Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2756-2766

  Zhang, Yiqun ^a   Guiguemde, W Armand ^a   Sigal, Martina ^a   Zhu, Fangyi ^a   Connelly, Michele C ^a   Nwaka, Solomon ^b   Guy, R Kiplin ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

Malaria; Plasmodium; Quinolones; Synthesis

Indexed keywords

QUINOLONE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CELL LINE; CELL SURVIVAL; DRUG RESISTANCE; ERYTHROCYTES; ESCHERICHIA COLI; HUMANS; INDICATORS AND REAGENTS; MEFLOQUINE; MEMBRANES, ARTIFICIAL; PERMEABILITY; PLASMODIUM FALCIPARUM; QUINOLONES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 77950031114     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.013     Document Type: Article

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