Evidence for RAD5ILI/HMGIC fusion in the pathogenesis of uterine leiomyoma

Genes Chromosomes and Cancer

Volumn 30, Issue 2, 2001, Pages 196-201

  Takahashi, Tomoko ^a   Nagai, Nobutaka ^b   Oda, Hiromune ^c   Ohama, Koso ^b   Kamada, Nanao ^a   Miyagawa, Kiyoshi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c TSUCHIYA GENERAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; DNA BINDING PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN; HIGH MOBILITY GROUP PROTEIN; ONCOPROTEIN; RAD51 PROTEIN; RAD51 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 12Q; CHROMOSOME 14Q; CHROMOSOME BAND; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; FEMALE; GENE FUSION; GENETIC RECOMBINATION; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS MYOMA; ADULT; ALTERNATIVE RNA SPLICING; GENE DELETION; GENE TRANSLOCATION; GENETICS; LEIOMYOMA; MIDDLE AGED; UTERUS CANCER;

ADULT; ALTERNATIVE SPLICING; DNA-BINDING PROTEINS; FEMALE; HIGH MOBILITY GROUP PROTEINS; HMGA2 PROTEIN; HUMANS; LEIOMYOMA; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; RAD51 RECOMBINASE; SEQUENCE DELETION; TRANSLOCATION, GENETIC; UTERINE NEOPLASMS;

EID: 0034746806     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1078>3.0.CO;2-8     Document Type: Article

References (30)

1. In vivo modulation of HMGIC reduces obesity
2. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains
3. Regulation of HMGIC expression: An architectural transcription factor involved in growth control and development
4. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis
5. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas
6. Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis
7. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
8. Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts
9. 1 delay and hypersensitivity to ultraviolet irradiation
10. HsRec2/Rad51L1, a protein influencing cell cycle progression, has protein kinase activity
11. Detection of chromosomal abnormalities in uterine leiomyoma using conventional cytogenetic method and interphase fluorescence in situ hybridization
12. A specific translocation, t(12; 14)(q14-q15; q23-q24), characterizes a subgroup of uterine leiomyomas
13. hREC2, a RAD51-like gene, is disrupted by t(12;14)(q15; q24A) in a uterine leiomyoma
14. Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene
15. Pure mesenchymal neoplasms of the uterine corpus
16. Novel gene fusion of COX6C at 8q22-q23 to HMGIC at 12q15 in a uterine leiomyoma
17. Chromosome analysis of 96 uterine lelonayomas
18. Expression and cDNA cloning of human HMGI-C phosphoprotein
19. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family
20. The A · T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure
21. Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis
22. Evidence for simultaneous protein interactions between human RAD51 paralogs
23. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyoma suggest dysregulation of this gene by a mechanism different from that in lipomas
24. Recurrent rearrangements in the high mobility group protein gene, HMGIC, in benign mesenchymal tumors
25. Allelic knockout of novel splice variants of human recombination repair gene RADS1B in t(12;14) uterine leiomyomas
26. -/- background
27. Chromosomal aberrations in soft tissue tumors. Relevance to diagnosis, classification, and molecular mechanisms
28. Architectural transcription factors
29. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C