Following evolution's lead to a single residue switch for diterpene synthase product outcome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 18, 2007, Pages 7387-7401

  Xu, Meimei ^a   Wilderman, P Ross ^a   Peters, Reuben J ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Biochemical evolution; Enzyme specificity; Natural product biosynthesis; Terpene synthase

Indexed keywords

AMINO ACID; GIBBERELLIN; ISOLEUCINE; KAURENE DERIVATIVE; NATURAL PRODUCT; PHYTOHORMONE; PIMARADIENE; RECOMBINANT PROTEIN; SYNTHETASE; TERPENE; TERPENE SYNTHASE; THREONINE; UNCLASSIFIED DRUG; DITERPENE; TRANSFERASE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ESCHERICHIA COLI; EVOLUTION; GENE EXPRESSION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PURIFICATION; CHEMISTRY; CYCLIZATION; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; RICE;

EMBRYOPHYTA;

ALKYL AND ARYL TRANSFERASES; AMINO ACIDS; CYCLIZATION; DITERPENES; EVOLUTION, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; ORYZA SATIVA;

EID: 34250688380     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0611454104     Document Type: Article

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