Cell-based medicinal chemistry optimization of high-throughput screening (HTS) hits for orally active antimalarials. part 1: Challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK)

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 7741-7749

  Chatterjee, Arnab K ^a  

^a Calibr   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; CLOPIDOL; ELQ 300; GNF 268; GNF 776; GW 308678; GW 844520; GW 932121; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; NITD 609; PIPERAZINE DERIVATIVE; POTASSIUM CHANNEL HERG; QUINOLONE DERIVATIVE; SPIRO COMPOUND; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; HIGH THROUGHPUT SCREENING; MALARIA; NONHUMAN; PHARMACOPHORE; PHENOTYPE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION;

ABSORPTION; ADMINISTRATION, ORAL; ANTIMALARIALS; CHEMISTRY, PHARMACEUTICAL; DRUG DISCOVERY; DRUG INDUSTRY; HUMANS; MALARIA, FALCIPARUM; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM;

EID: 84886543990     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400314m     Document Type: Article

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