Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15

Cancer Research

Volumn 63, Issue 6, 2003, Pages 1351-1358

  Quade, Bradley J ^a   Weremowicz, Stanislawa ^a   Neskey, David M ^a   Vanni, Roberta ^b   Ladd, Carll ^c   Cin, Paola Dal ^a   Morton, Cynthia C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c Conn Stt Police Forensic Sci Lab ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN; PROTEIN HMGA2; UNCLASSIFIED DRUG;

ARTICLE; CENTROMERE; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 12Q; CHROMOSOME 14; CHROMOSOME 14Q; CHROMOSOME 5; CHROMOSOME 8; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME INSERTION; CHROMOSOME MAP; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; DNA FLANKING REGION; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE LOCUS; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MOLECULAR MECHANICS; MOSAICISM; MYOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA SPLICING; SEQUENCE ANALYSIS; TELOMERE; TUMOR; TUMOR CELL; UTERUS MYOMA;

ALTERNATIVE SPLICING; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 12; DNA-BINDING PROTEINS; FEMALE; GENE REARRANGEMENT; HMGA2 PROTEIN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEIOMYOMA; ONCOGENE PROTEINS, FUSION; RAD51 RECOMBINASE; RNA, MESSENGER; TELOMERE; UTERINE NEOPLASMS;

EID: 0037444280     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Petit, M. M. R., Mols, R., Schoenmakers, E. F. P. M., Mandahl, N., and Van de Ven, W. J. M. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics, 36: 118-129, 1996.
2. Petit, M. M. R., Schoenmakers, E. F. P. M., Huysmans, C., Geurts, J. M. W., Mandahl, N., and Van de Ven, W. J. M. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. Genomics, 57: 438-441, 1999.
3. Schoenmakers, E. F. P. M., Huysmans, C., and Van de Ven, W. J. M. Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. Cancer Res., 59: 19-23, 1999.
4. Ingraham, S. E., Lynch, R. A., Kathiresan, S., Buckler, A. J., and Menon, A. G. hREC2, a RAD51-like gene, is disrupted by t(12;14)(q15;q24.1) in a uterine leiomyoma. Cancer Genet. Cytogenet., 115: 56-61, 1999.
5. Takahashi, T., Nagai, N., Oda, H., Ohama, K., Kamada, N., and Miyagawa, K. Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma. Genes Chromosomes Cancer, 30: 196-201, 2001.
6. Sornberger, K. S., Weremowicz, S., Williams, A. J., Quade, B. J., Ligon, A. H., Pedeutour, F., Vanni, R., and Morton, C. C. Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6. Cancer Genet. Cytogenet., 114: 9-16, 1999.
7. Schoenmakers, E. F. P. M., Wanschura, S., Mols, R., Bullerdiek, J., Van Den Berghe, H., and Van de Ven, W. J. M. Recurrent rearrangements in the high mobility group protein gene. HMGI-C, in benign mesenchymal tumours. Nat. Genet., 10: 436-444, 1995.
8. Schoenberg-Fejzo, M., Ashar, H. R., Krauter, K. S., Powell, W. L., Rein, M. S., Weremowicz, S., Yoon, S. J., Kucherlapati, R. S., Chada, K., and Morton, C. C. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosomes Cancer, 17: 1-6, 1996.
9. Doney, M. K., Gerken, S. C., Lynch, R., Bhugra, B., Hug, K., White, R., Weissenbach, J., and Menon, A. G. Precise mapping of t(12;14) leiomyoma breakpoint on chromosome 14 between D14S298 and D14S540. Cancer Lett., 96: 245-252, 1995.
10. Vandenberghe, A. E., Mecdel, T. H., and Hastings, K. E. mRNA 5′-leader trans-splicing in the chordates. Genes Dev., 15: 294-303, 2001.
11. Kazmierczak, B., Hennig, Y., Wanschura, S., Rogalla, P., Bartnitzke, S., Van de Ven, W. J. M., and Bullerdiek, J. Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res., 55: 6038-6039, 1995.
12. Kurose, K., Mine, N., Doi, D., Ota, Y., Yoneyama, K., Konishi, H., Araki, T., and Emi, M. Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma. Genes Chromosomes Cancer, 27: 303-307, 2000.
13. Kazmierczak, B., Pohnke, Y., and Bullerdiek, J. Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Genomics, 38: 223-226, 1996.
14. Mine, N., Kurose, K., Konishi, H., Araki, T., Nagai, H., and Emi, M. Fusion of a sequence from HEI1O (14q11) to the HMGIC gene at 12q15 in a uterine leiomyoma. Jpn. J. Cancer Res., 92: 135-139, 2001.
15. Klotzbucher, M., Wasserfall, A., and Fuhrmann, U. Misexpression of wild-type and truncated isoforms of the high-mobility group 1 proteins HMGI-C and HMGI(Y) in uterine leiomyomas. Am. J. Pathol., 155: 1535-1542, 1999.
16. Kurose, K., Mine, N., Iida, A., Nagai, H., Harada, H., Araki, T., and Emi, M. Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas. Genes Chromosomes Cancer, 30: 212-217, 2001.
17. Hauke, S., Rippe, V., and Bullerdiek, J. Chromosomal rearrangements leading to abnormal splicing within intron 4 of HMGIC? Genes Chromosomes Cancer, 30: 302-304, 2001.
18. Hauke, S., Flohr, A. M., Rogalla, P., and Bullerdiek, J. Sequencing of intron 3 of HMGA2 uncovers the existence of a novel exon. Genes Chromosomes Cancer, 34: 17-23, 2002.
19. Battista, S., Fidanza, V., Fedele, M., Klein-Szanto, A. J., Outwater, E., Brunner, H., Santoro, M., Croce, C. M., and Fusco, A. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res., 59: 4793-4797, 1999.
20. Croce, C. M., Thierfelder, W., Erikson, J., Nishikura, K., Finan, J., Lenoir, G. M., and Nowell, P. C. Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C λ locus in Burkitt. Proc. Natl. Acad. Sci. USA, 80: 6922-6926, 1983.
21. Kas, K., Voz, M. L., Roijer, E., Astrom, A. K., Meyen, E., Stenman, G., and Van de Ven, W. J. M. Promoter swapping between the genes for a novel zinc finger protein and β-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat. Genet., 15: 170-174, 1997.