-
1
-
-
75749122303
-
Methods in mammalian autophagy research
-
Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140:313-326.
-
(2010)
Cell
, vol.140
, pp. 313-326
-
-
Mizushima, N.1
Yoshimori, T.2
Levine, B.3
-
2
-
-
84893675756
-
Autophagy: A critical regulator of cellular metabolism and homeostasis
-
Ryter SW, Cloonan SM, Choi AMK. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cell 2013; 36:7-16.
-
(2013)
Mol Cell
, vol.36
, pp. 7-16
-
-
Ryter, S.W.1
Cloonan, S.M.2
Choi, A.M.K.3
-
3
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
5
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak Y, Bar-Peled L, Zoncu R, et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010; 141:290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
-
6
-
-
84866431363
-
Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1
-
Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. Cell 2012; 150:1196-1208.
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
8
-
-
84878357685
-
A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
-
Bar-Peled L, Chantranupong L, Cherniack AD, et al. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 2013; 340:1100-1106.
-
(2013)
Science
, vol.340
, pp. 1100-1106
-
-
Bar-Peled, L.1
Chantranupong, L.2
Cherniack, A.D.3
-
9
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han JM, Jeong SJ, Park MC, et al. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012; 149:410-424.
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
-
10
-
-
84873665112
-
Regulation of mTORC1 by the Rag && GTPases is necessary for neonatal autophagy and survival
-
Efeyan A, Zoncu R, Chang S, et al. Regulation of mTORC1 by the Rag && GTPases is necessary for neonatal autophagy and survival. Nature 2012; 493:679-683.
-
(2012)
Nature
, vol.493
, pp. 679-683
-
-
Efeyan, A.1
Zoncu, R.2
Chang, S.3
-
11
-
-
77951237303
-
The Beclin1 interactome
-
He C, Levine B. The Beclin1 interactome. Curr Opin CellBiol 2010; 22:140-149.
-
(2010)
Curr Opin CellBiol
, vol.22
, pp. 140-149
-
-
He, C.1
Levine, B.2
-
12
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe EL, Walker SA, Manifava M, et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182:685-701.
-
(2008)
J Cell Biol
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
Walker, S.A.2
Manifava, M.3
-
13
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of ULK1
-
Kim J, Kundu M, Viollet B, Guan K-L. AMPK and mTOR regulate autophagy through direct phosphorylation of ULK1. Nat Cell Biol 2011; 13:132-141.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.-L.4
-
14
-
-
84876488191
-
MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
-
Nazio F, Strappazzon F, Antonioli M, et al. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol 2013; 15:406-416.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 406-416
-
-
Nazio, F.1
Strappazzon, F.2
Antonioli, M.3
-
15
-
-
81855167585
-
DEPTOR, an mTOR Inhibitor, is a physiological substrate of SCF
-
Zhao Y, Xiong X, Sun Y. DEPTOR, an mTOR Inhibitor, is a physiological substrate of SCF. Mol Cell 2011; 44:304-316.
-
(2011)
Mol Cell
, vol.44
, pp. 304-316
-
-
Zhao, Y.1
Xiong, X.2
Sun, Y.3
-
16
-
-
81855181738
-
MTOR drives its own activation via SCF
-
Gao D, Inuzuka H, Tan M-KM, et al. mTOR drives its own activation via SCF. Mol Cell 2011; 44:290-303.
-
(2011)
Mol Cell
, vol.44
, pp. 290-303
-
-
Gao, D.1
Inuzuka, H.2
M-Km, T.3
-
17
-
-
84860172051
-
GSK3-TIP60-ULK1 signaling pathway links & growth factor deprivation to autophagy
-
Lin SY, Li TY, Liu Q, et al. GSK3-TIP60-ULK1 signaling pathway links & growth factor deprivation to autophagy. Science 2012; 336:477-481.
-
(2012)
Science
, vol.336
, pp. 477-481
-
-
Lin, S.Y.1
Li, T.Y.2
Liu, Q.3
-
18
-
-
84860203624
-
Function and molecular mechanism of acetylation in & autophagy regulation
-
Yi C, Ma M, Ran L, et al. Function and molecular mechanism of acetylation in & autophagy regulation. Science 2012; 336:474-477.
-
(2012)
Science
, vol.336
, pp. 474-477
-
-
Yi, C.1
Ma, M.2
Ran, L.3
-
19
-
-
65249106104
-
Regulation of autophagy by the p300 acetyltransferase
-
Lee IH, Finkel T. Regulation of autophagy by the p300 acetyltransferase. J Biol Chem 2008; 284:6322-6328.
-
(2008)
J Biol Chem
, vol.284
, pp. 6322-6328
-
-
Lee, I.H.1
Finkel, T.2
-
20
-
-
79951889242
-
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
-
Morselli E, Marino G, Bennetzen MV, et al. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol 2011; 192:615-629.
-
(2011)
J Cell Biol
, vol.192
, pp. 615-629
-
-
Morselli, E.1
Marino, G.2
Bennetzen, M.V.3
-
21
-
-
84880867651
-
The emerging role of acetylation in the regulation of autophagy
-
Bánréti A, Sass M, Graba Y. The emerging role of acetylation in the regulation of autophagy. Autophagy 2013; 9:819-829.
-
(2013)
Autophagy
, vol.9
, pp. 819-829
-
-
Bánréti, A.1
Sass, M.2
Graba, Y.3
-
23
-
-
84876296881
-
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
-
Sarraf SA, Raman M, Guarani-Pereira V, et al. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature 2013; 496:372-376.
-
(2013)
Nature
, vol.496
, pp. 372-376
-
-
Sarraf, S.A.1
Raman, M.2
Guarani-Pereira, V.3
-
24
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
Settembre C, Di Malta C, Polito VA, et al. TFEB links autophagy to lysosomal biogenesis. Science 2011; 332:1429-1433.
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
Di Malta, C.2
Polito, V.A.3
-
25
-
-
84878606239
-
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
-
Settembre C, De Cegli R, Mansueto G, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol 2013; 15:647-658.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 647-658
-
-
Settembre, C.1
De Cegli, R.2
Mansueto, G.3
-
26
-
-
84877601173
-
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
-
Spampanato C, Feeney E, Li L, et al. Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol Med 2013; 5:691-706.
-
(2013)
EMBO Mol Med
, vol.5
, pp. 691-706
-
-
Spampanato, C.1
Feeney, E.2
Li, L.3
-
27
-
-
84876090708
-
ZKSCAN3 is a master transcrip-tional repressor of atophagy
-
Chauhan S, Goodwin JG, Chauhan S, et al. ZKSCAN3 is a master transcrip-tional repressor of atophagy. Mol Cell 2013; 50:16-28.
-
(2013)
Mol Cell
, vol.50
, pp. 16-28
-
-
Chauhan, S.1
Goodwin, J.G.2
Chauhan, S.3
-
28
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147:728-741.
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
29
-
-
56249090667
-
Loss of the autophagy protein ATG16L1 enhances endotoxin-induced IL-1b production
-
Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein ATG16L1 enhances endotoxin-induced IL-1b production. Nature 2008; 456:264-268.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
-
30
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
DOI 10.1038/nature03029
-
Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032-1036. (Pubitemid 40052234)
-
(2004)
Nature
, vol.432
, Issue.7020
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
31
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
DOI 10.1083/jcb.200412022
-
Komatsu M. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169:425-434. (Pubitemid 40686693)
-
(2005)
Journal of Cell Biology
, vol.169
, Issue.3
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
-
32
-
-
84862994618
-
MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
-
Yilmaz OH, Katajisto P, Lamming DW, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 2012;486:490-495.
-
(2012)
Nature
, vol.486
, pp. 490-495
-
-
Yilmaz, O.H.1
Katajisto, P.2
Lamming, D.W.3
-
33
-
-
84857844643
-
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
-
Velikkakath AKG, Nishimura T, Oita E, et al. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Mol Biol Cell 2012; 23:896-909.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 896-909
-
-
Velikkakath, A.K.G.1
Nishimura, T.2
Oita, E.3
-
34
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature 2009; 458:1131-1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
-
35
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang L, Li P, Fu S, et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010; 11:467-478.
-
(2010)
Cell Metab
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
-
36
-
-
52749093177
-
Autophagy is important in islet home-ostasis and compensatory increase of beta cell mass in response to high-fat diet
-
Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet home-ostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 2008; 8:325-332.
-
(2008)
Cell Metab
, vol.8
, pp. 325-332
-
-
Ebato, C.1
Uchida, T.2
Arakawa, M.3
-
37
-
-
67349150186
-
Autophagy in human type 2 diabetes pancreatic beta cells
-
Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 2009; 52:1083-1086.
-
(2009)
Diabetologia
, vol.52
, pp. 1083-1086
-
-
Masini, M.1
Bugliani, M.2
Lupi, R.3
-
38
-
-
84876789628
-
Loss of acinar cell IKKa triggers spontaneous pancreatitis in mice
-
Li N, Wu X, Holzer RG, et al. Loss of acinar cell IKKa triggers spontaneous pancreatitis in mice. J Clin Invest 2013; 123:2231-2243.
-
(2013)
J Clin Invest
, vol.123
, pp. 2231-2243
-
-
Li, N.1
Wu, X.2
Holzer, R.G.3
-
39
-
-
84872057896
-
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
-
Kim KH, Jeong YT, Oh H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 2012; 19:83-92.
-
(2012)
Nat Med
, vol.19
, pp. 83-92
-
-
Kim, K.H.1
Jeong, Y.T.2
Oh, H.3
-
40
-
-
84863393597
-
Exercise-induced BCL2-regulated autop-hagy is required for muscle glucose homeostasis
-
He C, Bassik MC, Moresi V, et al. Exercise-induced BCL2-regulated autop-hagy is required for muscle glucose homeostasis. Nature 2012; 481:511-515.
-
(2012)
Nature
, vol.481
, pp. 511-515
-
-
He, C.1
Bassik, M.C.2
Moresi, V.3
-
41
-
-
84871005673
-
The pathways of mitophagy for quality control and clearance of mitochondria
-
Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2012; 20:31-42.
-
(2012)
Cell Death Differ
, vol.20
, pp. 31-42
-
-
Ashrafi, G.1
Schwarz, T.L.2
-
42
-
-
84861212393
-
Mitochondria and cell signalling
-
Tait SWGS, Green DRD. Mitochondria and cell signalling. J Cell Sci 2012; 125:807-815.
-
(2012)
J Cell Sci
, vol.125
, pp. 807-815
-
-
Tait, S.W.G.S.1
Green, D.R.D.2
-
43
-
-
84857032953
-
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin
-
Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012; 22:320-333.
-
(2012)
Dev Cell
, vol.22
, pp. 320-333
-
-
Lazarou, M.1
Jin, S.M.2
Kane, L.A.3
Youle, R.J.4
-
44
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler S, Holmström KM, Skujat D, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12:119-131.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmström, K.M.2
Skujat, D.3
-
45
-
-
82555187810
-
Image-based genome-wide siRNA screen identifies selective autophagy factors
-
Orvedahl A, Sumpter R Jr, Xiao G, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011; 480: 113-117.
-
(2011)
Nature
, vol.480
, pp. 113-117
-
-
Orvedahl, A.1
Sumpter, Jr.R.2
Xiao, G.3
-
46
-
-
84876341593
-
A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy
-
Barde I, Rauwel B, Marin-Florez RM, et al. A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy. Science 2013; 340:350-353.
-
(2013)
Science
, vol.340
, pp. 350-353
-
-
Barde, I.1
Rauwel, B.2
Marin-Florez, R.M.3
-
47
-
-
84877578621
-
Rheb regulates mitophagy induced by mitochondrial energetic status
-
Melser S, Chatelain EH, Lavie J, et al. Rheb regulates mitophagy induced by mitochondrial energetic status. Cell Metab 2013; 17:719-730.
-
(2013)
Cell Metab
, vol.17
, pp. 719-730
-
-
Melser, S.1
Chatelain, E.H.2
Lavie, J.3
-
48
-
-
84862789618
-
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
-
Liu L, Feng D, Chen G, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012; 14:177-185.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 177-185
-
-
Liu, L.1
Feng, D.2
Chen, G.3
-
50
-
-
84859736977
-
Aggrephagy: Selective disposal of protein aggregates by macroautophagy
-
Lamark T, Johansen T. Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol 2012; 2012:1-21.
-
(2012)
Int J Cell Biol
, vol.2012
, pp. 1-21
-
-
Lamark, T.1
Johansen, T.2
-
52
-
-
84871006349
-
The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella typhimurium
-
Huett A, Heath RJ, Begun J, et al. The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella typhimurium. Cell Host Microbe 2012; 12:778-790.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 778-790
-
-
Huett, A.1
Heath, R.J.2
Begun, J.3
-
53
-
-
74049126112
-
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway
-
Zheng YT, Shahnazari S, Brech A, et al. The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol 2009; 183:5909-5916.
-
(2009)
J Immunol
, vol.183
, pp. 5909-5916
-
-
Zheng, Y.T.1
Shahnazari, S.2
Brech, A.3
-
54
-
-
70350450808
-
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
-
Thurston TLM, Ryzhakov G, Bloor S, et al. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 2009; 10:1215-1221.
-
(2009)
Nat Immunol
, vol.10
, pp. 1215-1221
-
-
Thurston, T.L.M.1
Ryzhakov, G.2
Bloor, S.3
-
55
-
-
84857071710
-
Galectin8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
-
Thurston TLM, Wandel MP, von Muhlinen N, et al. Galectin8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 2012; 482:414-418.
-
(2012)
Nature
, vol.482
, pp. 414-418
-
-
Thurston, T.L.M.1
Wandel, M.P.2
Von Muhlinen, N.3
-
56
-
-
84862301902
-
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program
-
Tattoli I, Sorbara MT, Vuckovic D, et al. Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe 2012; 11:563-575.
-
(2012)
Cell Host Microbe
, vol.11
, pp. 563-575
-
-
Tattoli, I.1
Sorbara, M.T.2
Vuckovic, D.3
-
58
-
-
84870999066
-
Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically sup pressed in cancer stem-like cells
-
Tsugawa H, Suzuki H, Saya H, et al. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically sup pressed in cancer stem-like cells. Cell Host Microbe 2012; 12:764-777.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 764-777
-
-
Tsugawa, H.1
Suzuki, H.2
Saya, H.3
-
59
-
-
65249135604
-
Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells
-
Terebiznik MR, Raju D, Vazquez CL, et al. Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy 2009; 5:370-379.
-
(2009)
Autophagy
, vol.5
, pp. 370-379
-
-
Terebiznik, M.R.1
Raju, D.2
Vazquez, C.L.3
-
60
-
-
84866130509
-
Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA
-
Yahiro K, Satoh M, Nakano M, et al. Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA. J Biol Chem 2012; 287:31104-31115.
-
(2012)
J Biol Chem
, vol.287
, pp. 31104-31115
-
-
Yahiro, K.1
Satoh, M.2
Nakano, M.3
-
61
-
-
84860223287
-
Vacuolating cytotoxin and variants in ATG16L1 that disrupt autophagy promote Helicobacter pylori infection in humans
-
Raju D, Hussey S, Ang M, et al. Vacuolating cytotoxin and variants in ATG16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology 2012; 142:1160-1171.
-
(2012)
Gastroenterology
, vol.142
, pp. 1160-1171
-
-
Raju, D.1
Hussey, S.2
Ang, M.3
-
62
-
-
79959216005
-
Genetics and pathogenesis of inflammatory bowel disease
-
Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature 2011; 474:307-317.
-
(2011)
Nature
, vol.474
, pp. 307-317
-
-
Khor, B.1
Gardet, A.2
Xavier, R.J.3
-
63
-
-
70349627027
-
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
-
Hetz C, Thielen P, Matus S, et al. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev 2009; 23:2294-2306.
-
(2009)
Genes Dev
, vol.23
, pp. 2294-2306
-
-
Hetz, C.1
Thielen, P.2
Matus, S.3
-
64
-
-
84865466615
-
Puglielli L SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway
-
Pehar M, Jonas MC, Hare TM, Puglielli L SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway. J Biol Chem 2012; 287:29921-29930.
-
(2012)
J Biol Chem
, vol.287
, pp. 29921-29930
-
-
Pehar, M.1
Jonas, M.C.2
Hare, T.M.3
-
65
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee A-H, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008; 134:743-756.
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.-H.2
Franke, A.3
-
66
-
-
56249135538
-
A key role for autophagy and the autophagy gene ATG16L1 in mouse and human intestinal Paneth cells
-
Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene ATG16L1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-263.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
-
67
-
-
77953904042
-
Virus-plus-susceptibility gene interaction determines Crohn's disease gene ATG16L1 phenotypes in intestine
-
Cadwell K, Patel KK, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene ATG16L1 phenotypes in intestine. Cell 2010; 141:1135-1145.
-
(2010)
Cell
, vol.141
, pp. 1135-1145
-
-
Cadwell, K.1
Patel, K.K.2
Maloney, N.S.3
-
68
-
-
84861434652
-
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
-
McAfee QQ, Zhang ZZ, Samanta AA, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci USA 2012; 109:8253-8258.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 8253-8258
-
-
McAfee, Q.Q.1
Zhang, Z.Z.2
Samanta, A.A.3
-
69
-
-
77649194674
-
Crohn's disease-associated adherent-invasive E. Coli are selectively favoured by impaired autophagy to replicate intracellularly
-
Lapaquette P, Glasser A-L, Huett A, et al. Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 2010; 12:99-113.
-
(2010)
Cell Microbiol
, vol.12
, pp. 99-113
-
-
Lapaquette, P.1
Glasser, A.-L.2
Huett, A.3
-
70
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2009; 16:90-97.
-
(2009)
Nat Med
, vol.16
, pp. 90-97
-
-
Cooney, R.1
Baker, J.2
Brain, O.3
-
71
-
-
80051550866
-
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
-
Plantinga TS, Crisan TO, Oosting M, et al. Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 2011; 60:1229-1235.
-
(2011)
Gut
, vol.60
, pp. 1229-1235
-
-
Plantinga, T.S.1
Crisan, T.O.2
Oosting, M.3
-
72
-
-
84860136921
-
Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease
-
Thachil E, Hugot J-P, Arbeille B, et al. Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology 2012; 142:1097.e4-1099.e4.
-
(2012)
Gastroenterology
, vol.142
-
-
Thachil, E.1
Hugot, J.-P.2
Arbeille, B.3
-
73
-
-
54849421128
-
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
-
Kuballa P, Huett A, Rioux JD, et al. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One 2008; 3:e3391.
-
(2008)
PLoS One
, vol.3
-
-
Kuballa, P.1
Huett, A.2
Rioux, J.D.3
-
74
-
-
84875214777
-
TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3
-
Boada-Romero E, Letek M, Fleischer A, et al. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. EMBO J 2013; 32:566-582.
-
(2013)
EMBO J
, vol.32
, pp. 566-582
-
-
Boada-Romero, E.1
Letek, M.2
Fleischer, A.3
-
75
-
-
84891746717
-
Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in pa tients with Crohn's disease
-
doi: 10.1136/gutjnl-2012-303557. [Epub ahead of print]
-
Gutierrez A, Scharl M, Sempere L, et al. Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in pa tients with Crohn's disease. Gut 2013; doi: 10.1136/gutjnl-2012-303557. [Epub ahead of print]
-
(2013)
Gut
-
-
Gutierrez, A.1
Scharl, M.2
Sempere, L.3
-
76
-
-
84879107779
-
Intestinal epithelial autophagy is essential for host defense against invasive bacteria
-
Benjamin JL, Sumpter R Jr, Levine B, Hooper LV. Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe 2013; 13:723-734.
-
(2013)
Cell Host Microbe
, vol.13
, pp. 723-734
-
-
Benjamin, J.L.1
Sumpter, Jr.R.2
Levine, B.3
Hooper, L.V.4
-
77
-
-
50649125243
-
A multicenter, randomized, double blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease
-
Reinisch W, Panés J, Lemann M, et al. A multicenter, randomized, double blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease. Am J Gastroenterol 2008; 103:2284-2292.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 2284-2292
-
-
Reinisch, W.1
Panés, J.2
Lemann, M.3
|