Cytogenetic abnormalities in uterine myomas are associated with myoma size

Molecular Human Reproduction

Volumn 4, Issue 1, 1998, Pages 83-86

  Rein, Mitchell S ^a,b   Powell, W Lee ^a   Walters, Frederick C ^a   Weremowicz, Stanislawa ^a,b   Cantor, Rita M ^c   Barbieri, Robert L ^a,b   Morton, Cynthia C ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Chromosomes; Cytogenetics; Fibroids; Leiomyomata; Uterine myomas

Indexed keywords

ADULT; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME MOSAICISM; FEMALE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; KARYOTYPING; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; UTERUS MYOMA;

ADULT; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; FEMALE; HUMANS; KARYOTYPING; LEIOMYOMA; MIDDLE AGED; UTERINE NEOPLASMS;

EID: 0031910528     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/4.1.83     Document Type: Article

References (21)

1. Ashar, H R., Schoenberg Fejzo, M., Tkachenko, A. et al (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell. 82, 57-65.
2. Bullerdiek, J., Bartnitzke, S., Weinberg, M. et al. (1987) Rearrangements of chromosome region 12q13-15 in pleomorphic adenomas of the human salivary gland (PSA). Cytogenet. Cell Genet., 45, 187-190.
3. Fletcher, J.A., Morton, C.C., Pavelka, K. and Lage, J.M. (1990) Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability. Cancer Res., 50, 4092-4097.
4. Gambone, J.C , Reiter, R.C., Lench, J.B. and Moore, J.G. (1990) The impact of a quality assurance process on the frequency and confirmation rate of hysterectomy. Am. J. Obstet. Gynecol., 63, 545-550.
5. Hennig, Y., Wanschura, S., Deichert, U. et al. (1996) Rearrangements of the high mobility group protein family genes and the molecular genetic origin of uterine leiomyomas and endometrial polyps. Mol Hum. Reprod., 2, 277-83.
6. Kazmierczak, B., Hennig, Y., Wanschura, S. et al. (1995) Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res., 55, 6038-6039.
7. Kazmierczak, B., Pohnke, Y. and Bullerdiek, J. (1996a) Fusion transcripts between HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Genomics, 38, 223-226.
8. Kazmierczak, B , Bol, S., Wanschura, S. et al. (1996b) PAC clone containing the HMGI(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line. Genes Chromosom. Cancer, 17, 191-193.
9. Mandahl, N., Heim, S., Johannson, B. et al. (1987) Lipomas have characteristic structural chromosomal rearrangements of 12q13-14. Int. J. Cancer, 39, 685-688.
10. Mark, J., Havel, G., Grepp, C. et al. (1990) Chromosomal patterns in human benign uterine leiomyomas. Cancer Genet. Cytogenet., 44, 1-13.
11. Mashal, R.D., Fejzo, M.S., Friedman, A.J. et al. (1994) Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata. Genes Chromosom. Cancer, 11, 1-6.
12. Nilbert, M. and Heim, S. (1990) Uterine leiomyoma cytogenetics. Genes Chromosom. Cancer, 2, 3-13.
13. Rein, M.S., Friedman, A.J., Barbieri, R.L. et al. (1991) Cytogenetic abnormalities in uterine leiomyomata. Obstet. Gynecol., 77, 923-926.
14. Rein, M.S., Barbieri, R.L and Friedman, A.J. (1995) Progesterone: A critical role in the pathogenesis of uterine myomas. Am. J. Obstet. Gynecol., 172, 14-18.
15. Sargent, M.S., Weremowicz, S., Rein, M.S. and Morton, C.C. (1994) Translocations in 7q22 define a critical region in uterine leiomyomata. Cancer Genet. Cytogenet., 77, 65-68.
16. Schoenberg Fejzo, M., Yoon, S.-J., Montgomery, K. et al (1995) Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma and lipoma: physical mapping of the 12q14-q15 breakpoint region in uterine leiomyomata. Genomics, 26, 265-271.
17. Schoenberg Fejzo, M., Ashar, H.R., Krauter, K.S. et al. (1996) Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosom. Cancer, 17, 1-6.
18. Schoenmakers, E.F.P.M., Wanschura, S., Mols, R. et al. (1995) Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genet., 10, 436-443.
19. Townsend, D.E., Sparkes, R.S., Baluda, M.C. and McClelland, G. (1970) Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenase. Am. J. Obstet. Gynecol., 107, 1168-1173.
20. Williams, A.J., Powell, W.L., Coffins, T. and Morton, C.C. (1997) HMGI(Y) expression in human uterine leiomyomata: Involvement of another HMG architectural factor in a benign neoplasm. Am. J. Pathol., 150, 911-918.
21. Xing, Y.P., Powell, W.L. and Morton, C.C. (1997) The del(7q) subgroup in uterine leiomyomata: Genetic and biologic characteristics. Cancer Genet. Cytogenet., 98, 69-74.