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Volumn , Issue , 2011, Pages 525-566

Quantitative Drug Metabolism with Accelerator Mass Spectrometry

Author keywords

AMS metabolite studies, clinical aspects assuring that no unaccounted sources of 14C or carbon enter a defined sample; LC AMS analysis of drug metabolites; Quantitative drug metabolism with accelerator mass spectrometry (AMS) quantifying concentrations of metabolites in humans

Indexed keywords


EID: 84886550075     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470929278.ch16     Document Type: Chapter
Times cited : (9)

References (93)
  • 2
    • 0033059135 scopus 로고    scopus 로고
    • Biomedical applications of accelerator mass spectrometry-Isotope measurements at the level of the atom
    • Barker J, and Garner RC. Biomedical applications of accelerator mass spectrometry-Isotope measurements at the level of the atom. Rapid Commum Mass Spectrom 1999; 13(4): 285-23.
    • (1999) Rapid Commum Mass Spectrom , vol.13 , Issue.4 , pp. 285-223
    • Barker, J.1    Garner, R.C.2
  • 5
    • 0004633147 scopus 로고    scopus 로고
    • Accelerator mass spectrometry for assaying irreversible covalent modification of an enzyme by acetoacetic ester
    • Bennett JS, Bell DW, Buchholz BA, Kwok ESC, Vogel JS, and Morton TH. Accelerator mass spectrometry for assaying irreversible covalent modification of an enzyme by acetoacetic ester. In J Mass Spectrom 1998; 180: 185-193.
    • (1998) In J Mass Spectrom , vol.180 , pp. 185-193
    • Bennett, J.S.1    Bell, D.W.2    Buchholz, B.A.3    Kwok, E.S.C.4    Vogel, J.S.5    Morton, T.H.6
  • 6
    • 0031546851 scopus 로고    scopus 로고
    • Hybrid ion sources: Radiocarbon measurements form microgram to milligram
    • Bronk Ramsey C, and Hedges REM. Hybrid ion sources: Radiocarbon measurements form microgram to milligram. Nucl Instrum Methods Phys Res 1997; B 123: 539-545.
    • (1997) Nucl Instrum Methods Phys Res , vol.123 B , pp. 539-545
    • Bronk Ramsey, C.1    Hedges, R.E.M.2
  • 7
    • 30144437351 scopus 로고    scopus 로고
    • Accelerator mass spectrometry for biomedical research
    • Brown K, Dingley KH, Turteltaub KW. Accelerator mass spectrometry for biomedical research. Methods Enzymol 2005; 402: 423-434.
    • (2005) Methods Enzymol , vol.402 , pp. 423-434
    • Brown, K.1    Dingley, K.H.2    Turteltaub, K.W.3
  • 10
    • 20044386199 scopus 로고    scopus 로고
    • The application of sample pooling methods for determining AUC, AUMC and mean residence times in pharmacokinetic studies
    • Cheung BWY, Cartier LL, Russile HQ, Sawchuk RJ. The application of sample pooling methods for determining AUC, AUMC and mean residence times in pharmacokinetic studies. Fund Clin Pharmacol 2005; 19(3): 347-354.
    • (2005) Fund Clin Pharmacol , vol.19 , Issue.3 , pp. 347-354
    • Cheung, B.W.Y.1    Cartier, L.L.2    Russile, H.Q.3    Sawchuk, R.J.4
  • 11
    • 10844246474 scopus 로고    scopus 로고
    • Measurement of beryllium in biological samples by accelerator mass spectrometry: Applications for studdying chronic beryllium disease
    • Chaiarappa-Zucca ML, Finkel RC, Martinelli RE, McAnianch JE, Nelson DO, Turteltaub KW. Measurement of beryllium in biological samples by accelerator mass spectrometry: Applications for studdying chronic beryllium disease. Chem Res Toxicol 2004; 17(12): 1614-1620.
    • (2004) Chem Res Toxicol , vol.17 , Issue.12 , pp. 1614-1620
    • Chaiarappa-Zucca, M.L.1    Finkel, R.C.2    Martinelli, R.E.3    McAnianch, J.E.4    Nelson, D.O.5    Turteltaub, K.W.6
  • 12
    • 52649163984 scopus 로고    scopus 로고
    • Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations
    • Coldwell KE, Cutts SM, Ognibene TJ, Henderson PT, Phillips DR. Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations. Nucleic Acids Res 2008; 36: e100-110.
    • (2008) Nucleic Acids Res , vol.36
    • Coldwell, K.E.1    Cutts, S.M.2    Ognibene, T.J.3    Henderson, P.T.4    Phillips, D.R.5
  • 13
    • 34249066844 scopus 로고    scopus 로고
    • Metabolism, pharmacokinetics, and excretion of the substance preceptor antagonist CP-122,721 in humans: Structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by highperformance liquid chromatography-tandem mass spectrometry and NMR spectroscopy
    • Colizza, K, Awad M, Kamel A. Metabolism, pharmacokinetics, and excretion of the substance preceptor antagonist CP-122,721 in humans: Structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by highperformance liquid chromatography-tandem mass spectrometry and NMR spectroscopy. Drug Metab Dispos 2007; 35(6): 884-897.
    • (2007) Drug Metab Dispos , vol.35 , Issue.6 , pp. 884-897
    • Colizza, K.1    Awad, M.2    Kamel, A.3
  • 15
    • 0031428098 scopus 로고    scopus 로고
    • Tissue distribution and macromolecular binding of extremely low doses of C-14-benzene in B6C3F1 mice
    • Creek, MR, Mani C, Vogel JS, Turteltaub KW. Tissue distribution and macromolecular binding of extremely low doses of C-14-benzene in B6C3F1 mice. Carcinogenesis 1997; 18(12): 2421-2427.
    • (1997) Carcinogenesis , vol.18 , Issue.12 , pp. 2421-2427
    • Creek, M.R.1    Mani, C.2    Vogel, J.S.3    Turteltaub, K.W.4
  • 18
    • 53949121143 scopus 로고    scopus 로고
    • Improved liquid chromatography-Online radioactivity detection for metabolite profiling
    • Cuyckens F, Koppen V, Kembuegler R, Leclercq L. Improved liquid chromatography-Online radioactivity detection for metabolite profiling. J Chromatogr A 2008; 1209 (1-2): 128-135.
    • (2008) J Chromatogr A , vol.1209 , Issue.1-2 , pp. 128-135
    • Cuyckens, F.1    Koppen, V.2    Kembuegler, R.3    Leclercq, L.4
  • 19
    • 33644840258 scopus 로고    scopus 로고
    • Accelerator mass spectrometry allows for celluar quantification of doxorubicin at femtomolar concentrations
    • DeGregorio MW, Dingley KH, Wurz GT, Ubick E, Turteltaub KW. Accelerator mass spectrometry allows for celluar quantification of doxorubicin at femtomolar concentrations. Cancer Chemother Pharmacol 2006; 57(3): 335-342.
    • (2006) Cancer Chemother Pharmacol , vol.57 , Issue.3 , pp. 335-342
    • DeGregorio, M.W.1    Dingley, K.H.2    Wurz, G.T.3    Ubick, E.4    Turteltaub, K.W.5
  • 20
    • 38449092808 scopus 로고    scopus 로고
    • Evaluation of (41) calcium as a new approach to assess changes in bone metabolism: Effect of a bisphosphonate in tervention in postmenopausal women with low bone mass
    • Denk E, Hillegonds D, Hurrell RF, Vogel J, Fattinger K, Hauselmann HJ, Kraenzlin M, Walczyk T. Evaluation of (41) calcium as a new approach to assess changes in bone metabolism: Effect of a bisphosphonate in tervention in postmenopausal women with low bone mass. J Bone Mineral Res 2007; 22(10): 1518-1525.
    • (2007) J Bone Mineral Res , vol.22 , Issue.10 , pp. 1518-1525
    • Denk, E.1    Hillegonds, D.2    Hurrell, R.F.3    Vogel, J.4    Fattinger, K.5    Hauselmann, H.J.6    Kraenzlin, M.7    Walczyk, T.8
  • 22
    • 0032970624 scopus 로고    scopus 로고
    • DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relvant dose of 2-amino-1methyl-6-phenylimidazo[4,5-b]pyridine
    • Dingley KH, Curtis KD, Nowell S, Felton JS, Lang NP, Turteltaub KW. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relvant dose of 2-amino-1methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Epidemiol Biomakers Prev 1999; 8(6): 507-512.
    • (1999) Cancer Epidemiol Biomakers Prev , vol.8 , Issue.6 , pp. 507-512
    • Dingley, K.H.1    Curtis, K.D.2    Nowell, S.3    Felton, J.S.4    Lang, N.P.5    Turteltaub, K.W.6
  • 23
    • 0031844149 scopus 로고    scopus 로고
    • Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline to albumin and hemoglobin at environmentally relevant doses-Comparison of human subjects and F344 rats
    • Dingley KH, Freeman S, Nelson DO, Garner RC, Turteltuab KW. Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline to albumin and hemoglobin at environmentally relevant doses-Comparison of human subjects and F344 rats. Drug Metab Dispos 1998a; 26(8): 825-828.
    • (1998) Drug Metab Dispos , vol.26 , Issue.8 , pp. 825-828
    • Dingley, K.H.1    Freeman, S.2    Nelson, D.O.3    Garner, R.C.4    Turteltuab, K.W.5
  • 24
    • 0031595397 scopus 로고    scopus 로고
    • Attomole detection of 3H in biological samples using accelerator mass spectrometry: Application in low-dose, dual-isotope tracer studies in conjunction with C-14 accelerator mass spectrometry
    • Dingley KH, Roberts ML, Velsok CA, Turteltaub KW. Attomole detection of 3H in biological samples using accelerator mass spectrometry: Application in low-dose, dual-isotope tracer studies in conjunction with C-14 accelerator mass spectrometry. Chem Res Toxicol 1998b; 11(10)1217-1222.
    • (1998) Chem Res Toxicol , vol.11 , Issue.10 , pp. 1217-1222
    • Dingley, K.H.1    Roberts, M.L.2    Velsok, C.A.3    Turteltaub, K.W.4
  • 29
    • 46849106697 scopus 로고    scopus 로고
    • Intergration of continuous-flow accelerator mass spectrometry with chromatography and mass-selective detection
    • Flarakos J, Liberman RG, Tannenbaum SR, Skiper PI. Intergration of continuous-flow accelerator mass spectrometry with chromatography and mass-selective detection. Anal Chem 2008; 80(13): 5079-5085.
    • (2008) Anal Chem , vol.80 , Issue.13 , pp. 5079-5085
    • Flarakos, J.1    Liberman, R.G.2    Tannenbaum, S.R.3    Skiper, P.I.4
  • 31
    • 0035987901 scopus 로고    scopus 로고
    • Evaluation of accelerator mass spectrometry in human mass balance and pharmacokinetic study-Experience with 14Clabeled (R)-6-[amino(4-chlorophenyl)(1-methy-1H-imidazol-5-yl)]methyl-4-(3-chlorophenyl)-1-methy-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor
    • Garner RC, Goris I, Laenen AA, Vanhoutte E, Meuldermans W, Gregory S, Garner JV, Leong D, Whattam M, Calam A, Snel CA. Evaluation of accelerator mass spectrometry in human mass balance and pharmacokinetic study-Experience with 14Clabeled (R)-6-[amino(4-chlorophenyl)(1-methy-1H-imidazol-5-yl)]methyl-4-(3-chlorophenyl)-1-methy-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor. Drug Metab Disposl 2002; 30(7): 823-830.
    • (2002) Drug Metab Disposl , vol.30 , Issue.7 , pp. 823-830
    • Garner, R.C.1    Goris, I.2    Laenen, A.A.3    Vanhoutte, E.4    Meuldermans, W.5    Gregory, S.6    Garner, J.V.7    Leong, D.8    Whattam, M.9    Calam, A.10    Snel, C.A.11
  • 34
    • 62249176950 scopus 로고    scopus 로고
    • Introduction: Human metabolites in ssfety testing (MIST) issue
    • Guengerich FP. Introduction: Human metabolites in ssfety testing (MIST) issue. Chem Res Toxicol 2009; 22(2): 237-238.
    • (2009) Chem Res Toxicol , vol.22 , Issue.2 , pp. 237-238
    • Guengerich, F.P.1
  • 35
    • 0019461659 scopus 로고
    • Determination of mean valproic acid serum level by assay of a single pooled sample
    • Hamilton RA, Garnett WR, Kline BJ. Determination of mean valproic acid serum level by assay of a single pooled sample. Clin Pharmacol Ther 1981; 29(3): 408-413.
    • (1981) Clin Pharmacol Ther , vol.29 , Issue.3 , pp. 408-413
    • Hamilton, R.A.1    Garnett, W.R.2    Kline, B.J.3
  • 37
    • 67749113261 scopus 로고    scopus 로고
    • A minute dose of 14C-{beta}-carotene is absorbed and converted to retinoids in humans
    • Ho CC, de Moura FF, Kim SH, Burri BJ, Clifford AJ. A minute dose of 14C-{beta}-carotene is absorbed and converted to retinoids in humans. J Nutr 2009; 139 (8): 1480-1486.
    • (2009) J Nutr , vol.139 , Issue.8 , pp. 1480-1486
    • Ho, C.C.1    de Moura, F.F.2    Kim, S.H.3    Burri, B.J.4    Clifford, A.J.5
  • 38
    • 0031873679 scopus 로고    scopus 로고
    • Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening
    • Hop C, Wang Z, Chen Q, Kwei G. Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening. J Pharm Sci 1998; 87(7): 901-903.
    • (1998) J Pharm Sci , vol.87 , Issue.7 , pp. 901-903
    • Hop, C.1    Wang, Z.2    Chen, Q.3    Kwei, G.4
  • 39
    • 79953279303 scopus 로고
    • Tracers
    • Kamen M. Tracers. Sci Am 1949; 180(2): 30-40.
    • (1949) Sci Am , vol.180 , Issue.2 , pp. 30-40
    • Kamen, M.1
  • 40
    • 0030714940 scopus 로고    scopus 로고
    • Dose-dependent binding of trichloroethylene to hepatic DNA and protein at low doses in mice
    • Kautiainen A, Vogel JS, Turteltaub KW. Dose-dependent binding of trichloroethylene to hepatic DNA and protein at low doses in mice. Chem-Biol Interact 1997; 106 (2): 109-121.
    • (1997) Chem-Biol Interact , vol.106 , Issue.2 , pp. 109-121
    • Kautiainen, A.1    Vogel, J.S.2    Turteltaub, K.W.3
  • 41
    • 79952010877 scopus 로고    scopus 로고
    • Analytical validation of accelerator mass spectrometry for pharmaceutical development
    • Keck BD, Ognibene T, Vogel JS. Analytical validation of accelerator mass spectrometry for pharmaceutical development. Bioanalysis 2010; 2(3): 469-485.
    • (2010) Bioanalysis , vol.2 , Issue.3 , pp. 469-485
    • Keck, B.D.1    Ognibene, T.2    Vogel, J.S.3
  • 42
    • 67650770348 scopus 로고    scopus 로고
    • Accelerator mass spectrometry targets of submilligram carbonaceous samples using the high-throughput Zn reduction method
    • Kim SH, Kelly PB, Clifford AJ. Accelerator mass spectrometry targets of submilligram carbonaceous samples using the high-throughput Zn reduction method. Anal Chem 2009; 81(41): 5949-5954.
    • (2009) Anal Chem , vol.81 , Issue.41 , pp. 5949-5954
    • Kim, S.H.1    Kelly, P.B.2    Clifford, A.J.3
  • 43
    • 14844366135 scopus 로고    scopus 로고
    • Progress in isotope analysis at ultra-trace level by AMS
    • Kustschera W. Progress in isotope analysis at ultra-trace level by AMS. Int J Mass Spectrom 2005; 242(2-3): 145-160.
    • (2005) Int J Mass Spectrom , vol.242 , Issue.2-3 , pp. 145-160
    • Kustschera, W.1
  • 45
    • 33646823282 scopus 로고    scopus 로고
    • Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein
    • Lappin G, Garner RC, Meyers T, Powell J, Varely P. Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein. J Pharm Biomed Anal 2006; 41(4): 1299-1302.
    • (2006) J Pharm Biomed Anal , vol.41 , Issue.4 , pp. 1299-1302
    • Lappin, G.1    Garner, R.C.2    Meyers, T.3    Powell, J.4    Varely, P.5
  • 46
    • 51049120013 scopus 로고    scopus 로고
    • Biomedical accelerator mass spectrometry: Recent applications in metabolism and pharmacokinetics
    • Lappin G, Stevens L. Biomedical accelerator mass spectrometry: Recent applications in metabolism and pharmacokinetics. Expert Opin Drug Metab Toxico 2008; 4 (8): 1021-1033.
    • (2008) Expert Opin Drug Metab Toxico , vol.4 , Issue.8 , pp. 1021-1033
    • Lappin, G.1    Stevens, L.2
  • 50
    • 0034695041 scopus 로고    scopus 로고
    • Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6phenylimidazo[4,5-b]pyridine and benzo[a]pyrene
    • Lightfoot TJ, Coxhead JM, Cupid BC, Nicholson S, Garner RC. Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6phenylimidazo[4,5-b]pyridine and benzo[a]pyrene. Mutat Res 2000; 472(1-2): 119-17.
    • (2000) Mutat Res , vol.472 , Issue.1-2 , pp. 119-117
    • Lightfoot, T.J.1    Coxhead, J.M.2    Cupid, B.C.3    Nicholson, S.4    Garner, R.C.5
  • 52
    • 0033200379 scopus 로고    scopus 로고
    • Species and strain comparisons in the macromolecular binding of extremely low doses of C-14 benezene in rodents, using accelerator mass spectrometry
    • Mani C, Freeman S, Nelson DO, Vogel JS, Turteltaub KW. Species and strain comparisons in the macromolecular binding of extremely low doses of C-14 benezene in rodents, using accelerator mass spectrometry. Toxicol Appl Pharmacol 1999; 159(2): 83-90.
    • (1999) Toxicol Appl Pharmacol , vol.159 , Issue.2 , pp. 83-90
    • Mani, C.1    Freeman, S.2    Nelson, D.O.3    Vogel, J.S.4    Turteltaub, K.W.5
  • 55
    • 0033521847 scopus 로고    scopus 로고
    • Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose
    • Mauthe RJ, Dingley KH, Leveson SH, Freeman S, Turesky RJ, Garner RC, Turteltaub KW. Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose. Int J Cancer 1999; 80(4): 539-545.
    • (1999) Int J Cancer , vol.80 , Issue.4 , pp. 539-545
    • Mauthe, R.J.1    Dingley, K.H.2    Leveson, S.H.3    Freeman, S.4    Turesky, R.J.5    Garner, R.C.6    Turteltaub, K.W.7
  • 56
    • 68049111488 scopus 로고    scopus 로고
    • Gas chromatograph-combustion system for C-14-accelerator mass spectrometry
    • McIntyre CP, Sylva SP, Roberts ML, Gas chromatograph-combustion system for C-14-accelerator mass spectrometry. Anal Chem 2009; 81(15): 6422-6428.
    • (2009) Anal Chem , vol.81 , Issue.15 , pp. 6422-6428
    • McIntyre, C.P.1    Sylva, S.P.2    Roberts, M.L.3
  • 57
    • 3943112523 scopus 로고
    • Survey of negative-ion sources for tandem accelerators
    • Middleton R., Survey of negative-ion sources for tandem accelerators. Nucl Instrum Methods 1974; 122(1-2): 35-43.
    • (1974) Nucl Instrum Methods , vol.122 , Issue.1-2 , pp. 35-43
    • Middleton, R.1
  • 60
    • 0037442578 scopus 로고    scopus 로고
    • On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development
    • Nassar AEF, Bjorge SM, Lee DY. On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development. Anal Chem 2003; 75(4) 785-790.
    • (2003) Anal Chem , vol.75 , Issue.4 , pp. 785-790
    • Nassar, A.E.F.1    Bjorge, S.M.2    Lee, D.Y.3
  • 61
    • 0017670681 scopus 로고
    • Carbon-14: Direct detection at natural concentrations
    • Nelson DE, Korteling RG, Stott WR. Carbon-14: Direct detection at natural concentrations. Science 1977; 198(4316): 507-508.
    • (1977) Science , vol.198 , Issue.4316 , pp. 507-508
    • Nelson, D.E.1    Korteling, R.G.2    Stott, W.R.3
  • 62
    • 0035091873 scopus 로고    scopus 로고
    • Highperformance liquid chromatographic determination of ursodeoxycholic acid after solid phase extraction of blood serum and detection-oriented derivatization
    • Nobilis M, Kunes J, Kopecky J, Kvetina J, Svoboda Z, Sladkova K, Vorterl J. Highperformance liquid chromatographic determination of ursodeoxycholic acid after solid phase extraction of blood serum and detection-oriented derivatization. J Pharm Biomed Anal 2001; 24(5-6): 937-946.
    • (2001) J Pharm Biomed Anal , vol.24 , Issue.5-6 , pp. 937-946
    • Nobilis, M.1    Kunes, J.2    Kopecky, J.3    Kvetina, J.4    Svoboda, Z.5    Sladkova, K.6    Vorterl, J.7
  • 63
    • 34248144820 scopus 로고    scopus 로고
    • Ion-optics calculations and preliminary precision estimates of the gas-capable ion source for the 1-MV LLNL BioAMS spectrometer
    • Ognibene TJ, Bench G, Brown TA, Vogel JS. Ion-optics calculations and preliminary precision estimates of the gas-capable ion source for the 1-MV LLNL BioAMS spectrometer. Nucl Instrum Methods Phys Res Sect B Beam Interact Mater Atoms 2007; 259(1): 100-105.
    • (2007) Nucl Instrum Methods Phys Res Sect B Beam Interact Mater Atoms , vol.259 , Issue.1 , pp. 100-105
    • Ognibene, T.J.1    Bench, G.2    Brown, T.A.3    Vogel, J.S.4
  • 64
    • 0038709670 scopus 로고    scopus 로고
    • A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of C-14 via accelerator mass spectrometry
    • Ognibene TJ, Bench G, Vogel JS, Peaslee GF, Murov S. A high-throughput method for the conversion of CO2 obtained from biochemical samples to graphite in septa-sealed vials for quantification of C-14 via accelerator mass spectrometry. Anal Chem 2003; 75(9): 2192-2196.
    • (2003) Anal Chem , vol.75 , Issue.9 , pp. 2192-2196
    • Ognibene, T.J.1    Bench, G.2    Vogel, J.S.3    Peaslee, G.F.4    Murov, S.5
  • 65
    • 65249152385 scopus 로고    scopus 로고
    • Applications of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma
    • Prakash C, Shaffer CL, Tremaine LM, Liberman RG, Skipper PL, Flarakos J, Tannenbaum SR. Applications of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma. Drug Metab. Lett. 1, 226-231 (2007).
    • (2007) Drug Metab. Lett. , vol.1 , pp. 226-231
    • Prakash, C.1    Shaffer, C.L.2    Tremaine, L.M.3    Liberman, R.G.4    Skipper, P.L.5    Flarakos, J.6    Tannenbaum, S.R.7
  • 66
    • 0025890208 scopus 로고
    • Determination of the relative formation and elimination clearance of 2 major carbamazepine metabolites in humans-A comparison between traditional and pooled sample analysis
    • Riad LE, Chan KK, Sawchuk RJ. Determination of the relative formation and elimination clearance of 2 major carbamazepine metabolites in humans-A comparison between traditional and pooled sample analysis. Pharm Res 1991; 8(4): 541-543.
    • (1991) Pharm Res , vol.8 , Issue.4 , pp. 541-543
    • Riad, L.E.1    Chan, K.K.2    Sawchuk, R.J.3
  • 68
    • 37049219835 scopus 로고
    • The application of the nitrogen isotope N-15 for the study of protein metabolism
    • Schoenheimer R, Rittenberg D, Foster GL, Keston A, Ranter S. The application of the nitrogen isotope N-15 for the study of protein metabolism. Science 1938; 88: 599-600.
    • (1938) Science , vol.88 , pp. 599-600
    • Schoenheimer, R.1    Rittenberg, D.2    Foster, G.L.3    Keston, A.4    Ranter, S.5
  • 73
    • 0003998601 scopus 로고
    • Radiocarbon after Four Decades: An Interdisciplinary perspective
    • Springer-Verlag, New York
    • Taylor RE, Long A, Kra RS. Radiocarbon after Four Decades: An Interdisciplinary perspective, Springer-Verlag, New York, 1992.
    • (1992)
    • Taylor, R.E.1    Long, A.2    Kra, R.S.3
  • 74
    • 41549139685 scopus 로고    scopus 로고
    • High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-offlight system as a " first-line" approach for metabolite indentification studies
    • Tiller PR, Yu S, Castro-Perez J, Fillgrove KL, Baillie TA. High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-offlight system as a " first-line" approach for metabolite indentification studies. Rapid Commun Mass Spectrom 2008; 22(7)1053-1061.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.7 , pp. 1053-1061
    • Tiller, P.R.1    Yu, S.2    Castro-Perez, J.3    Fillgrove, K.L.4    Baillie, T.A.5
  • 79
    • 0003484310 scopus 로고    scopus 로고
    • Guidance for industry: Bioanalytical method validation
    • US FDA. Centre for Drug Evaluation and Research. UCM070107
    • US FDA. Centre for Drug Evaluation and Research. Guidance for industry: Bioanalytical method validation. UCM070107 (2001).
    • (2001)
  • 80
    • 53549097600 scopus 로고    scopus 로고
    • Guidance for Industry: Safety Testing of Drug Metabolites
    • US FDA. Centre for Drug Evaluation and Research. UCM065014
    • US FDA. Centre for Drug Evaluation and Research. Guidance for Industry: Safety Testing of Drug Metabolites. UCM065014 (2008).
    • (2008)
  • 81
    • 0003663988 scopus 로고    scopus 로고
    • Guidance for industry: ICH Q2B validation of analytical procedures: methodology CDER/CBER
    • US FDA
    • US FDA. Guidance for industry: ICH Q2B validation of analytical procedures: methodology CDER/CBER. (1996).
    • (1996)
  • 82
    • 0000677819 scopus 로고
    • Rapid production of graphite without contamination for biomedical AMS
    • Vogel JS. Rapid production of graphite without contamination for biomedical AMS. Radiocarbon 1992; 34: 344-350.
    • (1992) Radiocarbon , vol.34 , pp. 344-350
    • Vogel, J.S.1
  • 83
    • 0034935772 scopus 로고    scopus 로고
    • Attomole quantitation of protein separations with accelerator mass spectrometry
    • Vogel JS, Grant PG, Buchholz BA, Dingley K, Turteltaub KW. Attomole quantitation of protein separations with accelerator mass spectrometry. Electrophosesis 2001; 22 (10): 2037-2045.
    • (2001) Electrophosesis , vol.22 , Issue.10 , pp. 2037-2045
    • Vogel, J.S.1    Grant, P.G.2    Buchholz, B.A.3    Dingley, K.4    Turteltaub, K.W.5
  • 84
    • 30144435074 scopus 로고    scopus 로고
    • Quantitating isotopic molecular labels with accelerator mass spectrometry
    • Vogel JS, Love AH (2005). Quantitating isotopic molecular labels with accelerator mass spectrometry. Meth Enzm 402: 402-422.
    • (2005) Meth Enzm , vol.402 , pp. 402-422
    • Vogel, J.S.1    Love, A.H.2
  • 86
    • 30144432053 scopus 로고    scopus 로고
    • Counting statistics and ion interval density in AMS
    • Vogel JS, OgnibeneT, Palmblad M, Reimer P. Counting statistics and ion interval density in AMS. Radiocarbon 2004; 46(3): 1103-1109.
    • (2004) Radiocarbon , vol.46 , Issue.3 , pp. 1103-1109
    • Vogel, J.S.1    Ognibene, T.2    Palmblad, M.3    Reimer, P.4
  • 87
    • 25944446921 scopus 로고
    • Performance of catalytically condensed carbon for use in accelerator mass spectrometry
    • Vogel JS, Southon JR, Nelaon DE, Brown TA. Performance of catalytically condensed carbon for use in accelerator mass spectrometry. Nucl Instrum Methods 1984; B5: 289-293.
    • (1984) Nucl Instrum Methods , vol.5 B , pp. 289-293
    • Vogel, J.S.1    Southon, J.R.2    Nelaon, D.E.3    Brown, T.A.4
  • 89
    • 0030613674 scopus 로고    scopus 로고
    • Comparisons of the binding of C-14 radiolabelled tamoxifen or toremifene to rat DNA using accelerator mass spectrometry
    • White INH, Martin EA, Mauthel RJ, Vogel JS, Turteltaub, KW, and Smith LL. Comparisons of the binding of C-14 radiolabelled tamoxifen or toremifene to rat DNA using accelerator mass spectrometry. Chem-Biol Interact 1997; 106(2): 149-160.
    • (1997) Chem-Biol Interact , vol.106 , Issue.2 , pp. 149-160
    • White, I.N.H.1    Martin, E.A.2    Mauthel, R.J.3    Vogel, J.S.4    Turteltaub, K.W.5    Smith, L.L.6
  • 91
    • 60149111433 scopus 로고    scopus 로고
    • Comparison of a 250kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer-Fitness for purpose in bioanalysis
    • Young GC, Corless S, Felgate CC, Colthup PV. Comparison of a 250kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer-Fitness for purpose in bioanalysis. Rapid Commun Mass Spectrom 2008; 22 (24): 4035-4042.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.24 , pp. 4035-4042
    • Young, G.C.1    Corless, S.2    Felgate, C.C.3    Colthup, P.V.4
  • 92
    • 23444454671 scopus 로고    scopus 로고
    • Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: Method validation and application
    • Zhu MS, Zhao WP, Vazquez N, Mitroka JG. Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: Method validation and application. J Pharm Biomed Anal 2005; 39(1-2): 233-245.
    • (2005) J Pharm Biomed Anal , vol.39 , Issue.1-2 , pp. 233-245
    • Zhu, M.S.1    Zhao, W.P.2    Vazquez, N.3    Mitroka, J.G.4


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