Endochin optimization: Structure-activity and structure-property relationship studies of 3-substituted 2-Methyl-4(1 H)-quinolones with antimalarial activity

Journal of Medicinal Chemistry

Volumn 53, Issue 19, 2010, Pages 7076-7094

  Cross, R Matthew ^a   Monastyrskyi, Andrii ^a   Mutka, Tina S ^b   Burrows, Jeremy N ^c   Kyle, Dennis E ^b   Manetsch, Roman ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c Medicines for Malaria Venture   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 3 (3 NITROSTYRYL)QUINOLIN 4(1H)ONE; 2 METHYL 3 (NON 1 EN 2 YL)QUINOLIN 4(1H)ONE; 2 METHYL 3 (NON 1 ENYL)QUINOLIN 4(1H)ONE; 2 METHYL 3 (NON 2 ENYL)QUINOLIN 4(1H)ONE; 2 METHYL 3 NONYLQUINOLIN 4(1H)ONE; 2 METHYL 3 PHENYLQUINOLIN 4(1H)ONE; 2 METHYL 3 STYRYLQUINOLIN 4(1H)ONE; 3 (4 HYDROXYSTYRYL) 2 METHYLQUINOLIN 4(1H)ONE; 3 (HEX 1 YNYL) 2 METHYLQUINOLIN 4(1H)ONE; 3 (HEX 1 YNYL) 6 METHOXY 2 METHYLQUINOLIN 4(1H)ONE; 3 BENZYL 2 METHYLQUINOLIN 4(1H)ONE; 3 BROMO 2 METHYLQUINOLIN 4(1H)ONE; 3 BROMO 2,6 DIMETHYLQUINOLIN 4(1H)ONE; 3 BROMO 6 CHLORO 2 METHYLQUINOLIN 4(1H)ONE; 3 BROMO 6 FLUORO 2 METHYLQUINOLIN 4(1H)ONE; 3 BROMO 6 METHOXY 2 METHYLQUINOLIN 4(1H)ONE; 3 CYCLOHEXYL 2 METHYLQUINOLIN 4(1H)ONE; 3 HEPTYL 2 METHYLQUINOLIN 4(1H)ONE; 3 HEPTYL 7 METHOXY 2 METHYLQUINOLIN 4(1H)ONE; 3,6 DIBROMO 2 METHYLQUINOLIN 4(1H)ONE; 4 (BENZYLOXY) 3 BROMO 2 METHYLQUINOLINE; 4 (BENZYLOXY) 3 BROMO 6 CHLORO 2 METHYLQUINOLINE; 4 (BENZYLOXY) 3 BROMO 6 FLUORO 2 METHYLQUINOLINE; 4 (BENZYLOXY) 3 BROMO 6 METHOXY 2 METHYLQUINOLINE; 6 CHLORO 3 (HEX 1 YNYL) 2 METHYLQUINOLIN 4(1H)ONE; 7 METHOXY 2 METHYLQUINOLIN 4(1H)ONE; ANTIMALARIAL AGENT; QUINOLONE DERIVATIVE; TERT BUTYL 3 (2 METHYL 4 OXO 1,4 DIHYDROQUINOLIN 3 YL)ACRYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ATOVAQUONE; QUINOLINOL DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CROSS RESISTANCE; CYCLIZATION; DRUG EFFICACY; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; FOLLOW UP; MICROSOME; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG STABILITY; HUMAN; IN VITRO STUDY; ISOLATION AND PURIFICATION; LIVER MICROSOME; METABOLISM; PARASITOLOGY; PERMEABILITY; SOLUBILITY; STEREOISOMERISM; SYNTHESIS;

ANTIMALARIALS; ATOVAQUONE; DRUG RESISTANCE; DRUG STABILITY; ERYTHROCYTES; HUMANS; HYDROXYQUINOLINES; MICROSOMES, LIVER; PARASITIC SENSITIVITY TESTS; PERMEABILITY; PLASMODIUM FALCIPARUM; QUINOLONES; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; IN VITRO TECHNIQUES;

EID: 77957920392     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1007903     Document Type: Article

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