Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas

Genes Chromosomes and Cancer

Volumn 17, Issue 1, 1996, Pages 1-6

  Schoenberg Fejzo, Marlena ^a   Ashar, Hena R ^b   Krauter, Kenneth S ^c   Lee Powell, W ^d   Rein, Mitchell S ^a,d   Weremowicz, Stanislawa ^a,d   Yoon, Sung Joo ^c   Kucherlapati, Raju S ^c   Chada, Kiran ^b   Morton, Cynthia C ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 12Q; CHROMOSOME MAP; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 12; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CONTROL; GENE TRANSLOCATION; HUMAN; LIPOMA; PRIORITY JOURNAL; REGULATORY MECHANISM; UTERUS MYOMA;

CHROMOSOMES, HUMAN, PAIR 12; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEIOMYOMA; LIPOMA; TRANSLOCATION, GENETIC; UTERINE NEOPLASMS;

EID: 0001768750     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199609)17:1<1::AID-GCC1>3.0.CO;2-0     Document Type: Article

References (24)

1. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K (1995) Disruption of the architectural factor HMGIC: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82:57-65.
2. Berlingieri MT, Manfioletti G, Santoro M, Bandiera A, Visconti R, Giancotti V, Fusco A (1995) Inhibition of HMGIC protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Mol Cell Biol 15:1545-1553.
3. Bullerdiek J, Wobst G, Meyer-Bolte K, Chilla R, Haubrich J, Thode B, Bartnitzke S (1993) Cytogenetic subtyping of 220 salivary gland pleomorphic adenomas: Correlation to occurrence, histological subtype, and in vitro cellular behavior. Cancer Genet Cytogenet 65:27-31.
4. Cramer DW (1992) Epidemiology of myomas. Semin Reprod Endocrinol 10:320-324.
5. Dal Cin P, Kools P, De Jonge I, Moerman P, Van de Ven W, Van den Berghe H (1993) Rearrangements of 12q14-15 in pulmonary chondroid hamartoma. Genes Chromosom Cancer 8:131-133.
6. Fletcher JA, Longtine J, Wallace K, Mentzer SJ, Sugarbaker DJ (1995) Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: Evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosom Cancer 12:220-223.
7. Giancotti V, Buratti E, Perissin L, Zorzet S, Balmain A, Portella G, Fusco A, Goodwin GH (1989) Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures. Exp Cell Res 184:538-545.
8. Holt JT, Morton CC, Nienhuis AW, Leder P (1987) Molecular mechanisms of hematological neoplasms. In Stamatoyannopoulos G, Nienhuis AW, Leder P, Majerus PW (eds): The Molecular Basis of Blood Diseases. Philadelphia: W.B. Saunders Co., pp 360-362.
9. Kazmierczak B, Wanschura S, Meyer-Bolte K, Caselitz J, Meister P, Bartnitzke S, Van de Ven W, Bullerdiek J (1995a) Cytogenetic and molecular analysis of an aggressive angiomyxoma. Am J Path 147:580-585.
10. Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J (1995b) Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res 55:6038-6039.
11. Kazmierczak B, Rosigkeit J, Wanschura S, Meyer-Bolte K, Van de Ven W, Kayser K, Krieghoff B, Kastendiek H, Bartnitzke S, Bullerdiek J (1996) HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: A survey of 30 tumors. Oncogene 12:515-521.
12. Mandahl N, Orndal C, Heim S, Willen H, Rydholm A, Bauer HC, Mitelman F (1993) Aberrations of chromosome segment 12q13-15 characterize a subgroup of hemangiopericytomas. Cancer 71: 3009-3013.
13. National Center for Health Statistics (1987) Hysterectomies in the United States 1965-1984. Vital and Health Statistics, Series 13, No. 92. Washington, DC: US Department of Health and Human Services, Public Health Service, Centers for Disease Control, DHHS Publication no 88-1753.
14. Nilbert M, Heim S (1990) Uterine leiomyoma cytogenetics. Genes Chromosom Cancer 2:3-13.
15. Rein MS, Friedman AJ, Barbieri RL, Pavelka K, Fletcher JA, Morton CC (1991) Cytogenetic abnormalities in uterine leiomyomata. Obstet Gynecol 77:923-926.
16. Rohen C, Bonk U, Staats B, Bartnitzke S, Bullerdiek J (1993) Two human breast tumors with translocations involving 12q13-15 as the sole cytogenetic abnormality. Cancer Genet Cytogenet 69: 68-71.
17. Sandros J, Stenman G, Mark J (1990) Cytogenetic and molecular observations in human and experimental salivary gland tumors. Cancer Genet Cytogenet 44:153-167.
18. Sargent MS, Weremowicz S, Rein MS, Morton CC (1994) Translocations in 7q22 define a critical region in uterine leiomyomata. Cancer Genet Cytogenet 77:65-68.
19. Schoenberg Fejzo M, Yoon S-J, Montgomery KT, Rein MS, Weremowicz S, Krauter KS, Dorman TE, Fletcher JA, Mao J, Moir DT, Kucherlapati RS, Morton CC (1995) Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma, and lipoma: Physical mapping of the 12q14-q15 breakpoint region in uterine leiomyomata. Genomics 26:265-271.
20. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJM (1995) Recurrent rearrangements in the high mobility group protein gene, HMGIC, in benign mesenchymal tumours. Nature Genet 10:436-443.
21. Sreekantaiah C, Leong SLP, Karakousis CP, McGee DL, Rappaport WD, Villar HV, Neal D, Fleming S, Wankel A, Herrington PN, Carmona R, Sandberg AA (1991) Cytogenetic profile of 109 lipomas. Cancer Res 51:422-433.
22. Vanni R, Dal Cin P, Marras S, Moerman P, Andria M, Valdes E, Deprest J, Van den Berghe H (1993) Endometrial polyp: Another benign tumor characterized by 12q13-q15 changes. Cancer Genet Cytogenet 68:32-33.
23. Walter TA, Fan SX, Medchill MT, Berger CS, Decker H-JH, Sandberg AA (1989) Inv(12)(p11.2q13) in an endometrial polyp. Cancer Genet Cytogenet 41:99-103.
24. Xiang X, Benson KF, Chada K (1990) Mini-mouse: Disruption of the pygmy locus in a transgenic insertional mutant. Science 247: 967-969.