Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells

Biochemical Journal

Volumn 432, Issue 2, 2010, Pages 375-386

  Aoyagi, Kyota ^a   Ohara Imaizumi, Mica ^a   Nishiwaki, Chiyono ^a   Nakamichi, Yoko ^a   Nagamatsu, Shinya ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium influx; Exocytosis; Insulin; Pancreatic cell; Total internal reflection fluorescent (TIRF) microscopy; Transient receptor potential V2 (TrpV2) channel

Indexed keywords

3-KINASE PATHWAYS; BI-PHASIC; CALCIUM INFLUX; EXOCYTOSIS; FLUORESCENT MICROSCOPY; HAIRPIN RNA; INSULIN RECEPTORS; INSULIN SECRETION; INSULIN TREATMENT; INTRACELLULAR CA; MIN6 CELLS; PHASE RESPONSE; PHOSPHOINOSITIDE 3-KINASE; PLASMA MEMBRANES; PRE-TREATMENT; RAPID DEVELOPMENT; SECOND-PHASE; TOTAL INTERNAL REFLECTIONS; TRANSIENT RECEPTOR POTENTIAL V2 (TRPV2) CHANNEL; TRANSIENT RECEPTOR POTENTIALS;

CALCIUM; CELL MEMBRANES; CYTOLOGY; FLUORESCENCE; GLUCOSE; REFRACTIVE INDEX; RNA;

INSULIN;

BIPHASIC INSULIN; CALCIUM ION; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; SHORT HAIRPIN RNA; TRANILAST; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2 V2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHANNEL GATING; ENZYME ACTIVATION; ENZYME INHIBITION; EXOCYTOSIS; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CALCIUM CHANNELS; CELL LINE; DNA; DNA, COMPLEMENTARY; EXOCYTOSIS; GROWTH HORMONE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PHOSPHATIDYLINOSITOL 3-KINASES; TRANSFECTION; TRPV CATION CHANNELS;

EID: 78649536834     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100864     Document Type: Article

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