Seasonal changes in the interactions among leptin, ghrelin, and orexin in sheep

Journal of Animal Science

Volumn 90, Issue 8, 2012, Pages 2524-2531

  Kirsz, K ^a   Szczesna, M ^a   Molik, E ^a   Misztal, T ^b   Wojtowicz, A K ^a   Zieba, D A ^a  

^a UNIVERSITY OF AGRICULTURE IN KRAKOW   (Poland)

^b KIELANOWSKI INSTITUTE OF ANIMAL PHYSIOLOGY AND NUTRITION   (Poland)

Author keywords

Ghrelin; Leptin; Leptin antagonist; Orexin; Sheep

Indexed keywords

ESTRADIOL; GHRELIN; LEPTIN; MELATONIN; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

ANIMAL; ARTICLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; GENETICS; METABOLISM; PHOTOPERIODICITY; RANDOMIZED CONTROLLED TRIAL; SEASON; SHEEP;

ANIMALS; CROSS-OVER STUDIES; ESTRADIOL; GHRELIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MELATONIN; NEUROPEPTIDES; PHOTOPERIOD; SEASONS; SHEEP;

EID: 84882729177     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2011-4463     Document Type: Article

References (39)

1. Abizaid, A., Z. W. Liu, Z. B. Andrews, M. Shanabrough, E. Borok, J. D. Elsworth, R. H. Roth, M. W. Sleeman, M. R. Picciotto, M. H. Tschop, X. B. Gao, and T. L. Horvath. 2006. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116:3229-3239.
2. Adam, C. L., and P. A. Findlay. 2008. Decreased blood-brain leptin transfer in an ovine model of obesity and weight loss: Resolving the cause of leptin resistance. Intern. J. Obes. (Lond.) 34:980-988.
3. Adam, J. A., P. P. C. A. Menheere, F. M. H. van Dielen, P. B. Soeters, W. A. Buurman, and J. W. M. Greve. 2002. Decreased plasma orexin-A level in obese individuals. Intern. J. Obes. 26:274-276.
4. Anukulkitch, C., A. Rao, F. R. Dunshea, D. Blache, G. A. Lincoln, and I. J. Clarke. 2007. Influence of photoperiod and gonadal status on food intake, adiposity, and gene expression of hypothalamic appetite regulators in a seasonal mammal. Am. J. Physiol. Integr. Comp. Physiol. 292:R242-R252.
5. Anukulkitch, C., A. Rao, A. Pereira, J. McEwan, and I. J. Clarke. 2010. Expression of genes for appetite-regulating peptides in the hypothalamus of genetically selected lean and fat sheep. Neuroendocrinology 91:223-238.
6. Archer, Z. A., P. A. Findlay, S. M. Rhind, J. G. Mercer, and C. L. Adam. 2002. Orexin gene expression and regulation by photoperiod in the sheep hypothalamus. Regul. Pept. 104:41-45.
7. Bewick, G. A., J. V. Gardiner, W. S. Dhillo, A. S. Kent, N. E. White, Z. Webster, M. A. Ghatei, and S. R. Bloom. 2005. Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB 19:1680-1682.
8. Burdakov, D., B. Liss, and M. Ashcroft.2003. Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger. J. Neurosci. 23:4951-4957.
9. Cassoni, P., C. Ghe, T. Marrocco, E. Tarabra, E. Allia, F. Catapano, R. Deghenghi, E. Ghigo, M. Papotti, and G. Muccioli. 2004. Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur. J. Endocrinol. 150:173-184.
10. De Lecea, L., T. S. Kilduff, C. Peyron, X.-B. Gao, P. E. Foye, P. E. Danielson, C. Fukuhara, E. L. F. Battenberg, V. T. Gautvik, F. S. Bartlett II, W. N. Frankel, A. N. Van den Pol, F. E. Bloom, K. M. Gautvik, and J. G. Sutcliffe. 1998. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95:322-327.
11. Digby, J. E., J. Chen, J. Y. Tang, H. Lehnert, R. N. Matthews, and R. H. Randeva. 2006. Orexin receptor expression in human adipose tissue: Effects of orexin-A and orexin-B. J. Endocrinol. 191:129-136.
12. Fraser, S., P. Cowen, M. Franklin, C. Francy, and J. Arendt. 1983. Direct radioimmunoassay for plasma melatonin. Clin. Chemist. 29:386-397.
13. Funato, H., A. L. Tsai, J. T. Willie, Y. Kisanuki, S. C. Williams, T. Sakurai and M. Yanagisawa. 2009. Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab. 9(1):64-76.
14. Harrison, J. L., D. W. Miller, P. A. Findlay, and C. L. Adam. 2008. Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep. Neuroendocrinology 87:182-192.
15. Kirsz, K., and D. A. Zieba. 2011. Ghrelin-mediated appetite regulation in the central nervous system. Peptides 32:2256-2264.
16. Li, X. L., S. Aou, Y. Oomura, N. Hori, K. Fukunaga, and T. Hori. 2002. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 113:607-615.
17. Lopez, M., M. Tena-Sempere, and C. Diequeez. 2010. Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamicpituitary axes). Front. Neuroendocriol. 31(2):113-127.
18. Marie, M., P. A. Findlay, L. Thomas, and C. L. Adam. 2001. Daily patterns of plasma leptin in sheep: Effect of photoperiod and food intake. J. Endocrinol. 170:277-286.
19. Mendoza, J. 2007. Circadian clocks: Setting time by food. J. Neuroendocrinol. 19(2):127-137.
20. Mikkelsen, J. D., F. Hauser, L. deLecea, J. G. Sutcliffe, T. S. Kilduff, C. Calgari, P. Pévet, and V. Simonneaux. 2001. Hypocretin (orexin) in the rat pineal gland: A central transmitter with effects on noradrenaline-induced release of melatonin. Eur. J. Neurol. 14:419-425.
21. Misztal, T., K. Romanowicz, and B. Barcikowski. 1996. Seasonal changes of melatonin secretion in relation to the reproductive cycle in sheep J. Anim. Feed. Sci. 56:35-48.
22. Muroya, S., H. Funahashi, A. Yamanaka, D. Kohno, K. Uramura, T. Nambu, M. Shibahara, M. Kuramochi, M. Takigawa, and M. Yanagisawa. 2004. Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus. Eur. J. Neurosci. 19:1524-1534.
23. Myers, M. G., M. A. Cowley, and H. Münzberg. 2008. Mechanisms of leptin action and leptin resistance. Ann. Rev. Physiol. 70:537-556.
24. Norms. 1993. Nutrient requirements for cattle and sheep in the traditional system (in Polish). 6-th rev. ed. IZ Krakow, Poland.
25. Pirnik, Z., Bundzikova, J., Mikkelsen, J.D., Zelezna, B., Maletinska, L., Kiss, A. 2008. Fos expression in hypocretinergic neurons in C57B1/6 male and female mice after long-term consumption of high fat diet. Endocr. Regul. 42(4):137-146.
26. Russel A. J. F., J. M. Doney, and R. G. Gunn. 1969. Subjective assessment of body fat in live sheep. J. Agri. Sci. 72:451-454.
27. Sartin, J. L., C. Dyer, R. Matteri, D. Buxton, F. Buonomo, M. Shores, J. Baker, J. A. Osborne, T. Braden, and B. Steele. 2001. Effect of intracerebroventricular orexin-B on food intake in sheep. J. Anim. Sci. 79:1573-1577.
28. Shpilman, M., L. Niv-Spector, M. Katz, C. Varol, G. Solomon, M. Ayalon-Soffer, E. Boder, Z. Halpern, E. Elinav, and A. Gertler. 2011. Development and characterization of high affinity leptin and leptin antagonists. J. Biol. Chem. 286:4429-4442.
29. Smith, J. T. and I. J. Clarke. 2010. Gonadotropin inhibitory hormone function in mammals. Trends Endocrinol. Metab. 21:255-260.
30. Sun, G., T. Tian, Y. Yao, H. Li, and T. Higuchi. 2006. Central and/ or peripheral immunoreactivity of orexin-A in pregnant rat and women. J. Mol. Endocrinol. 36:131-138.
31. Toshinai, K., Y. Date, N. Murakami, S. Mitsushi, S. Muhtashan, T. Shimbara, L. Guan, Q.-P. Wang, H. Funashashi, and T. Sukurai. 2003. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 144:1506-1512.
32. Traczyk, W., and F. Przekop. 1963. Methods of investigation of the function of the hypothalamus and hypophysis in chronic experiments in sheep. Acta Physiol. Pol. 14:217-226.
33. Ueberberg, B., N. Unger, W. Saeger, K. Mann, and S. Petersenn. 2009. Expression of ghrelin and its receptor in human tissues. Horm. Metab. Res. 41:814-821.
34. Qi, Y., B. A. Henry, B. J. Oldfield, and I. J. Clarke. 2010. The action of leptin on appetite-regulating cells in the ovine hypothalamus: Demonstration of direct action in the absence of the arcuate nucleus. Endocrinology 151:2106-2116.
35. Zieba, D. A., M. Amstalden, M. N. Maciel, D. H. Keisler, N. Raver, A. Gertler, and G. L. Williams. 2003. Divergent effects of leptin on luteinizing hormone and insulin secretion are dose dependent. Exp. Biol. Med. (Maywood) 228:325-330.
36. Zieba, D. A., M. Amstalden, S. Morton, D. H. Keisler, and G. L. Williams. 2004. Regulatory roles of leptin at the hypothalamichypophyseal axis before and after sexual maturation in cattle. Biol. Reprod. 71:804-812.
37. Zieba, D. A., K. Kirsz, E. Molik, K. Romanowicz, and A. K. Wojtowicz. 2011 Effects of orexigenic peptides and leptin on melatonin secretion during different photoperiods in seasonal breeding ewes. An in vitro study. Domest. Anim. Endocrinol. 40:139-146.
38. Zieba, D. A., B. Klocek, G. L. Williams, K. Romanowicz, L. Boliglowa, and M. Wozniak. 2007. In vitro evidence that leptin suppresses melatonin secretion during long days and stimulates its secretion during short days in seasonal breeding ewes. Domest. Anim. Endocrinol. 33:358-365.
39. Zieba, D. A., M. Szczesna, B. Klocek-Gorka, E. Molik, T. Misztal, G. L. Williams, K. Romanowicz, E. Stepien, D. H. Keisler, and M. Murawski. 2008. Seasonal effects of central leptin infusion on secretion of melatonin and prolactin and on SOCS-3 gene expression in ewes. J. Endocrinol. 198:147-155.