Comparative genomic hybridization of microdissected familial ovarian carcinoma: Two deleted regions on chromosome 15q not previously identified in sporadic ovarian carcinoma

Laboratory Investigation

Volumn 81, Issue 10, 2001, Pages 1363-1370

  Zweemer, Ronald P ^a   Ryan, Andy ^b   Snijders, Antoine M ^a   Hermsen, Mario A J A ^a   Meijer, Gerrit A ^a   Beller, Uziel ^c   Menko, Fred H ^a   Jacobs, Ian J ^a   Baak, Jan P A ^a   Verheijen, René H M ^c   Kenemans, Peter ^c   Van Diest, Paul J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 11Q; CHROMOSOME 12Q; CHROMOSOME 15Q; CHROMOSOME 16Q; CHROMOSOME 17P; CHROMOSOME 18Q; CHROMOSOME 20Q; CHROMOSOME 22Q; CHROMOSOME 2Q; CHROMOSOME 3Q; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME 9Q; CHROMOSOME DELETION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FAMILIAL DISEASE; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; GERM LINE; HEREDITY; HUMAN; ONCOGENE; OVARY CARCINOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0034780110     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780350     Document Type: Article

References (41)

1. Overrepresentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer
2. c-myc amplification in ovarian cancer
3. Molecular genetics of hereditary ovarian cancer
4. Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis of CYP2D6, SREBP2 and NAGA
5. Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q
6. Xp22.2-3 loss of heterozygosity is associated with germline BRCA1 mutation in ovarian cancer
7. Human epithelial ovarian cancer allelotype
8. Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer
9. A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: Localization of the candidate region within a single 840 kb YAC
10. Genetic analysis of 53 lymph node-negative breast carcinomas by CGH and relation to clinical, pathological, morphometric, and DNA cytometric prognostic factors
11. Rapid detection of BRCA1 mutations by the protein truncation test
12. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
13. Genetic analysis of benign, low-grade, and high-grade ovarian tumors
14. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
15. Phosphatidylinositol 3-kinase
16. Ovarian cancer incidence (1989-1991) and mortality (1954-1993) in The Netherlands
17. Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer
18. Progression from colorectal adenoma to carcinoma is associated with nonrandom chromosomal gains as detected by comparative genomic hybridisation
19. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
20. Allelic loss on chromosome 9q is associated with lymph node metastasis of primary breast cancer
21. Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization
22. Distinct chromosomal imbalances in uterine serous and endometrioid carcinomas
23. Chromosomal imbalances in brain metastases of solid tumors
24. BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients
25. Loss of heterozygosity at 8p, 9p and 17q in laryngeal cytological specimens
26. Association of BRCA1 with Rad51 in mitotic and meiotic cells
27. Deletion mapping and linkage analysis provide strong indication for the involvement of the human chromosome region 8p12-p22 in breast carcinogenesis
28. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
29. PIK3CA is implicated as an oncogene in ovarian cancer
30. Evidence for two tumor suppressor loci associated with proximal chromosome 9p toq and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations
31. Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas
32. Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers
33. Genetic changes in inherited and sporadic ovarian carcinomas by comparative genomic hybridization: Extensive similarity except for a difference at chromosome 2q24-q32
34. Somatic genetic alterations in BRCA2-associated and sporadic male breast cancer
35. Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes
36. Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23
37. Allelic loss and microsatellite instability in prostate cancers in Japan
38. Comparative genomic hybridisation
39. Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer
40. Clinical and genetic evaluation of thirty ovarian cancer families
41. Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations