Tumors of the Female Genital Organs

Cancer Cytogenetics

Volumn , Issue , 2010, Pages 519-556

  Micci, Francesca ^a   Heim, Sverre ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Adenocarcinomas; Chromosome abnormalities; Comparative genomic hybridization; Female genital organs; Gynecologic malignancies

Indexed keywords

EID: 84886343376     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118010136.ch16     Document Type: Chapter

References (293)

1. Abe N, Watanabe T, Sugiyama M, Uchimura H, Chiappetta G, Fusco A, Atomi Y (1999): Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker. Cancer Res 59:1169-1174.
2. Allen DG, Hutchins AM, Hammet F, White DJ, Scurry JP, Tabrizi SN, Garland SM, Armes JE (2002): Genetic aberrations detected by comparative genomic hybridisation in vulvar cancers. Br J Cancer 86:924-928.
3. AmanP, Pejovic T, Wennborg A, HeimS, MitelmanF(1993): Mapping of the 19p 13 breakpoint in an ovarian carcinoma between the INSR and TCF3 loci. Genes Chromosomes Cancer 8:134-136.
4. Arnold N, Hagele L, Walz L, Schempp W, Pfisterer J, Bauknecht T, Kiechle M (1996): Overrepre- sentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer. Genes Chromosomes Cancer 16:46-54.
5. Ashar HR, Cherath L, Przybysz KM, Chada K (1996): Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas. Genomics 31:207-214.
6. Atkin NB, Baker MC (1979): Chromosome 1 in 26 carcinomas of the cervix uteri: structural and numerical changes. Cancer 44:604-613.
7. Atkin NB, Baker MC (1987a): Abnormal chromosomes including small metacentrics in 14 ovarian cancers. Cancer Genet Cytogenet 26:355-361.
8. Atkin NB, Baker MC (1987b): One or two double minutes in three carcinomas. Cancer Genet Cytogenet 25:189-190.
9. Atkin NB, Pickthall VJ (1977): Chromosomes 1 in 14 ovarian cancers. Heterochromatin variants and structural changes. Hum Genet 38:25-33.
10. Atkin NB, Baker MC, Ferti-Passantonopoulou A (1983): Chromosome changes in early gynecologic malignancies. Acta Cytol 27:450-453.
11. Atkin NB, Baker MC, Fox MF (1990): Chromosome changes in 43 carcinomas of the cervix uteri. Cancer Genet Cytogenet 44:229-241.
12. Augustus M, Bruderlein S, Gebhart E (1986): Cytogenetic and cell cycle studies in metastatic cells from ovarian carcinomas. Anticancer Res 6:283-289.
13. Bardi G, Sukhikh T, Pandis N, Holund B, Heim S (1994): Complex karyotypic abnormalities in a primary carcinoma of the fallopian tube. Genes Chromosomes Cancer 10:207-209.
14. Bardi G, Pandis N, Schousboe K, Holund B, Heim S (1995): Near-diploid karyotypes with recurrent chromosome abnormalities characterize early-stage endometrial cancer. Cancer Genet Cytogenet 80:110-114.
15. Bayani J, Brenton JD, Macgregor PR, Beheshti B, Albert M, Nallainathan D, Karaskova J, Rosen B, Murphy J, Laframboise S, Zanke B, Squire JA (2002): Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression micro-arrays. Cancer Res 62:3466-3476.
16. Bello MJ, Rey JA (1990): Chromosome aberrations in metastatic ovarian cancer: relationship with abnormalities in primary tumors. Int J Cancer 45:50-54.
17. Betz JL, Meloni AM, U'Ren LA, Moore GE, Sandberg AA (1995): Cytogenetic findings in a case of aggressive angiomyxoma of the vagina wall. Cancer Genet Cytogenet 84:157.
18. Blegen H, Einhorn N, Sjovali K, Roschke A, Ghadimi BM, McShane LM, Nilsson B, Shah K, Ried T, Auer G (2000): Prognostic significance of cell cycle proteins and genomic instability in borderline, early and advanced stage ovarian carcinomas. Int J Gynecol Cancer 10:477-487.
19. Boghosian L, Dal CP, Sandberg AA (1988): An interstitial deletion of chromosome 7 may characterize a subgroup of uterine leiomyoma. Cancer Genet Cytogenet 34:207-208.
20. Bol S, Wanschura S, Thode B, Deichert U, Van de Ven WJ, Bartnitzke S, Bullerdiek J (1996): An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12. Cancer Genet Cytogenet 90:88-90.
21. Brink AA, Wiegant JC, Szuhai K, Tanke HJ, Renter GG, Fleuren GJ, Schuuring E, Raap AK (2002): Simultaneous mapping of human papillomavirus integration sites and molecular karyotyping in short-term cultures of cervical carcinomas by using 49-color combined binary ratio labeling fluorescence in situ hybridization. Cancer Genet Cytogenet 134:145-150.
22. Brosens I, Johannisson E, Dal Cin P, Deprest J, Van den Berghe H (1996): Analysis of the karyotype and desoxyribonucleic acid content of uterine myomas in premenopausal, menopausal, and gonadotropin-releasing hormone agonist-treated females. Fertil Steril 66:376-379.
23. Brosens I, Deprest J, Dal Cin P, Van den Berghe H (1998): Clinical significance of cytogenetic abnormalities in uterine myomas. Fertil Steril 69:232-235.
24. Bullerdiek J, Rommel B (1999): Diagnostic and molecular implications of specific chromosomal translocations in mesenchymal tumors. Histol Histopathol 14:1165-1173.
25. Bussey KJ, Lawce HJ, Olson SB, Arthur DC, Kalousek DK, Krailo M, Giller R, Heifetz S, Womer R, Magenis RE (1999): Chromosome abnormalities of eighty-one pediatric germ cell tumors: sex-, age-, site-, and histopathology-related differences-a Children's Cancer Group study. Genes Chromosomes Cancer 25:134-146.
26. Bussey KJ, Lawce HJ, Himoe E, Shu XO, Suijkerbuijk RF, Olson SB, Magenis RE (2001): Chromosomes 1 and 12 abnormalities in pediatric germ cell tumors by interphase fluorescence in situ hybridization. Cancer Genet Cytogenet 125:112-118.
27. Bustin M, Reeves R (1996): High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function. Prog Nucleic Acid Res Mol Biol 54:35-100.
28. Caduff RF, Svoboda-Newman SM, Ferguson AW (1999): Comparison of mutations of Ki-RAS and p53 immunoreactivity in borderline and malignant epithelial ovarian tumors. Am J Surg Pathol 23:323-328.
29. Chen Z, Coffin CM, Smith LM, Issa B, Arndt S, Shepard R, Brothman L, Stratton J, Brothman AR, Zhou H (2001): Cytogenetic-clinicopathologic correlations in rhabdomyosarcoma: a report of five cases. Cancer Genet Cytogenet 131:31-36.
30. Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke T, Hamilton TC, Tsichlis PN, Testa JR (1992): AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 89:9267-9271.
31. Chenvix-Trench G, Leary J, Kerr J, Michel J, Kefford R, Hurst T, Parsons PG, Friedlander M, Khoo SK (1992): Frequent loss of heterozygosity on chromosome 18 in ovarian adenocarcinoma which does not always include the DCC locus. Oncogene 7:1059-1065.
32. Chiappetta G, Bandiera A, Berlingieri MT, Visconti R, Manfioletti G, Battista S, Martinez-Tello FJ, Santoro M, Giancotti V, Fusco A (1995): The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene 10:1307-1314.
33. Chiappetta G, Tallini G, De Biasio MC, Manfioletti G, Martinez-Tello FJ, Pentimalli F, de Nigris F, Mastro A, Botti G, Fedele M, Berger N, Santoro M, Giancotti V, Fusco A (1998): Detection of high mobility group I HMG1(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res 58:4193-4198.
34. Christacos NC, Quade BJ, Dal Cin P, Morton CC (2006): Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic features. Genes Chromosomes Cancer 45:304-312.
35. Clawson K, Donner LR, Dobin SM (2001): Isochromosome (17)(ql0) as the sole structural chromosomal rearrangement in a case of botryoid rhabdomyosarcoma. Cancer Genet Cytogenet 128:11-13.
36. Cornelis RS, Neuhausen SL, Johansson O (1995): High allele loss rates at 17ql2-q21 in breast and ovarian tumors from BRCA1-linked families. The breast cancer linkage consortium. Genes Chromosomes Cancer 13:203-210.
37. Couturier J, Vielh P, Salmon R, Dutrillaux B (1986): Trisomy and tetrasomy for long arm of chromosome 1 in near-diploid human endometrial adenocarcinomas. Int J Cancer 38:17-19.
38. Couturier J, Vielh P, Salmon RJ, Lombard M, Dutrillaux B (1988): Chromosome imbalance in endometrial adenocarcinoma. Cancer Genet Cytogenet 33:67-76.
39. Curcio S (1966): Cytogenetic study of a primary carcinoma of the fallopian tube. Arch Obstet Gynecol 71:450-456.
40. Dal Cin P, Morton CC (2002): lq42 approximately q44 is rarely cytogenetically involved in sporadic uterine leiomyomata. Cancer Genet Cytogenet 138:92-93.
41. Dal Cin P, Boghosian L, Crickard K, Sandberg AA (1988): t(10; 17) as the sole chromosome change in a uterine leiomyosarcoma. Cancer Genet Cytogenet 32:263-266.
42. Dal Cin P, Van den Berghe H, Brosens I (1991): Involvement of 6p in an endometrial polyp. Cancer Genet Cytogenet 51:279-280.
43. Dal Cin P, Aly MS, De Wever I, Moeiman P, Van den Berghe H (1992a): Endometrial stromal sarcoma t(7; 17)(pl 5-21 ;q 12-21) is a nonrandom chromosome change. Cancer Genet Cytogenet 63:43-46.
44. Dal Cin P, De Wolf F, Klerckx P, Van den Berghe H (1992b): The 6p21 chromosome region is nonrandomly involved in endometrial polyps. Gynecol Oncol 46:393-396.
45. Dal Cin P, Moerman P, Deprest J, Brosens I, Van den Berghe H (1995a): A new cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3. Genes Chromosomes Cancer 13:219-220.
46. Dal Cin P, Vanni R, Marras S, Moerman P, Kools P, Andria M, Valdes E, Deprest J, Van de Ven W, Van den Berghe H (1995b): Four cytogenetic subgroups can be identified in endometrial polyps. Cancer Res 55:1565-1568.
47. Dal Cin P, Marynen P, Moerman P, Vergot I, Van den Berghe H (1996): Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). Cancer Genet Cytogenet 91:61-64.
48. Dal Cin P, Pauwels P, Van den Berghe H (1998): Fibrosarcoma versus cellular fibroma of the ovary. Am J Surg Pathol 22:50S-5\0.
49. Debiec-Rychter M, Sciot R, Hagemeijer A (2000): Common chromosome aberrations in the proximal type of epithelioid sarcoma. Cancer Genet Cytogenet 123:133-136.
50. Deger RB, Faruqi SA, Noumoff JS (1997): Karyotypic analysis of 32 malignant epithelial ovarian tumors. Cancer Genet Cytogenet 96:166-173.
51. Delias A, Torhorst J, Jiang F, Proffitt J, Schultheiss E, Holzgreve W, Sauter G, Mihatsch MJ, Moch H (1999): Prognostic value of genomic alterations in invasive cervical squamous cell carcinoma of clinical stage IB detected by comparative genomic hybridization. Cancer Res 59:3475-3479.
52. Dent J, Hall GD, Wilkinson N, Perren TJ, Richmond I, Markham AF, Murphy H, Bell SM (2003): Cytogenetic alterations in ovarian clear cell carcinoma detected by comparative genomic hybridisation. Br J Cancer 88:1578-1583.
53. Dene J, Lagace R, Nicolas A, Mairal A, Chibon F, Coindre JM, Terrier P, Sastre X, Aurias A (2001): Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas. Lab Invest 81:211-215.
54. Dutrillaux B, Couturier J (1986): Chromosome imbalances in endometrial adenocarcinomas: a possible adaptation to abnormal metabolic pathways. Ann Genet 29:76-81.
55. Eccles DM, Brett L, Lessells A (1992): Overexpression of the p53 protein and allele loss at 17pl 3 in ovarian carcinoma. Br J Cancer 65:40-44.
56. Filmus J, Trent J, Pullano R, Buick RN (1986): A cell line from an ovarian carcinoma with amplification of the K-ras gene. Cancer Res 46:5179-5182.
57. Fishman A, Shalom-Paz E, Fejgin M, Gaber E, Altaras M, Amiel A (2005): Comparing the genetic changes detected in the primary and secondary tumor sites of ovarian cancer using comparative genomic hybridization. Int J Gynecol Cancer 15:261-266.
58. Fletcher JA, Morton CC, Pavelka K, Lage JM (1990): Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability. Cancer Res 50:4092-4097.
59. Fletcher JA, Gibas Z, Donovan K, Perez-Atayde A, Genest D, Morton CC, Lage JM (199 la): Ovarian granulosa-stromal cell tumors are characterized by trisomy 12. Am J Pathol 138:515-520.
60. Fletcher JA, Kozakewich HP, Hoffer FA, Lage JM, Weidner N, Tepper R, Pinkus GS, Morton CC, Corson JM (1991b): Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors. N Engl J Med 324:436-442.
61. Fletcher JA, Pinkus JL, Lage JM, Morton CC, Pinkus GS (1992): Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp. Genes Chromosomes Cancer 5:260-263.
62. Foulkes W, Black D, Solomon E, Trowsdale J (1991): Allele loss on chromosome 17q in sporadic ovarian cancer. Lancet 338:444-445.
63. Fresia AE, Currie JL, Farrington JE, Laxman R, Griffin CA (1992): Uterine stromal sarcoma cell line. A cytogenetic and electron microscopic study. Cancer Genet Cytogenet 60:60-66.
64. Fujita H, Wake N, Kutsuzawa T, Ichinoe K, Hreshchyshyn MM, Sandberg AA (1985): Marker chromosomes of the long arm of chromosome 1 in endometrial carcinoma. Cancer Genet Cytogenet 18:283-293.
65. Fuzesi L, Gunawan B, Braun S, Karl MC (1995): Endometrial stromal sarcoma with clonal chromosomal aberrations and mixed phenotype. Cancer Genet Cytogenet 84:85-88.
66. Gibas Z, Rubin SC (1987): Well-differentiated adenocarcinoma of endometrium with simple karyotypic changes: a case report. Cancer Genet Cytogenet 25:21-26.
67. Gibas Z, Griffin CA, Emanuel BS (1988): Clonal chromosome rearrangements in a uterine myoma. Cancer Genet Cytogenet 32:19-24.
68. Gil-Benso R, Lopez-Gines C, Navarro S, Carda C, Llombart-Bosch A (1999): Endometrial stromal sarcomas: immunohistochemical, electron microscopical and cytogenetic findings in two cases. Virchows Arch 434:307-314.
69. Godwin AK, Vanderveer L, Schultz DC (1994): A common region of deletion on chromosome 17q in both sporadic and familial epithelial ovarian tumors distal to BRCA1. Am J Hum Genet 55:666-677.
70. Grammatico P, Catricala C, Potenza C, Amantea A, Roccella M, Roccella F, Eibenschutz L, Del PG (1993): Cytogenetic findings in 20 melanomas. Melanoma Res 3:169-172.
71. Gross KL, Panhuysen CI, Kleinman MS, Goldhammer H, Jones ES, Nassery N, Stewart EA, Morton CC (2004): Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studies. Genes Chromosomes Cancer 41:183-190.
72. Guan XY, Cargile CB, Anzick SL, Thompson FH, Meltzer PS, Bittner ML, Taetle R, McGill JR, Trent JM (1995): Chromosome microdissection identifies cryptic sites of DNA sequence amplification in human ovarian carcinoma. Cancer Res 55:3380-3385.
73. Halbwedl I, Ullmann R, Kremser ML, Man YG, Isadi-Moud N, Lax S, Denk H, Popper HH, Tavassoli FA, Moinfar F (2005): Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. Gynecol Oncol 97:582-587.
74. Halperin D, Visscher DW, Wallis T, Lawrence WD (1995): Evaluation of chromosome 12 copy number in ovarian granulosa cell tumors using interphase cytogenetics. Int J Gynecol Pathol 14:319-323.
75. Hauke S, Rippe V, Bullerdiek J (2001): Chromosomal rearrangements leading to abnormal splicing within intron 4 of HMGIC? Genes Chromosomes Cancer 30:302-304.
76. Hauptmann S, Denkert C, Koch I, Petersen S, Schluns K, Reles A, Dietel M, Petersen I (2002): Genetic alterations in epithelial ovarian tumors analyzed by comparative genomic hybridization. Hum Pathol 33:632-641.
77. Heim S, Nilbert M, Vanni R, Floderus UM, Mandahl N, Liedgren S, Lecca U, Mitelman F (1988): A specific translocation, t(12; 14)(ql4-l 5;q23-24), characterizes a subgroup of uterine leiomyomas. Cancer Genet Cytogenet 32:13-17.
78. Heimann P, Devalck C, Debusscher C, Sariban E, Vamos E (1998): Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. Genes Chromosomes Cancer 23:194-197.
79. Helou K, Padilla-Nash H, Wangsa D, Karlsson E, Osterberg L, Karlsson P, Ried T, Knutsen T (2006): Comparative genome hybridization reveals specific genomic imbalances during the genesis from benign through borderline to malignant ovarian tumors. Cancer Genet Cytogenet 170:1-8.
80. Hennig Y, Deichert U, Stern C, Ghassemi A, Thode B, Bonk U, Meister P, Bartnitzke S, Bullerdiek J (1996): Structural aberrations of chromosome 6 in three uterine smooth muscle tumors. Cancer Genet Cytogenet 87:148-151.
81. Hennig Y, Caselitz J, Bartnitzke S, Bullerdiek J (1997a): A third case of a low-grade endometrial stromal sarcoma with a t(7;l7)(p14 approximately 21;qll.2 approximately 21). Cancer Genet Cytogenet 98:84-86.
82. Hennig Y, Rogalla P, Wanschura S, Frey G, Deichert U, Bartnitzke S, Bullerdiek J (1997b): HMGIC expressed in a uterine leiomyoma with a deletion of the long arm of chromosome 7 along with a 12ql4-15 rearrangement but not in tumors showing del(7) as the sole cytogenetic abnormality. Cancer Genet Cytogenet 96:129-133.
83. Heselmeyer K, Schrock E, du Manoir S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T (1996): Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci USA 93:479-484.
84. Heselmeyer K, Macville M, Schrock E, Blegen H, Hellstrom AC, Shah K, Auer G, Ried T (1997): Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q. Genes Chromosomes Cancer 19:233-240.
85. Heselmeyer K, Hellstrom AC, Blegen H, Schrock E, Silfversward C, Shah K, Auer G, Ried T (1998): Primary carcinoma of the fallopian tube: comparative genomic hybridization reveals high genetic instability and a specific, recurring pattern of chromosomal aberrations, Int J Gynecol Pathol 17:245-254.
86. Hidalgo A, Baudis M, Petersen I, Arreola H, Pina P, Vazquez-Ortiz G, Hernandez D, Gonzalez J, Lazos M, Lopez R, Perez C. Garcia J, Vazquez K, Alatorre B, Salcedo M (2005): Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma. BMC Cancer 5:77.
87. Hirasawa A, Aoki D, lnoue J, Imoto I, Susumu N, Sugano K, Nozawa S, Inazawa J (2003): Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer. Clin Cancer Res 9:5675-5682.
88. Hoffner L, Shen-Schwarz S, Deka R, Chakravarti A, Surti U (1992): Genetics and biology of human ovarian teratomas. III. Cytogenetics and origins of malignant ovarian germ cell tumors. Cancer Genet Cytogenet 62:58-65.
89. Hoglund M, Gisselsson D, Hansen GB, Sail T, Mitelman F (2003): Ovarian carcinoma develops through multiple modes of chromosomal evolution. Cancer Res 63:3378-3385.
90. Horton E, Dobin SM, Debiec-Rychter M, Donner LR (2006): A clonal translocation (7;8)(pl3;q 11.2) in a leiomyoma of the vulva. Cancer Genet Cytogenet 170:58-60.
91. Hruza C, Dobianer K, Beck A, Czerwenka K, Hanak H, Klein M, Leodolter S, Medl M, Miillauer-Ertl S, Preiser J, Rosen A, Salzer H, Sevelda P, Spona J (1993): HER-2 and INT-2 amplification estimated by quantitative PCR in paraffin-embedded ovarian tissue samples. Eur J Cancer 29A.1593-1597.
92. Hrynchak M, Horsman D, Salski C, Berean K, Benedet JL (1994): Complex karyotypic alterations in an endometrial stromal sarcoma. Cancer Genet Cytogenet 77:45-49.
93. Hu J, Khanna V, Jones M, Surti U (2001): Genomic alterations in uterine leiomyosarcomas: potential markers for clinical diagnosis and prognosis. Genes Chromosomes Cancer 31:117-124.
94. Hu J, Khanna V, Jones MM, Surti U (2002): Genomic imbalances in ovarian borderline serous and mucinous tumors. Cancer Genet Cytogenet 139:18-23.
95. Hu J, Khanna V, Jones MW, Surti U (2003): Comparative study of primary and recurrent ovarian serous carcinomas: comparative genomic hybridization analysis with a potential application for prognosis. Gynecol Oncol 89:369-375.
96. Iliszko M, Mandahl N, Mrozek K, Denis A, Pandis N, Pejovic T, Babinska M, Nedoszytko B, Debniak J, Emerich J, Hrabowska M, Bloomfield CD, Limon J (1998): Cytogenetics of uterine sarcomas: presentation of eight new cases and review of the literature. Gynecol Oncol 71:172-176.
97. Ingraham SE, Lynch RA, Kathiresan S, Buckler AJ, Menon AG (1999): hREC2, a RAD51 -like gene, is disrupted by t(12;14) (q!5;q24.1) in a uterine leiomyoma. Cancer Genet Cytogenet 115:56-61.
98. Israeli O, Gotlieb WH, Friedman E, Goldman B, Ben-Baruch G, Aviram-Goldring A, Rienstein S (2003): Familial vs sporadic ovarian tumors: characteristic genomic alterations analyzed by CGH. Gynecol Oncol 90:629-636.
99. Israeli O, Gotlieb WH, Friedman E, Korach J, Friedman E, Goldman B, Zeltser A, Ben-Baruch G, Rienstein S, Aviram-Goldring A (2004): Genomic analyses of primary and metastatic serous epithelial ovarian cancer. Cancer Genet Cytogenet 154:16-21.
100. Iwabuchi H, Sakamoto M, Sakunaga H, Ma YY, Carcangiu ML, Pinkel D, Yang-Feng TL, Gray JW (1995): Genetic analysis of benign, low-grade, and high-grade ovarian tumors. Cancer Res 55:6172-6180.
101. Jee KJ, Kim YT, Kim KR, Kim HS, Yan A, Knuutila S (2001): Loss in 3p and 4p and gain of 3q are concomitant aberrations in squamous cell carcinoma of the vulva. Mod Pathol 14:377-381.
102. Jenkins RB, Bartelt D, Stalboerger P, Persons D, Dahl RJ, Podratz K, Keeney G, Hartmann L (1993): Cytogenetic studies of epithelial ovarian carcinoma. Cancer Genet Cytogenet 71:76-86.
103. Jenkyn DJ, McCartney AJ (1987): A chromosome study of three ovarian tumors. Cancer Genet Cytogenet 26:327-337.
104. Kadan-Lottick NS, Stork L, Ruyle SZ, Koyle M, Hunger SP, McGavran L (2000): Cytogenetic abnormalities in a case of botryoid rhabdomyosarcoma. Med Pediatr Oncol 34:293-295.
105. Kataoka S, Yamada H, Hoshi N, Kudo M, Hareyama H, Sakuragi N, Fujimoto S (2003): Cytogenetic analysis of uterine leiomyoma: the size, histopathology and GnRHa-response in relation to chromosome karyotype. Eur J Obstetr Gynecol Reprod Biol 110:58-62.
106. Kawauchi S, Fukuda T, Miyamoto S, Joshioka JI, Shirahama S, Saito T, Tsukamoto N (1998): Pheripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLY1 chimeric mRNA. Am J Surg Pathol 22:1417-1422.
107. Kawauchi S, Okuda S, Morioka H, Iwasaki F, Fukuma F, Chochi Y, Furuya T, Oga A, Sasaki K (2005): Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study. Hum Pathol 36:1096-1100.
108. Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J (1995a): Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res 55:6038-6039.
109. Kazmierczak B, Wanschura S, Meyer-Bolte K, Caselitz J, Meister P, Bartnitzke S, Van de Ven W, Bullerdiek J (1995b): Cytogenic and molecular analysis of an aggressive angiomyxoma. Am J Pathol 147:580-585.
110. Kazmierczak B, Pohnke Y, Bullerdiek J (1996): Fusion transcripts between the HMGIC gene and RTVL- H-related sequences in mesenchymal tumors without cytogeneticaberrations. Genomics 38:223-226.
111. Kazmierczak B, Dal Cin P, Wanschura S, Borrmann L, Fusco A, Van den Berghe H, Bullerdiek J (1998): HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors. Genes Chromosomes Cancer 23:279-285.
112. Kenny-Moynihan MB, Hagen J, Richman B, Mcintosh DG, Bridge JA (1996): Loss of an X chromosome in aggressive angiomyxoma of female soft parts: a case report. Cancer Genet Cytogenet 89:61-64.
113. Kiechle M, Hinrichs M, Jacobsen A, Luttges J, Pfisterer J, Kommoss F, Arnold N (2000): Genetic imbalances in precursor lesions of endometrial cancer detected by comparative genomic hybridization. Am J Pathol 156:1827-1833.
114. Kiechle M, Jacobsen A, Schwarz-Boeger U, Hedderich J, Pfisterer J, Arnold N (2001): Comparative genomic hybridization detects genetic imbalances in primary ovarian carcinomas as correlated with grade of differentiation. Cancer 91:534-540.
115. Kiechle-Schwarz M, Sreekantaiah C, Berger CS, Pedron S, Medchill MT, Surti U, Sandberg AA (1991): Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract. A report of 35 cases. Cancer Genet Cytogenet 53:125-136.
116. Kiechle-Schwarz M, Kommoss F, Schmidt J, Lukovic L, Walz L, Bauknecht T, Pfleiderer A (1992): Cytogenetic analysis of an adenoid cystic carcinoma of the Bartholin's gland. A rare, semima- lignant tumor of the female genitourinary tract. Cancer Genet Cytogenet 61:26-30.
117. Kim J, Reeves R, Rothman P, Boothby M (1995): The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter. Eur J Immunol 25:798-808.
118. King ME, Micha JP, Allen SL, Mouradian JA, Chaganti RS (1985): Immature teratoma of the ovary with predominant malignant retinal anlage component. A parthenogenically derived tumor. Am J Surg Pathol 9:221-231.
119. King ME, Di Giovanni LM, Yung JF, Clarke-Pearson DL (1990): Immature teratoma of the ovary grade 3, with karyotype analysis, lnt J Gynecol Pathol 9:178-184.
120. Kirchhoff M, Rose H, Petersen BL, Maahr J, Gerdes T, Lundsteen C, Bryndorf T, Kryger-Baggesen N, Christensen L, Engelholm SA, Philip J (1999): Comparative genomic hybridization reveals a recurrent pattern of chromosomal aberrations in severe dysplasia/carcinoma in situ of the cervix and in advanced-stage cervical carcinoma. Genes Chromosomes Cancer 24:144-150.
121. Kiuru M, Launonen V, Hietala M, Aittomaki K, Vierimaa O, Salovaara R, Arola J, Pukkala E, Sistonen P, Herva R, Aaltonen LA (2001): Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology. Am J Pathol 159:825-829.
122. Koontz Jl, Soreng AL, Nucci M, Kuo FC, Pauwels P, Van den Berghe H, Dal Cin P, Fletcher JA, Sklar J (2001): Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl AcadSci USA 98:6348-6353.
123. Kraggerud SM, Szymanska J, Abeler VM, Kaern J, Eknaes M, Heim S, Teixeira MR, Trope CG, Peltomaki P, Lothe RA (2000): DNA copy number changes in malignant ovarian germ cell tumors. Cancer Res 60:3025-3030.
124. Kurose K, Mine N, Doi D, Ota Y, Yoneyama K, Konishi H, Araki T, Emi M (2000): Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12ql5 in a uterine leiomyoma. Genes Chromosomes Cancer 27:303-307.
125. Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, Healey JH, Ueda T, Yoshikawa H, Meloni-Ehrig A, Sorensen PH, Mertens F, Mandahl N, Van den Berghe H, Sciot R, Dal Cin P, Bridge J (2001): The der(17)t(X;l 7)(pl 1 ;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene 20:48-57.
126. Lamie A, Peters G (1991): Chromosome 11 q abnormalities in human cancer. Cancer Cells 3:413-420.
127. Laxman R, Currie JL, Kurman RJ, Dudzinski M, Griffin CA (1993): Cytogenetic profile of uterine sarcomas. Cancer 71:1283-1288.
128. Leung W Y, Schwartz PE, Ng HT, Yang-Feng TL (1990): Trisomy 12 in benign fibroma and granulosa cell tumor of the ovary. Gynecol Oncol 38:28-31.
129. Levan K, Partheen K, Osterberg L, Helou K, Horvath G (2006): Chromosomal alterations in 98 endometrioid adenocarcinomas analyzed with comparative genomic hybridization. Cytogenet Genome Res 115:16-22.
130. Levy B, Mukherjee T, Hirschhorn K (2000): Molecular cytogenetic analysis of uterine leiomyoma and leiomyosarcoma by comparative genomic hybridization. Cancer Genet Cytogenet 121:1-8.
131. Liang SB, Sonobe H, Taguchi T, Takeuchi T, Furihata M, Yuri K, Ohtsuki Y (2001): Tetrasomy 12 in ovarian tumors of thecoma-fibroma group: a fluorescence in situ hybridization analysis using paraffin sections. Pathol Int 51:37-42.
132. Ligon AH, Morton CC (2000): Genetics of uterine leiomyomata. Genes Chromosomes Cancer 28:235-245.
133. Lin YS, Eng HL, Jan YJ, Lee HS, Ho WL, Liou CP, Lee WY, Tzeng CC (2005): Molecular cytogenetics of ovarian granulosa cell tumors by comparative genomic hybridization. Gynecol Oncol 97:68-73.
134. Lindgren V, Waggoner S, Rotmensch J (1996): Monosomy 22 in two ovarian granulosa cell tumors. Cancer Genet Cytogenet 89:93-97.
135. Lorenzato M, Doco M, Visseaux-Coletto B, Ferre D, Bellaoui H, Evrard G, Adnet JJ (1993): Discrepancies of DNA content of various solid tumours before and after culture measured by image analysis. Comparison of cytogenetical data. Pathol Res Pract 189:1161-1168.
136. Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK, Shen CY (2000): P1K3CA as an oncogene in cervical cancer. Oncogene 19:2739-2744.
137. Manegold E, Tietze L, Gunther K, Fleischer A, Amo-Takyi BK, Schroder W, Handt S (2001): Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor. Hum Pathol 32:559-562.
138. Mark J, Havel G, Grepp C, Dahlenfors R, Wedell B (1988): Cytogenetical observations in human benign uterine leiomyomas. Anticancer Res 8:621-626.
139. Mark J, Havel G, Grepp C, Dahlenfors R, Wedell B (1990): Chromosomal patterns in human benign uterine leiomyomas. Cancer Genet Cytogenet 44:1-13.
140. Mayr D, Kaltz-Wittmer C, Arbogast S, Amann G, Aust DE, Diebold J (2002): Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors. Mod Pathol 15:951-957.
141. McCluggage WG (2002): Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer 12:687-690.
142. Meloni AM, Surti U, Contento AM, Davare J, Sandberg AA (1992): Uterine leiomyomas: cytogenetic and histologic profile. Obstetr Gynecol 80:209-217.
143. Mertens F, Kullendorff CM, Hjorth L, Alumets J, Mandahl N (1998): Trisomy 3 as the sole karyotypic change in a pediatric immature teratoma. Cancer Genet Cytogenet 102:83-85.
144. Mhawech P, Kinkel K, Vlastos G, Pelte MF (2002): Ovarian carcinomas in endometriosis: an immuno-histochemical and comparative genomic hybridization study. Int J Gynecol Pathol 21:401-406.
145. Micci F, Teixeira MR, Scheistroen M, Abeler VM, Heim S (2003a): Cytogenetic characterization of tumors of the vulva and vagina. Genes Chromosomes Cancer 38:137-148.
146. Micci F, Walter CU, Teixeira MR, Panagopoulos I, Bjerkehagen B, Saeter G, Heim S (2003b): Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). Cancer Genet Cytogenet 144:119-124.
147. Micci F, Teixeira MR, Haugom L, Kristensen G, Abeler VM, Heim S (2004): Genomic aberrations in carcinomas of the uterine corpus. Genes Chromosomes Cancer 40:229-246.
148. Micci F, Panagopoulos I, Bjerkehagen B, Heim S (2006a): Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res 66:107-112.
149. Micci F, Panagopoulos I, Bjerkehagen B, Heim S (2006b): Deregulation of HMGA2 in an aggressive angiomyxoma with t(ll;12)(q23;ql5). Virchows Arch 448:838-842.
150. Micci F, Haugom L, Abeler VM, Bjerkehagen B, Heim S (2007): Trisomy 7 in postoperative spindle cell nodules. Cancer Genet Cytogenet 174:147-150.
151. Micci F, Haugom L, Abeler MV, Trope CG, Danielsen H, Heim S (2008): Consistent numerical chromosome aberrations in thecofibromas of the ovary. Virchows Arch 452:269-276.
152. Milatovich A, Heerema NA, Palmer CG (1990): Cytogenetic studies of endometrial malignancies. Cancer Genet Cytogenet 46:41-53.
153. Mine N, Kurose K., Konishi H, Araki T, Nagai H, Emi M (2001): Fusion of a sequence from HEI10 (14qll) to the HMGIC gene at 12ql5 in a uterine leiomyoma. Jpn J Cancer Res 92:135-139.
154. Mitelman F, Johansson B, Mertens F, editors (2008): Mitelman Database of Chromosome Aberrations in Cancer. http://cgap.nci.nih.gov/Chromosomes/Mitelman.
155. Moore SD, Herrick SR, Ince TA, Kleinman MS, Dal Cin P, Morton CC, Quade BJ (2004): Uterine leiomyomata with t(l0;17) disrupt the histone acety(transferase MORF. Cancer Res 64:5570-5577.
156. Mrozek K, Limon J, Debniak J, Emerich J (1992): Trisomy 12 and 4 in a thecoma of the ovary. Gynecol Oncol 45:66-68.
157. Muslumanoglu HM, Oner U, Ozalp S, Acikalin MF, Yalcin OT, Ozdemir M, Artan S (2005): Genetic imbalances in endometrial hyperplasia and endometrioid carcinoma detected by comparative genomic hybridization. Eur J Obstetr Gynecol Reprod Biol 120:107-114.
158. Namiq AL, Persons DL, Piehler J, Damjanov I (2005): Monosomy 22 and trisomy 14 in a granulosa tumor metastatic to the lung 20 years after the removal of the primary tumor. Cancer Genet Cytogenet 159:192-193.
159. Narayan G, Pulido HA, KouJ S, Lu XY, Harris CP, Yeh YA, Vargas H, Posso H, Terry MB, Gissmann L, Schneider A, Mansukhani M, Rao PH, Murty VV (2003): Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36. 3-q37. 1 involved in cervical cancer progression. Oncogene 22:3489-3499.
160. Nilbert M, Heim S (1990): Uterine leiomyoma cytogenetics. Genes Chromosomes Cancer 2:3-13.
161. Nilbert M, Heim S, Mandahl N, Floderus UM, Willen H, Akerman M, Mitelman F (1988a): Ring formation and structural rearrangements of chromosome 1 as secondary changes in uterine leiomyomas with t(12;14)(ql4-15;q23-24). Cancer Genet Cytogenet 36:183-190.
162. Nilbert M, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F (1988b): Karyotypic rearrangements in 20 uterine leiomyomas. Cytogenet Cell Genet 49:300-304.
163. Nilbert M, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F (1989): Different karyotypic abnormalities, t(l ;6) and del(7), in two uterine leiomyomas from the same patient. Cancer Genet Cytogenet 42:51-53.
164. Nilbert M, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F (1990a): Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), + 12, and t(12;14), in 44 uterine leiomyomas. Hum Genet 85:605-611.
165. Nilbert M, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F (1990b): Trisomy 12 in uterine leiomyomas. A new cytogenetic subgroup. Cancer Genet Cytogenet 45:63-66.
166. Nilbert M, Mandahl N, Heim S, Rydholm A, Helm G, Willen H, Baldetorp B, Mitelman F (1990c): Complex karyotypic changes, including rearrangements of 12ql3 and 14q24, in two leiomyosarcomas. Cancer Genet Cytogenet 48:217-223.
167. Nilbert M, Jin YS, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F (1990d): Chromosome rearrangements in two uterine sarcomas. Cancer Genet Cytogenet 44:27-35.
168. Nowee ME, Snijders AM, Rockx DA, de Wit RM, Kosma VM, Hamalainen K, Schouten JP, Verheijen RH, van Diest PJ, Albertson DG, Dorsman JC (2007): DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation- dependent probe amplification. J Pathol 213:46-55.
169. Nucci MR, Weremowicz S, Neskey DM, Sornberger K, Tallini G, Morton CC, Quade BJ (2001): Chromosomal translocation t(8;12) induces aberrant HMG1C expression in aggressive angiomyx- oma of the vulva. Genes Chromosomes Cancer 32:172-176.
170. Osterberg L, Akeson M, Levan K, Partheen K, Zetterqvist BM, Brannstrom M, Horvath G (2006): Genetic alterations of serous borderline tumors of the ovary compared to stage I serous ovarian carcinomas. Cancer Genet Cytogenet 167:103-108.
171. Ozisik YY, Meloni AM, Surti U, Sandberg AA (1993a): Deletion 7q22 in uterine leiomyoma. A cytogenetic review. Cancer Genet Cytogenet 71:1-6.
172. Ozisik YY, Meloni AM, Surti U, Sandberg AA (1993b): Involvement of I0q22 in leiomyoma. Cancer Genet Cytogenet 69:132-135.
173. Ozisik YY, Meloni AM, Stone JF, Sandberg AA, Surti U (1994): Spontaneous expression of the chromosome fragile site at 10q23 in leiomyoma. Cancer Genet Cytogenet 74:73-75.
174. Ozisik YY, Meloni AM, Altungoz O, Surti U, Sandberg AA (1995): Translocation (6; 10)(p21 ;q22) in uterine leiomyomas. Cancer Genet Cytogenet 79:136-138.
175. Packenham JP, du Manoir S, Schrock E, Risinger Jl, Dixon D, Denz DN, Evans JA, Berchuck A, Barrett JC, Devereux TR, Ried T (1997): Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. Mot Carcinogen 19:273-279.
176. Palazzo JP, Gibas Z, Dunton CJ, Talerman A (1993): Cytogenetic study of botryoid rhabdomyosarcoma of the uterine cervix. Virchows Arch A Pathol Anat Histopathol 422:87-91.
177. Panagopoulos I, Fioretos T, Isaksson M, Samuelsson U, Billstrom R, Strombeck B, Mitelman F, Johansson B (2001): Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;pl3). Hum Mol Genet 10:395-404.
178. Panani A, Ferti-Passantonopoulou A (1985): Common marker chromosomes in ovarian cancer. Cancer Genet Cytogenet 16:65-71.
179. Panani AD, Roussos C (2006): Non-random structural chromosomal changes in ovarian cancer: i(5p) a novel recurrent abnormality. Cancer Lett 235:130-135.
180. Pandis N, Heim S, Bardi G, Floderus UM, Willen H, Mandahl N, Mitelman F (1990): Parallel karyotypic evolution and tumor progression in uterine leiomyoma. Genes Chromosomes Cancer 2:311-317.
181. Pandis N, Heim S, Bardi G, Floderus UM, Willen H, Mandahl N, Mitelman F (1991): Chromosome analysis of 96 uterine leiomyomas. Cancer Genet Cytogenet 55:11-18.
182. Partheen K, Levan K, Osterberg L, Helou K, Horvath G (2004): Analysis of cytogenetic alterations in stage III serous ovarian adenocarcinoma reveals a heterogeneous group regarding survival, surgical outcome, and substage. Genes Chromosomes Cancer 40:342-348.
183. Patael-Karasik Y, Daniely M, Gotlieb WH, Ben-Baruch G, Schiby J, Barakai G, Goldman B, Aviram A, Friedman E (2000): Comparative genomic hybridization in inherited and sporadic ovarian tumors in [srael. Cancer Genet Cytogenet 121:26-32.
184. Pauwels P, Dal Cin P, Van de Moosdijk CN, Vrints L, Sciot R, Van den Berghe H (1996): Cytogenetics revealing the diagnosis in a metastatic endometrial stromal sarcoma. Histopathology 29:84-87.
185. Pejovic T, Heim S, Mandahl N, Elmfors B, Floderus UM, Furgyik S, Helm G, Willen H, Mitelman F (1989): Consistent occurrence of a 19p + marker chromosome and loss of 11 p material in ovarian seropapillary cystadenocarcinomas. Genes Chromosomes Cancer 1:167-171.
186. Pejovic T, Heim S, Orndal C, Jin YS, Mandahl N, Willen H, Mitelman F (1990a): Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors. Cancer Genet Cytogenet 49:95-101.
187. Pejovic T, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F (1990b): Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary. Cancer Genet Cytogenet 46:65-69.
188. Pejovic T, Heim S, Mandahl N, Elmfors B, Furgyik S, Floderus UM, Helm G, Willen H, Mitelman F (1991): Bilateral ovarian carcinoma: cytogenetic evidence of unicentric origin. Int J Cancer 47:358-361.
189. Pejovic T, Heim S, Mandahl N, Baldetorp B, Elmfors B, Floderus UM, Furgyik S, Helm G, Himmelmann A, Willen H, Mitelman F (1992a): Chromosome aberrations in 35 primary ovarian carcinomas. Genes Chromosomes Cancer 4:58-68.
190. Pejovic T, Himmelmann A, Heim S, Mandahl N, Floderus UM, Furgyik S, Elmfors B, Helm G, Willen H, Mitelman F (1992b): Prognostic impact of chromosome aberrations in ovarian cancer. Br J Cancer 65:282-286.
191. Pejovic T, Heim S, Aim P, Iosif S, Himmelmann A, Skjaerris J, Mitelman F (1993): Isochromosome lq as the sole karyotypic abnormality in a Sertoli cell tumor of the ovary. Cancer Genet Cytogenet 65:79-80.
192. Pejovic T, Aim P, losif SC, Mitelman F, Heim S (1996a): Cytogenetic findings in four malignant mixed mesodermal tumors of the ovary. Cancer Genet Cytogenet 88:53-56.
193. Pejovic T, Iosif CS, Mitelman F, Heim S (1996b): Karyotypic characteristics of borderline malignant tumors of the ovary: trisomy 12, trisomy 7, and r(l) as nonrandom features. Cancer Genet Cytogenet 92:95-98.
194. Pejovic T, Burki N, Odunsi K, Fiedler P, Achong N, Schwartz PE, Ward DC (1999): Well-differentiated mucinous carcinoma of the ovary and a coexisting Brenner tumor both exhibit amplification of 12q 14-21 by comparative genomic hybridization. Gynecol Oncol 74:134-137.
195. Pere H, Tapper J, Seppala M, Knuutila S, Butzow R (1998a): Genomic alterations in fallopian tube carcinoma: comparison to serous uterine and ovarian carcinomas reveals similarity suggesting likeness in molecular pathogenesis. Cancer Res 58:4274-4276.
196. Pere H, Tapper J, Wahlstrom T, Knuutila S, Butzow R (1998b): Distinct chromosomal imbalances in uterine serous and endometrioid carcinomas. Cancer Res 58:892-895.
197. Persons DL, Hartmann LC, Herath JF, Keeney GL, Jenkins RB (1994): Fluorescence in situ hybridization analysis of trisomy 12 in ovarian tumors. Am J Clin Pathol 102:775-779.
198. Phillips NJ, Ziegler MR, Radford DM (1996): Allelic deletion on chromosome 17pl3.3 in early ovarian cancer. Int J Cancer 54:85-91.
199. Polito P, Dal Cin P, Kazmierczak B, Rogalla P, Bullerdiek J, Van den Berghe H (1999): Deletion of HMG17 in uterine leiomyomas with ring chromosome 1. Cancer Genet Cytogenet 108:107-109.
200. Quade BJ, McLachlin CM, Soto-Wright V, Zuckerman J, Mutter GL, Morton CC (1997): Disseminated peritoneal leiomyomatosis. Clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation. Am J Pathol 150:2153-2166.
201. Quade BJ, Pinto AP, Howard DR, Peters WA III, Crum CP (1999): Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma. Am J Pathol 154:945-950.
202. Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC (2003): Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12ql5. Cancer Res 63:1351-1358.
203. Ram TG, Reeves R, Hosick HL (1993): Elevated high mobility group-I(Y) gene expression is associated with progressive transformation of mouse mammary epithelial cells. Cancer Res 53:2655-2660.
204. Rao PH, Arias-Pulido H, Lu XY, Harris CP, Vargas H, Zhang FF, Narayan G, Schneider A, Terry MB, Murty VV (2004): Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma. BMC Cancer 4:5.
205. Rein MS, Powell WL, Walters FC, Weremowicz S, Cantor RM, Barbieri RL, Morton CC (1998): Cytogenetic abnormalities in uterine myomas are associated with myoma size. Mol Hum Reprod 4:83-86.
206. Riopel MA, Spellerberg A, Griffin CA, Perlman EJ (1998): Genetic analysis of ovarian germ cell tumors by comparative genomic hybridization. Cancer Res 58:3105-3110.
207. Rodriguez E, Melamed J, Reuter V, Chaganti RS (1995): Chromosomal abnormalities in choriocarcinomas of the female. Cancer Genet Cytogenet 80:9-12.
208. Russell SEH, Hickey GI, Lowry WS, White P, Atkinson RJ (1990): Allele loss from chromosome 17 in human ovarian cancer. Oncogene 5:1581-1583.
209. Sandberg AA (2005): Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer Genet Cytogenet 158:1-26.
210. Saretzki G, Hoffmann U, Rohlke P (1997): Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome. Cancer 80:1241-1249.
211. Sargent MS, Weremowicz S, Rein MS, Morton CC (1994): Translocations in 7q22 define a critical region in uterine leiomyomata. Cancer Genet Cytogenet 77:65-68.
212. Sato T, Saito H, Morita R, Koi S, Nakamura Y (1991): Allelotype of human ovarian cancer. Cancer Res 51:5118-5122.
213. Satoh Y, Ishikawa Y, Miyoshi T, Mukai H, Okumura S, Nakagawa K (2003): Pulmonary metastases from a low-grade endometrial stromal sarcoma confirmed by chromosome aberration and fluorescence in-situ hybridization approaches: a case of recurrence 13 years after hysterectomy. Virchows Arch 442:173-178.
214. Schoenberg Fejzo M, Ashar HR, Krauter KS, Powell WL, Rein MS, Weremowicz S, Yoon SJ, Kucherlapati RS, Chada K, Morton CC (1996): Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosomes Cancer 17:1-6.
215. Schoenmakers EF, Van de Ven WJ (1997): From chromosome aberrations to the high mobility group protein gene family: evidence for a common genetic denominator in benign solid tumor development. Cancer Genet Cytogenei 95:51-58.
216. Schoenmakers EF, Huysmans C, Van de Ven WJ (1999): Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(l2;14) uterine leiomyomas. Cancer Res 59:19-23.
217. Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, King W, Wilber K, Mihatsch MJ, Moch H (2003): Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at Ilql3.5-ql4 as a critical oncogene target in ovarian carcinoma. Am J Pathol 163:985-992.
218. Schulten HJ, Gunawan B, Enders C, Donhuijsen K, Emons G, Fuzesi L (2004): Overrepresentation of 8q in carcinosarcomas and endometrial adenocarcinomas. Am J Clin Pathol 122:546-551.
219. Schultz DC, Vanderveer L, Berman DB (1996): Identification of two candidate tumor suppressor genes on chromosome 17pl3.3. Cancer Res 56:1997-2002.
220. Schuyer M, Berns EMJJ (2003): TP53 and ovarian cancer. Human Mutation 21:285-291.
221. Schuyer M, Henzen-Logmans SC, van der Burg ME, Fieret JH, Derksen C, Look MP, Meijer-van Gelder ME, Klijn JG, Foekens JA, Berns EM (1999): Genetic alterations in ovarian borderline tumors and ovarian carcinomas. Eur J Obstet Gynecol Reprod Biol 82:147-150.
222. Sell SM, Tullis C, Stracner D, Song CY, Gewin J (2005): Minimal interval defined on 7q in uterine leiomyoma. Cancer Genet Cytogenet 157:67-69.
223. Shah NK, Currie JL, Rosenshein N, Campbell J, Long P, Abbas F, Griffin CA (1994): Cytogenetic and FISH analysis of endometrial carcinoma. Cancer Genet Cytogenet 73:142-146.
224. Sham JS, Tang TC, Fang Y, Sun L, Qin LX, Wu QL, Xie D, Guan XY (2002): Recurrent chromosome alterations in primary ovarian carcinoma in Chinese women. Cancer Genet Cytogenet 133:39-44.
225. Shashi V, Golden WL, von Kap-Herr C, Andersen WA, Gaffey MJ (1994): Interphase fluorescence in situ hybridization for trisomy 12 on archival ovarian sex cord-stromal tumors. Gynecol Oncol 55:349-354.
226. Shelling AN, Cooke IE, Ganesan TS (1995): The genetic analysis of ovarian cancer. Br J Cancer 72:521-527.
227. Shen DH, Khoo US, Xue WC, Ngan HY, Wang JL, Liu VW, Chan YK, Cheung AN (2001): Primary peritoneal malignant mixed Mullerian tumors. A clinicopathologic, immunohistochemical, and genetic study. Cancer 91:1052-1060.
228. Shu Z, Smith S, Wang L, Rice MC, Kmiec EB (1999): Disruption of muREC2/RAD51Ll in mice results in early embryonic lethality which can be partially rescued in a p53(-/-) background. Mol Cell Biol 19:8686-8693.
229. Simon D, Heyner S, Satyaswaroop PG, Farber M, Noumoff JS (1990): Is chromosome 10 a primary chromosomal abnormality in endometrial adenocarcinoma? Cancer Genet Cytogenet 47:155-162.
230. Sirchia SM, Pariani S, Rossella F, Garagiola I, De A, Andreis C, Bulfamante G, Zannoni E, Radaelli U, Simoni G (1997): Cytogenetic abnormalities and microsatellite instability in endometrial adenocarcinoma. Cancer Genet Cytogenet 94:113-119.
231. Skilling JS, Sood A, Niemann T (1996): An abundance of p53 null mutations in ovarian carcinoma. Oncogene 13:117-123.
232. Skomedal H, Kristensen GB, Abeler VM (1997): TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas. 7 Pflf/io/ 181:158-165.
233. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A (1989): Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244:707-712.
234. Smith LM, Hu P, Meyer LJ, Coffin CM (2002): Complex karyotypic abnormality in ovarian fibroma associated with Gorlin syndrome. Am J Med Genet 112:61-64.
235. Snijders AM, Nowee ME, Fridlyand J, Piek JM, Dorsman JC, Jain AN, Pinkel D, van Diest PJ, Verheijen RH, Albertson DG (2003): Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma. Oncogene 22:A2%\-M%t.
236. Sonobe H, Iwata J, Furihata M, Ohtsuki Y, Taguchi T, Shimizu K (1999): Endometrial stromal sarcoma with clonal complex chromosome abnormalities. Report of a case and review of the literature. Cancer Genet Cytogenet 112:34-37.
237. SonodaG, PalazzoJ,DuManoirS, Godwin AK, FederM, Yakushiji M,Testa JR (1997a): Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20ql3 in human ovarian carcinomas. Genes Chromosomes Cancer 20:320-328.
238. Sonoda G, du Manoir S, Godwin AK, Bell DW, Liu Z, Hogan M, Yakushiji M, Testa JR (1997b): Detection of DNA gains and losses in primary endometrial carcinomas by comparative genomic hybridization. Genes Chromosomes Cancer 18:115-125.
239. Sornberger KS, Weremowicz S, Williams AJ, Quade BJ, Ligon AH, PedeutourF, Vanni R, Morton CC (1999): Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6. Cancer Genet Cytogenet J 14:9-16.
240. Speleman F, De Potter C, Dal Cin P, Mangelschots K, Ingelaere H, Laureys G, Benoit Y, Leroy J, Van den Berghe H (1990): i(12p) in a malignant ovarian tumor. Cancer Genet Cytogenet 45:49-53.
241. Speleman F, Laureys G, Benoit Y, Cuvelier C, Suijkerbuijk R, de Jong B (1992): i(12p) in a near-diploid mature ovarian teratoma. Cancer Genet Cytogenet 60:216-218.
242. Sreekantaiah C, Sandberg AA (1991): Clustering of aberrations to specific chromosome regions in benign neoplasms. Int J Cancer 48:194-198.
243. Sreekantaiah C, Bhargava MK, Shetty NJ (1987): Cytogenetic findings in two cases of carcinoma in situ of the cervix uterus. Gynecol Oncol 28:337-341.
244. Sreekantaiah C, Li FP, Weidner N, Sandberg AA (1991): An endometrial stromal sarcoma with clonal cytogenetic abnormalities. Cancer Genet Cytogenet 55:163-166.
245. Staebler A, Heselmeyer-Haddad K, Bell K, Riopel M, Perlman E, Ried T, Kurman RJ (2002): Micropapillary serous carcinoma of the ovary has distinct patterns of chromosomal imbalances by comparative genomic hybridization compared with atypical proliferative serous tumors and serous carcinomas. Hum Pathol 33:47-59.
246. Stern C, Deichert U, Thode B, Bartnitzke S, Bullerdiek J (1992): Cytogenetic subtyping of 139 uterine leiomyoma. Geburtshilfe Frauenheilkunde 52:767-772.
247. Streblow RC, Dafferner AJ, Nelson M, Fletcher M, West WW, Stevens RK, Gatalica Z, Novak D, Bridge JA (2007): Imbalances of chromosomes 4,9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Cancer Genet Cytogenet 178:135-140.
248. Suehiro Y, Sakamoto M, Umayahara K, Iwabuchi H, Sakamoto H, Tanaka N, Takeshima N, Yamauchi K, Hasumi K, Akiya T, Sakunaga H, Muroya T, Numa F, Kato H, Tenjin Y, Sugishita T (2000a): Genetic aberrations detected by comparative genomic hybridization in ovarian clear cell adenocarcinomas. Oncology 59:50-56.
249. Suehiro Y, Umayahara K, Ogata H, Numa F, Yamashita Y, Oga A, Morioka H, Ito T, Kato H, Sasaki K (2000b): Genetic aberrations detected by comparative genomic hybridization predict outcome in patients with endometrioid carcinoma. Genes Chromosomes Cancer 29:75-82.
250. Suzuki A, Fukushige S, Nagase S, Ohuchi N, Satomi S, Horii A (1997): Frequent gains on chromosome arms lq and/or 8q in human endometrial cancer. Hum Genet 100:629-636.
251. Suzuki S, Moore DH, Ginzinger DG, Godfrey TE, Barclay J, Powell B, Pinkel D, Zaloudek C, Lu K, Mills G, Berchuck A, Gray JW (2000): An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res 60:5382-5385.
252. Takahashi T, Nagai N, Oda H, Ohama K, Kamada N, Miyagawa K (2001): Evidence for RAD51L1/ HMGIC fusion in the pathogenesis of uterine leiomyoma. Genes Chromosomes Cancer 30:196-201.
253. Tallini G, Dal Cin P (1999): HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors. Adv Anat Pathol 6:237-246.
254. Tamimi Y, van der Poel HG, Denyn MM, Umbas R, Karthaus HF, Debruyne FM, Schalken JA (1993): Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization. Cancer Res 53:5512-5516.
255. Tanaka K, Boice CR, Testa JR (1989): Chromosome aberrations in nine patients with ovarian cancer. Cancer Genet Cytogenet 43:1-14.
256. Tapper J, Butzow R, Wahlstrom T, Seppala M, Knuutila S (1997): Evidence for divergence of DNA copy number changes in serous, mucinous and endometrioid ovarian carcinomas. Br J Cancer 75:1782-1787.
257. Tapper J, Sarantaus L, Vahteristo P, Nevanlinna H, Hemmer S, Seppala M, Knuutila S, Butzow R (1998): Genetic changes in inherited and sporadic ovarian carcinomas by comparative genomic hybridization: extensive similarity except for a difference at chromosome 2q24-q32. Cancer Res 58:2715-2719.
258. Taruscio D, Carcangiu ML, Ward DC (1993): Detection of trisomy 12 on ovarian sex cord stromal tumors by fluorescence in situ hybridization. Diagn Mol Pathol 2:94-98.
259. Teixeira MR, Kristensen GB, Abeler VM, Heim S (1999): Karyotypic findings in tumors of the vulva and vagina. Cancer Genet Cytogenet 111:87-91.
260. Teyssier JR (1987): Nonrandom chromosomal changes in human solid tumors: application of an improved culture method. J Natl Cancer Inst 79:1189-1198.
261. Tharapel SA, Qumsiyeh MB, Photopulos G (1991): Numerical chromosome abnormalities associated with early clinical stages of gynecologic tumors. Cancer Genet Cytogenet 55:89-96.
262. Thompson FH, Emerson J, Alberts D, Liu Y, Guan X Y, Burgess A, Fox S, Taetle R, Weinstein R, Makar R, Powell D, Trent J (1994a): Clonal chromosome abnormalities in 54 cases of ovarian carcinoma. Cancer Genet Cytogenet 73:33-45.
263. Thompson FH, Liu Y, Emerson J, Weinstein R, Makar R, Trent JM, Taetle R, Alberts DS (1994b): Simple numeric abnormalities as primary karyotype changes in ovarian carcinoma. Genes Chromosomes Cancer 10:262-266.
264. Tibiletti MG, Bernasconi B, Furlan D, Riva C, Trubia M, Buraggi G, Franchi M, Bolis P, Mariani A, Frigerio L, Capella C, Taramelli R (1996): Early involvement of 6q in surface epithelial ovarian tumors. Cancer Res 56:4493-4498.
265. Tibiletti MG, Bernasconi B, Taborelli M, Facco C, Riva C, Capella C, Franchi M, Binelli G, Acquati F, Taramelli R (2003): Genetic and cytogenetic observations among different types of ovarian tumors are compatible with a progression model underlying ovarian tumorigenesis. Cancer Genet Cytogenet 146:145-153.
266. Tomlinson IP, Alam NA, Rowan AS, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomaki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen LA (2002): Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30:406-410.
267. Trent JM, Salmon SE (1981): Karyotypic analysis of human ovarian carcinoma cells cloned in short term agar culture. Cancer Genet Cytogenet 3:279-291.
268. Truss L, Dobin SM, Rao A, Donner LR (2004): Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. Cancer Genet Cytogenet 148:118-122.
269. Turc-Care] C, Dai Cin P, Boghosian L, Terk-Zakarian J, Sandberg AA (1988): Consistent breakpoints in region 14q22-q24 in uterine leiomyoma. Cancer Genet Cytogenet 32:25-31.
270. Van den Berg E, Molenaar WM, Hoekstra HJ, Kamps WA, de Jong B (1992): DNA ploidy and karyotype in recurrent and metastatic soft tissue sarcomas. Mod Pathol 5:505-514.
271. Van den Berghe I, Dal Cin P, De Groef K, Michielssen P, Van den Berghe H (1999): Monosomy 22 and trisomy 14 may be early events in the tumorigenesis of adult granulosa cell tumor. Cancer Genet Cytogenet 112:46-48.
272. Vanni R, Nieddu M, Paoli R, Lecca U (1989): Uterine leiomyoma cytogenetics. I. Rearrangements of chromosome 12. Cancer Genet Cytogenet 37:49-54.
273. Vanni R, Dal Cin P, Van den Berghe H (1990): Is the chromosome band lp36 another hot-spot for rearrangements in uterine leiomyoma? Genes Chromosomes Cancer 2:255-256.
274. Vanni R, Lecca U, Faa G (1991): Uterine leiomyoma cytogenetics. II. Report of forty cases. Cancer Genet Cytogenet 53:247-256.
275. Vanni R, Dal Cin P, Marras S, Moerman P, Andria M, Valdes E, Deprest J, Van den Berghe H (1993): Endometrial polyp: another benign tumor characterized by 12ql3-qI5 changes. Cancer Genet Cytogenet 68:32-33.
276. Vanni R, Marras S, Andria M, Faa G (1995): Endometrial polyps with predominant stromal component are characterized by a t(6;14)(p21;q24) translocation. Cancer Res 55:31-33.
277. Verdorfer I, Horst D, Hollrigl A, Rogatsch H, Mikuz G (2007): Sertoli-Leydig cell tumours of the ovary and testis: a CGH and FISH study. Virchows Arch 450:267-271.
278. Verhest A, Simonart T, Noel JC (1996): A unique clonal chromosome 2 deletion in endomyometriosis. Cancer Genet Cytogenet 86:174-176.
279. Wake N, Hreshchyshyn MM, Piver SM, Matsui S, Sandberg AA (1980): Specific cytogenetic changes in ovarian cancer involving chromosomes 6 and 14. Cancer Res 40:4512-4518.
280. Wanschura S, Dal Cin P, Kazmierczak B, Bartnitzke S, Van den Berghe H, Bullerdiek J (1997): Hidden paracentric inversions of chromosome arm 12q affecting the HMGIC gene. Genes Chromosomes Cancer 18:322-323.
281. Weise W, Buttner HH (1972): Analysis of chromosomes in a primary Fallopian tube carcinoma with interpretation of chromosomal peculiarities in uterine corpus carcinoma. Zentralbl Gynakol 94:1761-1767.
282. Weremowicz S, Morton CC (1999): Is HMGIC rearranged due to cryptic paracentric inversion of I2q in karyotypically normal uterine leiomyomas? Genes Chromosomes Cancer 24:172-173.
283. Whang-Peng J, Knutsen T, Douglass EC, Chu E, Ozols RF, Hogan WM, Young RC (1984): Cytogenetic studies in ovarian cancer. Cancer Genet Cytogenet 11:91-106.
284. Williams AJ, Powell WL, Collins T, Morton CC (1997): HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasm. Am J Pathol 150:911-918.
285. Wilting SM, Snijders PJ, Meijer GA, Ylstra B, van den Ijssel PR, Snijders AM, Albertson DG, Coffa J, Schouten JP, van de Wiel MA, Meijer CJ, Steenbergen RD (2006): Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix. J Pathol 209:220-230.
286. Wolf NG, Abdul-Karim FW, Farver C, Schrock E, du Manoir S, Schwartz S (1999): Analysis of ovarian borderline tumors using comparative genomic hybridization and fluorescence in situ hybridization. Genes Chromosomes Cancer 25:307-315.
287. Worsham MJ, Van Dyke DL, Grenman SE, Grenman R, Hopkins MP, Roberts JA, Gasser KM, Schwartz DR. Carey TE (1991): Consistent chromosome abnormalities in squamous cell carcinoma of the vulva. Genes Chromosomes Cancer 3:420-432.
288. Yang-Feng TL, Katz SN, Cacangiu ML, Schwartz PE (1988): Cytogenetic analysis of ependymoma and teratoma of the ovary. Cancer Genet Cytogenet 35:83-89.
289. Yang-Feng TL, Li SB, Leung WY, Carcangiu ML, Schwartz PE (1991): Trisomy 12 and K-ras-2 amplification in human ovarian tumors. Int J Cancer 48:678-681.
290. Yonescu R, Currie JL, Hedrick L, Campbell J, Griffin CA (1996): Chromosome abnormalities in primary endometrioid ovarian carcinoma. Cancer Genet Cytogenet 87:167-171.
291. Yoshida MA, Ohyashiki K, Piver SM, Sandberg AA (1986): Recurrent endometrial adenocarcinoma with rearrangement of chromosomes 1 and 11. Cancer Genet Cytogenet 20:159-162.
292. Zahn S, Sievers S, Alemazkour K, Orb S, Harms D, Schulz WA, Calaminus G, Gobel U, Schneider DT (2006): Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: a combined comparative genomic hybridization and microsatellite analysis. Genes Chromosomes Cancer 45:995-1006.
293. Zweemer RP, Ryan A, Snijders AM, Hermsen MA, Meijer GA, Beller U, Menko FH, Jacobs U, Baak JP, Verheijen RH, Kenemans P, van Diest PJ (2001): Comparative genomic hybridization of microdissected familial ovarian carcinoma: two deleted regions on chromosome 15q not previously identified in sporadic ovarian carcinoma. Lab Invest 81:1363-1370.