Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 472, Issue 1-2, 2000, Pages 119-127

  Lightfoot, T J ^a   Coxhead, J M ^a   Cupid, B C ^a   Nicholson, S ^b   Garner, R C ^a,c  

^a UNIVERSITY OF YORK   (United Kingdom)

^b YORK HOSPITAL   (United Kingdom)

^c Centre for Biomedical Accelerator Mass Spectrometry (CBAMS Ltd)   (United Kingdom)

Author keywords

AMS; Breast cancer; Heterocyclic amines; Polycyclic aromatic hydrocarbons

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; BENZO[A]PYRENE; CELL DNA;

ADULT; AGED; ARTICLE; BIOAVAILABILITY; BREAST CARCINOGENESIS; BREAST CARCINOMA; CARCINOGEN DNA INTERACTION; CONTROLLED STUDY; DNA ADDUCT; DNA DETERMINATION; DOSE TIME EFFECT RELATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MASTECTOMY; PRIORITY JOURNAL; TISSUE LEVEL;

AGED; BENZO(A)PYRENE; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; BREAST; BREAST NEOPLASMS; CARBON RADIOISOTOPES; CARCINOGENS; DNA; DNA ADDUCTS; FEMALE; HUMANS; IMIDAZOLES; LYMPH NODES; MASS SPECTROMETRY; MIDDLE AGED; PARTICLE ACCELERATORS;

ANIMALIA; RODENTIA;

EID: 0034695041     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00134-0     Document Type: Article

References (39)

1. Well-done meat intake and the risk of breast cancer
2. Dietary factors and risk of breast cancer: Combined analysis of 12 case-control studies
3. Cohort studies of fat intake and the risk of breast cancer: A pooled analysis
4. The isolation and identification of a new mutagen from fried ground beef, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)
5. Some perspectives on the nutritional aspects of breast cancer research. Food derived heterocyclic amines as etiologic agents in human mammary cancer
6. DNA adducts of heterocyclic amine food mutagens: Implications for mutagenesis and carcinogenesis
7. Distribution and metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in female rats and their pups at dietary doses
8. Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female sprague-dawley rats
9. Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
10. Polycyclic aromatic hydrocarbons in the diet
11. Factors associated with human exposures to polycyclic aromatic hydrocarbons
12. Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice
13. Relationship between DNA adduct levels and tumor incidence in mice fed coal tar or benzo[a]pyrene for 2 years
14. DNA adduct measurements in relation to small intestine and forestomach tumour incidence during the chronic feeding of coal tar or benzo[a]pyrene to mice
15. Evidence of anti-benzo[a]pyrene diolepoxide-DNA adduct formation in human colon mucosa
16. The role of DNA adducts in chemical carcinogenesis
17. Human cDNA-expressed cytochrome P4501A2: Mutagen activation and substrate specificity
18. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
19. Bioactivation of the proximal food mutagen 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to DNA-binding species by human mammary gland enzymes
20. N-acetyltransferase expression and metabolic activation of food-derived heterocyclic amines in the human mammary gland
21. Benzo[a]pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes
22. 50 Years of benzo[a]pyrene
23. Metabolism of benzo[a]pyrene-7,8-diol by human cytochrome P4501B1
24. Comparative biotransformation studies of MeIQx and PhIP in animal models and humans
25. Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in mice at a human dietary equivalent dose
26. Dose-response studies of MeIQx in rat liver and liver DNA at low doses
27. Rapid production of graphite without contamination for biomedical AMS
28. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
29. Interindividual variation in metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells
30. Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyrdine by estrogen sulfotransferase in cultured human mammary epithelial cells
31. Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells
32. Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone
33. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1
34. Developmental stage of the rat mammary gland as a determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene
35. Inhibtion of cell death in human mammary epithelial cells by the cooked meat mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine