Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q

Genes Chromosomes and Cancer

Volumn 19, Issue 4, 1997, Pages 233-240

  Heselmeyer, Kerstin ^a,b   Macville, Merryn ^a   Schröck, Evelin ^a   Blegen, Harald ^b   Hellström, Ann Cathrin ^c   Shah, Keerti ^d   Auer, Gert ^b   Ried, Thomas ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED CANCER; ARTICLE; CHROMOSOME 3Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; FEMALE; GENE MAPPING; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 3; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; KARYOTYPING; MIDDLE AGED; NEOPLASM STAGING; NUCLEIC ACID HYBRIDIZATION; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PLOIDIES; TUMOR VIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS;

HUMAN PAPILLOMA VIRUS; PAPILLOMAVIRUS;

EID: 0030841013     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199708)19:4<233::AID-GCC5>3.0.CO;2-Y     Document Type: Article

References (29)

1. Shepherd JH (1989) Revised FIGO-staging for gynaecological cancer. Br J Obstet Gynaecol 96:889-892.
2. Atkin NB, Baker MC, Fox MF (1990) Chromosome changes in 43 carcinomas of the cervix uteri. Cancer Genet Cytogenet 44:229-241.
3. Auer G, Askensten U, Ahrens O (1989) Cytophotometry. Hum Pathol 20:518-527.
4. Auer GU, Heselmeyer KM, Steinbeck RG, Munck-Wikland E, Zetterberg A (1994) The relationship between aneuploidy and p53 overexpression during genesis of colorectal adenocarcinomas. Virchows Arch 424:343-347.
5. Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV (1995) Prevalence of human papillomavirus in cervical cancer: A worldwide perspective. J Natl Cancer Inst 87:796-802.
6. du Manoir S, Schröck E, Bentz M, Speicher MR, Joos S, Ried T, Lichter P, Cremer T (1995) Quantification of comparative genomic hybridization. Cytometry 19:27-11.
7. Fearon ER, Vogelstein B (1990) A genetic model for colorectal carcinogenesis. Cell 61:759-767.
8. Hakama M, Miller AB, Day NE (1986) Screening for Cancer of the Uterine Cervix. IARC Scientific Publications No. 76. Lyon: IARC.
9. Heselmeyer K, du Manoir S, Blegen H, Friberg B, Svensson C, Schröck E, Veldman T, Shah K, Auer G, Ried T. A recurrent pattern of chromosomal aberrations and immunophenotypic appearance defines and squamous cell carcinomas. Br J Cancer, in press.
10. Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T (1996) Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci USA 93:479-484.
11. Hildesheim A, Schiffman MH, Gravitt PE, Glass AG, Greer CE, Zhang T, Scott DR, Rush BB, Lawler P, Sherman ME, Kurman RJ, Manos MM (1994) Persistence of type specific human papillomavirus infection among cytologically normal women. J Infect Dis 169:235-240.
12. International Agency for Research on Cancer (IARC) (1995) IARC Monograph on the Evaluation of Carcinogenic Risks to Humans. Vol 64. Human Papillomaviruses. Lyon: IARC.
13. Isola J, DeVries S, Chu L, Ghazrini S, Waldman F (1994) Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples. Am J Pathol 145:1301-1308.
14. Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821.
15. Kallioniemi A, Kallioniemi O-P, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM (1994) Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci USA 91:2156-2160.
16. Kim DH, Mohapatra G, Bollen A, Waldman FM, Feuerstein BG (1995) Chromosomal abnormalities in glioblastoma multiforme and glioma cell lines detected by comparative genomic hybridization. Int J Cancer 16:812-819.
17. Levin NA, Brzoska PM, Warnock ML, Gray JW, Christman MF (1995) Identification of novel regions of altered DNA copy number in small cell lung tumors. Genes Chromosom Cancer 13:175-185.
18. Mitra AB, Murty VV, Singh V, Li RG, Pratap M, Sodhani P, Luthra UK, Chaganti RS (1995) Genetic alterations at 5p15: A potential marker for progression. J Natl Cancer Inst 87:742-745.
19. Mullokandov MR, Kholodilov NG, Atkin NB, Burk RD, Johnson AB, Klinger HP (1996) Genomic alterations in cervical carcinoma: Losses of chromosomal heterozygosity and human papilloma virus tumor status. Cancer Res 56:197-205.
20. Pisani P, Parkin DM, Ferlay J (1993) Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int J Cancer 55:891-903.
21. Popescu NC, DiPaolo JA (1992) Cytogenetics of cervical neoplasia. Cancer Genet Cytogenet 60:214-215.
22. Ried T, Just KE, Holtgreve-Grez H, du Manoir S, Speicher MR, Schröck E, Latham C, Blegen H, Zetterberg A, Cremer T, Auer G (1995) Comparative genomic hybridization of formalin fixed, paraffin embedded breast carcinomas reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res 55:5415-5423.
23. Ried T, Knutzen R, Steinbeck R, Blegen H, Schröck E, Heselmeyer K, du Manoir S, Auer G (1996) Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosom Cancer 15:234-245.
24. Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schröck E, du Manoir S, Cremer T (1994) Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization. Cancer Res 54:1801-1806.
25. Schröck E, Thiel G, Lozanova T, du Manoir S, Meffert MC, Jauch A, Speicher MR, Nürnberg P, Vogel S, Jänisch W, Donis-Keller H, Ried T, Witkowski R, Cremer T (1994) Comparative genomic hybridization of human glioma reveals consistent genetic imbalances and multiple amplification sites. Am J Pathol 144:1203-1218.
26. Speicher MR, du Manoir S, Schröck E, Holtgreve-Grez H, Schoell B, Lengauer C, Cremer T, Ried T (1993) Molecular cytogenetic analysis of formalin fixed, paraffin embedded solid tumors by comparative hybridization after universal DNA-amplification. Hum Mol Genet 2:1907-1914.
27. Srivatsan ES, Misra BC, Venugopalan M, Wilczynski SP (1991) Loss of heterozygosity for alleles on chromosome 11 in cervical carcinoma. Am J Hum Genet 49:868-877.
28. Steinbeck RG, Heselmeyer K, Moberger H, Auer G (1995) The relationship between proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 during genesis of cervical carcinoma. Acta Oncol 34:171-175.
29. Zur Hausen H (1994) Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix. Lancet 343:955-957.