Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 11022-11030

  González Cabrera, Diego ^a   Douelle, Frederic ^a   Younis, Yassir ^a   Feng, Tzu Shean ^a   Le Manach, Claire ^a   Nchinda, Aloysius T ^a   Street, Leslie J ^a   Scheurer, Christian ^b,f   Kamber, Jolanda ^b,f   White, Karen L ^c   Montagnat, Oliver D ^c   Ryan, Eileen ^c   Katneni, Kasiram ^c   Zabiulla, K Mohammed ^d   Joseph, Jayan T ^d   Bashyam, Sridevi ^d   Waterson, David ^e   Witty, Michael J ^e   Charman, Susan A ^c   Wittlin, Sergio ^b,f   Chibale, Kelly ^a   more..

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c MONASH UNIVERSITY   (Australia)

^d SYNGENE INTERNATIONAL LTD   (India)

^e ICC   (Switzerland)

^f UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

(4 (6 AMINO 5 (6 (TRIFLUOROMETHYL)PYRIDIN 3 YL)PYRIDIN 3 YL)PHENYL (4 METHYLPIPERAZIN 1 YL)METHANONE; (4 (6 AMINO 5 (6 (TRIFLUOROMETHYL)PYRIDIN 3 YL)PYRIDIN 3 YL)PHENYL (PIPERAZIN 1 YL)METHANONE; 3 (6 METHOXYPYRIDIN 3 YL) 5 (3 (METHYLSULFONYL)PHENYL)PYRIDIN 2 AMINE; 4 (6 AMINO 5 (6 (TRIFLUOROMETHYL)PYRIDIN 3 YL)PYRIDIN 3 YL)PHENYL) (MORPHOLINO)METHANONE; ANTIMALARIAL AGENT; ARTESUNATE; CHLOROQUINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMINOPYRIDINES; ANIMALS; ANTIMALARIALS; DRUG RESISTANCE, MULTIPLE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MALARIA; MICE; MICROSOMES, LIVER; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871642734     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301476b     Document Type: Article

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