cycle
    • Lee MG, Hassani OK, Jones BE. Discharge of identified orexin/ hypocretin neurons across the sleep-waking cycle. J Neurosci. 2005; 25: 6716-6720.
    • (2005) J Neurosci , vol.25 , pp. 6716-6720
    • Lee, M.G.1    Hassani, O.K.2    Jones, B.E.3
  • 6
    • 77950864319 scopus 로고    scopus 로고
    • Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
    • López M, Tena-Sempere M, Diéguez C. Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes). Front Neuroendocrinol. 2010;31: 113-127.
    • (2010) Front Neuroendocrinol , vol.31 , pp. 113-127
    • López, M.1    Tena-Sempere, M.2    Diéguez, C.3
  • 8
    • 0033305118 scopus 로고    scopus 로고
    • Orexin receptors are expressed in the adrenal medulla of the rat
    • López M, Señarís R, Gallego R, et al. Orexin receptors are expressed in the adrenal medulla of the rat. Endocrinology. 1999;140: 5991-5994.
    • (1999) Endocrinology , vol.140 , pp. 5991-5994
    • López, M.1    Señarís, R.2    Gallego, R.3
  • 9
    • 0033826856 scopus 로고    scopus 로고
    • A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    • Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000;6: 991-997.
    • (2000) Nat Med , vol.6 , pp. 991-997
    • Peyron, C.1    Faraco, J.2    Rogers, W.3
  • 10
    • 0033710848 scopus 로고    scopus 로고
    • Reduced number of hypocretin neurons in human narcolepsy
    • Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 2000;27: 469-474.
    • (2000) Neuron , vol.27 , pp. 469-474
    • Thannickal, T.C.1    Moore, R.Y.2    Nienhuis, R.3
  • 11
    • 2342602218 scopus 로고    scopus 로고
    • Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy- cataplexy in the rat
    • Beuckmann CT, Sinton CM, Williams SC, et al. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy- cataplexy in the rat. J Neurosci. 2004;24: 4469-4477.
    • (2004) J Neurosci , vol.24 , pp. 4469-4477
    • Beuckmann, C.T.1    Sinton, C.M.2    Williams, S.C.3
  • 13
  • 14
    • 12344282972 scopus 로고    scopus 로고
    • Neuronal distribution of melaninconcentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus)
    • Khorooshi RM, Klingenspor M. Neuronal distribution of melaninconcentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus). J Chem Neuroanat. 2005;29: 137-148.
    • (2005) J Chem Neuroanat , vol.29 , pp. 137-148
    • Khorooshi, R.M.1    Klingenspor, M.2
  • 15
    • 0026646891 scopus 로고
    • Thermal influences on nervous system function
    • Janssen R. Thermal influences on nervous system function. Neurosci Biobehav Rev. 1992;16: 399-413.
    • (1992) Neurosci Biobehav Rev , vol.16 , pp. 399-413
    • Janssen, R.1
  • 16
    • 30044447392 scopus 로고    scopus 로고
    • Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
    • Boutrel B, Kenny PJ, Specio SE, et al. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci USA. 2005;102: 19168-19173.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19168-19173
    • Boutrel, B.1    Kenny, P.J.2    Specio, S.E.3
  • 17
    • 79953739393 scopus 로고    scopus 로고
    • Orexin links emotional stress to autonomic functions
    • Kuwaki T. Orexin links emotional stress to autonomic functions. Auton Neurosci. 2011;161: 20-27.
    • (2011) Auton Neurosci , vol.161 , pp. 20-27
    • Kuwaki, T.1
  • 18
    • 52949108437 scopus 로고    scopus 로고
    • Alertness and feeding behaviors in ADHD: Does the hypocretin/orexin system play a role?
    • Cortese S, Konofal E, Lecendreux M. Alertness and feeding behaviors in ADHD: does the hypocretin/orexin system play a role? Med Hypotheses. 2008;71: 770-775.
    • (2008) Med Hypotheses , vol.71 , pp. 770-775
    • Cortese, S.1    Konofal, E.2    Lecendreux, M.3
  • 19
    • 24344508790 scopus 로고    scopus 로고
    • Brain structures and receptors involved in alertness
    • Aston-Jones G. Brain structures and receptors involved in alertness. Sleep Med. 2005;6(suppl 1):S3-S7.
    • (2005) Sleep Med , vol.6 , Issue.SUPPL. 1
    • Aston-Jones, G.1
  • 20
    • 80053928150 scopus 로고    scopus 로고
    • Orexin is required for brown adipose tissue development, differentiation, and function
    • Sellayah D, Bharaj P, Sikder D. Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab. 2011; 14: 478-490.
    • (2011) Cell Metab , vol.14 , pp. 478-490
    • Sellayah, D.1    Bharaj, P.2    Sikder, D.3
  • 21
    • 84885941266 scopus 로고    scopus 로고
    • Orexin receptor-1 mediates brown fat developmental differentiation
    • Sellayah D, Sikder D. Orexin receptor-1 mediates brown fat developmental differentiation. Adipocyte. 2012;1: 58-63.
    • (2012) Adipocyte , vol.1 , pp. 58-63
    • Sellayah, D.1    Sikder, D.2
  • 22
    • 84886542481 scopus 로고    scopus 로고
    • Orexin modulates brown adipose tissue thermogenesis
    • Madden CJ, Tupone D, Morrison SF. Orexin modulates brown adipose tissue thermogenesis. Biomol Concepts. 2012;3: 381-386.
    • (2012) Biomol Concepts , vol.3 , pp. 381-386
    • Madden, C.J.1    Tupone, D.2    Morrison, S.F.3
  • 23
    • 84883805981 scopus 로고    scopus 로고
    • An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis
    • Morrison SF, Madden CJ, Tupone D. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. Adipocyte. 2012;1: 116-120.
    • (2012) Adipocyte , vol.1 , pp. 116-120
    • Morrison, S.F.1    Madden, C.J.2    Tupone, D.3
  • 24
    • 80155147930 scopus 로고    scopus 로고
    • An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis
    • Tupone D, Madden CJ, Cano G, Morrison SF. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J Neurosci. 2011;31: 15944-15955.
    • (2011) J Neurosci , vol.31 , pp. 15944-15955
    • Tupone, D.1    Madden, C.J.2    Cano, G.3    Morrison, S.F.4
  • 25
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84: 277-359.
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 26
    • 0021490562 scopus 로고
    • Preferential utilization of brown adipose tissue lipids during arousal from hibernation in hamsters
    • Nedergaard J, Cannon B. Preferential utilization of brown adipose tissue lipids during arousal from hibernation in hamsters. Am J Physiol. 1984;247:R506-R512.
    • (1984) Am J Physiol , vol.247
    • Nedergaard, J.1    Cannon, B.2
  • 27
    • 80053647653 scopus 로고    scopus 로고
    • SR59230A, aβ-3 adrenoceptor antagonist, inhibits ultradianbrown adipose tissue thermogenesis and interrupts associated episodic brain and body heating
    • Ootsuka Y, Kulasekara K, de Menezes RC, Blessing WW. SR59230A, aβ-3 adrenoceptor antagonist, inhibits ultradianbrown adipose tissue thermogenesis and interrupts associated episodic brain and body heating. Am J Physiol Regul Integr Comp Physiol. 2011;301:R987-R994.
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301
    • Ootsuka, Y.1    Kulasekara, K.2    De Menezes, R.C.3    Blessing, W.W.4
  • 28
    • 0036087731 scopus 로고    scopus 로고
    • Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus)
    • Demas GE, Bowers RR, Bartness TJ, Gettys TW. Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus). Am J Physiol Regul Integr Comp Physiol. 2002;282:R114-R121.
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.282
    • Demas, G.E.1    Bowers, R.R.2    Bartness, T.J.3    Gettys, T.W.4
  • 29
    • 0028878453 scopus 로고
    • Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: A new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake
    • Himms-Hagen J. Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: a new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake. Proc Soc Exp Biol Med. 1995;208: 159-169.
    • (1995) Proc Soc Exp Biol Med , vol.208 , pp. 159-169
    • Himms-Hagen, J.1
  • 30
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus- specific peptides with neuroexcitatory activity
    • de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus- specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. 1998;95: 322-327.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 322-327
    • De Lecea, L.1    Kilduff, T.S.2    Peyron, C.3
  • 31
    • 0034704445 scopus 로고    scopus 로고
    • A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
    • Haynes AC, Jackson B, Chapman H, et al. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept. 2000;96: 45-51.
    • (2000) Regul Pept , vol.96 , pp. 45-51
    • Haynes, A.C.1    Jackson, B.2    Chapman, H.3
  • 32
  • 33
    • 79953127787 scopus 로고    scopus 로고
    • Single gene deletions of orexin, leptin, neuropeptide Y, and ghrelin do not appreciably alter food anticipatory activity in mice
    • Gunapala KM, Gallardo CM, Hsu CT, Steele AD. Single gene deletions of orexin, leptin, neuropeptide Y, and ghrelin do not appreciably alter food anticipatory activity in mice. PLoS One. 2011;6: e18377.
    • (2011) PLoS One , vol.6
    • Gunapala, K.M.1    Gallardo, C.M.2    Hsu, C.T.3    Steele, A.D.4
  • 34
    • 79951679430 scopus 로고    scopus 로고
    • Decreased intake of sucrose solutions in orexin knockout mice
    • Matsuo E, Mochizuki A, Nakayama K, et al. Decreased intake of sucrose solutions in orexin knockout mice. J Mol Neurosci. 2011; 43: 217-224.
    • (2011) J Mol Neurosci , vol.43 , pp. 217-224
    • Matsuo, E.1    Mochizuki, A.2    Nakayama, K.3
  • 36
    • 0038521277 scopus 로고    scopus 로고
    • Hypothalamic orexin neurons regulate arousal according to energy balance in mice
    • YamanakaA,BeuckmannCT,Willie JT, et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron. 2003;38: 701-713.
    • (2003) Neuron , vol.38 , pp. 701-713
    • Yamanaka, A.1    Beuckmann, C.T.2    Willie, J.T.3
  • 37
    • 14644396121 scopus 로고    scopus 로고
    • Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
    • Burdakov D, Gerasimenko O, Verkhratsky A. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci. 2005;25: 2429-2433.
    • (2005) J Neurosci , vol.25 , pp. 2429-2433
    • Burdakov, D.1    Gerasimenko, O.2    Verkhratsky, A.3
  • 38
    • 0042047377 scopus 로고    scopus 로고
    • Leptin regulation of preproorexin and orexin receptor mRNA levels in the hypothalamus
    • López M, Seoane L, García MC, et al. Leptin regulation of preproorexin and orexin receptor mRNA levels in the hypothalamus. Biochem Biophys Res Commun. 2000;269: 41-45.
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 41-45
    • López, M.1    Seoane, L.2    García, M.C.3
  • 40
    • 0033811876 scopus 로고    scopus 로고
    • Orexin A activates leptin-responsive neurons in the arcuate nucleus
    • Rauch M, Riediger T, Schmid HA, Simon E. Orexin A activates leptin-responsive neurons in the arcuate nucleus. Pflugers Arch. 2000;440: 699-703.
    • (2000) Pflugers Arch , vol.440 , pp. 699-703
    • Rauch, M.1    Riediger, T.2    Schmid, H.A.3    Simon, E.4
  • 41
    • 0037382853 scopus 로고    scopus 로고
    • Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channeldependent mechanisms and cross-talk with leptin and orexin
    • KohnoD,GaoHZ,MuroyaS, Kikuyama S,YadaT. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channeldependent mechanisms and cross-talk with leptin and orexin. Diabetes. 2003;52: 948-956.
    • (2003) Diabetes , vol.52 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 42
    • 0036161931 scopus 로고    scopus 로고
    • Neuropeptide y but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus
    • López M, Seoane LM, García Mdel C, Diéguez C, Señarís R. Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus. Neuroendocrinology. 2002;75: 34-44.
    • (2002) Neuroendocrinology , vol.75 , pp. 34-44
    • López, M.1    Seoane, L.M.2    García Mdel, C.3    Diéguez, C.4    Señarís, R.5
  • 43
    • 0032576592 scopus 로고    scopus 로고
    • Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
    • Elias CF, Saper CB, Maratos-Flier E, et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol. 1998;402: 442-459.
    • (1998) J Comp Neurol , vol.402 , pp. 442-459
    • Elias, C.F.1    Saper, C.B.2    Maratos-Flier, E.3
  • 44
    • 0027215033 scopus 로고
    • Feeding responses to perifornical hypothalamic injection of neuropeptide y in relation to circadian rhythms of eating behavior
    • Stanley BG, Thomas WJ. Feeding responses to perifornical hypothalamic injection of neuropeptide Y in relation to circadian rhythms of eating behavior. Peptides. 1993;14: 475-481.
    • (1993) Peptides , vol.14 , pp. 475-481
    • Stanley, B.G.1    Thomas, W.J.2
  • 45
    • 0037086815 scopus 로고    scopus 로고
    • Feeding and activity induced by orexin A in the lateral hypothalamus in rats
    • Kotz CM, Teske JA, Levine JA, Wang C. Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regul Pept. 2002;104: 27-32.
    • (2002) Regul Pept , vol.104 , pp. 27-32
    • Kotz, C.M.1    Teske, J.A.2    Levine, J.A.3    Wang, C.4
  • 46
    • 33847121297 scopus 로고    scopus 로고
    • The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness
    • Sakurai T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci. 2007;8: 171-181.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 171-181
    • Sakurai, T.1
  • 47
    • 21544471830 scopus 로고    scopus 로고
    • OrexinAin the nucleus accumbens stimulates feeding and locomotor activity
    • Thorpe AJ, KotzCM.OrexinAin the nucleus accumbens stimulates feeding and locomotor activity. Brain Res. 2005;1050: 156-162.
    • (2005) Brain Res , vol.1050 , pp. 156-162
    • Thorpe, A.J.1    Kotz, C.M.2
  • 48
    • 0036791834 scopus 로고    scopus 로고
    • The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
    • Mignot E, Lammers GJ, Ripley B, et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol. 2002;59: 1553-1562.
    • (2002) Arch Neurol , vol.59 , pp. 1553-1562
    • Mignot, E.1    Lammers, G.J.2    Ripley, B.3
  • 49
    • 84873668797 scopus 로고    scopus 로고
    • The neurobiology of sleep
    • Saper CB. The neurobiology of sleep. Continuum (Minneap Minn). 2013;19: 19-31.
    • (2013) Continuum (Minneap Minn) , vol.19 , pp. 19-31
    • Saper, C.B.1
  • 50
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • Lin L, Faraco J, Li R, et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999;98: 365-376.
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3
  • 52
    • 67649448978 scopus 로고    scopus 로고
    • Orexin/hypocretin: A neuropeptide at the interface of sleep, energy homeostasis, and reward system
    • Tsujino N, Sakurai T. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev. 2009;61: 162-176.
    • (2009) Pharmacol Rev , vol.61 , pp. 162-176
    • Tsujino, N.1    Sakurai, T.2
  • 53
    • 0034992322 scopus 로고    scopus 로고
    • Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    • Hara J, Beuckmann CT, Nambu T, et al. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron. 2001;30: 345-354.
    • (2001) Neuron , vol.30 , pp. 345-354
    • Hara, J.1    Beuckmann, C.T.2    Nambu, T.3
  • 54
    • 24944518715 scopus 로고    scopus 로고
    • Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
    • Crocker A, España RA, Papadopoulou M, et al. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology. 2005; 65: 1184-1188.
    • (2005) Neurology , vol.65 , pp. 1184-1188
    • Crocker, A.1    España, R.A.2    Papadopoulou, M.3
  • 55
    • 84878361343 scopus 로고    scopus 로고
    • Genetic association, seasonal infections and autoimmune basis of narcolepsy
    • Singh AK, Mahlios J, Mignot E. Genetic association, seasonal infections and autoimmune basis of narcolepsy. J Autoimmun. 2013; 43: 26-31.
    • (2013) J Autoimmun , vol.43 , pp. 26-31
    • Singh, A.K.1    Mahlios, J.2    Mignot, E.3
  • 56
    • 0033582175 scopus 로고    scopus 로고
    • Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
    • Date Y, Ueta Y, Yamashita H, et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA. 1999;96: 748-753.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 748-753
    • Date, Y.1    Ueta, Y.2    Yamashita, H.3
  • 58
    • 0032402181 scopus 로고    scopus 로고
    • Neurons containing hypocretin (orexin) project to multiple neuronal systems
    • Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 1998;18: 9996-10015.
    • (1998) J Neurosci , vol.18 , pp. 9996-10015
    • Peyron, C.1    Tighe, D.K.2    Van Den Pol, A.N.3
  • 59
    • 18444375874 scopus 로고    scopus 로고
    • Orexins activate histaminergic neurons via the orexin 2 receptor
    • Yamanaka A, Tsujino N, Funahashi H, et al. Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun. 2002;290: 1237-1245.
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 1237-1245
    • Yamanaka, A.1    Tsujino, N.2    Funahashi, H.3
  • 60
    • 0033552658 scopus 로고    scopus 로고
    • Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
    • Horvath TL, Peyron C, Diano S, et al. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol. 1999;415: 145-159.
    • (1999) J Comp Neurol , vol.415 , pp. 145-159
    • Horvath, T.L.1    Peyron, C.2    Diano, S.3
  • 61
    • 0036848635 scopus 로고    scopus 로고
    • Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions
    • Liu RJ, van den Pol AN, Aghajanian GK. Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci. 2002;22: 9453-9464.
    • (2002) J Neurosci , vol.22 , pp. 9453-9464
    • Liu, R.J.1    Van Den Pol, A.N.2    Aghajanian, G.K.3
  • 63
    • 27844592708 scopus 로고    scopus 로고
    • Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
    • Takakusaki K, Takahashi K, Saitoh K, et al. Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy. J Physiol. 2005;568: 1003-1020.
    • (2005) J Physiol , vol.568 , pp. 1003-1020
    • Takakusaki, K.1    Takahashi, K.2    Saitoh, K.3
  • 65
    • 9244242062 scopus 로고    scopus 로고
    • Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: Implications for the circadian control of behavioural state
    • Deurveilher S, Semba K. Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: implications for the circadian control of behavioural state. Neuroscience. 2005;130: 165-183.
    • (2005) Neuroscience , vol.130 , pp. 165-183
    • Deurveilher, S.1    Semba, K.2
  • 67
    • 35148895159 scopus 로고    scopus 로고
    • Eating disorder and metabolism in narcoleptic patients
    • Chabas D, Foulon C, Gonzalez J, et al. Eating disorder and metabolism in narcoleptic patients. Sleep. 2007;30: 1267-1273.
    • (2007) Sleep , vol.30 , pp. 1267-1273
    • Chabas, D.1    Foulon, C.2    Gonzalez, J.3
  • 68
    • 0343742214 scopus 로고    scopus 로고
    • Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats
    • Challet E, Pevet P, Malan A. Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats. Behav Brain Res. 1997;84: 275-284.
    • (1997) Behav Brain Res , vol.84 , pp. 275-284
    • Challet, E.1    Pevet, P.2    Malan, A.3
  • 69
    • 0025120247 scopus 로고
    • Effects of 24-hr fasting on methamphetamine- and apomorphine-induced locomotor activities, and on monoamine metabolism in mouse corpus striatum and nucleus accumbens
    • Itoh T, Murai S, Nagahama H, et al. Effects of 24-hr fasting on methamphetamine- and apomorphine-induced locomotor activities, and on monoamine metabolism in mouse corpus striatum and nucleus accumbens. Pharmacol Biochem Behav. 1990;35: 391-396.
    • (1990) Pharmacol Biochem Behav , vol.35 , pp. 391-396
    • Itoh, T.1    Murai, S.2    Nagahama, H.3
  • 70
    • 84875868192 scopus 로고    scopus 로고
    • Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain
    • Markwald RR, Melanson EL, Smith MR. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci USA. 2013;110: 5695-5700.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 5695-5700
    • Markwald, R.R.1    Melanson, E.L.2    Smith, M.R.3
  • 71
    • 66149138417 scopus 로고    scopus 로고
    • Neurophysiology of sleep and wakefulness: Basic science and clinical implications
    • Schwartz JR, Roth T. Neurophysiology of sleep and wakefulness: basic science and clinical implications. Curr Neuropharmacol. 2008;6: 367-378.
    • (2008) Curr Neuropharmacol , vol.6 , pp. 367-378
    • Schwartz, J.R.1    Roth, T.2
  • 72
    • 79952210164 scopus 로고    scopus 로고
    • Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity
    • Balbo M, Leproult R, Van Cauter E. Impact of sleep and its disturbances on hypothalamo-pituitary-adrenal axis activity. Int J Endocrinol. 2010;2010:759234.
    • (2010) Int J Endocrinol , vol.2010 , pp. 759234
    • Balbo, M.1    Leproult, R.2    Van Cauter, E.3
  • 73
    • 1842584959 scopus 로고    scopus 로고
    • Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
    • Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci USA. 2004;101: 4649-4654.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4649-4654
    • Mieda, M.1    Willie, J.T.2    Hara, J.3    Sinton, C.M.4    Sakurai, T.5    Yanagisawa, M.6
  • 76
    • 18144370824 scopus 로고    scopus 로고
    • Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions
    • Hara J, Yanagisawa M, Sakurai T. Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci Lett. 2005;380: 239-242.
    • (2005) Neurosci Lett , vol.380 , pp. 239-242
    • Hara, J.1    Yanagisawa, M.2    Sakurai, T.3
  • 78
    • 77953809603 scopus 로고    scopus 로고
    • Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)
    • Cannon B, Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond). 2010;34(suppl 1): S7-S16.
    • (2010) Int J Obes (Lond) , vol.34 , Issue.SUPPL. 1
    • Cannon, B.1    Nedergaard, J.2
  • 79
    • 79955670313 scopus 로고    scopus 로고
    • Three years with adult human brown adipose tissue
    • Nedergaard J, Bengtsson T, Cannon B. Three years with adult human brown adipose tissue. AnnNYAcad Sci. 2010;1212:E20-E36.
    • (2010) AnnNYAcad Sci , vol.1212
    • Nedergaard, J.1    Bengtsson, T.2    Cannon, B.3
  • 80
    • 77950237717 scopus 로고    scopus 로고
    • The changed metabolic world with human brown adipose tissue: Therapeutic visions
    • Nedergaard J, Cannon B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab. 2010;11: 268-272.
    • (2010) Cell Metab , vol.11 , pp. 268-272
    • Nedergaard, J.1    Cannon, B.2
  • 81
    • 79955032433 scopus 로고    scopus 로고
    • Brown fat biology and thermogenesis
    • Richard D, Picard F. Brown fat biology and thermogenesis. Front Biosci. 2011;16: 1233-1260.
    • (2011) Front Biosci , vol.16 , pp. 1233-1260
    • Richard, D.1    Picard, F.2
  • 82
    • 65349151258 scopus 로고    scopus 로고
    • Have we entered the brown adipose tissue renaissance?
    • Ravussin E, Kozak LP. Have we entered the brown adipose tissue renaissance? Obes Rev. 2009;10: 265-268.
    • (2009) Obes Rev , vol.10 , pp. 265-268
    • Ravussin, E.1    Kozak, L.P.2
  • 83
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature. 2000;404: 652-660.
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 85
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in dietinduced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in dietinduced thermogenesis. Nature. 1979;281: 31-35.
    • (1979) Nature , vol.281 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 86
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9: 203-209.
    • (2009) Cell Metab , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 87
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360: 1518-1525.
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 88
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans.NEngl J Med. 2009; 360: 1509-1517.
    • (2009) NEngl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 89
    • 0022499231 scopus 로고
    • Brown adipose tissue uncoupling protein content in human infants, children and adults
    • Lean ME, James WP, Jennings G, Trayhurn P. Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin Sci (Lond). 1986;71: 291-297.
    • (1986) Clin Sci (Lond) , vol.71 , pp. 291-297
    • Lean, M.E.1    James, W.P.2    Jennings, G.3    Trayhurn, P.4
  • 90
    • 0022360654 scopus 로고
    • Factors influencing brown fat and the capacity for diet-induced thermogenesis
    • Stock MJ, Rothwell NJ. Factors influencing brown fat and the capacity for diet-induced thermogenesis. Int J Obes (Lond). 1985; 9(suppl 2):9-15.
    • (1985) Int J Obes (Lond) , vol.9 , Issue.SUPPL. 2 , pp. 9-15
    • Stock, M.J.1    Rothwell, N.J.2
  • 91
    • 50049127055 scopus 로고    scopus 로고
    • New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    • Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454: 1000-1004.
    • (2008) Nature , vol.454 , pp. 1000-1004
    • Tseng, Y.H.1    Kokkotou, E.2    Schulz, T.J.3
  • 92
    • 84860850964 scopus 로고    scopus 로고
    • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
    • Whittle AJ, Carobbio S, Martins L, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell. 2012;149: 871-885.
    • (2012) Cell , vol.149 , pp. 871-885
    • Whittle, A.J.1    Carobbio, S.2    Martins, L.3
  • 93
    • 84870502357 scopus 로고    scopus 로고
    • Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals
    • Tsukita S, Yamada T, Uno K, et al. Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals. Cell Metab. 2012;16: 825-832.
    • (2012) Cell Metab , vol.16 , pp. 825-832
    • Tsukita, S.1    Yamada, T.2    Uno, K.3
  • 94
    • 0037323398 scopus 로고    scopus 로고
    • Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor γ during bone morphogenetic protein 2-induced adipogenesis
    • Hata K, Nishimura R, Ikeda F, et al. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor γ during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell. 2003;14: 545-555.
    • (2003) Mol Biol Cell , vol.14 , pp. 545-555
    • Hata, K.1    Nishimura, R.2    Ikeda, F.3
  • 95
    • 69149091047 scopus 로고    scopus 로고
    • BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • Huang H, Song TJ, Li X, et al. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA. 2009;106: 12670-12675.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12670-12675
    • Huang, H.1    Song, T.J.2    Li, X.3
  • 96
    • 84879804486 scopus 로고    scopus 로고
    • α-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling
    • He Q, Huang C, Zhao L, et al. α-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling. Int J Clin Exp Pathol. 2013;6: 168-178.
    • (2013) Int J Clin Exp Pathol , vol.6 , pp. 168-178
    • He, Q.1    Huang, C.2    Zhao, L.3
  • 97
    • 75149173154 scopus 로고    scopus 로고
    • The role of ATF-2 family transcription factors in adipocyte differentiation: Antiobesity effects of p38 inhibitors
    • Maekawa T, Jin W, Ishii S. The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Mol Cell Biol. 2010;30: 613-625.
    • (2010) Mol Cell Biol , vol.30 , pp. 613-625
    • Maekawa, T.1    Jin, W.2    Ishii, S.3
  • 98
    • 14544298335 scopus 로고    scopus 로고
    • The role of MAPKs in adipocyte differentiation and obesity
    • Bost F, Aouadi M, Caron L, Binétruy B. The role of MAPKs in adipocyte differentiation and obesity. Biochimie. 2005;87: 51-56.
    • (2005) Biochimie , vol.87 , pp. 51-56
    • Bost, F.1    Aouadi, M.2    Caron, L.3    Binétruy, B.4
  • 99
    • 79958206576 scopus 로고    scopus 로고
    • Retinoic acid inhibits BMP4- induced C3H10T1/2 stem cell commitment to adipocyte via downregulating Smad/p38MAPK signaling
    • Lee JS, Park JH, Kwon IK, Lim JY. Retinoic acid inhibits BMP4- induced C3H10T1/2 stem cell commitment to adipocyte via downregulating Smad/p38MAPK signaling. Biochem Biophys Res Commun. 2011;409: 550-555.
    • (2011) Biochem Biophys Res Commun , vol.409 , pp. 550-555
    • Lee, J.S.1    Park, J.H.2    Kwon, I.K.3    Lim, J.Y.4
  • 100
    • 33244484109 scopus 로고    scopus 로고
    • Risperidone potentiates the sympathetic and hyperthermic reactions induced by orexin A in the rat
    • Monda M, Viggiano A, Viggiano A, Viggiano E, De Luca V. Risperidone potentiates the sympathetic and hyperthermic reactions induced by orexin A in the rat. Physiol Res. 2006;55: 73-78.
    • (2006) Physiol Res , vol.55 , pp. 73-78
    • Monda, M.1    Viggiano, A.2    Viggiano, A.3    Viggiano, E.4    De Luca, V.5
  • 102
    • 78049464825 scopus 로고    scopus 로고
    • Orexin neurons are indispensable for stress-induced thermogenesis in mice
    • Zhang W, Sunanaga J, Takahashi Y, et al. Orexin neurons are indispensable for stress-induced thermogenesis in mice. J Physiol. 2010;588: 4117-4129.
    • (2010) J Physiol , vol.588 , pp. 4117-4129
    • Zhang, W.1    Sunanaga, J.2    Takahashi, Y.3
  • 103
    • 84893685572 scopus 로고    scopus 로고
    • Orexin modulation of adipose tissue [published online June 18, 2013]
    • doi:10.1016/j.bbadis.2013.06.007
    • Perez-Leighton CE, Billington CJ, KotzCM.Orexin modulation of adipose tissue [published online June 18, 2013]. Biochim Biophys Acta. doi:10.1016/j.bbadis.2013.06.007.
    • Biochim Biophys Acta
    • Perez-Leighton, C.E.1    Billington, C.J.2    Kotz, C.M.3
  • 104
    • 84861464553 scopus 로고    scopus 로고
    • Energy expenditure: Role of orexin
    • Teske JA, Mavanji V. Energy expenditure: role of orexin. Vitam Horm. 2012;89: 91-109.
    • (2012) Vitam Horm , vol.89 , pp. 91-109
    • Teske, J.A.1    Mavanji, V.2
  • 106
    • 0037086848 scopus 로고    scopus 로고
    • Orexin gene expression and regulation by photoperiod in the sheep hypothalamus
    • Archer ZA, Findlay PA, Rhind SM, Mercer JG, Adam CL. Orexin gene expression and regulation by photoperiod in the sheep hypothalamus. Regul Pept. 2002;104: 41-45.
    • (2002) Regul Pept , vol.104 , pp. 41-45
    • Archer, Z.A.1    Findlay, P.A.2    Rhind, S.M.3    Mercer, J.G.4    Adam, C.L.5
  • 107
    • 0026605565 scopus 로고
    • Circadian changes of brown adipose tissue thermogenesis in juvenile rats
    • Redlin U, Nuesslein B, Schmidt I. Circadian changes of brown adipose tissue thermogenesis in juvenile rats. Am J Physiol. 1992; 262:R504-R508.
    • (1992) Am J Physiol , vol.262
    • Redlin, U.1    Nuesslein, B.2    Schmidt, I.3
  • 108
    • 33645790960 scopus 로고    scopus 로고
    • Characterization of peripheral circadian clocks in adipose tissues
    • Zvonic S, Ptitsyn AA, Conrad SA, et al. Characterization of peripheral circadian clocks in adipose tissues. Diabetes. 2006;55: 962-970.
    • (2006) Diabetes , vol.55 , pp. 962-970
    • Zvonic, S.1    Ptitsyn, A.A.2    Conrad, S.A.3
  • 109
    • 0024356402 scopus 로고
    • Brown adipose tissue of mice with GTGinduced obesity: Altered circadian control
    • Eley J, Himms-Hagen J. Brown adipose tissue of mice with GTGinduced obesity: altered circadian control. Am J Physiol. 1989; 256:E773-E779.
    • (1989) Am J Physiol , vol.256
    • Eley, J.1    Himms-Hagen, J.2
  • 110
    • 0022549880 scopus 로고
    • Short photoperiod stimulates brown adipose tissue growth and thermogenesis but not norepinephrine turnover in Syrian hamsters
    • McElroy JF, Wade GN. Short photoperiod stimulates brown adipose tissue growth and thermogenesis but not norepinephrine turnover in Syrian hamsters. Physiol Behav. 1986;37: 307-311.
    • (1986) Physiol Behav , vol.37 , pp. 307-311
    • McElroy, J.F.1    Wade, G.N.2
  • 111
    • 48849107624 scopus 로고    scopus 로고
    • Brain circuits regulating energy homeostasis
    • Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Regul Pept. 2008;149: 3-10.
    • (2008) Regul Pept , vol.149 , pp. 3-10
    • Abizaid, A.1    Horvath, T.L.2
  • 112
    • 2342484365 scopus 로고    scopus 로고
    • Hypothalamic control of energy balance: Different peptides, different functions
    • Leibowitz SF, Wortley KE. Hypothalamic control of energy balance: different peptides, different functions. Peptides. 2004;25: 473-504.
    • (2004) Peptides , vol.25 , pp. 473-504
    • Leibowitz, S.F.1    Wortley, K.E.2
  • 113
    • 33644768285 scopus 로고    scopus 로고
    • Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus
    • Huo L, Grill HJ, Bjørbaek C. Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes. 2006;55: 567-573.
    • (2006) Diabetes , vol.55 , pp. 567-573
    • Huo, L.1    Grill, H.J.2    Bjørbaek, C.3
  • 115
    • 0034802108 scopus 로고    scopus 로고
    • Minireview: Ghrelin and the regulation of energy balance - A hypothalamic perspective
    • Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology. 2001;142: 4163-4169.
    • (2001) Endocrinology , vol.142 , pp. 4163-4169
    • Horvath, T.L.1    Diano, S.2    Sotonyi, P.3    Heiman, M.4    Tschöp, M.5
  • 116
    • 84871936444 scopus 로고    scopus 로고
    • Ultradian episodes of thermogenesis in mammals
    • Ruf T, Bieber C, Arnold W, Millesi E, ed., NewYork: Springer;
    • Meyer CW. Ultradian episodes of thermogenesis in mammals. In: Ruf T, Bieber C, Arnold W, Millesi E, ed. Living in Seasonal World Thremoregulatory and Metabolic Adaptations.NewYork: Springer; 2012;219-227.
    • (2012) Living in Seasonal World Thremoregulatory and Metabolic Adaptations , pp. 219-227
    • Meyer, C.W.1
  • 117
    • 3543017385 scopus 로고    scopus 로고
    • Natural hypometabolism during hibernation and daily torpor in mammals
    • Heldmaier G, Ortmann S, Elvert R. Natural hypometabolism during hibernation and daily torpor in mammals. Respir Physiol Neurobiol. 2004;141: 317-329.
    • (2004) Respir Physiol Neurobiol , vol.141 , pp. 317-329
    • Heldmaier, G.1    Ortmann, S.2    Elvert, R.3
  • 118
    • 2342501936 scopus 로고    scopus 로고
    • Metabolic rate and body temperature reduction during hibernation and daily torpor
    • Geiser F. Metabolic rate and body temperature reduction during hibernation and daily torpor. Annu Rev Physiol. 2004;66: 239-274.
    • (2004) Annu Rev Physiol , vol.66 , pp. 239-274
    • Geiser, F.1
  • 120
    • 79955009080 scopus 로고    scopus 로고
    • Hibernating above the permafrost: Effects of ambient temperature and season on expression of metabolic genes in liver and brown adipose tissue of arctic ground squirrels
    • Williams CT, Goropashnaya AV, Buck CL, et al. Hibernating above the permafrost: effects of ambient temperature and season on expression of metabolic genes in liver and brown adipose tissue of arctic ground squirrels. J Exp Biol. 2011;214: 1300-1306.
    • (2011) J Exp Biol , vol.214 , pp. 1300-1306
    • Williams, C.T.1    Goropashnaya, A.V.2    Buck, C.L.3
  • 121
    • 0014513094 scopus 로고
    • Unusually high mitochondrial α glycerophosphate dehydrogenase activity in rat brown adipose tissue
    • Ohkawa KI, Vogt MT, Farber E. Unusually high mitochondrial α glycerophosphate dehydrogenase activity in rat brown adipose tissue. J Cell Biol. 1969;41: 441-449.
    • (1969) J Cell Biol , vol.41 , pp. 441-449
    • Ohkawa, K.I.1    Vogt, M.T.2    Farber, E.3
  • 122
    • 0024496706 scopus 로고
    • Brown fat thermogenesis during hibernation and arousal in Richardson's ground squirrel
    • Milner RE, Wang LC, Trayhurn P. Brown fat thermogenesis during hibernation and arousal in Richardson's ground squirrel. Am J Physiol. 1989;256:R42-R48.
    • (1989) Am J Physiol , vol.256
    • Milner, R.E.1    Wang, L.C.2    Trayhurn, P.3
  • 123
    • 0038535777 scopus 로고
    • Brown fat: Thermogenic effect during arousal from hibernation in the bat
    • Smalley RL, Dryer RL. Brown fat: thermogenic effect during arousal from hibernation in the bat. Science. 1963;140: 1333-1334.
    • (1963) Science , vol.140 , pp. 1333-1334
    • Smalley, R.L.1    Dryer, R.L.2
  • 124
    • 0013939180 scopus 로고
    • Quantitative aspects of brown adipose tissue thermogenesis during arousal from hibernation
    • Hayward JS, Ball EG. Quantitative aspects of brown adipose tissue thermogenesis during arousal from hibernation. Biol Bull. 1966; 131: 94-103.
    • (1966) Biol Bull , vol.131 , pp. 94-103
    • Hayward, J.S.1    Ball, E.G.2
  • 125
    • 78650763158 scopus 로고    scopus 로고
    • Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice
    • Oelkrug R, Heldmaier G, Meyer CW. Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice. J Comp Physiol B. 2011;181: 137-145.
    • (2011) J Comp Physiol B , vol.181 , pp. 137-145
    • Oelkrug, R.1    Heldmaier, G.2    Meyer, C.W.3
  • 126
    • 85081800072 scopus 로고    scopus 로고
    • Involvement of the orexin system in thermoregulation of Syrian hamsters during arousal from hibernation
    • Tamura Y MM, Odani M, Shiomi H. Involvement of the orexin system in thermoregulation of Syrian hamsters during arousal from hibernation. Neurosci Res. 2011;7: 72-73.
    • (2011) Neurosci Res , vol.7 , pp. 72-73
    • Tamura, Y.M.M.1    Odani, M.2    Shiomi, H.3
  • 127
    • 13044249865 scopus 로고    scopus 로고
    • Orexin A activates locus coeruleus cell firing and increases arousal in the rat
    • Hagan JJ, Leslie RA, Patel S, et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA. 1999;96: 10911-10916.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10911-10916
    • Hagan, J.J.1    Leslie, R.A.2    Patel, S.3
  • 129
    • 64849092435 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons
    • Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS. Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons. J Neurosci. 2009;29: 3705-3714.
    • (2009) J Neurosci , vol.29 , pp. 3705-3714
    • Hara, J.1    Gerashchenko, D.2    Wisor, J.P.3    Sakurai, T.4    Xie, X.5    Kilduff, T.S.6
  • 130
    • 14044265763 scopus 로고    scopus 로고
    • Excitatory effects of thyrotropinreleasing hormone in the thalamus
    • Broberger C, McCormick DA. Excitatory effects of thyrotropinreleasing hormone in the thalamus. J Neurosci. 2005;25: 1664-1673.
    • (2005) J Neurosci , vol.25 , pp. 1664-1673
    • Broberger, C.1    McCormick, D.A.2
  • 131
    • 84255184286 scopus 로고    scopus 로고
    • Increased thermogenic capacity of brown adipose tissue under low temperature and its contribution to arousal from hibernation in Syrian hamsters
    • Kitao N, Hashimoto M. Increased thermogenic capacity of brown adipose tissue under low temperature and its contribution to arousal from hibernation in Syrian hamsters. Am J Physiol Regul Integr Comp Physiol. 2012;302:R118-R125.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.302
    • Kitao, N.1    Hashimoto, M.2
  • 132
    • 36248950214 scopus 로고    scopus 로고
    • Histamine H3 receptor and orexin A expression during daily torpor in the Djungarian hamster (Phodopus sungorus)
    • Herwig A, Ivanova EA, Lydon H, Barrett P, Steinlechner S, Loudon AS. Histamine H3 receptor and orexin A expression during daily torpor in the Djungarian hamster (Phodopus sungorus). J Neuroendocrinol. 2007;19: 1001-1007.
    • (2007) J Neuroendocrinol , vol.19 , pp. 1001-1007
    • Herwig, A.1    Ivanova, E.A.2    Lydon, H.3    Barrett, P.4    Steinlechner, S.5    Loudon, A.S.6
  • 133
    • 84875185857 scopus 로고    scopus 로고
    • Seasonal and regional differences in gene expression in the brain of a hibernating mammal
    • Schwartz C, Hampton M, Andrews MT. Seasonal and regional differences in gene expression in the brain of a hibernating mammal. PLoS One. 2013;8:e58427.
    • (2013) PLoS One , vol.8
    • Schwartz, C.1    Hampton, M.2    Andrews, M.T.3
  • 134
    • 77957368747 scopus 로고    scopus 로고
    • Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant
    • Dietrich H, Jenck F. Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. Psychopharmacology (Berl). 2010;212: 145-154.
    • (2010) Psychopharmacology (Berl) , vol.212 , pp. 145-154
    • Dietrich, H.1    Jenck, F.2
  • 135
    • 84866741292 scopus 로고    scopus 로고
    • The brain orexin system and almorexant in fear-conditioned startle reactions in the rat
    • Steiner MA, Lecourt H, Jenck F. The brain orexin system and almorexant in fear-conditioned startle reactions in the rat. Psychopharmacology (Berl). 2012;223: 465-475.
    • (2012) Psychopharmacology (Berl) , vol.223 , pp. 465-475
    • Steiner, M.A.1    Lecourt, H.2    Jenck, F.3
  • 136
    • 84861881414 scopus 로고    scopus 로고
    • Hypocretin (orexin) loss in Alzheimer's disease
    • Fronczek R, van Geest S, Frölich M, et al. Hypocretin (orexin) loss in Alzheimer's disease. Neurobiol Aging. 2012;33: 1642-1650.
    • (2012) Neurobiol Aging , vol.33 , pp. 1642-1650
    • Fronczek, R.1    Van Geest, S.2    Frölich, M.3
  • 137
    • 34250841699 scopus 로고    scopus 로고
    • Hypocretin (orexin) loss in Parkinson's disease
    • Fronczek R, Overeem S, Lee SY, et al. Hypocretin (orexin) loss in Parkinson's disease. Brain. 2007;130: 1577-1585.
    • (2007) Brain , vol.130 , pp. 1577-1585
    • Fronczek, R.1    Overeem, S.2    Lee, S.Y.3
  • 138
    • 33846126276 scopus 로고    scopus 로고
    • Impaired defense of core temperature in aged humans during mild cold stress
    • Degroot DW, Kenney WL. Impaired defense of core temperature in aged humans during mild cold stress. Am J Physiol Regul Integr Comp Physiol. 2007;292:R103-R108.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Degroot, D.W.1    Kenney, W.L.2
  • 139
    • 84856111681 scopus 로고    scopus 로고
    • Aging and circadian disruption: Causes and effects
    • Brown SA, Schmitt K, Eckert A. Aging and circadian disruption: causes and effects. Aging (Albany NY). 2011;3: 813-817.
    • (2011) Aging (Albany NY) , vol.3 , pp. 813-817
    • Brown, S.A.1    Schmitt, K.2    Eckert, A.3
  • 140
    • 33645888693 scopus 로고    scopus 로고
    • Nutrition and aging: Changes in the regulation of energy metabolism with aging
    • Roberts SB, Rosenberg I. Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol Rev. 2006;86: 651-667.
    • (2006) Physiol Rev , vol.86 , pp. 651-667
    • Roberts, S.B.1    Rosenberg, I.2
  • 141
    • 78751665588 scopus 로고    scopus 로고
    • Gene expression inhuman brown adipose tissue
    • Svensson PA, JernåsM,Sjöholm K, et al. Gene expression inhuman brown adipose tissue. Int J Mol Med. 2011;27: 227-232.
    • (2011) Int J Mol Med , vol.27 , pp. 227-232
    • Svensson, P.A.1    Jernås, M.2    Sjöholm, K.3
  • 142
    • 78449291034 scopus 로고    scopus 로고
    • Brown fat thermogenesis and body weight regulation in mice: Relevance to humans
    • Kozak LP, Koza RA, Anunciado-Koza R. Brown fat thermogenesis and body weight regulation in mice: relevance to humans. Int J Obes (Lond). 2010;34(suppl 1):S23-S27.
    • (2010) Int J Obes (Lond) , vol.34 , Issue.SUPPL. 1
    • Kozak, L.P.1    Koza, R.A.2    Anunciado-Koza, R.3
  • 143
    • 0033305646 scopus 로고    scopus 로고
    • Current and potential drugs for treatment of obesity
    • Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev. 1999;20: 805-875.
    • (1999) Endocr Rev , vol.20 , pp. 805-875
    • Bray, G.A.1    Greenway, F.L.2
  • 144
    • 17144409447 scopus 로고    scopus 로고
    • Advances in anti-obesity therapeutics
    • Fong TM. Advances in anti-obesity therapeutics. Expert Opin Investig Drugs. 2005;14: 243-250.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 243-250
    • Fong, T.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.