Dose-dependent binding of trichloroethylene to hepatic DNA and protein at low doses in mice

Chemico-Biological Interactions

Volumn 106, Issue 2, 1997, Pages 109-121

  Kautiainen, Antti ^a   Vogel, John S ^a   Turteltaub, Kenneth W ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Accelerator mass spectrometry; DNA adduct; Low level dosimetery; Protein adduct; Radiotracing; TCE

Indexed keywords

GROUND WATER; TRICHLOROETHYLENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; DRUG DNA BINDING; GENOTOXICITY; LIVER CANCER; MALE; MOUSE; MUTAGENICITY; NONHUMAN; WATER CONTAMINATION;

ANIMALS; CARBON RADIOISOTOPES; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED STRAINS; NUCLEOTIDES; PROTEIN BINDING; PROTEINS; TIME FACTORS; TRICHLOROETHYLENE;

EID: 0030714940     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00061-6     Document Type: Article

References (40)

1. International Agency for Research on Cancer, Trichloroethylene, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 20, Lyon, France, 1979, pp. 545-572.
2. Murray A.J., Riley J.P. Occurrence of some chlorinated aliphatic hydrocarbons in the environment. Nature. 242:1973;37-38.
3. Fan A.M. Trichloroethylene: water contamination and health risk assessment. Rev. Environ. Contam. Toxicol. 101:1988;55-93.
4. United States Environmental Protection Agency, Health Assessment Document for Trichloroethylene. Final Report E-600/8-82-006B, Washington, DC, 1985.
5. Bruckner J.V., Davis B.D., Blancato J.N. Metabolism, toxicity, and carcinogenicity of trichloroethylene. Crit. Rev. Toxicol. 20:1989;31-50.
6. Crebelli R., Carere A. Genetic toxicology of 1,1,2-trichloroethylene. Mutat. Res. 221:1989;11-37.
7. Crebelli R., Bignami M., Conti L., Carere A. Mutagenicity of trichloroethylene in Salmonella typhimurium TA100. Ann. Ist. Super. Sanità 18:1982;117-122.
8. Duprat P., Gradinski D. Cytogenetic effect of trichloroethylene in the mouse as evaluated by the micronucleus test. IRCS Med. Sci. 8:1980;182.
9. National Toxicology Program (NTP) Carcinogenesis Studies of Trichloroethylene (without epichlorohydrin), (CAS No. 79-01-6) in F344/N Rats and B6C3F1 Mice (gavage study). NTP TR 243. US Department of Health and Human Services, Research Triangle Park, NC, 1990.
10. Maltoni C., Lefemine G., Cotti G., Perino G. Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice. Ann. New York Acad. Sci. 534:1988;316-342.
11. Fucuda K., Takemoto K., Tsuruta H. Inhalation carcinogenicity of trichloroethylene in mice and rats. Ind. Health. 21:1983;243-245.
12. Nakajima T., Wang R.-S., Elovaara E., Park S.S., Gelboin H.V., Vainio H.A. A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem. Pharmacol. 43:1992;251-257.
13. Stott W.T., Quast J.F., Watanabe P.G. The pharmacokinetics and macromolecular interactions of trichloroethylene in mice and rats. Toxicol. Appl. Pharmacol. 62:1982;137-151.
14. Kimmerle G., Eben A. Metabolism, excretion and toxicology of trichloroethylene after inhalation. Arch. Toxicol. 30:1973;115-126.
15. Larsson J.L., Bull R.J. Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate. Toxicol. Appl. Pharmacol. 115:1992;278-285.
16. Hathway D.E. Consideration of the evidence for mechanisms of 1,1,2-trichloroethylene metabolism including new identification of its dichloroacetic acid and trichloroacetic acid metabolites in mice. Cancer Lett. 8:1980;263-269.
17. Elfarra A.A., Jakobson I., Anders M.W. Mechanisms of S-(1,2-dichlorovinyl) glutathione-induced nephrotoxicity. Biochem. Pharmacol. 35:1986;283-288.
18. Miller R.E., Guengerich F.P. Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450. Cancer Res. 43:1983;1145-1152.
19. 2 and interaction of a metabolite with liver DNA in rats and mice. J. Toxicol. Environ. Health. 9:1982;797-813.
20. C.R. Elcombe, Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: a biochemical human hazard assessment, Arch. Toxicol. (8) (1985) 6-17.
21. Prout M.S., Provan W.M., Green T. Species differences in response to trichloroethylene. Toxicol. Appl. Pharmacol. 79:1985;389-400.
22. K.W. Turteltaub, J.S. Vogel, C.E. Frantz, E. Fultz, Studies on DNA adduction with heterocyclic amines by accelerator mass spectrometry: a new technique for tracing isotope-labeled DNA adduction, in: D.H. Phillips, M. Castegnaro, H. Bartsch, (Eds.), Postlabeling Methods for Detection of DNA Adducts. IARC, Lyon, 1993, pp. 293-301.
23. K.W. Turteltaub, J.S. Vogel, Application of accelerator mass spectrometry in toxicology: a highly sensitive tool for low-level isotope measurements, in: A.L. Burlingame, S.A. Carr (Eds.), Mass Spectrometry in the Biological Sciences, Humana Press, Totawa, NJ, 1995, pp. 477-495.
24. Vogel J.S., W Turteltaub K., Finkel R.C., Nelson D.E. Accelerator mass spectrometry: isotope detection at attomole sensitivity. Anal. Chem. 67:1995;353A-359A.
25. Turteltaub K.W., Felton J.S., Gledhill B.L., Vogel J.S., Southon J.R., Caffee M.W., Finkel R.C., Nelson D.E., Proctor I.D., Davis J.C. Accelerator mass spectrometry in biomedical dosimetry: Relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. Proc. Natl. Acad. Sci. USA. 87:1990;5288-5292.
26. Frantz C., Bangerter C., Fultz E., Mayer K., Vogel J., Turteltaub K. Dose-response studies of MeIQx in rat and liver DNA at low doses. Carcinogenesis. 16:1995;367-373.
27. 14C]benzene in B6C3F1 mice, Carcinogenesis (in press).
28. Vogel J.S. Rapid production of graphite without contamination for biomedical AMS. Radiocarbon. 3:1992;344-350.
29. Davis J.C., Proctor I.D., Southon J.R., Caffee M.W., Heikkinen D.W., Roberts B., Moore T.L., Turteltaub K.W., Nelson D.E., Loyd D.H., Vogel J.S. LLNL/UC AMS Facility and Research Program. Nucl. Inst. Method Phys. Res. B52:1990;269-272.
30. 14C data. Radiocarbon. 19:1977;355-363.
31. Bergman K. Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo. Arch. Toxicol. 54:1983;181-193.
32. A. Kautiainen, In Vivo Dosimetry of Aldehydes and Studies on the Origin of Malonaldehyde. Ph.D. Thesis, Stockholm University, Stockholm, Sweden, 1992.
33. Kautiainen A., Vaca C.E., Granath F. Studies on the relationship between hemoglobin and DNA adducts of malonaldehyde and their stability in vivo. Carcinogenesis. 14:1993;705-708.
34. Swenberg J.A., Fedtke N., Ciroussel F., Barbin A., Bartsch H. Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver. Carcinogenesis. 13:1992;727-729.
35. Dekant W., Schulz A., Metzler M., Henschler D. Absorption, elimination and metabolism of trichloroethylene: a quantitative comparison between rats and mice. Xenobiotica. 16:1986;143-152.
36. Herren-Freund S.L., Pereira M.A., Khoury M.D., Olson G. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid in mouse liver. Toxicol. Appl. Pharmacol. 90:1987;183-189.
37. DeAngelo A.B., Daniel F.B., McMillan L., Wernsing P., Savage R.E. Jr. Species and strain sensitivity to the induction of peroxisome proliferation. Toxicol. Appl. Pharmacol. 101:1989;285-298.
38. Ward J.M., Diwan B.A., Ohshima M., Hu H., Schuller H.M., Rice J.M. Tumor-initiating and promoting activities of di(2-ethylhexyl)pthalate in vivo and in vitro. Environ. Health Perspect. 65:1986;279-291.
39. Cattley R.C., Popp J.A. Differences between the promoting activities of the peroxisome proliferator WY-JA14 643 and phenobarbital in rat liver. Cancer Res. 49:1989;3246-3251.
40. Marnett L.J., Burcham P.C. Endogenous DNA adducts: potential and paradox. Chem. Res. Toxicol. 6:1993;771-785.